Keyphrases
Drug Discovery
84%
Trypanosoma Cruzi (T. cruzi)
82%
Mycobacterium Tuberculosis (M. tb)
59%
Chagas Disease
53%
Trypanosoma Brucei
51%
Plasmodium Falciparum
50%
Visceral Leishmaniasis
47%
Membrane Protein
46%
Drug Target
42%
Dundee
35%
Metabolism
35%
Leishmania
34%
Small Molecules
33%
Escherichia Coli
33%
Mode of Action
32%
Mechanism of Action
30%
Trypanocidal Activity
29%
Leishmania Donovani
29%
Human African Trypanosomiasis
28%
Mouse Model
27%
Phenotypic Screening
26%
Medicinal Chemistry
25%
Structure-activity Relationship
23%
Malaria
22%
Molecular Dynamics Simulation
22%
Molecular Targets
22%
New Drugs
22%
High-throughput
22%
Active Sites
22%
Antitrypanosomal Activity
21%
Amino
21%
Trypanosomatids
20%
Recombinant
20%
Pharmacokinetic Properties
19%
Bicyclol
19%
Infectious Diseases
19%
Selective Inhibitor
18%
Wellcome
17%
Synthetic Cannabinoid Receptor Agonists
17%
T. Brucei
17%
In Vivo Efficacy
17%
Amides
17%
5-HT3 Receptor
16%
Pseudouridine
16%
Antimalarial Activity
16%
Drug Resistance
16%
Structure-based Design
16%
Putative Drug Targets
16%
Protein Kinase
16%
Antimalarial Drugs
16%
IC50
16%
ATP-binding Cassette Transporter A1 (ABCA1)
16%
Protozoan Parasites
15%
LysR Family
15%
Drug Metabolism
15%
Mitochondria
15%
Anti-infective
15%
Pharmacophore
15%
Natural Products
15%
Novel Inhibitors
15%
Benznidazole
15%
Kinetoplastid
15%
Fragment Molecular Orbital Method
15%
High-throughput Screening
15%
Leishmania Infantum
15%
Preclinical Candidate
14%
Leishmania Major
14%
Fluoro
14%
N-myristoyltransferase
14%
Causative Agents
14%
Acetogenins
14%
5-hydroxytryptamine
14%
Neglected Tropical Diseases
14%
Methyl
14%
Drug pipeline
14%
ATP Synthase
14%
Prodrug
13%
Pyrazolo
13%
Public Engagement
13%
2-pyridone
13%
N-Myristoyltransferase Inhibitors
13%
Life Sciences
13%
Drug Candidates
13%
Motility
13%
Methylenetetrahydrofolate Reductase (MTHFR)
13%
Protease Inhibitors
13%
Chemical Probes
13%
Potent Inhibitor
13%
Benzoxaborole
12%
Heterocycles
12%
Structural Insights
12%
Therapeutic Potential
12%
Brucei
12%
COVID-19
12%
Cytochrome P450 Enzymes
12%
Anti-trypanosomatid Drugs
12%
Lipid Particles
12%
Cardiac Progenitor Cells
12%
Sarolaner
12%
Multicomponent Reactions
12%
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
100%
Disease
65%
Trypanosoma Cruzi
65%
Chagas Disease
61%
Pharmacokinetics
57%
Infection
51%
Visceral Leishmaniasis
47%
Antimalarial Agent
47%
Mycobacterium Tuberculosis
45%
Carboxamide
42%
Trypanosoma Brucei
40%
Structure Activity Relationship
37%
Plasmodium falciparum
33%
Leishmania
32%
Malignant Neoplasm
30%
African Trypanosomiasis
30%
Mouse Model
29%
High-Throughput Screening
28%
Phosphotransferase
28%
Receptor
26%
Trypanosomatidae
25%
Infectious Agent
23%
Pharmaceutical Chemistry
22%
Protozoon
22%
Cytotoxicity
22%
Adenosine Triphosphate
22%
IC50
21%
Prodrug
20%
Antitrypanosomal
20%
Tropical Disease
20%
Clinical Trial
18%
Trypanosoma
18%
Cannabinoid Receptor Agonist
18%
Neoplasm
17%
Molecular Target
17%
Natural Product
17%
Lead Compound
16%
Amino Acid
16%
Drug Metabolism
16%
Proteasome
16%
Antimalarial Activity
16%
Amastigote
16%
Plasmodium
16%
Leishmania donovani
15%
Binding Site
15%
Acetogenin
14%
Protein Kinases
14%
Benznidazole
14%
Cytochrome P450
13%
Kinetoplastida
13%
Cyclin Dependent Kinase
13%
Drug Development
13%
Pseudouridine
13%
Triazole
13%
Biological Activity
13%
Lipophilicity
13%
Parasitosis
12%
Synthetase
12%
EC50
12%
Dihydrofolate Reductase
12%
Cysteine
12%
Lysine Transfer RNA Ligase
12%
Indazole Derivative
12%
Phosphotransferase Inhibitor
11%
Antiinfective Agent
10%
Proteasome Inhibitor
10%
Hexachlorophene
10%
Target Identification
10%
Anticarcinogen
9%
Leishmaniasis
9%
Receptor Subunit
9%
Serine
9%
Leishmania Major
9%
Drug Resistance
9%
Pyrazole Derivative
9%
Serotonin 3 Receptor
9%
Permethrin
9%
Deltamethrin
9%
Glutamate Transporter
9%
Cytosol Aminopeptidase
9%
Limonene
9%
Glycyrrhizin
9%
Tubulin
9%
Cryptosporidium
9%
Sarolaner
9%
Cannabinoid
9%
Antibiotics
8%
Nifurtimox
8%
Sulfonamide
8%
Oxidoreductase
8%
4 Aminobutyric Acid
8%
Base
8%
Biological Marker
8%
Side Effect
8%
Granisetron
8%
Functional Groups
8%
Antimicrobial Agent
8%
Carboxylesterase
7%
Phosphodiesterase Inhibitor
7%
Ethanol
7%
Biochemistry, Genetics and Molecular Biology
Enzyme
53%
RNA
42%
Transmembrane Protein
41%
Escherichia coli
34%
Membrane Protein
33%
Adenosine Triphosphate
26%
Mycobacterium Tuberculosis
24%
Conformation
24%
Plasmodium falciparum
24%
Metabolic Pathway
24%
Small Molecule
23%
Kinase
23%
Phosphotransferase
23%
Binding Site
23%
Transfer RNA
22%
Crystal Structure
22%
Computer Simulation
21%
Dynamics
21%
Copurification
20%
Pseudouridine
19%
Infectious Agent
17%
Cryoelectron Microscopy
15%
Ligand Binding
15%
Active Site
15%
Amino Acids
15%
Mitochondrion
14%
Lipid
14%
Trypanosoma Cruzi
14%
Trypanosoma Brucei
14%
Wild Type
14%
Plasmodium
14%
ABC Transporter
14%
C-Terminus
13%
Anabolism
13%
Methyltransferase
13%
Adenosine Diphosphate
13%
Retention Time
12%
Cell Membrane
12%
Drug Resistance
11%
Agonist
11%
N-Terminus
11%
Genetics
10%
Hydrolase
10%
Mass Spectrometry
10%
Metabolite
10%
Genomics
10%
Proteomics
10%
Conformational Change
9%
Progenitor Cell
9%
Trypanosomatidae
9%
Precursor
9%
Structure Activity Relation
9%
Nucleoside
9%
Riboswitch
9%
Quantum Mechanics
9%
Protein Kinases
9%
23S Ribosomal RNA
9%
ATP-binding Cassette Transporter
9%
Cancer Cell
8%
Energy Transfer
8%
IC50
8%
Carrier Protein
8%
Secretory Pathway
8%
Posttranslational Modification
8%
Kinetoplastida
8%
Trypanosoma
8%
Serine
7%
Coenzyme A
7%
Leishmania donovani
7%
ATPase
7%
Poly ADP Ribose Polymerase
7%
Oxidoreductase
7%
Inner Mitochondrial Membrane
7%
Peroxisome
7%
Cross-Link
7%
Biogenesis
7%
Isoform
7%
Binding Protein
7%
Cysteine
7%
Blood Plasma
7%
Uridine
7%
Adenosine Monophosphate
7%
Transcription
6%
Angiogenesis
6%
Peptidoglycan
6%
Proline
6%
Stem Cell
6%
Ubiquitin-Conjugating Enzyme
6%
Biological Phenomena and Functions Concerning the Entire Organism
6%
Homeostasis
6%
Lysine
6%
Pharmacokinetics
6%
X Ray
6%
Protein Complexes
6%
RNA Polymerase
6%
Biological Target
6%
Hypoxia-Inducible Factors
6%
B Cell
6%
Long Noncoding RNA
6%
Ion Transport
6%