Gene Regulation and Expression

  • United Kingdom

Research Output 1989 2018

2018

6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

Offenburger, S-L. & Gartner, A., 20 Sep 2018, In : Bio-Protocol. 8, 18, 12 p., e3025.

Research output: Contribution to journalArticle

Open Access
File
Oxidopamine
Dopaminergic Neurons
Caenorhabditis elegans
Oxidative Stress
Cell Death
1 Citations
Open Access
File
prealbumin
Prealbumin
Oxidopamine
Caenorhabditis elegans
Oxidative Stress

A call for public archives for biological image data

Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bioinformatics
Imaging techniques
Computational Biology
Databases
Technology
3 Citations

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination
3 Citations

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11

Piscitello, D., Varshney, D., Lilla, S., Vizioli, M. G., Reid, C., Gorbunova, V., Seluanov, A., Gillespie, D. A. & Adams, P. D., 25 Jan 2018, In : Oncogene. 37, 4, p. 427-438 12 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair
Phosphotransferases
Down-Regulation
DNA Damage
Recombinational DNA Repair

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
Natural Killer Cells
mice
amino acids
Lymphocytes
Glutamine

Analysis of novel missense ATR mutations reveals new splicing defects underlying Seckel Syndrome

Llorens-Agost, M., Luessing, J., van Beneden, A., Eykelenboom, J., O'Reilly, D., Bicknell, L. S., Reynolds, J. J., van Koegelenberg, M., Hurles, M. E., Brady, A. F., Jackson, A. P., Stewart, G. S. & Lowndes, N. F., 17 Nov 2018, In : Human Mutation. 39, 12, p. 1847-1853 7 p.

Research output: Contribution to journalArticle

Ataxia Telangiectasia
Missense Mutation
Mutation
Microcephaly
Inborn Genetic Diseases
1 Citations

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Liakath-Ali, K., Mills, E. W., Sequeira, I., Lichtenberger, B. M., Pisco, A. O., Sipilä, K. H., Mishra, A., Yoshikawa, H., Wu, C. C-C., Ly, T., Lamond, A. I., Adham, I. M., Green, R. & Watt, F. M., 11 Apr 2018, In : Nature. 556, p. 376-380 5 p.

Research output: Contribution to journalLetter

Open Access
File
Ribosomes
Homeostasis
Stem Cells
Sirolimus
Quality Control

Biochemical and Structural Properties of Fungal Holliday Junction-Resolving Enzymes

Liu, Y., Freeman, A., Déclais, A-C., Gartner, A. & Lilley, D. M. J., 2018, Mechanisms of DNA Recombination and Genome Rearrangements: Methods to Study Homologous Recombination. Spies, M. & Malkova, A. (eds.). Academic Press, Vol. 600. p. 543-568 26 p. (Methods in Enzymology; vol. 600).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Cruciform DNA
Structural properties
Enzymes
Chaetomium
DNA
1 Citations

Computational Modelling of Cancer Development and Growth: Modelling at Multiple Scales and Multiscale Modelling

Szymańska, Z., Cytowski, M., Mitchell, E., Macnamara, C. K. & Chaplain, M., May 2018, In : Bulletin of Mathematical Biology. 80, 5, p. 1366-1403 38 p.

Research output: Contribution to journalArticle

growth modeling
Multiscale Modeling
Multiple Scales
Computational Modeling
Growth and Development

Designing engaging learning experiences in programming

Martin, C., Hughes, J. & Richards, J., 2018, Computers Supported Education: 9th International Conference, CSEDU 2017, Revised Selected Papers. Escudeiro, P., Costagliola, G., Zvacek, S., Uhomoibhi, J. & McLaren, B. M. (eds.). Switzerland: Springer Verlag, p. 221-245 25 p. (Communications in Computer and Information Science; vol. 865).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Programming
mole
Field Study
Students
Experience

DHX15 regulates CMTR1-dependent gene expression and cell proliferation

Inesta-Vaquera, F., Chaugule, V. K., Galloway, A., Chandler, L., Rojas-Fernandez, A., Weidlich, S., Peggie, M. & Cowling, V., 18 Jun 2018, In : Life Science Alliance. 1, 3, 18 p., e201800092.

Research output: Contribution to journalArticle

Open Access
File
RNA Polymerase II
Cell Proliferation
Ribosomes
Gene Expression
Messenger RNA

E1B-55K mediated regulation of RNF4 STUbL promotes HAdV gene expression

Müncheberg, S., Hay, R. T., Ip, W. H., Meyer, T., Weiß, C., Brenke, J., Masser, S., Hadian, K., Dobner, T. & Schreiner, S., Jul 2018, In : Journal of Virology. 92, 13, 18 p., e00164-18.

Research output: Contribution to journalArticle

Open Access
File
Ligases
ubiquitin
Ubiquitin
ligases
Antiviral Agents

Effects of hypo O-GlcNAcylation on Drosophila development

Mariappa, D. N., Ferenbach, A. & van Aalten, D. M. F., 11 May 2018, In : Journal of Biological Chemistry. 293, 19, p. 7209-7221 13 p.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Drosophila
Genes
Phenotype
Mediator Complex

Efficient Analysis of Mammalian Polysomes in cells and tissues using Ribo Mega-SEC

Yoshikawa, H., Larance, M., Ly, T. & Lamond, A., 10 Aug 2018, In : eLife. 2018, 7, 26 p., e36530.

Research output: Contribution to journalArticle

Open Access
File
Polyribosomes
Size exclusion chromatography
Liver
Cells
Tissue

Evidence for substrate assisted catalysis in N-acetylphosphoglucosamine mutase

Raimi, O. G., Hurtado Guerrero, R. & van Aalten, D. M. F., 16 Aug 2018, In : The Biochemical journal. 475, 15, p. 2547-2557 11 p.

Research output: Contribution to journalArticle

Open Access
File
Intramolecular Transferases
Phosphoglucomutase
Hexosamines
Phosphoserine
Mutagenesis

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, B. B. & Hartmann-Petersen, R., 23 Oct 2018, In : Cell Reports. 25, 4, p. 862-870 9 p.

Research output: Contribution to journalArticle

Open Access
File
Septins
Intrinsically Disordered Proteins
ATP Citrate (pro-S)-Lyase
Schizosaccharomyces
Proteasome Endopeptidase Complex
1 Citations

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Shoaib, M., Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, M., Johansen, J. V., Hansen, K., Julien, E., Blow, J. J. & Sørensen, C. S., 12 Sep 2018, In : Nature Communications. 9, 1, 11 p., 3704.

Research output: Contribution to journalArticle

Open Access
File
licensing
chromatin
methylation
Methylation
genome

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., 12 Nov 2018, In : PLoS Genetics. 14, 11, p. e1007783

Research output: Contribution to journalArticle

Open Access
File
DNA replication
DNA Replication
Chromatin
chromatin
Proliferating Cell Nuclear Antigen

Inhibitors against Fungal Cell Wall Remodeling Enzymes

Delso, I., Valero-Gonzalez, J., Gomollón-Bel, F., Castro-López, J., Fang, W., Navratilova, I., van Aalten, D. M. F., Tejero, T., Merino, P. & Hurtado-Guerrero, R., 22 Jan 2018, In : ChemMedChem. 13, 2, p. 128-132 5 p.

Research output: Contribution to journalArticle

Open Access
File
Triazoles
Aspergillus fumigatus
Glucans
X Ray Crystallography
Enzyme Inhibitors

Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system

Ostrowski, A., Cianfanelli, F. R., Porter, M., Mariano, G., Peltier, J., Wong, J. J., Swedlow, J. R., Trost, M. & Coulthurst, S. J., 27 Jul 2018, In : PLoS Pathogens. 14, 7, e1007230.

Research output: Contribution to journalArticle

Open Access
File
Threonine
Phosphorylation
Serratia marcescens
Proteins
Weapons
2 Citations

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

Research output: Contribution to journalArticle

Open Access
File
Lunar Module
nuclease
mitosis
chromatin
Deoxyribonucleases
1 Citations

Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta

Almohammed, R., Osborn, K., Ramasubramanyan, S., Perez-Fernandez, I. B. N., Godfrey, A., Mancini, E. J. & Sinclair, A. J., 1 Jun 2018, In : Journal of General Virology. 99, p. 805-817 13 p.

Research output: Contribution to journalArticle

Open Access
File
Immune Evasion
Human Herpesvirus 4
Response Elements
Virus Latency
Genes

Morphological and genetic characterisation of the root system architecture of selected barley recombinant chromosome substitution lines using an integrated phenotyping approach

Canto, C. D. L. F., Kalogiros, D. I., Ptashnyk, M., George, T. S., Waugh, R., Bengough, A. G., Russell, J. & Dupuy, L. X., 14 Jun 2018, In : Journal of Theoretical Biology. 447, p. 84-97 14 p.

Research output: Contribution to journalArticle

Root Growth
substitution lines
Barley
Root System
Hordeum
2 Citations

mRNA cap methyltransferase, RNMT-RAM, promotes RNA pol II-dependent transcription

Varshney, D., Lombardi, O., Schweikert, G., Dunn, S., Suska, O. & Cowling, V., May 2018, In : Cell Reports. 23, 5, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

Open Access
File
RNA Polymerase II
Methyltransferases
Random access storage
Transcription
Messenger RNA
Open Access
Cells
Messenger RNA
RNA Polymerase II
RNA
Cell Physiological Phenomena
2 Citations

Mutational signatures of DNA mismatch repair deficiency in and human cancers

Meier, B., Volkova, N. V., Hong, Y., Schofield, P., Campbell, P. J., Gerstung, M. & Gartner, A., May 2018, In : Genome Research. 28, 5, p. 666-675 10 p.

Research output: Contribution to journalArticle

Open Access
File
DNA Repair-Deficiency Disorders
DNA Mismatch Repair
Neoplasms
Genome
Cytosine
4 Citations
Open Access
File
Oxidopamine
apoptosis
Caenorhabditis elegans
mutation
Dopaminergic Neurons
Open Access
File
Somites
Maintenance
Mesoderm
Genes
Embryonic Development

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry

Borodkin, V. S., Rafie, K., Selvan, N., Aristotelous, T., Navratilova, I., Ferenbach, A. T. & Van Aalten, D. M. F., 18 May 2018, In : ACS Chemical Biology. 13, 5, p. 1353-1360 8 p.

Research output: Contribution to journalArticle

Polarimeters
Fluorescence
Assays
Hexosaminidase B
Cardiovascular Diseases

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

Research output: Contribution to journalArticle

Open Access
File
Cell Movement
Actins
Clustered Regularly Interspaced Short Palindromic Repeats
Focal Adhesions
Osteosarcoma

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 othersSmith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, 18 p., 181108.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
serine
Serine
phosphorylation
Chemical activation

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

Jonik-Nowak, B., Menneteau, T., Fesquet, D., Baldin, V., Bonne-Andrea, C., Méchali, F., Fabre, B., Boisguerin, P., de Rossi, S., Henriquet, C., Pugnière, M., Ducoux-Petit, M., Burlet-Schiltz, O., Lamond, A., Fort, P., Boulon, S., Bousquet, M-P. & Coux, O., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. E6477-E6486 10 p., 201722299.

Research output: Contribution to journalArticle

Open Access
File
Proteasome Endopeptidase Complex
Casein Kinase II
Ubiquitin
Dissection
Proteins

Positioning Europe for the EPITRANSCRIPTOMICS challenge

Jantsch, M., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J-Y., Balatsos, N., Dinnyes, A., Baranov, P., Kelly, V. & 40 othersLamm, A., Rechavi, G., Pelizzola, M., Liepins, J., Holodnuka Kholodnyuk, I., Zammit, V., Ayers, D., Drablos, F., Dahl, J. A., Bujnicki, J., Jeronimo, C., Almeida, R., Neagu, M., Costache, M., Bankovic, J., Banovic, B., Kyselovic, J., Valor, L. M., Selbert, S., Pir, P., Demircan, T., Cowling, V., Schäfer, M., Rossmanith, W., Lafontaine, D., David, A., Carre, C., Lyko, F., Schaffrath, R., Schwartz, S., Verdel, A., Klungland, A., Purta, E., Timotijevic, G., Cardona, F., Davalos, A., Ballana, E., O Carroll, D., Ule, J. & Fray, R., 3 Jun 2018, In : RNA Biology. 15, 6, p. 829-831 8 p.

Research output: Contribution to journalArticle

Open Access
File
Epigenomics
DNA
RNA
Research
Regeneration
File
Proteome
Breast
Epithelial Cells
Proteins
Oncogenes
1 Citations

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei

Crozier, T. W. M., Tinti, M., Wheeler, R. J., Ly, T., Ferguson, M. A. J. & Lamond, A. I., 1 Jun 2018, In : Molecular & Cellular Proteomics. 17, p. 1184-1195 12 p.

Research output: Contribution to journalArticle

Open Access
File
Trypanosoma brucei brucei
Proteomics
Trypanosomiasis
Cell Cycle
Cells

Publisher Correction: Image Data Resource: a bioimage data integration and publication platform

Williams, E., Moore, J., Li, S. W., Rustici, G., Tarkowska, A., Chessel, A., Leo, S., Antal, B., Ferguson, R. K., Sarkans, U., Brazma, A., Carazo Salas, R. E. & Swedlow, J. R., 4 Oct 2018, In : Nature Methods. 1 p.

Research output: Contribution to journalArticle

Open Access
Data integration
Publications
Licensure
2 Citations

Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila

Clemente, G. D., Hannaford, M. R., Beati, H., Kapp, K., Januschke, J., Griffis, E. R. & Müller, H-A. J., 30 Mar 2018, In : Journal of Developmental Biology. 6, 2, 23 p., 9.

Research output: Contribution to journalArticle

Open Access
File
Dyneins
Drosophila
Kinetochores
Germ Cells
Prometaphase
1 Citations

RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation

Bustos, F., Segarra Fas, A., Chaugule, V. K., Brandenburg, L., Branigan, E., Toth, R., Macartney, T., Knebel, A., Hay, R., Walden, H. & Findlay, G., 8 May 2018, In : Cell Reports. 23, p. 1599-1611 14 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Protein Ligases
Stem cells
Intellectual Disability
Mutation
Genes
2 Citations

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron

Gray, K. M., Kaifer, K. A., Baillat, D., Wen, Y., Bonacci, T. R., Ebert, A. D., Raimer, A. C., Spring, A. M., Have, S. T., Glascock, J. J., Gupta, K., Van Duyne, G. D., Emanuele, M. J., Lamond, A. I., Wagner, E. J., Lorson, C. L. & Matera, A. G., 15 Jan 2018, In : Molecular Biology of the Cell. 29, 2, p. 96-110 15 p.

Research output: Contribution to journalArticle

Open Access
File
Motor Neurons
Protein Isoforms
Spinal Muscular Atrophy
Exons
Duplicate Genes

SINHCAF/FAM60A and SIN3A specifically repress HIF 2α expression

Biddlestone, J., Batie, M., Bandarra, D., Munoz, I. & Rocha, S., 21 May 2018, In : Biochemical Journal. 475, 12, p. 2073-2090 18 p.

Research output: Contribution to journalArticle

Open Access
File
Co-Repressor Proteins
Transcription Factors
Messenger RNA
Proteins
Hypoxia
1 Citations

Spindly is required for rapid migration of human cells

Conte, C., Baird, M. A., Davidson, M. W. & Griffis, E. R., 29 May 2018, In : Open Biology. 7, 5, 9 p., 033233 .

Research output: Contribution to journalArticle

Open Access
File
Dyneins
Cell Movement
Cells
microtubules
cell movement

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, 28 p., e35720.

Research output: Contribution to journalArticle

Open Access
File
Chromatin Assembly and Disassembly
Nucleosomes
Chromatin
Histones
DNA

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

Research output: Contribution to journalArticle

Open Access
File
Spliceosomes
Cell- and Tissue-Based Therapy
Squamous Cell Carcinoma
Skin
Neoplasms
2 Citations

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Barini, E., Miccoli, A., Tinarelli, F., Mulholland, K., Kadri, H., Khanim, F., Stojanovski, L., Read, K. D., Burness, K., Blow, J. J., Mehellou, Y. & Muqit, M. M. K., 2 Mar 2018, In : ChemBioChem. 19, 5, p. 425-429 5 p.

Research output: Contribution to journalArticle

Open Access
File
Niclosamide
Anthelmintics
Protein Kinases
Parkinson Disease
Mitochondrial Membrane Potential
1 Citations

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

Research output: Contribution to journalArticle

Open Access
File
3'-nucleotidase
Recombinational DNA Repair
Chromosome Segregation
chromosome segregation
nucleases

The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT: UDP-GlcNAc glycosylation and proteolysis activities

Kapuria, V., Röhrig, U. F., Waridel, P., Lammers, F., Borodkin, V. S., van Aalten, D. M. F., Zoete, V. & Herr, W., 16 Nov 2018, In : Journal of Biological Chemistry. 293, 46, p. 17754-17768 15 p.

Research output: Contribution to journalArticle

Open Access
File
Proteolysis
Glycosylation
Host Factor 1 Protein
Uridine Diphosphate
Threonine

The Encyclopedia of Proteome Dynamics: The KinoViewer

Brenes Murillo, A. & Lamond, A., 19 Sep 2018, In : Bioinformatics. bty823.

Research output: Contribution to journalArticle

Open Access
File
Encyclopedias
Proteome
Phosphotransferases
Proteins
Mouse
4 Citations

The Encyclopedia of Proteome Dynamics – A big data ecosystem for (prote)omics

Brenes Murillo, A., Afzal, V., Kent, R. & Lamond, A., 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1202-D1209 8 p.

Research output: Contribution to journalArticle

Open Access
File
Encyclopedias
Proteome
Proteomics
Ecosystem
Genomics
1 Citations

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, e0201263.

Research output: Contribution to journalArticle

Open Access
File
bloodstream forms
Trypanosoma brucei
Null Lymphocytes
Trypanosoma brucei brucei
methyltransferases