Research output per year
Research output per year
Research output
- 1 - 50 out of 399 results
Search results
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2025
A Tensioned Human Skin Explant Model Used for Preliminary Assessment of Chemexfoliant-Stimulated Bioeffects
Conneely, M. J. (Lead / Corresponding author), Namkoong, J., Allison, F., Hirata Tsutsumi, S. K., Grussu, D., Willis, R., Henderson, K., Campbell, P. A., Moy, M., Lesniak, E., Wu, J. & Hickerson, R. P., Jan 2025, In: JID innovations : skin science from molecules to population health. 5, 1, 9 p., 100305.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure) -
Characterisation of RNA guanine-7 methyltransferase (RNMT) using a small molecule approach
Gray, D. (Lead / Corresponding author), Pearson, L.-A., Petit, A.-P., Mendoza Martinez, C., Bellany, F., Lin, D., Niven, S., Swift, R., Eadsforth, T., Fyfe, P., Paul, M., Postis, V., Hu, X. & Cowling, V., 17 Feb 2025, In: Biochemical Journal. p. 209-224 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase
Gade, P., Chang, C., Pryde, D., Fletcher, D., Niven, S., Godoy Magalhaes, L., Robinson, D. A., Saini, J., Ezzat Girgis Fahmy Ibrahim, P., Forte, B., Wower, J., Bodkin, M., Baragana, B. (Lead / Corresponding author), Gilbert, I., Michalska, K. & Joachimiak, A., 5 Apr 2025, In: European Journal of Medicinal Chemistry. 287, 12 p., 117335.Research output: Contribution to journal › Article › peer-review
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Recombinant production platform for Group A Streptococcus glycoconjugate vaccines
Ajay Castro, S., Passmore, I. J., Ndeh, D., Shaw, H. A., Rudas, A., Burns, K., Thomson, S., Nagar, R., Alagesan, K., Reglinski, M., Lucas, K., Abouelhadid, S., Schwarz-Linek, U., Mawas, F., Widmalm, G., Wren, B. W. (Lead / Corresponding author) & Dorfmueller, H. C. (Lead / Corresponding author), 22 Jan 2025, (E-pub ahead of print) In: NPJ Vaccines. 10, 14 p., 16.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
2024
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism
MacLeod, A. K., Coquelin, K.-S., Huertas, L., Simeons, F. R. C., Riley, J., Casado, P., Guijarro, L., Casanueva, R., Frame, L., Pinto, E. G., Ferguson, L., Duncan, C., Mutter, N., Shishikura, Y., Henderson, C. J., Cebrian, D., Wolf, C. R. & Read, K. D. (Lead / Corresponding author), 13 Feb 2024, In: Proceedings of the National Academy of Sciences. 121, 7, p. 1-12 12 p., 2315069121.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)143 Downloads (Pure) -
Accurate prediction of dynamic protein-ligand binding using P-score ranking
E. G. F. Ibrahim, P., Zuccotto, F., Zachariae, U., Gilbert, I. & Bodkin, M. (Lead / Corresponding author), 30 Jul 2024, In: Journal of Computational Chemistry. 45, 20, p. 1762-1778 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)79 Downloads (Pure) -
Acute response to pathogens in the early human placenta at single-cell resolution
Hoo, R., Ruiz-Morales, E. R., Kelava, I., Rawat, M., Mazzeo, C. I., Tuck, E., Sancho-Serra, C., Chelaghma, S., Predeus, A. V., Murray, S., Fernandez-Antoran, D., Waller, R. F., Álvarez-Errico, D., Lee, M. C. S. & Vento-Tormo, R. (Lead / Corresponding author), 15 May 2024, In: Cell Systems. 15, 5, p. 425-444.e9 30 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)100 Downloads (Pure) -
Antiplasmodial and anti-trypanosomial monoterpene indole alkaloids from Picralima nitida
Laryea, M. K., Abotsi, K. M. W., Woode, E., Dickson, R. A., Webster, L. & Ekuadzi, E. (Lead / Corresponding author), 28 Nov 2024, In: Natural Product Research.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments
Lang, S., Fletcher, D. A., Petit, A.-P., Luise, N., Fyfe, P., Zuccotto, F., Porter, D., Hope, A., Bellany, F., Kerr, C., Mackenzie, C. J., Wyatt, P. G. & Gray, D. W. (Lead / Corresponding author), 2 Jul 2024, In: ChemMedChem. 19, 13, 12 p., e202400025.Research output: Contribution to journal › Article › peer-review
Open AccessFile73 Downloads (Pure) -
Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy
Caldwell, N., Peet, C., Miller, P., Colon, B., Taylor, M., Cocco, M., Dawson, A., Lukac, I., Teixeira, J. E., Robinson, L., Frame, L., Seizova, S., Damerow, S., Tamaki, F., Post, J., Riley, J., Mutter, N., Hanna, J. C., Ferguson, L. & Hu, X. & 13 others, , 23 Oct 2024, In: Science Translational Medicine. 16, 770, p. 1-12 12 p., eadm8631.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)164 Downloads (Pure) -
Detection of the synthetic cathinone N,N-dimethylpentylone in seized samples from prisons
Norman, C. (Lead / Corresponding author), Schwelm, H. M., Semenova, O., Reid, R., Marland, V. & Nic Daeid, N., Aug 2024, In: Forensic Science International. 361, 5 p., 112145.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)92 Downloads (Pure) -
Discovery and characterization of noncanonical E2-conjugating enzymes
Abdul Rehman, S. A., Cazzaniga, C., Di Nisio, E., Antico, O., Knebel, A., Johnson, C., Şahin, A. T., Ibrahim, P. E. G. F., Lamoliatte, F., Negri, R., Miratul Muqit, M. K. & De Cesare, V. (Lead / Corresponding author), 29 Mar 2024, In: Science Advances. 10, 13, 18 p., adh0123.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)72 Downloads (Pure) -
Editorial: Strategies in the drug discovery and development for leishmaniasis: immunomodulators, natural products, synthetic compounds, and drug repositioning
de Almeida, T. F., Cunha-Junior, E. F., Wanderley, J. L. M., Pacheco, J. D. S., Pinto-da-Silva, L. H., Andrade-Neto, V. V. & Passos Chaves, S., 13 Mar 2024, In: Frontiers in Cellular and Infection Microbiology. 14, 3 p., 1384244.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)82 Downloads (Pure) -
Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6
Howie, J., Tulloch, L. B., Brown, E., Reilly, L., Ashford, F. B., Kennedy, J., Wypijewski, K. J., Aughton, K. L., Mak, J. K. C., Shattock, M. J., Fraser, N. J. (Lead / Corresponding author) & Fuller, W. (Lead / Corresponding author), 27 Feb 2024, In: Cell Reports. 43, 2, 13 p., 113679.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)98 Downloads (Pure) -
hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole
Mambwe, D., Coertzen, D., Leshabane, M., Mulubwa, M., Njoroge, M., Gibhard, L., Girling, G., Wicht, K. J., Lee, M. C. S., Wittlin, S., Moreira, D. R. M., Birkholtz, L. M. & Chibale, K. (Lead / Corresponding author), 11 Apr 2024, In: ACS Medicinal Chemistry Letters. 15, 4, p. 463-469 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile88 Downloads (Pure) -
HTS Library Plate Rejuvenation Using a DMSO-Rich Atmosphere
Hughes, F., Cookson, A. (Lead / Corresponding author), Tamaki, F., Bailey, C., Gray, D., Wrobel, K., Cookson, K., Bell, S. & Tarver, G., Dec 2024, In: SLAS Technology. 29, 6, 10 p., 100204.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Downloads (Pure) -
Human metabolism of the semi‐synthetic cannabinoids hexahydrocannabinol, hexahydrocannabiphorol and their acetates using hepatocytes and urine samples
Lindbom, K., Norman, C., Baginski, S., Krebs, L., Stalberga, D., Rautio, T., Wu, X., Kronstrand, R. & Gréen, H. (Lead / Corresponding author), 28 May 2024, (E-pub ahead of print) In: Drug Testing and Analysis. 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)161 Downloads (Pure) -
Identification and Validation of Compounds Targeting Leishmania major Leucyl-Aminopeptidase M17
Aguado, M. E., Carvalho, S., Valdés-Tresanco, M. E., Lin, D., Padilla-Mejia, N., Corpas-Lopez, V., Tesařová, M., Lukeš, J., Gray, D., González-Bacerio, J. (Lead / Corresponding author), Wyllie, S. (Lead / Corresponding author) & Field, M. C. (Lead / Corresponding author), 14 Jun 2024, In: ACS Infectious Diseases. 10, 6, p. 2002-2017 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)72 Downloads (Pure) -
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
Izquierdo, M., Lin, D., O'Neill, S., Webster, L. A., Paterson, C., Thomas, J., Aguado, M. E., Colina Araújo, E., Alpízar-Pedraza, D., Joji, H., MacLean, L., Hope, A., Gray, D. W., Zoltner, M., Field, M. C., González-Bacerio, J. (Lead / Corresponding author) & De Rycker, M. (Lead / Corresponding author), 15 Feb 2024, In: PLoS Neglected Tropical Diseases. 18, 2, 20 p., e0011956.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)81 Downloads (Pure) -
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors
Eadsforth, T., Torrie, L., Rowland, P., Edgar, E. V., MacLean, L., Paterson, C., Robinson, D. A., Shepherd, S. M., Thomas, J., Thomas, M., Gray, D., Postis, V. & De Rycker, M. (Lead / Corresponding author), 3 Dec 2024, (E-pub ahead of print) In: Journal of Biological Chemistry. 108049.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule interaction
Pinzi, L., Conze, C., Bisi, N., Torre, G. D., Soliman, A., Monteiro-Abreu, N., Trushina, N. I., Krusenbaum, A., Dolouei, M. K., Hellwig, A., Christodoulou, M. S., Passarella, D., Bakota, L., Rastelli, G. (Lead / Corresponding author) & Brandt, R. (Lead / Corresponding author), 23 Feb 2024, In: Nature Communications. 15, 16 p., 1679.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)89 Downloads (Pure) -
Rational Exploration of 2,4-Diaminopyrimidines as DHFR Inhibitors Active against Mycobacterium abscessus and Mycobacterium avium, Two Emerging Human Pathogens
Andrade Meirelles, M., Almeida, V. M., Sullivan, J. R., de Toledo, I., dos Reis, C. V., Cunha, M. R., Zigweid, R., Shim, A., Sankaran, B., Woodward, E. L., Seibold, S., Liu, L., Mian, M. R., Battaile, K. P., Riley, J., Duncan, C., Simeons, F. R. C., Ferguson, L., Joji, H. & Read, K. D. & 5 others, , 14 Nov 2024, In: Journal of Medicinal Chemistry. 67, 21, p. 19143-19164 22 p.Research output: Contribution to journal › Article › peer-review
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Sperm Toolbox-A selection of small molecules to study human spermatozoa
Gruber, F. S., Richardson, A., Johnston, Z. C., Myles, R., Norcross, N. R., Day, D. P., Georgiou, I., Sesma-Sanz, L., Wilson, C., Read, K. D., Martins da Silva, S., Barratt, C. L. R., Gilbert, I. H. & Swedlow, J. R. (Lead / Corresponding author), 20 Feb 2024, In: PLoS ONE. 19, 2, 16 p., e0297666.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)99 Downloads (Pure) -
Sterol 14-alpha demethylase (CYP51) activity in Leishmania donovani is likely dependent upon cytochrome P450 reductase 1
Tulloch, L., Tinti, M., Wall, R., Weidt, S. K., Corpas Lopez, V., Dey, G., Smith, T. K., Fairlamb, A., Barrett, M. P. & Wyllie, S. (Lead / Corresponding author), 11 Jul 2024, In: PLoS Pathogens. 20, 7, 23 p., e1012382.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)76 Downloads (Pure) -
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency
Gardner, S., Jin, Y., Fyfe, P. K., Voisin, T. B., Sotolongo Bellón, J., Pohler, E., Piehler, J., Moraga, I. (Lead / Corresponding author) & Bubeck, D. (Lead / Corresponding author), 7 Mar 2024, In: Nature Communications. 15, 11 p., 2071.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)84 Downloads (Pure) -
Superior Anticancer and Antifungal Activities of New Sulfanyl-Substituted Niclosamide Derivatives
Ma, J., Veeragoni, D., Ghosh, H., Mutter, N., Barbosa, G., Webster, L., Schobert, R., Sande, W. V. D. (Lead / Corresponding author), Dandawate, P. (Lead / Corresponding author) & Biersack, B., 21 Jul 2024, In: Biomedicines. 12, 7, 18 p., 1621.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)54 Downloads (Pure) -
The major surface protein of malaria sporozoites is GPI-anchored to the plasma membrane
Nagar, R., Garcia Castillo, S. S., Pinzon-Ortiz, M., Patray, S., Coppi, A., Kanatani, S., Mortiz, R. L., Swearingen, K. E., Ferguson, M. A. J. (Lead / Corresponding author) & Sinnis, P. (Lead / Corresponding author), Aug 2024, In: Journal of Biological Chemistry. 300, 8, 107557.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)9 Downloads (Pure) -
Validation of Trypanosoma cruzi inactivation techniques for laboratory use
MacLean, L. M. (Lead / Corresponding author), Ariyanayagam, M., Sastry, L., Paterson, C., De Rycker, M. & Fairlamb, A. H. (Lead / Corresponding author), 18 Apr 2024, In: PLoS ONE. 19, 4, 12 p., e0300021.Research output: Contribution to journal › Article › peer-review
Open AccessFile65 Downloads (Pure) -
Waxy- or putty-like materials as a novel drug preparation for synthetic cannabinoid receptor agonists: Detection in prisons and in vitro cannabinoid receptor activity
Timmerman, A., Deventer, M. H., Andrews, R., Reid, R., Marland, V., Edwards, D., Pudney, C. R., Nic Daeid, N., Stove, C. P. & Norman, C. (Lead / Corresponding author), 15 Oct 2024, (E-pub ahead of print) In: Drug Testing and Analysis.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)45 Downloads (Pure) -
2023
Antileishmanial effects of Crotalaria spectabilis Roth aqueous extracts on Leishmania amazonensis
Pacheco, J. S., Teixeira, É. M. G. F., Paschoal, R. G., Torres-Santos, E. C., De Simone, S. G. & Da Silva-López, R. E. (Lead / Corresponding author), 2023, In: Anais da Academia Brasileira de Ciências. 95, Supplement 1, 23 p., e20220613.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Downloads (Pure) -
Bespoke drug discovery training for low-middle income countries
Webster, L. A., Farrell, S. J. (Lead / Corresponding author), Gilbert, I. H. & Read, K. D., 10 Aug 2023, In: ACS Medicinal Chemistry Letters. 14, 8, p. 1014-1016 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)71 Downloads (Pure) -
Clinical and genomic evolution of carbapenem-resistant klebsiella pneumoniae bloodstream infections over two time periods at a tertiary care hospital in South India: A prospective cohort study
Manesh, A., Shankar, C., George, M. M., Jasrotia, D. S., Lal, B., George, B., Mathews, V., Eapen, C. E., Joseph, P., Subramani, K., Rao, S., Peter, J. V., Chacko, B., Zachariah, A., Sathyendra, S., Hansdak, S. G., Abraham, O. C., Iyadurai, R., Vijayakumar, S. & Karthik, R. & 5 others, , May 2023, In: Infectious Diseases and Therapy. 12, 5, p. 1319-1335 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)106 Downloads (Pure) -
Comparative analysis of RNA secondary structure accuracy on predicted RNA 3D models
Kulkarni, M., Thangappan, J., Deb, I. & Wu, S. (Lead / Corresponding author), Sept 2023, In: PLoS ONE. 18, 9, p. e0290907 33 p., e0290907.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)207 Downloads (Pure) -
Design and synthesis of covalent inhibitors of FabA
Martin, J. S., Mackenzie, C. J., Lin, D., Homeyer, N., Gray, D. W., Zuccotto, F. & Gilbert, I. H. (Lead / Corresponding author), 11 Apr 2023, In: ACS Omega. 8, 14, p. 12787–12804 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)113 Downloads (Pure) -
Design of the Global Health chemical diversity library v2 for screening against infectious diseases
Wilson, C., Gardner, J. M. F., Gray, D., Baragana, B., Wyatt, P., Cookson, A., Thompson, S., Mendoza Martinez, C., Bodkin, M., Gilbert, I. (Lead / Corresponding author) & Tarver, G. (Lead / Corresponding author), 27 Dec 2023, In: PLoS Neglected Tropical Diseases. 17, 12, 13 p., e0011799.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)103 Downloads (Pure) -
Development of a 2,4-diaminothiazole series for the treatment of human African trypanosomiasis highlights the importance of static-cidal screening of analogues
Cleghorn, L. A. T., Wall, R. J., Albrecht, S., MacGowan, S. A., Norval, S., De Rycker, M., Woodland, A., Spinks, D., Thompson, S., Patterson, S., Corpas Lopez, V., Dey, G., Collie, I. T., Hallyburton, I., Kime, R., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Wyatt, P. G. & Read, K. D. & 2 others, , 13 Jul 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8896–8916 21 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)103 Downloads (Pure) -
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity
Green, S. R. (Lead / Corresponding author), Wilson, C., Eadsforth, T. C., Punekar, A. S., Tamaki, F. K., Wood, G., Caldwell, N., Forte, B., Norcross, N. R., Kiczun, M., Post, J. M., Lopez-Román, E. M., Engelhart, C. A., Lukac, I., Zuccotto, F., Epemolu, O., Boshoff, H. I. M., Schnappinger, D., Walpole, C. & Gilbert, I. H. & 3 others, , 23 Nov 2023, In: Journal of Medicinal Chemistry. 66, 22, p. 15380-15408 29 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)89 Downloads (Pure) -
Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity
West, C. E. (Lead / Corresponding author), Karim, M., Falaguera, M. J., Speidel, L., Green, C. J., Logie, L., Schwartzentruber, J., Ochoa, D., Lord, J. M., Ferguson, M. A. J., Bountra, C., Wilkinson, G. F., Vaughan, B., Leach, A. R., Dunham, I. & Marsden, B. D., 25 Sept 2023, In: Scientific Data. 10, 13 p., 655.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)78 Downloads (Pure) -
LNA-induced dynamic stability in a therapeutic aptamer: insights from molecular dynamics simulations
Pal, R., Deb, I., Sarzynska, J. (Lead / Corresponding author) & Lahiri, A. (Lead / Corresponding author), 2023, In: Journal of Biomolecular Structure and Dynamics. 41, 6, p. 2221-2230 10 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Log D7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity
Brandon, A. M. (Lead / Corresponding author), Baginski, S. R., Peet, C., Dugard, P., Green, H., Sutcliffe, O. B., Daéid, N. N., Nisbet, L. A. (Lead / Corresponding author), Read, K. D. & McKenzie, C., 8 Dec 2023, In: Drug Testing and Analysis. 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile87 Downloads (Pure) -
Mode of action studies confirm on-target engagement of lysyl-tRNA synthetase inhibitor and lead to new selection marker for Cryptosporidium
Hanna, J. C. .., Corpas Lopez, V., Seizova, S., Colon, B. L., Bacchetti, R., Hall, G. M. J., Sands, E. M., Robinson, L., Baragaña, B., Wyllie, S. (Lead / Corresponding author) & Pawlowic, M. (Lead / Corresponding author), 4 Aug 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 14 p., 1236814.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)134 Downloads (Pure) -
Peptidyl tRNA hydrolase is required for robust prolyl-tRNA turnover in mycobacterium tuberculosis
Tomasi, F. G., Schweber, J. T. P., Kimura, S., Zhu, J., Cleghorn, L. A. T., Davis, S. H., Green, S. R., Waldor, M. K. & Rubin, E. J. (Lead / Corresponding author), 28 Feb 2023, In: MBio. 14, 1, 13 p., e03469-22.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)121 Downloads (Pure) -
Perspective on schistosomiasis drug discovery: highlights from a schistosomiasis drug discovery workshop at Wellcome Collection, London, September 2022
Caldwell, N., Afshar, R., Baragaña, B., Bustinduy, A. L., Caffrey, C. R., Collins, J. J., Fusco, D., Garba, A., Gardner, M., Gomes, M., Hoffman, K. F., Hsieh, M., Lo, N. C., McNamara, C. W., Nono, J. K., Padalino, G., Read, K. D., Roestenberg, M., Spangenberg, T. & Specht, S. & 1 others, , 12 May 2023, In: ACS Infectious Diseases. 9, 5, p. 1046-1055 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)149 Downloads (Pure) -
Proximity-Based Modalities for Biology and Medicine
Liu, X. & Ciulli, A. (Lead / Corresponding author), 26 Jul 2023, In: ACS Central Science. 9, 7, p. 1269-1284 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile72 Citations (Scopus)175 Downloads (Pure) -
RES-Seq – a barcoded library of drug-resistant Leishmania donovani allowing rapid assessment of cross-resistance and relative fitness
Tulloch, L. B., Carvalho, S., Lima, M., Wall, R. J., Tinti, M., Pinto, E. G., MacLean, L. & Wyllie, S. (Lead / Corresponding author), 19 Dec 2023, In: MBio. 14, 6, 15 p., e01803-23.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
Short-course combination treatment for experimental chronic Chagas disease
González, S., Wall, R. J., Thomas, J., Braillard, S., Brunori, G., Camino Díaz, I., Cantizani, J., Carvalho, S., Castañeda Casado, P., Chatelain, E., Cotillo, I., Fiandor, J. M., Francisco, A. F., Grimsditch, D., Keenan, M., Kelly, J. M., Kessler, A., Luise, C., Lyon, J. J. & MacLean, L. & 10 others, , 13 Dec 2023, In: Science Translational Medicine. 15, 726, 17 p., adg8105.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)112 Downloads (Pure) -
Small-molecule antibiotic drug development: need and challenges
Bergkessel, M. (Lead / Corresponding author), Forte, B. (Lead / Corresponding author) & Gilbert, I. H. (Lead / Corresponding author), 10 Nov 2023, In: ACS Infectious Diseases. 9, 11, p. 2032-2071 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)162 Downloads (Pure) -
SophosQM: Accurate Binding Affinity Prediction in Compound Optimization
Guareschi, R., Lukac, I., Gilbert, I. H. (Lead / Corresponding author) & Zuccotto, F. (Lead / Corresponding author), 2 May 2023, In: ACS Omega. 8, 17, p. 15083-15098 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)197 Downloads (Pure) -
Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand
Chauvier, A., Porta, J. C., Deb, I., Ellinger, E., Meze, K., Frank, A. T., Ohi, M. D. (Lead / Corresponding author) & Walter, N. G. (Lead / Corresponding author), Jul 2023, In: Nature Structural & Molecular Biology. 30, 7, p. 902–913 12 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Structural insights into hydrolytic defluorination of difluoroacetate by microbial fluoroacetate dehalogenases
Khusnutdinova, A. N., Batyrova, K. A., Brown, G., Fedorchuk, T., Chai, Y. S., Skarina, T., Flick, R., Petit, A.-P., Savchenko, A., Stogios, P. & Yakunin, A. F. (Lead / Corresponding author), 18 Oct 2023, In: FEBS Journal. 290, 20, p. 4966-4983 18 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus)