Drug Discovery Unit

  • United Kingdom

Research Output

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Review article
2020

A One Health Approach to Tackle Cryptosporidiosis

Innes, E. A., Chalmers, R. M., Wells, B. & Pawlowic, M. C., Mar 2020, In : Trends in Parasitology. 36, 3, p. 290-303 14 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Targeting epigenetic reader domains by chemical biology

Cipriano, A., Sbardella, G. & Ciulli, A., Aug 2020, In : Current Opinion in Chemical Biology. 57, p. 82-94 13 p.

Research output: Contribution to journalReview article

Treating age-related multimorbidity: the drug discovery challenge

Ermogenous, C., Green, C., Jackson, T., Ferguson, M. & Lord, J. M., 20 Jun 2020, In : Drug Discovery Today. 13 p.

Research output: Contribution to journalReview article

Open Access
2019

Essential oils as topical anti-infective agents: A systematic review and meta-analysis

Deyno, S., Mtewa, A. G., Abebe, A., Hymete, A., Makonnen, E., Bazira, J. & Alele, P. E., Dec 2019, In : Complementary Therapies in Medicine. 47, p. 1-8 8 p., 102224.

Research output: Contribution to journalReview article

2 Citations (Scopus)
2018

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer's Disease

Prati, F., Bottegoni, G., Bolognesi, M. L. & Cavalli, A., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 619-637 19 p.

Research output: Contribution to journalReview article

Open Access
File
42 Citations (Scopus)
115 Downloads (Pure)

Challenges and recent progress in drug discovery for tropical diseases

De Rycker, M., Baragaña, B., Duce, S. L. & Gilbert, I. H., 25 Jul 2018, In : Nature. 559, 7715, p. 498-506 9 p.

Research output: Contribution to journalReview article

Open Access
File
30 Citations (Scopus)
217 Downloads (Pure)

Direct and indirect approaches to identify drug modes of action

Tulloch, L. B., Menzies, S. K., Coron, R. P., Roberts, M. D., Florence, G. J. & Smith, T. K., Jan 2018, In : IUBMB Life. 70, 1, p. 9-22 14 p.

Research output: Contribution to journalReview article

8 Citations (Scopus)

The trypanosome alternative oxidase: a potential drug target?

Menzies, S. K., Tulloch, L. B., Florence, G. J. & Smith, T. K., Feb 2018, In : Parasitology. 145, 2, p. 175-183 9 p.

Research output: Contribution to journalReview article

Open Access
File
13 Citations (Scopus)
87 Downloads (Pure)
2017
Open Access
File
138 Citations (Scopus)
297 Downloads (Pure)

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ

Slominski, A. T., Kim, T-K., Hobrath, J. V., Oak, A. S. W., Tang, E. K. Y., Tieu, E. W., Li, W., Tuckey, R. C. & Jetten, A. M., Oct 2017, In : Journal of Steroid Biochemistry and Molecular Biology. 173, p. 42-56 15 p.

Research output: Contribution to journalReview article

Open Access
File
51 Citations (Scopus)
180 Downloads (Pure)

Fragment library design, synthesis and expansion: nurturing a synthesis and training platform

Ray, P. C., Kiczun, M., Huggett, M., Lim, A., Prati, F., Gilbert, I. H. & Wyatt, P. G., Jan 2017, In : Drug Discovery Today. 22, 1, p. 43-56 14 p.

Research output: Contribution to journalReview article

Open Access
File
16 Citations (Scopus)
353 Downloads (Pure)
2016

Drug Resistance in Eukaryotic Microorganisms

Fairlamb, A. H., Gow, N. A. R., Matthews, K. R. & P. Waters, A., Jul 2016, In : Nature Microbiology. 1, p. 1-14 14 p., 16092.

Research output: Contribution to journalReview article

Open Access
File
54 Citations (Scopus)
190 Downloads (Pure)
2010

Through the "gatekeeper door": exploiting the active kinase conformation

Zuccotto, F., Ardini, E., Casale, E. & Angiolini, M., 8 Apr 2010, In : Journal of Medicinal Chemistry. 53, 7, p. 2681-2694 14 p.

Research output: Contribution to journalReview article

307 Citations (Scopus)
2003

Altered calcium regulation in freshly isolated aortic smooth muscle cells from bile duct-ligated rats: Role of nitric oxide

Atucha, N. M., Iyu, D., De Rycker, M., Soler, A. & García-Estañ, J., Feb 2003, In : Cell Calcium. 33, 2, p. 129-135 7 p.

Research output: Contribution to journalReview article

16 Citations (Scopus)