DArcy Thompson Unit

Research Output 1987 2020

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1987
156 Citations (Scopus)

Modulation of GABAA receptor activity by alphaxalone

Cottrell, G. A., Lambert, J. J. & Peters, J. A., Mar 1987, In : British Journal of Pharmacology. 90, 3, p. 491-500 10 p.

Research output: Contribution to journalArticle

GABA-A Receptors
gamma-Aminobutyric Acid
Membranes
Acetylcholine
Chromaffin Cells
1988
15 Citations (Scopus)

Immunogenic and Antigenic Epitopes of Immunoglobulins Binding of Human Monoclonal Anti‐D Antibodies to FcRI on the Monocyte‐Like U937 Cell Line

Walker, M. R., Kumpel, B. M., Thompson, K., Woof, J. M., Burton, D. R. & Jefferis, R., Nov 1988, In : Vox Sanguinis. 55, 4, p. 222-228 7 p.

Research output: Contribution to journalArticle

U937 Cells
Rosette Formation
Immunoglobulins
Epitopes
Immunoglobulin G
252 Citations (Scopus)

Modulation of the GABAA receptor by depressant barbiturates and pregnane steroids

Peters, J. A., Kirkness, E. F., Callachan, H., Lambert, J. J. & Turner, A. J., Aug 1988, In : British Journal of Pharmacology. 94, 4, p. 1257-1269 13 p.

Research output: Contribution to journalArticle

Pregnanes
Muscimol
Barbiturates
GABA-A Receptors
Steroids
1989
38 Citations (Scopus)
Chromaffin Cells
GABA-A Receptors
gamma-Aminobutyric Acid
Action Potentials
Acetylcholine
78 Citations (Scopus)

Electrophysiology of 5-HT3 receptors in neuronal cell lines

Peters, J. A. & Lambert, J. J., May 1989, In : Trends in Pharmacological Sciences. 10, 5, p. 172-175 4 p.

Research output: Contribution to journalArticle

Electrophysiology
Receptors, Serotonin, 5-HT3
Serotonin
Cells
Serotonin 5-HT3 Receptor Antagonists
24 Citations (Scopus)

Interaction of human IgG chimeric antibodies with the human FcRI and FcRII receptors: Requirements for antibody-mediated host cell-target cell interaction

Walker, M. R., Woof, J. M., Brüggemann, M., Jefferis, R. & Burton, D. R., Apr 1989, In : Molecular Immunology. 26, 4, p. 403-411 9 p.

Research output: Contribution to journalArticle

Cell Communication
Immunoglobulin G
Antibodies
Erythrocytes
U937 Cells
78 Citations (Scopus)
Molecular Mechanisms of Pharmacological Action
Chromaffin Cells
Anticonvulsants
Cell Culture Techniques
Neuroblastoma
105 Citations (Scopus)

The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques

Lambert, J. J., Peters, J. A., Hales, T. G. & Dempster, J., May 1989, In : British Journal of Pharmacology. 97, 1, p. 27-40 14 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Patch-Clamp Techniques
Serotonin
Cell Line
Ondansetron
1990
2 Citations (Scopus)

5-Hydroxytryptamine3 receptor mediated responses on adult rabbit nodose ganglion neurones in cell culture

Peters, J. A., Malone, H. M. & Lambert, J. J., 1 Jan 1990, In : European Journal of Pharmacology. 183, 3, p. 1112 1 p.

Research output: Contribution to journalArticle

1991
137 Citations (Scopus)

Human Fc gamma RI and Fc gamma RII interact with distinct but overlapping sites on human IgG

Lund, J., Winter, G., Jones, P. T., Pound, J. D., Tanaka, T., Walker, M. R., Artymiuk, P. J., Arata, Y., Burton, D. R., Jefferis, R. & Woof, J. M., 15 Oct 1991, In : Journal of Immunology. 147, 8, p. 2657-2662 6 p.

Research output: Contribution to journalArticle

IgG Receptors
Immunoglobulin G
Mutation
Superoxides
Antibodies
26 Citations (Scopus)

Ketamine potentiates 5‐HT3 receptor‐mediated currents in rabbit nodose ganglion neurones

Peters, J. A., Malone, H. M. & Lambert, J. J., Jul 1991, In : British Journal of Pharmacology. 103, 3, p. 1623-1625 3 p.

Research output: Contribution to journalArticle

Nodose Ganglion
Ketamine
Rabbits
Neurons
37 Citations (Scopus)

Physiological and pharmacological properties of 5-HT3 receptors - A patch clamp-study

Malone, H. M., Peters, J. A. & Lambert, J. J., Jul 1991, In : Neuropeptides. 19, Supplement, p. 25-30 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Nodose Ganglion
Pharmacology
Serotonin
Rabbits
1992
47 Citations (Scopus)

A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin cells in culture.

Nooney, J. M., Peters, J. A. & Lambert, J. J., 1 Sep 1992, In : The Journal of Physiology. 455, 1, p. 503-527 25 p.

Research output: Contribution to journalArticle

Hexamethonium
Chromaffin Cells
Nicotinic Receptors
Trimethaphan
Mecamylamine
27 Citations (Scopus)

Association between rDNA alleles and quantitative traits in doubled haploid populations of barley

Powell, W., Thomas, W. T. B., Thompson, D. M., Swanston, J. S. & Waugh, R., 1 Jan 1992, In : Genetics. 130, 1, p. 187-194 8 p.

Research output: Contribution to journalArticle

Haploidy
Hordeum
Ribosomal DNA
Alleles
Population
211 Citations (Scopus)

Human Antibody Effector Function

Burton, D. R. & Woof, J. M., 1992, In : Advances in Immunology. 51, p. 1-84 84 p.

Research output: Contribution to journalArticle

Immunoglobulin Fab Fragments
Antibodies
Immunoglobulin G
Antigens
Complement Membrane Attack Complex
1 Citation (Scopus)

The interaction of steroids with inhibitory and excitatory amino acid receptors

Hill-Venning, C., Peters, J. A. & Lambert, J. J., 1992, In : Clinical Neuropharmacology. 15, Suppl. 1 Part A, p. 683A-684A 2 p.

Research output: Contribution to journalArticle

1993
48 Citations (Scopus)
Nodose Ganglion
Inhibitory Concentration 50
Rabbits
Neurons
Baths
72 Citations (Scopus)

Anoxia-tolerant hepatocytes: Model system for study of reversible metabolic suppression

Buck, L. T., Land, S. C. & Hochachka, P. W., 1 Jul 1993, In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 265, 1 , p. R49-R56 8 p.

Research output: Contribution to journalArticle

Hepatocytes
Adenosine Triphosphate
Trypan Blue
Lactic Acid
Staining and Labeling
138 Citations (Scopus)

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

Hope, A. G., Downie, D. L., Sutherland, L. A., Lambert, J. J., Peters, J. A. & Burchell, B., 15 Apr 1993, In : European Journal of Pharmacology: Molecular Pharmacology. 245, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Organism Cloning
Clone Cells
Hybridomas
Alternative Splicing
97 Citations (Scopus)

Genetic differentiation of cocoa (Theobrotna cacao L.) populations revealed by RAPD analysis

Russell, J. R., Hosein, F., Johnson, E., Waugh, R. & Powell, W., Apr 1993, In : Molecular Ecology. 2, 2, p. 89-97 9 p.

Research output: Contribution to journalArticle

cocoa
Cacao
genetic differentiation
assay
Polymerase Chain Reaction
100 Citations (Scopus)

Identification of RAPD markers linked to a rhynchosporium seca/is resistance locus in barley using near-isogenic lines and bulked segregant analysis

Barua, U. M., Chalmers, K. J., Hackett, C. A., Thomas, W. T. B., Powell, W. & Waugh, R., 1 Jan 1993, In : Heredity. 71, 2, p. 177-184 8 p.

Research output: Contribution to journalArticle

Haploidy
Hordeum
Chromosomes
Chromosomes, Human, Pair 3
DNA
77 Citations (Scopus)

Molecular mapping of genes determining height, time to heading, and growth habit in barley (Hordeum vulgare)

Barua, U. M., Chalmers, K. J., Thomas, W. T. B., Hackett, C. A., Lea, V., Jack, P., Forster, B. P., Waugh, R. & Powell, W., 1 Jan 1993, In : Genome. 36, 6, p. 1080-1087 8 p.

Research output: Contribution to journalArticle

Chromosome Mapping
growth habit
Hordeum
heading
Hordeum vulgare
66 Citations (Scopus)

Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and Chinese hamster ovary cells

Morton, H. C., Atkin, J. D., Owens, R. J. & Woof, J. M., 1993, In : Journal of Immunology. 151, 9, p. 4743-4752 10 p.

Research output: Contribution to journalArticle

Cricetulus
Immunoglobulin A
Ovary
IgA-specific serine endopeptidase
Antibodies
110 Citations (Scopus)

Response of protein synthesis to anoxia and recovery in anoxia-tolerant hepatocytes

Land, S. C., Buck, L. T. & Hochachka, P. W., 1 Jul 1993, In : American Journal of Physiology: Regulatory Integrative and Comparative Physiology. 265, 1 , p. R41-R48 8 p.

Research output: Contribution to journalArticle

Hepatocytes
Adenosine Triphosphate
Proteins
Cycloheximide
Guanosine Triphosphate
1994
64 Citations (Scopus)

Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor

Chen, R., Belelli, D., Lambert, J. J., Peters, J. A., Reyes, A. & Lan, N. C., 21 Jun 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 13, p. 6069-6073 5 p.

Research output: Contribution to journalArticle

GABA Receptors
gamma-Aminobutyric Acid
Drosophila
Organism Cloning
GABA-A Receptors
44 Citations (Scopus)

Pharmacological characterization of the apparent splice variants of the murine 5-HT3 R-A subunit expressed in Xenopus laevis oocytes

Downie, D. L., Hope, A. G., Lambert, J. J., Peters, J. A., Blackburn, T. P. & Jones, B. J., Mar 1994, In : Neuropharmacology. 33, 3-4, p. 473-482 10 p.

Research output: Contribution to journalArticle

Xenopus laevis
Oocytes
Serotonin
Pharmacology
Granisetron
56 Citations (Scopus)

Protein turnover during metabolic arrest in turtle hepatocytes: role and energy dependence of proteolysis

Land, S. C. & Hochachka, P. W., 1 Apr 1994, In : American Journal of Physiology: Cell Physiology. 266, 4 , p. C1028-C1036 9 p.

Research output: Contribution to journalArticle

Proteolysis
Turtles
Hepatocytes
Adenosine Triphosphate
Proteins
1995
40 Citations (Scopus)
Hemeproteins
Turtles
Hepatocytes
Oxygen
Proteins
75 Citations (Scopus)
HEK293 Cells
Inhibitory Concentration 50
Zinc
Pharmacology
Methysergide
140 Citations (Scopus)

Detection of quantitative trait loci for agronomic, yield, grain and disease characters in spring barley (Hordeum vulgare L.)

Thomas, W. T. B., Powell, W., Waugh, R., Chalmers, K. J., Barua, U. M., Jack, P., Lea, V., Forster, B. P., Swanston, J. S., Ellis, R. P., Hanson, P. R. & Lance, R. C. M., 1 Nov 1995, In : Theoretical and Applied Genetics. 91, 6-7, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

Quantitative Trait Loci
spring barley
Hordeum
Hordeum vulgare
quantitative trait loci
25 Citations (Scopus)

Evidence that the atypical 5‐HT3 receptor ligand, [3H]‐BRL46470, labels additional 5‐HT3 binding sites compared to [3H]‐granisetron

Steward, L. J., Ge, J., Bentley, K. R., Barber, P. C., Hope, A. G., Lambert, J. J., Peters, J. A., Blackburn, T. P. & Barnes, N. M., Sep 1995, In : British Journal of Pharmacology. 116, 2, p. 1781-1788 8 p.

Research output: Contribution to journalArticle

Granisetron
Binding Sites
Ligands
Ileum
Hippocampus
59 Citations (Scopus)

Human neutrophil Fc receptor-mediated adhesion under flow: A hollow fibre model of intravascular arrest

D'Arrigo, C., Candal-Couto, J. J., Greer, M., Veale, D. J. & Woof, J. M., Apr 1995, In : Clinical and Experimental Immunology. 100, 1, p. 173-179 7 p.

Research output: Contribution to journalArticle

Fc Receptors
Neutrophils
Immunoglobulin G
Hot Temperature
L Cells (Cell Line)
3 Citations (Scopus)
45 Citations (Scopus)

The interaction of trichloroethanol with murine recombinant 5‐HT3 receptors

Downie, D. L., Hope, A. G., Belelli, D., Lambert, J. J., Peters, J. A., Bentley, K. R., Steward, L. J., Chen, CY. & Barnes, N. M., Apr 1995, In : British Journal of Pharmacology. 114, 8, p. 1641-1651 11 p.

Research output: Contribution to journalArticle

Granisetron
Oocytes
Quipazine
Chloral Hydrate
Ondansetron
1996
37 Citations (Scopus)

Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils

Pleass, R. J., Andrews, P. D., Kerr, M. A. & Woof, J. M., 15 Sep 1996, In : Biochemical Journal. 318, 3, p. 771-777 7 p.

Research output: Contribution to journalArticle

Fc Receptors
Alternative Splicing
Eosinophils
Immunoglobulin A
Neutrophils
43 Citations (Scopus)

Characterization of a human 5‐hydroxytryptamine3 receptor type A (h5‐HT3R‐AS) subunit stably expressed in HEK 293 cells

Hope, A. G., Peters, J. A., Brown, A. M., Lambert, J. J. & Blackburn, T. P., Jul 1996, In : British Journal of Pharmacology. 118, 5, p. 1237-1245 9 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
HEK293 Cells
Granisetron
Serotonin
Pharmacology
69 Citations (Scopus)

Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes

Belelli, D., Callachan, H., Hill-Venning, C., Peters, J. A. & Lambert, J. J., Jun 1996, In : British Journal of Pharmacology. 118, 3, p. 563-576 14 p.

Research output: Contribution to journalArticle

Xenopus laevis
gamma-Aminobutyric Acid
Oocytes
Invertebrates
Pentobarbital
35 Citations (Scopus)

Modulation of human recombinant GABA(A) receptors by pregnanediols

Belelli, D., Lambert, J. J., Peters, J. A., Gee, K. W. & Lan, N. C., 1996, In : Neuropharmacology. 35, 9-10, p. 1223-1231 9 p.

Research output: Contribution to journalArticle

Pregnanediol
GABA-A Receptors
Steroids
gamma-Aminobutyric Acid
Neurotransmitter Agents
58 Citations (Scopus)

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

Atkin, J. D., Pleass, R. J., Owens, R. J. & Woof, J. M., 1 Jul 1996, In : Journal of Immunology. 157, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

Mutagenesis
Immunoglobulin A
Protein Engineering
Terminator Codon
Dimerization
73 Citations (Scopus)

Quantitative trait loci for germination and malting quality characters in a spring barley cross

Thomas, W. T. B., Powell, W., Swanston, J. S., Ellis, R. P., Chalmers, K. J., Barua, U. M., Jack, P., Lea, V., Forster, B. P., Waugh, R. & Smith, D. B., 1 Mar 1996, In : Crop Science. 36, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

malting quality
spring barley
quantitative trait loci
germination
chromosomes
33 Citations (Scopus)

The anaesthetic action and modulation of GABA(A) receptor activity by the novel water-soluble aminosteroid Org 20599

Hill-Venning, C., Peters, J. A., Callachan, H., Lambert, J. J., Gemmell, D. K., Anderson, A., Byford, A., Hamilton, N., Hill, D. R., Marshall, R. J. & Campbell, A. C., 1996, In : Neuropharmacology. 35, 9-10, p. 1209-1222 14 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Anesthetics
Water
Intravenous Anesthetics
Thiopental
758 Citations (Scopus)

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack

Hochachka, P. W., Buck, L. T., Doll, C. J. & Land, S. C., 3 Sep 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 18, p. 9493-9498 6 p.

Research output: Contribution to journalArticle

Oxygen
Adenosine Triphosphate
Hepatocytes
Hemeproteins
Hypoxia
1997
103 Citations (Scopus)

Analysis of quantitative traits in barley by the use of amplified fragment length polymorphisms

Powell, W., Thomas, W. T. B., Baird, E., Lawrence, P., Booth, A., Harrower, B., McNicol, J. W. & Waugh, R., 1 Jul 1997, In : Heredity. 79, 1, p. 48-59 12 p.

Research output: Contribution to journalArticle

Hordeum
Genome
Enzymes
Restriction Fragment Length Polymorphisms
Chromosomes, Human, Pair 5
55 Citations (Scopus)

Anesthetic activity of novel water-soluble 2β-morpholinyl steroids and their modulatory effects at GABA(A) receptors

Anderson, A., Boyd, A. C., Byford, A., Campbell, A. C., Gemmell, D. K., Hamilton, N. M., Hill, D. R., Hill-Venning, C., Lambert, J. J., Maidment, M. S., May, V., Marshall, R. J., Peters, J. A., Rees, D. C., Stevenson, D. & Sundaram, H., 23 May 1997, In : Journal of Medicinal Chemistry. 40, 11, p. 1668-1681 14 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Anesthetics
Steroids
Water
Pregnanolone
5 Citations (Scopus)

Consumption of Oxygen by Isolated Skate Retinal Photoreceptors

Malchow, R. P., Land, S. C., Patel, L. S. & Smith, P. J. S., Oct 1997, In : Biological Bulletin. 193, 2, p. 231-232 2 p.

Research output: Contribution to journalArticle

422 Citations (Scopus)

Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs

Russell, J. R., Fuller, J. D., Macaulay, M., Hatz, B. G., Jahoor, A., Powell, W. & Waugh, R., Sep 1997, In : Theoretical and Applied Genetics. 95, 4, p. 714-722 9 p.

Research output: Contribution to journalArticle

Hordeum
Restriction Fragment Length Polymorphisms
amplified fragment length polymorphism
restriction fragment length polymorphism
barley
134 Citations (Scopus)

Discriminating between barley genotypes using microsatellite markers

Russell, J., Fuller, J., Young, G., Thomas, B., Macaulay, M., Waugh, R., Powell, W. & Taramino, G., Aug 1997, In : Genome. 40, 4, p. 442-450 9 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
Pedigree
barley
Genotype
369 Citations (Scopus)

Genetic distribution of Bare-1-like retrotransposable elements in the barley genome revealed by sequence-specific amplification polymorphisms (S-SAP)

Waugh, R., McLean, K., Flavell, A. J., Pearce, S. R., Kumar, A., Thomas, B. B. T. & Powell, W., Feb 1997, In : Molecular and General Genetics. 253, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Hordeum
Retroelements
Genome
Terminal Repeat Sequences
Plant Genome
149 Citations (Scopus)

Homology of AFLP products in three mapping populations of barley

Waugh, R., Bonar, N., Baird, E., Thomas, B., Graner, A., Hayes, P. & Powell, W., Jul 1997, In : Molecular and General Genetics. 255, 3, p. 311-321 11 p.

Research output: Contribution to journalArticle

Hordeum
Population
Genetic Linkage
Genetic Loci
Haploidy
56 Citations (Scopus)

Locating genotypes and genes for abiotic stress tolerance in barley: a strategy using maps, markers and the wild species

Forster, B. P., Russell, J. R., Ellis, R. P., Handley, L. L., Robinson, D., Hackett, C. A., Nevo, E., Waugh, R., Gordon, D. C., Keith, R. & Powell, W., Sep 1997, In : New Phytologist. 137, 1, p. 141-147 7 p.

Research output: Contribution to journalArticle

Hordeum
stress tolerance
abiotic stress
barley
Genotype