DArcy Thompson Unit

Research Output 1987 2020

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Article
2002
53 Citations (Scopus)

Immunopharmacological Potential of Selective Phosphodiesterase Inhibition. II. Evidence for the Involvement of an Inhibitory-κB/Nuclear Factor-κB-Sensitive Pathway in Alveolar Epithelial Cells

Haddad, J. J., Land, S. C., Tarnow-Mordi, W. O., Zembala, M., Kowalczyk, D. & Lauterbach, R., 1 Feb 2002, In : Journal of Pharmacology and Experimental Therapeutics. 300, 2, p. 567-576 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Phosphoric Diester Hydrolases
Endotoxins
Pentoxifylline
Lipopolysaccharides
52 Citations (Scopus)

Isolation and detection of human IgA using a streptococcal IgA-binding peptide

Sandin, C., Linse, S., Areschoug, T., Woof, J. M., Reinholdt, J. & Lindahl, G., 1 Aug 2002, In : Journal of Immunology. 169, 3, p. 1357-1364 8 p.

Research output: Contribution to journalArticle

Immunoglobulin A
Peptides
Secretory Immunoglobulin A
Bacterial Proteins
Allergy and Immunology
121 Citations (Scopus)
Mitogen-Activated Protein Kinases
Oxidation-Reduction
Lipopolysaccharides
Phosphorylation
Acetylcysteine
35 Citations (Scopus)
Alveolar Epithelial Cells
Biosynthesis
Oxidation-Reduction
Lipopolysaccharides
Phosphorylation
25 Citations (Scopus)

Sample sequencing of a selected region of the genome of Erwinia carotovora subsp. atroseptica reveals candidate phytopathogenicity genes and allows comparison with Escherichia coli

Bell, K. S., Avrova, A. O., Holeva, M. C., Cardle, L., Morris, W., De Jong, W., Toth, I. K., Waugh, R., Bryan, G. J. & Birch, P. R. J., 1 Jan 2002, In : Microbiology. 148, 5, p. 1367-1378 12 p.

Research output: Contribution to journalArticle

Pectobacterium carotovorum
Bacterial Artificial Chromosomes
Genome
Escherichia coli
Erwinia amylovora
2001
206 Citations (Scopus)

A non-hypoxic, ROS-sensitive pathway mediates TNF-α-dependent regulation of HIF-1α

Haddad, J. J. & Land, S. C., 14 Sep 2001, In : FEBS Letters. 505, 2, p. 269-274 6 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Reactive Oxygen Species
Tumor Necrosis Factor-alpha
Chemical activation
Mitochondria
98 Citations (Scopus)

A representative, highly informative 'genotyping set' of barley SSRs

Macaulay, M., Ramsay, L., Powell, W. & Waugh, R., 26 Jun 2001, In : Theoretical and Applied Genetics. 102, 6-7, p. 801-809 9 p.

Research output: Contribution to journalArticle

Hordeum
genotyping
barley
Genotype
genotype
69 Citations (Scopus)

Chemioxyexcitation (ΔpO2/ROS)-dependent release of IL-1β, IL-6 and TNF-α: Evidence of cytokines as oxygen-sensitive mediators in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E., Kanaan, S. A. & Land, S. C., 7 Feb 2001, In : Cytokine. 13, 3, p. 138-147 10 p.

Research output: Contribution to journalArticle

Interleukin-1
Interleukin-6
Reactive Oxygen Species
Epithelium
Cytokines
38 Citations (Scopus)

Neurosteroid modulation of recombinant and synaptic GABAA receptors

Lambert, J., Harney, S. C., Belelli, D. & Peters, J. A., 2001, In : International Review of Neurobiology. 46, p. 177-205 29 p.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
GABA-A Receptors
Neurotransmitter Agents
Steroids
Pregnanes
21 Citations (Scopus)

NF-κB blockade reduces the O2-evoked rise in Na+ conductance in fetal alveolar cells

Haddad, J. J. E., Collett, A., Land, S. C., Olver, R. E. & Wilson, S. M., 9 Mar 2001, In : Biochemical and Biophysical Research Communications. 281, 4, p. 987-992 6 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Sulfasalazine
Chemical activation
Electrophoretic mobility
Rats
19 Citations (Scopus)
Alveolar Epithelial Cells
Biosynthesis
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Sulfasalazine
50 Citations (Scopus)

Physical mapping across an avirulence iocus of phytophthora infestans using a highly representative, large-insert bacterial artificial chromosome library

Whisson, S. C., Van Der Lee, T., Bryan, G. J., Waugh, R., Govers, F. & Birch, P. R. J., 16 Oct 2001, In : Molecular Genetics and Genomics. 266, 2, p. 289-295 7 p.

Research output: Contribution to journalArticle

Phytophthora infestans
Bacterial Artificial Chromosomes
Clone Cells
Oomycetes
Genes
85 Citations (Scopus)

Streptococcal IgA-binding Proteins Bind in the Cα2-Cα3 Interdomain Region and Inhibit Binding of IgA to Human CD89

Pleass, R. J., Areschoug, T., Lindahl, G. & Woof, J. M., 16 Mar 2001, In : Journal of Biological Chemistry. 276, 11, p. 8197-8204 8 p.

Research output: Contribution to journalArticle

Open Access
Immunoglobulin A
Carrier Proteins
Proteins
Bacterial Proteins
Respiratory Burst
25 Citations (Scopus)

The biphasic immunoregulation of pyrimidylpiperazine (Y-40138) is IL-10 sensitive and requires NF-κB targeting in the alveolar epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., May 2001, In : British Journal of Pharmacology. 133, 1, p. 49-60 12 p.

Research output: Contribution to journalArticle

Interleukin-10
Epithelium
Anti-Inflammatory Agents
Cytokines
Interleukin-1
20 Citations (Scopus)
Oxygenation
Respiration
Apoptosis
Lung
Proto-Oncogenes
72 Citations (Scopus)

Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium

Haddad, J. J. E., Safieh-Garabedian, B., Saadé, N. E. & Land, S. C., 1 Mar 2001, In : Journal of Pharmacology and Experimental Therapeutics. 296, 3, p. 996-1005 10 p.

Research output: Contribution to journalArticle

Sulfhydryl Compounds
Glutathione
Reactive Oxygen Species
Epithelium
Cytokines
20 Citations (Scopus)

α-amino acid phenolic ester derivatives: Novel water-soluble general anesthetic agents which allosterically modulate gabaa receptors

Anderson, A., Belelli, D., Bennett, J., Buchanan, K. I., Casula, A., Cooke, A., Feilden, H., Gemmell, D. K., Hamilton, N. M., Hutchinson, E. J., Lambert, J. J., Maidment, M. S., McGuire, R., McPhail, P., Miller, S., Muntoni, A., Peters, J. A., Sansbury, F. H., Stevenson, D. & Sundaramt, H., 25 Oct 2001, In : Journal of Medicinal Chemistry. 44, 22, p. 3582-3591 10 p.

Research output: Contribution to journalArticle

General Anesthetics
GABA-A Receptors
Anesthetics
Esters
Anesthesia
68 Citations (Scopus)
prolylvaline
Interleukins
Melanocytes
Endotoxins
Lipopolysaccharides
2000
223 Citations (Scopus)

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1a and NF-kB Redox Sensitivity: EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS

Haddad, J. J. E., Olver, R. E. & Land, S. C., 14 Jul 2000, In : Journal of Biological Chemistry. 275, 28, p. 21130-21139 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Glutathione Disulfide
NF-kappa B
Oxidation-Reduction
Glutathione
105 Citations (Scopus)

A retrospective analysis of spring barley germplasm development from 'foundation genotypes' to currently successful cultivars

Russell, J. R., Ellis, R. P., Thomas, W. T. B., Waugh, R., Provan, J., Booth, A., Fuller, J., Lawrence, P., Young, G. & Powell, W., 1 Dec 2000, In : Molecular Breeding. 6, 6, p. 553-568 16 p.

Research output: Contribution to journalArticle

spring barley
Hordeum
germplasm
Genotype
genotype
493 Citations (Scopus)

A simple sequence repeat-based linkage map of Barley

Ramsay, L., Macaulay, M., Degli Ivanissevich, S., MacLean, K., Cardle, L., Fuller, J., Edwards, K. J., Tuvesson, S., Morgante, M., Massari, A., Maestri, E., Marmiroli, N., Sjakste, T., Ganal, M., Powell, W. & Waugh, R., 1 Dec 2000, In : Genetics. 156, 4, p. 1997-2005 9 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
Population
Cluster Analysis
Flax
31 Citations (Scopus)

Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases

Senior, B. W., Dunlop, J. I., Batten, M. R., Kilian, M. & Woof, J. M., Feb 2000, In : Infection and Immunity. 68, 2, p. 463-469 7 p.

Research output: Contribution to journalArticle

Open Access
IgA-specific serine endopeptidase
Bacterial Antibodies
varespladib methyl
Immunoglobulins
Haemophilus influenzae
27 Citations (Scopus)

Cleavage of human IgE mediated by Schistosoma mansoni

Pleass, R. J., Kusel, J. R. & Woof, J. M., Mar 2000, In : International Archives of Allergy and Immunology. 121, 3, p. 194-204 11 p.

Research output: Contribution to journalArticle

Schistosoma mansoni
Immunoglobulin E
Pancreatic Elastase
Immunoglobulin A
Amino Acid Chloromethyl Ketones
366 Citations (Scopus)

Computational and experimental characterization of physically clustered simple sequence repeats in plants

Cardle, L., Ramsay, L., Milbourne, D., Macaulay, M., Marshall, D. & Waugh, R., 30 Oct 2000, In : Genetics. 156, 2, p. 847-854 8 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Expressed Sequence Tags
Hordeum
Plant Genome
Intergenic DNA
23 Citations (Scopus)
Circulating Thymic Factor
Endotoxins
Interleukin-10
Inhibitory Concentration 50
Amplification
113 Citations (Scopus)

Mapping new EMBL-derived barley microsatellites and their use in differentiating German barley cultivars

Pillen, K., Binder, A., Kreuzkam, B., Ramsay, L., Waugh, R., Förster, J. & Léon, J., Sep 2000, In : Theoretical and Applied Genetics. 101, 4, p. 652-660 9 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
barley
microsatellite repeats
cultivars
89 Citations (Scopus)

Mapping quantitative and qualitative disease resistance genes in a doubled haploid population of barley (Hordeum vulgare)

Toojinda, T., Broers, L. H., Chen, X. M., Hayes, P. M., Kleinhofs, A., Korte, J., Kudrna, D., Leung, H., Line, R. F., Powell, W., Ramsay, L., Vivar, H. & Waugh, R., 1 Jan 2000, In : Theoretical and Applied Genetics. 101, 4, p. 580-589 10 p.

Research output: Contribution to journalArticle

Disease Resistance
Luteovirus
Haploidy
doubled haploids
Hordeum
113 Citations (Scopus)
Hypoxia-Inducible Factor 1
Alveolar Epithelial Cells
Glutathione
Epithelium
Lung
72 Citations (Scopus)

Scaling effects on hypoxia tolerance in the Amazon fish Astronotus ocellatus (Perciformes: Cichlidae): Contribution of tissue enzyme levels

Almeida-Val, V. M. F., Val, A. L., Duncan, W. P., Souza, F. C. A., Paula-Silva, M. N. & Land, S., 19 May 2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 125, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

Perciformes
Cichlids
Fish
Fishes
Tissue
27 Citations (Scopus)

The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-MT(3A) receptors

Gunthorpe, M. J., Peters, J. A., Gill, C. H., Lambert, J. J. & Lummis, S. C. R., Jan 2000, In : Journal of Physiology. 522, 2, p. 187-198 12 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Lysine
Receptors, Serotonin, 5-HT3
Serotonin
Glycine
54 Citations (Scopus)
Alveolar Epithelial Cells
Oxidation-Reduction
Epithelium
Apoptosis
Glutamate-Cysteine Ligase
14 Citations (Scopus)

UK CropNet: A collection of databases and bioinformatics resources for crop plant genomics

Dicks, J., Anderson, M., Cardle, L., Cartinhour, S., Couchman, M., Davenport, G., Dickson, J., Gale, M., Marshall, D., May, S., McWilliam, H., O'Malia, A., Ougham, H., Trick, M., Walsh, S. & Waugh, R., 1 Jan 2000, In : Nucleic Acids Research. 28, 1, p. 104-107 4 p.

Research output: Contribution to journalArticle

Genomics
Computational Biology
Databases
Chromosome Mapping
Software
1999
37 Citations (Scopus)

A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor

Belelli, D., Pau, D., Cabras, G., Peters, J. A. & Lambert, J. J., Jun 1999, In : British Journal of Pharmacology. 127, 3, p. 601-604 4 p.

Research output: Contribution to journalArticle

General Anesthetics
GABA Receptors
GABA-A Receptors
Amino Acids
gamma-Aminobutyric Acid
46 Citations (Scopus)

Complementary regulation of anaesthetic activation of human (α6β3γ(2L)) and Drosophila (RDL) GABA receptors by a single amino acid residue

Pistis, M., Belelli, D., McGurk, K., Peters, J. A. & Lambert, J. J., Feb 1999, In : Journal of Physiology. 515, 1, p. 3-18 16 p.

Research output: Contribution to journalArticle

Propofol
Anesthetics
Pentobarbital
Amino Acids
gamma-Aminobutyric Acid
89 Citations (Scopus)

Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human Fcα receptor (FcαR) CD89

Pleass, R. J., Dunlop, J. I., Anderson, C. M. & Woof, J. M., 13 Aug 1999, In : Journal of Biological Chemistry. 274, 33, p. 23508-23514 7 p.

Research output: Contribution to journalArticle

Open Access
Fc Receptors
Immunoglobulin A
Substitution reactions
Ablation
Tail
141 Citations (Scopus)

Intimate association of microsatellite repeats with retrotransposons and other dispersed repetitive elements in barley

Ramsay, L., Macaulay, M., Cardle, L., Morgante, M., Degli Ivanissevich, S., Maestri, E., Powell, W. & Waugh, R., 1 Feb 1999, In : Plant Journal. 17, 4, p. 415-425 11 p.

Research output: Contribution to journalArticle

Retroelements
retrotransposons
Hordeum
DNA Transposable Elements
Microsatellite Repeats
39 Citations (Scopus)

Molecular determinants of (+)-tubocurarine binding at recombinant 5- hydroxytryptamine(3A) receptor subunits

Hope, A. G., Belelli, D., Mair, I. D., Lambert, J. J. & Peters, J. A., 1 Jan 1999, In : Molecular Pharmacology. 55, 6, p. 1037-1043 7 p.

Research output: Contribution to journalArticle

Tubocurarine
Serotonin Receptors
Serotonin
Amino Acids
Receptors, Serotonin, 5-HT3
118 Citations (Scopus)

QTL for field resistance to late blight in potato are strongly correlated with maturity and vigour

Collins, A., Milbourne, D., Ramsay, L., Meyer, R., Chatot-Balandras, C., Oberhagemann, P., De Jong, W., Gebhardt, C., Bonnel, E. & Waugh, R., 1 Jan 1999, In : Molecular Breeding. 5, 5, p. 387-398 12 p.

Research output: Contribution to journalArticle

Phytophthora infestans
Solanum tuberosum
vigor
quantitative trait loci
potatoes
172 Citations (Scopus)

The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: A study by X-ray and neutron solution scattering and homology modelling

Boehm, M. K., Woof, J. M., Kerr, M. A. & Perkins, S. J., 12 Mar 1999, In : Journal of Molecular Biology. 286, 5, p. 1421-1447 27 p.

Research output: Contribution to journalArticle

Immunoglobulin Fc Fragments
Immunoglobulin Fab Fragments
Neutrons
Immunoglobulin A
Immunoglobulin G
72 Citations (Scopus)

The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors

Belelli, D., Pistis, M., Peters, J. A. & Lambert, J. J., May 1999, In : Neurochemistry International. 34, 5, p. 447-452 6 p.

Research output: Contribution to journalArticle

Etomidate
Glycine Receptors
General Anesthetics
Propofol
Pentobarbital
82 Citations (Scopus)

The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells

Land, S. C., Porterfield, D. M., Sanger, R. H. & Smith, P. J. S., 1999, In : Journal of Experimental Biology. 202, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Microelectrodes
Oxygen
oxygen
cells
Chloroplasts
25 Citations (Scopus)

Using molecular markers to determine barleys most suitable for malt whisky distilling

Swanston, J. S., Thomas, W. T. B., Powell, W., Young, G. R., Lawrence, P. E., Ramsay, L. & Waugh, R., 1 Jan 1999, In : Molecular Breeding. 5, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

whisky
malt
Hordeum
barley
genetic markers
1998
48 Citations (Scopus)

Identification of a QTL decreasing yield in barley linked to Mlo powdery mildew resistance

Thomas, W. T. B., Baird, E., Fuller, J. D., Lawrence, P., Young, G. R., Russell, J., Ramsay, L., Waugh, R. & Powell, W., Oct 1998, In : Molecular Breeding. 4, 5, p. 381-393 13 p.

Research output: Contribution to journalArticle

Hordeum
powdery mildew
quantitative trait loci
Alleles
barley
98 Citations (Scopus)

Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT(3A))

Brown, A. M., Hope, A. G., Lambert, J. J. & Peters, J. A., Mar 1998, In : Journal of Physiology. 507, 3, p. 653-665 13 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Serotonin
Inhibitory Concentration 50
Ions
Patch-Clamp Techniques
242 Citations (Scopus)

Isolation, characterisation and mapping of simple sequence repeat loci in potato

Milbourne, D., Meyer, R. C., Collins, A. J., Ramsay, L. D., Gebhardt, C. & Waugh, R., 1 Oct 1998, In : Molecular and General Genetics. 259, 3, p. 233-245 13 p.

Research output: Contribution to journalArticle

Solanum tuberosum
Microsatellite Repeats
Restriction Fragment Length Polymorphisms
Genetic Linkage
Tetraploidy
28 Citations (Scopus)

Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT(3A(b)) expressed in Xenopus laevis oocytes

Mair, I. D., Lambert, J. J., Yang, J., Dempster, J. & Peters, J. A., Aug 1998, In : British Journal of Pharmacology. 124, 8, p. 1667-1674 8 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Xenopus laevis
Oocytes
Serotonin
Pharmacology
311 Citations (Scopus)

The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions

Mattu, T. S., Pleass, R. J., Willis, A. C., Kilian, M., Wormald, M. R., Lellouch, A. C., Rudd, P. M., Woof, J. M. & Dwek, R. A., 23 Jan 1998, In : Journal of Biological Chemistry. 273, 4, p. 2260-2272 13 p.

Research output: Contribution to journalArticle

Glycosylation
Fc Receptors
Immunoglobulin A
Polysaccharides
Serum
1997
103 Citations (Scopus)

Analysis of quantitative traits in barley by the use of amplified fragment length polymorphisms

Powell, W., Thomas, W. T. B., Baird, E., Lawrence, P., Booth, A., Harrower, B., McNicol, J. W. & Waugh, R., 1 Jul 1997, In : Heredity. 79, 1, p. 48-59 12 p.

Research output: Contribution to journalArticle

Hordeum
Genome
Enzymes
Restriction Fragment Length Polymorphisms
Chromosomes, Human, Pair 5
55 Citations (Scopus)

Anesthetic activity of novel water-soluble 2β-morpholinyl steroids and their modulatory effects at GABA(A) receptors

Anderson, A., Boyd, A. C., Byford, A., Campbell, A. C., Gemmell, D. K., Hamilton, N. M., Hill, D. R., Hill-Venning, C., Lambert, J. J., Maidment, M. S., May, V., Marshall, R. J., Peters, J. A., Rees, D. C., Stevenson, D. & Sundaram, H., 23 May 1997, In : Journal of Medicinal Chemistry. 40, 11, p. 1668-1681 14 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Anesthetics
Steroids
Water
Pregnanolone
5 Citations (Scopus)

Consumption of Oxygen by Isolated Skate Retinal Photoreceptors

Malchow, R. P., Land, S. C., Patel, L. S. & Smith, P. J. S., Oct 1997, In : Biological Bulletin. 193, 2, p. 231-232 2 p.

Research output: Contribution to journalArticle