Drug Discovery Unit

  • United Kingdom

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Drug Discovery Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Parasites Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences
Chagas Disease Medicine & Life Sciences
Visceral Leishmaniasis Medicine & Life Sciences

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Profiles

No photo of Rafael Alves Ferreira

Alves Ferreira, Rafael

Person: Research Postgraduate Student

No photo of Soneela Asghar

Asghar, Soneela

Person: Research

No photo of Mark Bell

Bell, Mark

Person: Research

20132019

Projects 2012 2022

Research Output 1993 2019

A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments

Luise, N., Wyatt, E. W., Tarver, G. & Wyatt, P., 14 Feb 2019, In : European Journal of Organic Chemistry. 2019, 6, p. 1341-1349 9 p.

Research output: Contribution to journalArticle

fragments
synthesis
Hydrogenation
Quality control
Hydrogen

A preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Wyllie, S., Brand, S., Thomas, M., De Rycker, M., Chung, C-W., Peña, I., Bingham, R., Bueren-Calabuig, J., Cantizani, J., Cebrian, D., Craggs, P. D., Ferguson, L., Goswami, P., Hobrath, J., Howe, J., Jeacock, L., Ko, E. J., Korczynska, J., MacLean, L., Manthri, S. & 29 othersSantos Martinez, M., Mata-Cantero, L., Moniz, S., Nuhs, A., Osuna-Cabello, M., Pinto, E., Riley, J., Robinson, S., Rowland, P., Simeons, F., Shishikura, Y., Spinks, D., Stojanovski, L., Thomas, J., Thompson, S., Viayna Gaza, E., Wall, R., Zuccotto, F., Horn, D., Ferguson, M., Fairlamb, A., Fiandor, J. M., Martín, J., Gray, D., Miles, T. J., Gilbert, I., Read, K., Marco, M. & Wyatt, P., 8 Apr 2019, In : Proceedings of the National Academy of Sciences. p. 1-6 6 p., 201820175.

Research output: Contribution to journalArticle

Open Access
File
Visceral Leishmaniasis
Proteasome Endopeptidase Complex
Leishmania infantum
Parasites
miltefosine

Characterising Covalent Warhead Reactivity

Martin, J., Mackenzie, C., Fletcher, D. & Gilbert, I., 3 Apr 2019, In : Bioorganic & Medicinal Chemistry. 9 p.

Research output: Contribution to journalArticle

Open Access
Toxicity
Pharmaceutical Preparations
Aptitude
Pharmacokinetics
Threonine

Press / Media

Tuberculosis drug may also target visceral leishmaniasis

Alan Fairlamb & Kevin Read

24/05/16

1 item of media coverage

Press/Media: Research

Student theses

Spontaneous Raman spectroscopy: Exploring applicability in drug discovery and the medical sciences

Author: Rabl, T., 2018

Supervisor: Read, K. (Supervisor) & McGloin, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy

To Design and Develop Semi-Saturated and Unsaturated Bicyclic Heterocycles for Fragment-Based Drug Discovery (FBDD) Campaigns

Author: Luise, N., 2019

Supervisor: Wyatt, P. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy