DArcy Thompson Unit

Research Output

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Article
2003

ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins

Puntervoll, P., Linding, R., Gemünd, C., Chabanis-Davidson, S., Mattingsdal, M., Cameron, S., Martin, D. M. A., Ausiello, G., Brannetti, B., Costantini, A., Ferrè, F., Maselli, V., Via, A., Cesareni, G., Diella, F., Superti-Furga, G., Wyrwicz, L., Ramu, C., McGuigan, C., Gudavalli, R. & 8 others, Letunic, I., Bork, P., Rychlewski, L., Küster, B., Helmer-Citterich, M., Hunter, W. N., Aasland, R. & Gibson, T. J., 1 Jul 2003, In : Nucleic Acids Research. 31, 13, p. 3625-30 6 p.

Research output: Contribution to journalArticle

475 Citations (Scopus)

GABAA receptor modulation by the novel intravenous general anaesthetic E-6375

Pau, D., Belelli, D., Callachan, H., Peden, D. R., Dunlop, J. I., Peters, J. A., Guitart, X., Gutierrez, B. & Lambert, J. J., Dec 2003, In : Neuropharmacology. 45, 8, p. 1029-1040 12 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Visual representation of database search results: the RHIMS Plot

Martin, D. M. A., Hill, P., Barton, G. J. & Flavell, A. J., 22 May 2003, In : Bioinformatics. 19, 8, p. 1037-1038 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2002
51 Citations (Scopus)
79 Citations (Scopus)

Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-κB/Nuclear Factor-κB-Sensitive Pathway in Alveolar Epithelial Cells

Haddad, J. J., Land, S. C., Tarnow-Mordi, W. O., Zembala, M., Kowalczyk, D. & Lauterbach, R., 1 Feb 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 2, p. 567-576 10 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Isolation and detection of human IgA using a streptococcal IgA-binding peptide

Sandin, C., Linse, S., Areschoug, T., Woof, J. M., Reinholdt, J. & Lindahl, G., 1 Aug 2002, In : Journal of Immunology. 169, 3, p. 1357-1364 8 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)
122 Citations (Scopus)
36 Citations (Scopus)

Sample sequencing of a selected region of the genome of Erwinia carotovora subsp. atroseptica reveals candidate phytopathogenicity genes and allows comparison with Escherichia coli

Bell, K. S., Avrova, A. O., Holeva, M. C., Cardle, L., Morris, W., De Jong, W., Toth, I. K., Waugh, R., Bryan, G. J. & Birch, P. R. J., 1 Jan 2002, In : Microbiology. 148, 5, p. 1367-1378 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
2001

A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α

Haddad, J. J. & Land, S. C., 14 Sep 2001, In : FEBS Letters. 505, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

207 Citations (Scopus)

A representative, highly informative 'genotyping set' of barley SSRs

Macaulay, M., Ramsay, L., Powell, W. & Waugh, R., 26 Jun 2001, In : Theoretical and Applied Genetics. 102, 6-7, p. 801-809 9 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

Chemioxyexcitation (ΔpO2/ROS)-dependent release of IL-1β, IL-6 and TNF-α: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E., Kanaan, S. A. & Land, S. C., 7 Feb 2001, In : Cytokine. 13, 3, p. 138-147 10 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

Neurosteroid modulation of recombinant and synaptic GABAA receptors

Lambert, J., Harney, S. C., Belelli, D. & Peters, J. A., 2001, In : International Review of Neurobiology. 46, p. 177-205 29 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

NF-κB blockade reduces the O2-evoked rise in Na+ conductance in fetal alveolar cells

Haddad, J. J. E., Collett, A., Land, S. C., Olver, R. E. & Wilson, S. M., 9 Mar 2001, In : Biochemical and Biophysical Research Communications. 281, 4, p. 987-992 6 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
19 Citations (Scopus)

Physical mapping across an avirulence iocus of phytophthora infestans using a highly representative, large-insert bacterial artificial chromosome library

Whisson, S. C., Van Der Lee, T., Bryan, G. J., Waugh, R., Govers, F. & Birch, P. R. J., 16 Oct 2001, In : Molecular Genetics and Genomics. 266, 2, p. 289-295 7 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Streptococcal IgA-binding Proteins Bind in the Cα2-Cα3 Interdomain Region and Inhibit Binding of IgA to Human CD89

Pleass, R. J., Areschoug, T., Lindahl, G. & Woof, J. M., 16 Mar 2001, In : Journal of Biological Chemistry. 276, 11, p. 8197-8204 8 p.

Research output: Contribution to journalArticle

Open Access
87 Citations (Scopus)

The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., May 2001, In : British Journal of Pharmacology. 133, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
20 Citations (Scopus)

Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., 1 Mar 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 3, p. 996-1005 10 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

α-amino acid phenolic ester derivatives: Novel water-soluble general anesthetic agents which allosterically modulate gabaa receptors

Anderson, A., Belelli, D., Bennett, J., Buchanan, K. I., Casula, A., Cooke, A., Feilden, H., Gemmell, D. K., Hamilton, N. M., Hutchinson, E. J., Lambert, J. J., Maidment, M. S., McGuire, R., McPhail, P., Miller, S., Muntoni, A., Peters, J. A., Sansbury, F. H., Stevenson, D. & Sundaramt, H., 25 Oct 2001, In : Journal of Medicinal Chemistry. 44, 22, p. 3582-3591 10 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)
69 Citations (Scopus)
2000

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1a and NF-kB Redox Sensitivity: EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS

Haddad, J. J. E., Olver, R. E. & Land, S. C., 14 Jul 2000, In : Journal of Biological Chemistry. 275, 28, p. 21130-21139 10 p.

Research output: Contribution to journalArticle

224 Citations (Scopus)

A retrospective analysis of spring barley germplasm development from 'foundation genotypes' to currently successful cultivars

Russell, J. R., Ellis, R. P., Thomas, W. T. B., Waugh, R., Provan, J., Booth, A., Fuller, J., Lawrence, P., Young, G. & Powell, W., 1 Dec 2000, In : Molecular Breeding. 6, 6, p. 553-568 16 p.

Research output: Contribution to journalArticle

105 Citations (Scopus)

A simple sequence repeat-based linkage map of Barley

Ramsay, L., Macaulay, M., Degli Ivanissevich, S., MacLean, K., Cardle, L., Fuller, J., Edwards, K. J., Tuvesson, S., Morgante, M., Massari, A., Maestri, E., Marmiroli, N., Sjakste, T., Ganal, M., Powell, W. & Waugh, R., 1 Dec 2000, In : Genetics. 156, 4, p. 1997-2005 9 p.

Research output: Contribution to journalArticle

495 Citations (Scopus)

Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases

Senior, B. W., Dunlop, J. I., Batten, M. R., Kilian, M. & Woof, J. M., Feb 2000, In : Infection and Immunity. 68, 2, p. 463-469 7 p.

Research output: Contribution to journalArticle

Open Access
31 Citations (Scopus)

Cleavage of human IgE mediated by Schistosoma mansoni

Pleass, R. J., Kusel, J. R. & Woof, J. M., Mar 2000, In : International Archives of Allergy and Immunology. 121, 3, p. 194-204 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Computational and experimental characterization of physically clustered simple sequence repeats in plants

Cardle, L., Ramsay, L., Milbourne, D., Macaulay, M., Marshall, D. & Waugh, R., 30 Oct 2000, In : Genetics. 156, 2, p. 847-854 8 p.

Research output: Contribution to journalArticle

368 Citations (Scopus)
23 Citations (Scopus)

Mapping new EMBL-derived barley microsatellites and their use in differentiating German barley cultivars

Pillen, K., Binder, A., Kreuzkam, B., Ramsay, L., Waugh, R., Förster, J. & Léon, J., Sep 2000, In : Theoretical and Applied Genetics. 101, 4, p. 652-660 9 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Mapping quantitative and qualitative disease resistance genes in a doubled haploid population of barley (Hordeum vulgare)

Toojinda, T., Broers, L. H., Chen, X. M., Hayes, P. M., Kleinhofs, A., Korte, J., Kudrna, D., Leung, H., Line, R. F., Powell, W., Ramsay, L., Vivar, H. & Waugh, R., 1 Jan 2000, In : Theoretical and Applied Genetics. 101, 4, p. 580-589 10 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
113 Citations (Scopus)

Scaling effects on hypoxia tolerance in the Amazon fish Astronotus ocellatus (Perciformes: Cichlidae): Contribution of tissue enzyme levels

Almeida-Val, V. M. F., Val, A. L., Duncan, W. P., Souza, F. C. A., Paula-Silva, M. N. & Land, S., 19 May 2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 125, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-MT(3A) receptors

Gunthorpe, M. J., Peters, J. A., Gill, C. H., Lambert, J. J. & Lummis, S. C. R., Jan 2000, In : Journal of Physiology. 522, 2, p. 187-198 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)
54 Citations (Scopus)

UK CropNet: A collection of databases and bioinformatics resources for crop plant genomics

Dicks, J., Anderson, M., Cardle, L., Cartinhour, S., Couchman, M., Davenport, G., Dickson, J., Gale, M., Marshall, D., May, S., McWilliam, H., O'Malia, A., Ougham, H., Trick, M., Walsh, S. & Waugh, R., 1 Jan 2000, In : Nucleic Acids Research. 28, 1, p. 104-107 4 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
1999

A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor

Belelli, D., Pau, D., Cabras, G., Peters, J. A. & Lambert, J. J., Jun 1999, In : British Journal of Pharmacology. 127, 3, p. 601-604 4 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Complementary regulation of anaesthetic activation of human (α6β3γ(2L)) and Drosophila (RDL) GABA receptors by a single amino acid residue

Pistis, M., Belelli, D., McGurk, K., Peters, J. A. & Lambert, J. J., Feb 1999, In : Journal of Physiology. 515, 1, p. 3-18 16 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human Fcα receptor (FcαR) CD89

Pleass, R. J., Dunlop, J. I., Anderson, C. M. & Woof, J. M., 13 Aug 1999, In : Journal of Biological Chemistry. 274, 33, p. 23508-23514 7 p.

Research output: Contribution to journalArticle

Open Access
89 Citations (Scopus)

Intimate association of microsatellite repeats with retrotransposons and other dispersed repetitive elements in barley

Ramsay, L., Macaulay, M., Cardle, L., Morgante, M., Degli Ivanissevich, S., Maestri, E., Powell, W. & Waugh, R., 1 Feb 1999, In : Plant Journal. 17, 4, p. 415-425 11 p.

Research output: Contribution to journalArticle

143 Citations (Scopus)

Molecular determinants of (+)-tubocurarine binding at recombinant 5- hydroxytryptamine(3A) receptor subunits

Hope, A. G., Belelli, D., Mair, I. D., Lambert, J. J. & Peters, J. A., 1 Jan 1999, In : Molecular Pharmacology. 55, 6, p. 1037-1043 7 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

QTL for field resistance to late blight in potato are strongly correlated with maturity and vigour

Collins, A., Milbourne, D., Ramsay, L., Meyer, R., Chatot-Balandras, C., Oberhagemann, P., De Jong, W., Gebhardt, C., Bonnel, E. & Waugh, R., 1 Jan 1999, In : Molecular Breeding. 5, 5, p. 387-398 12 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: A study by X-ray and neutron solution scattering and homology modelling

Boehm, M. K., Woof, J. M., Kerr, M. A. & Perkins, S. J., 12 Mar 1999, In : Journal of Molecular Biology. 286, 5, p. 1421-1447 27 p.

Research output: Contribution to journalArticle

173 Citations (Scopus)

The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors

Belelli, D., Pistis, M., Peters, J. A. & Lambert, J. J., May 1999, In : Neurochemistry International. 34, 5, p. 447-452 6 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells

Land, S. C., Porterfield, D. M., Sanger, R. H. & Smith, P. J. S., 1999, In : Journal of Experimental Biology. 202, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Using molecular markers to determine barleys most suitable for malt whisky distilling

Swanston, J. S., Thomas, W. T. B., Powell, W., Young, G. R., Lawrence, P. E., Ramsay, L. & Waugh, R., 1 Jan 1999, In : Molecular Breeding. 5, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)
1998

Identification of a QTL decreasing yield in barley linked to Mlo powdery mildew resistance

Thomas, W. T. B., Baird, E., Fuller, J. D., Lawrence, P., Young, G. R., Russell, J., Ramsay, L., Waugh, R. & Powell, W., Oct 1998, In : Molecular Breeding. 4, 5, p. 381-393 13 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT(3A))

Brown, A. M., Hope, A. G., Lambert, J. J. & Peters, J. A., Mar 1998, In : Journal of Physiology. 507, 3, p. 653-665 13 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Isolation, characterisation and mapping of simple sequence repeat loci in potato

Milbourne, D., Meyer, R. C., Collins, A. J., Ramsay, L. D., Gebhardt, C. & Waugh, R., 1 Oct 1998, In : Molecular and General Genetics. 259, 3, p. 233-245 13 p.

Research output: Contribution to journalArticle

245 Citations (Scopus)