Drug Discovery Unit

  • United Kingdom

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Drug Discovery Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences
Parasites Medicine & Life Sciences
Trypanosoma brucei brucei Medicine & Life Sciences
African Trypanosomiasis Medicine & Life Sciences
Chagas Disease Medicine & Life Sciences
Trypanosoma cruzi Medicine & Life Sciences
Receptors, Serotonin, 5-HT3 Medicine & Life Sciences

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Profiles

No photo of Rafael Alves Ferreira

Alves Ferreira, Rafael

No photo of Mark Bell

Bell, Mark

20132018
No photo of Fiona Bellany

Bellany, Fiona

Research Output 1993 2018

2,4-Diamino-6-methylpyrimidines for the potential treatment of Chagas’ disease

Thomas, M. G., De Rycker, M., Cotillo Torrejon, I., Thomas, J., Riley, J., Spinks, D., Read, K. D., Miles, T. J., Gilbert, I. H. & Wyatt, P. G., 1 Oct 2018, In : Bioorganic & Medicinal Chemistry Letters. 28, 18, p. 3025-3030 6 p.

Research output: Contribution to journalArticle

Chagas Disease
Parasites
Nifurtimox
Trypanosoma cruzi
Screening
2 Citations

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization

Murugesan, D., Ray, P. C., Bayliss, T., Prosser, G. A., Harrison, J. R., Green, K., Soares De Melo, C., Feng, T. S., Street, L. J., Chibale, K., Warner, D. F., Mizrahi, V., Epemolu, O., Scullion, P., Ellis, L., Riley, J., Shishikura, Y., Ferguson, L., Osuna-Cabello, M., Read, K. D. & 10 othersGreen, S. R., Lamprecht, D. A., Steyn, A. J. C., Ioerger, T. R., Sacchettini, J., Rhee, K. Y., Arora, K., Barry, C. E., Wyatt, P. G. & Boshoff, H. I. M., 8 Jun 2018, In : ACS Infectious Diseases. 4, 6, p. 954-969 16 p.

Research output: Contribution to journalArticle

Open Access
File
Quinazolinones
Structure-Activity Relationship
Mycobacterium tuberculosis
Adenosine Triphosphate
Allosteric Site

Activity of the antiarrhythmic drug amiodarone against Leishmania (L.) infantum: an in vitro and in vivo approach

Pinto, E. G. & Tempone, A. G., 25 Oct 2018, 24, 1, p. 1-6 6 p., 29.

Research output: Contribution to journalArticle

Open Access
File
Leishmania infantum
Amiodarone
Anti-Arrhythmia Agents
Visceral Leishmaniasis
Inhibitory Concentration 50

Press / Media

Tuberculosis drug may also target visceral leishmaniasis

Alan Fairlamb & Kevin Read

24/05/16

1 item of media coverage

Press/Media: Research

Student theses

Spontaneous Raman spectroscopy: Exploring applicability in drug discovery and the medical sciences

Author: Rabl, T., 2018

Supervisor: Read, K. (Supervisor) & McGloin, D. (Supervisor)

Student thesis: Doctoral ThesisDoctor of Philosophy