DArcy Thompson Unit

Research Output 1987 2020

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Article
2001
68 Citations (Scopus)
prolylvaline
Interleukins
Melanocytes
Endotoxins
Lipopolysaccharides
2000
222 Citations (Scopus)

Antioxidant/Pro-oxidant Equilibrium Regulates HIF-1a and NF-kB Redox Sensitivity: EVIDENCE FOR INHIBITION BY GLUTATHIONE OXIDATION IN ALVEOLAR EPITHELIAL CELLS

Haddad, J. J. E., Olver, R. E. & Land, S. C., 14 Jul 2000, In : Journal of Biological Chemistry. 275, 28, p. 21130-21139 10 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Glutathione Disulfide
NF-kappa B
Oxidation-Reduction
Glutathione
104 Citations (Scopus)

A retrospective analysis of spring barley germplasm development from 'foundation genotypes' to currently successful cultivars

Russell, J. R., Ellis, R. P., Thomas, W. T. B., Waugh, R., Provan, J., Booth, A., Fuller, J., Lawrence, P., Young, G. & Powell, W., 1 Dec 2000, In : Molecular Breeding. 6, 6, p. 553-568 16 p.

Research output: Contribution to journalArticle

spring barley
Hordeum
germplasm
Genotype
genotype
493 Citations (Scopus)

A simple sequence repeat-based linkage map of Barley

Ramsay, L., Macaulay, M., Degli Ivanissevich, S., MacLean, K., Cardle, L., Fuller, J., Edwards, K. J., Tuvesson, S., Morgante, M., Massari, A., Maestri, E., Marmiroli, N., Sjakste, T., Ganal, M., Powell, W. & Waugh, R., 1 Dec 2000, In : Genetics. 156, 4, p. 1997-2005 9 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
Population
Cluster Analysis
Flax
30 Citations (Scopus)

Cleavage of a recombinant human immunoglobulin A2 (IgA2)-IgA1 hybrid antibody by certain bacterial IgA1 proteases

Senior, B. W., Dunlop, J. I., Batten, M. R., Kilian, M. & Woof, J. M., Feb 2000, In : Infection and Immunity. 68, 2, p. 463-469 7 p.

Research output: Contribution to journalArticle

Open Access
IgA-specific serine endopeptidase
Bacterial Antibodies
varespladib methyl
Immunoglobulins
Haemophilus influenzae
27 Citations (Scopus)

Cleavage of human IgE mediated by Schistosoma mansoni

Pleass, R. J., Kusel, J. R. & Woof, J. M., Mar 2000, In : International Archives of Allergy and Immunology. 121, 3, p. 194-204 11 p.

Research output: Contribution to journalArticle

Schistosoma mansoni
Immunoglobulin E
Pancreatic Elastase
Immunoglobulin A
Amino Acid Chloromethyl Ketones
362 Citations (Scopus)

Computational and experimental characterization of physically clustered simple sequence repeats in plants

Cardle, L., Ramsay, L., Milbourne, D., Macaulay, M., Marshall, D. & Waugh, R., 30 Oct 2000, In : Genetics. 156, 2, p. 847-854 8 p.

Research output: Contribution to journalArticle

Microsatellite Repeats
Expressed Sequence Tags
Hordeum
Plant Genome
Intergenic DNA
23 Citations (Scopus)
Circulating Thymic Factor
Endotoxins
Interleukin-10
Inhibitory Concentration 50
Amplification
113 Citations (Scopus)

Mapping new EMBL-derived barley microsatellites and their use in differentiating German barley cultivars

Pillen, K., Binder, A., Kreuzkam, B., Ramsay, L., Waugh, R., Förster, J. & Léon, J., Sep 2000, In : Theoretical and Applied Genetics. 101, 4, p. 652-660 9 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
barley
microsatellite repeats
cultivars
89 Citations (Scopus)

Mapping quantitative and qualitative disease resistance genes in a doubled haploid population of barley (Hordeum vulgare)

Toojinda, T., Broers, L. H., Chen, X. M., Hayes, P. M., Kleinhofs, A., Korte, J., Kudrna, D., Leung, H., Line, R. F., Powell, W., Ramsay, L., Vivar, H. & Waugh, R., 1 Jan 2000, In : Theoretical and Applied Genetics. 101, 4, p. 580-589 10 p.

Research output: Contribution to journalArticle

Disease Resistance
Luteovirus
Haploidy
doubled haploids
Hordeum
113 Citations (Scopus)
Hypoxia-Inducible Factor 1
Alveolar Epithelial Cells
Glutathione
Epithelium
Lung
71 Citations (Scopus)

Scaling effects on hypoxia tolerance in the Amazon fish Astronotus ocellatus (Perciformes: Cichlidae): Contribution of tissue enzyme levels

Almeida-Val, V. M. F., Val, A. L., Duncan, W. P., Souza, F. C. A., Paula-Silva, M. N. & Land, S., 19 May 2000, In : Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 125, 2, p. 219-226 8 p.

Research output: Contribution to journalArticle

Perciformes
Cichlids
Fish
Fishes
Tissue
27 Citations (Scopus)

The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-MT(3A) receptors

Gunthorpe, M. J., Peters, J. A., Gill, C. H., Lambert, J. J. & Lummis, S. C. R., Jan 2000, In : Journal of Physiology. 522, 2, p. 187-198 12 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Lysine
Receptors, Serotonin, 5-HT3
Serotonin
Glycine
54 Citations (Scopus)
Alveolar Epithelial Cells
Oxidation-Reduction
Epithelium
Apoptosis
Glutamate-Cysteine Ligase
14 Citations (Scopus)

UK CropNet: A collection of databases and bioinformatics resources for crop plant genomics

Dicks, J., Anderson, M., Cardle, L., Cartinhour, S., Couchman, M., Davenport, G., Dickson, J., Gale, M., Marshall, D., May, S., McWilliam, H., O'Malia, A., Ougham, H., Trick, M., Walsh, S. & Waugh, R., 1 Jan 2000, In : Nucleic Acids Research. 28, 1, p. 104-107 4 p.

Research output: Contribution to journalArticle

Genomics
Computational Biology
Databases
Chromosome Mapping
Software
1999
37 Citations (Scopus)

A single amino acid confers barbiturate sensitivity upon the GABA ρ1 receptor

Belelli, D., Pau, D., Cabras, G., Peters, J. A. & Lambert, J. J., Jun 1999, In : British Journal of Pharmacology. 127, 3, p. 601-604 4 p.

Research output: Contribution to journalArticle

General Anesthetics
GABA Receptors
GABA-A Receptors
Amino Acids
gamma-Aminobutyric Acid
46 Citations (Scopus)

Complementary regulation of anaesthetic activation of human (α6β3γ(2L)) and Drosophila (RDL) GABA receptors by a single amino acid residue

Pistis, M., Belelli, D., McGurk, K., Peters, J. A. & Lambert, J. J., Feb 1999, In : Journal of Physiology. 515, 1, p. 3-18 16 p.

Research output: Contribution to journalArticle

Propofol
Anesthetics
Pentobarbital
Amino Acids
gamma-Aminobutyric Acid
88 Citations (Scopus)

Identification of residues in the CH2/CH3 domain interface of IgA essential for interaction with the human Fcα receptor (FcαR) CD89

Pleass, R. J., Dunlop, J. I., Anderson, C. M. & Woof, J. M., 13 Aug 1999, In : Journal of Biological Chemistry. 274, 33, p. 23508-23514 7 p.

Research output: Contribution to journalArticle

Open Access
Fc Receptors
Immunoglobulin A
Substitution reactions
Ablation
Tail
138 Citations (Scopus)

Intimate association of microsatellite repeats with retrotransposons and other dispersed repetitive elements in barley

Ramsay, L., Macaulay, M., Cardle, L., Morgante, M., Degli Ivanissevich, S., Maestri, E., Powell, W. & Waugh, R., 1 Feb 1999, In : Plant Journal. 17, 4, p. 415-425 11 p.

Research output: Contribution to journalArticle

Retroelements
retrotransposons
Hordeum
DNA Transposable Elements
Microsatellite Repeats
39 Citations (Scopus)

Molecular determinants of (+)-tubocurarine binding at recombinant 5- hydroxytryptamine(3A) receptor subunits

Hope, A. G., Belelli, D., Mair, I. D., Lambert, J. J. & Peters, J. A., 1 Jan 1999, In : Molecular Pharmacology. 55, 6, p. 1037-1043 7 p.

Research output: Contribution to journalArticle

Tubocurarine
Serotonin Receptors
Serotonin
Amino Acids
Receptors, Serotonin, 5-HT3
118 Citations (Scopus)

QTL for field resistance to late blight in potato are strongly correlated with maturity and vigour

Collins, A., Milbourne, D., Ramsay, L., Meyer, R., Chatot-Balandras, C., Oberhagemann, P., De Jong, W., Gebhardt, C., Bonnel, E. & Waugh, R., 1 Jan 1999, In : Molecular Breeding. 5, 5, p. 387-398 12 p.

Research output: Contribution to journalArticle

Phytophthora infestans
Solanum tuberosum
vigor
quantitative trait loci
potatoes
169 Citations (Scopus)

The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: A study by X-ray and neutron solution scattering and homology modelling

Boehm, M. K., Woof, J. M., Kerr, M. A. & Perkins, S. J., 12 Mar 1999, In : Journal of Molecular Biology. 286, 5, p. 1421-1447 27 p.

Research output: Contribution to journalArticle

Immunoglobulin Fc Fragments
Immunoglobulin Fab Fragments
Neutrons
Immunoglobulin A
Immunoglobulin G
71 Citations (Scopus)

The interaction of general anaesthetics and neurosteroids with GABA(A) and glycine receptors

Belelli, D., Pistis, M., Peters, J. A. & Lambert, J. J., May 1999, In : Neurochemistry International. 34, 5, p. 447-452 6 p.

Research output: Contribution to journalArticle

Etomidate
Glycine Receptors
General Anesthetics
Propofol
Pentobarbital
82 Citations (Scopus)

The self-referencing oxygen-selective microelectrode: detection of transmembrane oxygen flux from single cells

Land, S. C., Porterfield, D. M., Sanger, R. H. & Smith, P. J. S., 1999, In : Journal of Experimental Biology. 202, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Microelectrodes
Oxygen
oxygen
cells
Chloroplasts
25 Citations (Scopus)

Using molecular markers to determine barleys most suitable for malt whisky distilling

Swanston, J. S., Thomas, W. T. B., Powell, W., Young, G. R., Lawrence, P. E., Ramsay, L. & Waugh, R., 1 Jan 1999, In : Molecular Breeding. 5, 2, p. 103-109 7 p.

Research output: Contribution to journalArticle

whisky
malt
Hordeum
barley
genetic markers
1998
47 Citations (Scopus)

Identification of a QTL decreasing yield in barley linked to Mlo powdery mildew resistance

Thomas, W. T. B., Baird, E., Fuller, J. D., Lawrence, P., Young, G. R., Russell, J., Ramsay, L., Waugh, R. & Powell, W., Oct 1998, In : Molecular Breeding. 4, 5, p. 381-393 13 p.

Research output: Contribution to journalArticle

Hordeum
powdery mildew
quantitative trait loci
Alleles
barley
97 Citations (Scopus)

Ion permeation and conduction in a human recombinant 5-HT3 receptor subunit (h5-HT(3A))

Brown, A. M., Hope, A. G., Lambert, J. J. & Peters, J. A., Mar 1998, In : Journal of Physiology. 507, 3, p. 653-665 13 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
Serotonin
Inhibitory Concentration 50
Ions
Patch-Clamp Techniques
240 Citations (Scopus)

Isolation, characterisation and mapping of simple sequence repeat loci in potato

Milbourne, D., Meyer, R. C., Collins, A. J., Ramsay, L. D., Gebhardt, C. & Waugh, R., 1 Oct 1998, In : Molecular and General Genetics. 259, 3, p. 233-245 13 p.

Research output: Contribution to journalArticle

Solanum tuberosum
Microsatellite Repeats
Restriction Fragment Length Polymorphisms
Genetic Linkage
Tetraploidy
28 Citations (Scopus)

Pharmacological characterization of a rat 5-hydroxytryptamine type3 receptor subunit (r5-HT(3A(b)) expressed in Xenopus laevis oocytes

Mair, I. D., Lambert, J. J., Yang, J., Dempster, J. & Peters, J. A., Aug 1998, In : British Journal of Pharmacology. 124, 8, p. 1667-1674 8 p.

Research output: Contribution to journalArticle

Serotonin Receptors
Xenopus laevis
Oocytes
Serotonin
Pharmacology
307 Citations (Scopus)

The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fcα receptor interactions

Mattu, T. S., Pleass, R. J., Willis, A. C., Kilian, M., Wormald, M. R., Lellouch, A. C., Rudd, P. M., Woof, J. M. & Dwek, R. A., 23 Jan 1998, In : Journal of Biological Chemistry. 273, 4, p. 2260-2272 13 p.

Research output: Contribution to journalArticle

Glycosylation
Fc Receptors
Immunoglobulin A
Polysaccharides
Serum
1997
103 Citations (Scopus)

Analysis of quantitative traits in barley by the use of amplified fragment length polymorphisms

Powell, W., Thomas, W. T. B., Baird, E., Lawrence, P., Booth, A., Harrower, B., McNicol, J. W. & Waugh, R., 1 Jul 1997, In : Heredity. 79, 1, p. 48-59 12 p.

Research output: Contribution to journalArticle

Hordeum
Genome
Enzymes
Restriction Fragment Length Polymorphisms
Chromosomes, Human, Pair 5
55 Citations (Scopus)

Anesthetic activity of novel water-soluble 2β-morpholinyl steroids and their modulatory effects at GABA(A) receptors

Anderson, A., Boyd, A. C., Byford, A., Campbell, A. C., Gemmell, D. K., Hamilton, N. M., Hill, D. R., Hill-Venning, C., Lambert, J. J., Maidment, M. S., May, V., Marshall, R. J., Peters, J. A., Rees, D. C., Stevenson, D. & Sundaram, H., 23 May 1997, In : Journal of Medicinal Chemistry. 40, 11, p. 1668-1681 14 p.

Research output: Contribution to journalArticle

GABA-A Receptors
Anesthetics
Steroids
Water
Pregnanolone
5 Citations (Scopus)

Consumption of Oxygen by Isolated Skate Retinal Photoreceptors

Malchow, R. P., Land, S. C., Patel, L. S. & Smith, P. J. S., Oct 1997, In : Biological Bulletin. 193, 2, p. 231-232 2 p.

Research output: Contribution to journalArticle

420 Citations (Scopus)

Direct comparison of levels of genetic variation among barley accessions detected by RFLPs, AFLPs, SSRs and RAPDs

Russell, J. R., Fuller, J. D., Macaulay, M., Hatz, B. G., Jahoor, A., Powell, W. & Waugh, R., Sep 1997, In : Theoretical and Applied Genetics. 95, 4, p. 714-722 9 p.

Research output: Contribution to journalArticle

Hordeum
Restriction Fragment Length Polymorphisms
amplified fragment length polymorphism
restriction fragment length polymorphism
barley
134 Citations (Scopus)

Discriminating between barley genotypes using microsatellite markers

Russell, J., Fuller, J., Young, G., Thomas, B., Macaulay, M., Waugh, R., Powell, W. & Taramino, G., Aug 1997, In : Genome. 40, 4, p. 442-450 9 p.

Research output: Contribution to journalArticle

Hordeum
Microsatellite Repeats
Pedigree
barley
Genotype
368 Citations (Scopus)

Genetic distribution of Bare-1-like retrotransposable elements in the barley genome revealed by sequence-specific amplification polymorphisms (S-SAP)

Waugh, R., McLean, K., Flavell, A. J., Pearce, S. R., Kumar, A., Thomas, B. B. T. & Powell, W., Feb 1997, In : Molecular and General Genetics. 253, 6, p. 687-694 8 p.

Research output: Contribution to journalArticle

Hordeum
Retroelements
Genome
Terminal Repeat Sequences
Plant Genome
149 Citations (Scopus)

Homology of AFLP products in three mapping populations of barley

Waugh, R., Bonar, N., Baird, E., Thomas, B., Graner, A., Hayes, P. & Powell, W., Jul 1997, In : Molecular and General Genetics. 255, 3, p. 311-321 11 p.

Research output: Contribution to journalArticle

Hordeum
Population
Genetic Linkage
Genetic Loci
Haploidy
56 Citations (Scopus)

Locating genotypes and genes for abiotic stress tolerance in barley: a strategy using maps, markers and the wild species

Forster, B. P., Russell, J. R., Ellis, R. P., Handley, L. L., Robinson, D., Hackett, C. A., Nevo, E., Waugh, R., Gordon, D. C., Keith, R. & Powell, W., Sep 1997, In : New Phytologist. 137, 1, p. 141-147 7 p.

Research output: Contribution to journalArticle

Hordeum
stress tolerance
abiotic stress
barley
Genotype
4 Citations (Scopus)

Mutagenesis of J chain residues critical for IgA dimer assembly

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1 May 1997, In : Biochemical Society Transactions. 25, 2, p. 323S 1 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

O2 availability modulates transmembrane Ca2+ flux via second- messenger pathways in anoxia-tolerant hepatocytes

Land, S. C., Sanger, R. H. & Smith, P. J. S., 1 Mar 1997, In : Journal of Applied Physiology. 82, 3, p. 776-783 8 p.

Research output: Contribution to journalArticle

Second Messenger Systems
Adenosine
Protein Kinase C
Hepatocytes
Sphingosine
40 Citations (Scopus)

Structural Requirements for Assembly of Dimeric IgA Probed by Site-Directed Mutagenesis of J Chain and a Cysteine Residue of the α-Chain CH2 Domain

Krugmann, S., Pleass, R. J., Atkin, J. D. & Woof, J. M., 1 Jul 1997, In : Journal of Immunology. 159, 1, p. 244-249 6 p.

Research output: Contribution to journalArticle

Site-Directed Mutagenesis
Immunoglobulin A
Cysteine
CHO Cells
Dimerization
184 Citations (Scopus)

Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor

Hill-Yenning, C., Belelli, D., Peters, J. A. & Lambert, J. J., Feb 1997, In : British Journal of Pharmacology. 120, 5, p. 749-756 8 p.

Research output: Contribution to journalArticle

Etomidate
Aminobutyrates
General Anesthetics
gamma-Aminobutyric Acid
Protein Isoforms
116 Citations (Scopus)
Glycine Receptors
General Anesthetics
Xenopus laevis
GABA-A Receptors
Oocytes
320 Citations (Scopus)
Etomidate
Aminobutyrates
General Anesthetics
Amino Acids
GABA-A Receptors
1996
37 Citations (Scopus)

Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils

Pleass, R. J., Andrews, P. D., Kerr, M. A. & Woof, J. M., 15 Sep 1996, In : Biochemical Journal. 318, 3, p. 771-777 7 p.

Research output: Contribution to journalArticle

Fc Receptors
Alternative Splicing
Eosinophils
Immunoglobulin A
Neutrophils
42 Citations (Scopus)

Characterization of a human 5‐hydroxytryptamine3 receptor type A (h5‐HT3R‐AS) subunit stably expressed in HEK 293 cells

Hope, A. G., Peters, J. A., Brown, A. M., Lambert, J. J. & Blackburn, T. P., Jul 1996, In : British Journal of Pharmacology. 118, 5, p. 1237-1245 9 p.

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT3
HEK293 Cells
Granisetron
Serotonin
Pharmacology
69 Citations (Scopus)

Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes

Belelli, D., Callachan, H., Hill-Venning, C., Peters, J. A. & Lambert, J. J., Jun 1996, In : British Journal of Pharmacology. 118, 3, p. 563-576 14 p.

Research output: Contribution to journalArticle

Xenopus laevis
gamma-Aminobutyric Acid
Oocytes
Invertebrates
Pentobarbital
35 Citations (Scopus)

Modulation of human recombinant GABA(A) receptors by pregnanediols

Belelli, D., Lambert, J. J., Peters, J. A., Gee, K. W. & Lan, N. C., 1996, In : Neuropharmacology. 35, 9-10, p. 1223-1231 9 p.

Research output: Contribution to journalArticle

Pregnanediol
GABA-A Receptors
Steroids
gamma-Aminobutyric Acid
Neurotransmitter Agents
58 Citations (Scopus)

Mutagenesis of the human IgA1 heavy chain tailpiece that prevents dimer assembly

Atkin, J. D., Pleass, R. J., Owens, R. J. & Woof, J. M., 1 Jul 1996, In : Journal of Immunology. 157, 1, p. 156-159 4 p.

Research output: Contribution to journalArticle

Mutagenesis
Immunoglobulin A
Protein Engineering
Terminator Codon
Dimerization
73 Citations (Scopus)

Quantitative trait loci for germination and malting quality characters in a spring barley cross

Thomas, W. T. B., Powell, W., Swanston, J. S., Ellis, R. P., Chalmers, K. J., Barua, U. M., Jack, P., Lea, V., Forster, B. P., Waugh, R. & Smith, D. B., 1 Mar 1996, In : Crop Science. 36, 2, p. 265-273 9 p.

Research output: Contribution to journalArticle

malting quality
spring barley
quantitative trait loci
germination
chromosomes