Gene Regulation and Expression

  • United Kingdom

Research Output

2020

An intellectual disability syndrome with single nucleotide variants in O-GlcNAc Transferase

Pravata, V., Omelkova, M., Stavridis, M., Desbiens, C. M., Stephen, H. M., Lefeber, D. J., Gécz, J., Gundogdu, M., Õunap, K., Joss, S., Schwartz, C. E., Wells, L. & van Aalten, D., 20 Feb 2020, In : European Journal of Human Genetics. 9 p.

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

CAP-MAP: cap analysis protocol with minimal analyte processing, a rapid and sensitive approach to analysing mRNA cap structures

Galloway, A., Atrih, A., Grzela, R., Darzynkiewicz, E., Ferguson, M. A. J. & Cowling, V. H., 26 Feb 2020, In : Open Biology. 10, 2, p. 1-13 13 p., 190306.

Research output: Contribution to journalArticle

Open Access
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18 Downloads (Pure)

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes

Alabert, C., Loos, C., Voelker-Albert, M., Graziano, S., Forné, I., Reveron-Gomez, N., Schuh, L., Hasenauer, J., Marr, C., Imhof, A. & Groth, A., 28 Jan 2020, In : Cell Reports. 30, 4, p. 1223-1234.e8 21 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
26 Downloads (Pure)

High-content imaging zur Identifikation von Replikationsfehlern

Szczesna, K. & Denninger, V., Feb 2020, In : BioSpektrum. 26, 1, p. 66-68 3 p.

Research output: Contribution to journalComment/debate

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

Parker, M. T., Knop, K., Sherwood, A. V., Schurch, N. J., Mackinnon, K., Gould, P. D., Hall, A. J. W., Barton, G. J. & Simpson, G. G., 14 Jan 2020, In : eLife. 9, p. 1-35 35 p., e49658.

Research output: Contribution to journalArticle

Open Access
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30 Downloads (Pure)

O-GlcNAcase contributes to cognitive function in Drosophila

Muha, V., Fenckova, M., Ferenbach, A., Catinozzi, M., Eidhof, I., Storkebaum, E., Schenck, A. & van Aalten, D., 24 Feb 2020, In : Journal of Biological Chemistry. 22 p.

Research output: Contribution to journalArticle

Open Access
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15 Downloads (Pure)

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

Belotserkovskaya, R., Raga Gil, E., Lawrence, N., Butler, R., Clifford, G., Wilson, M. D. & Jackson, S. P., 10 Feb 2020, In : Nature Communications. 11, 1, p. 1-11 11 p., 819.

Research output: Contribution to journalArticle

Open Access
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20 Downloads (Pure)

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

Fernandez-Alonso, R., Bustos, F., Budzyk, M., Kumar, P., Helbig, A. O., Hukelmann, J., Lamond, A. I., Lanner, F., Zhou, H., Petsalaki, E. & Findlay, G. M., 13 Mar 2020, In : Nature Communications. 11, 1, p. 1-13 13 p., 1357.

Research output: Contribution to journalArticle

Open Access
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10 Downloads (Pure)

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases

Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. & Virdee, S., 16 Jan 2020, In : Cell Chemical Biology. 27, 1, p. 74-82.e6 16 p.

Research output: Contribution to journalArticle

Open Access
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57 Downloads (Pure)

Publisher Correction: Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression

Cuomo, A. S. E., Seaton, D. D., McCarthy, D. J., Martinez, I., Vallier, L., Marioni, J. C., Chhatriwala, M. & Stegle, O., 23 Mar 2020, In : Nature Communications. 11, 1 p., 1572.

Research output: Contribution to journalComment/debate

Open Access
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Open Access
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10 Downloads (Pure)

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

Bustamante, H. A., Cereceda, K., González, A. E., Valenzuela, G. E., Cheuquemilla, Y., Hernández, S., Arias-Muñoz, E., Cerda-Troncoso, C., Bandau, S., Soza, A., Kausel, G., Kerr, B., Mardones, G. A., Cancino, J., Hay, R. T., Rojas-Fernandez, A. & Burgos, P. V., 23 Mar 2020, In : Cells. 9, 3, p. 1-24 24 p., 777.

Research output: Contribution to journalArticle

Open Access
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5 Downloads (Pure)

Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers

Stubbe, M., Mai, J., Paulus, C., Stubbe, H. C., Berscheminski, J., Karimi, M., Hofmann, S., Weber, E., Hadian, K., Hay, R., Groitl, P., Nevels, M., Dobner, T. & Schreiner, S., 17 Mar 2020, In : MBio. 11, 2, p. 1-21 21 p., e00049-20.

Research output: Contribution to journalArticle

Open Access
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4 Downloads (Pure)

Widespread arginine phosphorylation in human cells–a novel protein PTM revealed by mass spectrometry

Fu, S., Fu, C., Zhou, Q., Lin, R., Ouyang, H., Wang, M., Sun, Y., Liu, Y. & Zhao, Y., 18 Feb 2020, In : Science China Chemistry. 6 p.

Research output: Contribution to journalArticle

2019

A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In : FEBS Letters.

Research output: Contribution to journalArticle

2 Citations (Scopus)

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Schmidt, N., Domingues, P., Golebiowski, F., Patzina, C., Tatham, M. H., Hay, R. T. & Hale, B. G., 27 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17399-17408 10 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
65 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, p. 1-29 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
95 Downloads (Pure)

APETALA2 control of barley internode elongation

Patil, V., McDermott, H. I., Mcallister, T., Cummins, M., Clara Silva, J., Mollison, E., Meikle, R., Morris, J. A., Hedley, P. E., Waugh, R., Dockter, C., Hansson, M. & McKim, S., 12 Jun 2019, In : Development. 146, 11, p. 1-16 16 p., 170373.

Research output: Contribution to journalArticle

Open Access
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2 Citations (Scopus)
75 Downloads (Pure)

Aurora B–INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast

García-Rodríguez, L. J., Kasciukovic, T., Denninger, V. & Tanaka, T., 6 May 2019, In : Current Biology. 29, 9, p. 1536-1544.e4 13 p.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
106 Downloads (Pure)

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

Farnaby, W., Koegl, M., Roy, M. J., Whitworth, C., Diers, E., Trainor, N., Zollman, D., Steurer, S., Karolyi-Oezguer, J., Riedmueller, C., Gmaschitz, T., Wachter, J., Dank, C., Galant, M., Sharps, B., Rumpel, K., Traxler, E., Gerstberger, T., Schnitzer, R., Petermann, O. & 17 others, Greb, P., Weinstabl, H., Bader, G., Zoephel, A., Weiss-Puxbaum, A., Ehrenhöfer-Wölfer, K., Wöhrle, S., Boehmelt, G., Rinnenthal, J., Arnhof, H., Wiechens, N., Wu, M-Y., Owen-Hughes, T., Ettmayer, P., Pearson, M., McConnell, D. B. & Ciulli, A., Jul 2019, In : Nature Chemical Biology. 15, 7, p. 672-680 9 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
46 Downloads (Pure)

Bringing Open Data to Whole Slide Imaging

Besson, S., Leigh, R., Linkert, M., Allan, C., Burel, J-M., Carroll, M., Gault, D., Gozim, R., Li, S., Lindner, D., Moore, J., Moore, W., Walczysko, P., Wong, F. & Swedlow, J., 2019, Digital Pathology: 15th European Congress, ECDP 2019, Warwick, UK, April 10–13, 2019, Proceedings. Reyes-Aldasoro, C. C., Janowczyk, A., Veta, M., Bankhead, P. & Sirinukunwattana, K. (eds.). Switzerland: Springer , p. 3-10 8 p. (Lecture Notes in Computer Science; vol. 11435).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Open Access
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116 Downloads (Pure)

CAPAM: the mRNA cap adenosine N6 methyltransferase

Cowling, V., 1 Mar 2019, In : Trends in Biochemical Sciences. 44, 3, p. 183-185 3 p., 1545.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
87 Downloads (Pure)

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

Pravata, V., Muha, V., Gundogdu, M., Ferenbach, A., Kakade, P., Vandadi, V., Wilmes, A. C., Borodkin, V., Joss, S., Stavridis, M. & van Aalten, D., 23 Jul 2019, In : Proceedings of the National Academy of Sciences. 116, 30, p. 14961-14970 10 p.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
104 Downloads (Pure)

Composition of the Survival Motor Neuron (SMN) complex in Drosophila melanogaster

Matera, A. G., Raimer, A. C., Schmidt, C. A., Kelly, J. A., Droby, G. N., Baillat, D., Ten Have, S., Lamond, A. I., Wagner, E. J. & Gray, K. M., 1 Feb 2019, In : G3 : Genes, Genomes, Genetics. 9, 2, p. 491-503 13 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
115 Downloads (Pure)

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

Booth, A. J. R., Yue, Z., Eykelenboom, J. K., Stiff, T., Luxton, G. W. G., Hochegger, H. & Tanaka, T., 16 Jul 2019, In : eLife. 8, p. 1-21 21 p., e46902.

Research output: Contribution to journalArticle

Open Access
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70 Downloads (Pure)

Controlling and co-ordinating chitinase secretion in a Serratia marcescens population

Costa, M. D. A. A., Owen, R. A., Tammsalu, T., Buchanan, G., Palmer, T. & Sargent, F., Nov 2019, In : Microbiology. 165, 11, p. 1233-1244 12 p.

Research output: Contribution to journalArticle

Detection and Mitigation of Spurious Antisense RNA-seq Reads with RoSA

Mourão, K., Schurch, N. J., Lukoszek, R., Froussios, K., Mackinnon, K., Duc, C., Simpson, G. & Barton, G., 7 Jun 2019, In : F1000 Research. 8, p. 1-7 7 p., 819.

Research output: Contribution to journalArticle

Open Access
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79 Downloads (Pure)

Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

Matai, L., Sarkar, G. C., Chamoli, M., Malik, Y., Kumar, S. S., Rautela, U., Jana, N. R., Chakraborty, K. & Mukhopadhyay, A., 27 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17383-17392 10 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
77 Downloads (Pure)

EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis

Elias, M. S., Wright, S. C., Remenyi, J., Abbott, J. C., Bray, S. E., Cole, C., Edwards, S., Gierlinski, M., Glok, M., McGrath, J. A., Nicholson, W. V., Paternoster, L., Prescott, A. R., Have, S. T., Whitfield, P. D., Lamond, A. I. & Brown, S. J., Aug 2019, In : Journal of Allergy and Clinical Immunology. 144, 2, p. 470-481 12 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Full volume super-resolution imaging of thick mitotic spindle using 3D AO STED microscope

McGloin, D., Swedlow, J. & Zdankowski, P., 1 Apr 2019, In : Biomedical Optics Express. 10, 4, p. 1999-2009 11 p., #352466.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
118 Downloads (Pure)
Open Access
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42 Downloads (Pure)

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

Gorelik, A., Galan Bartual, S., Borodkin, V., Varghese, J., Ferenbach, A. & van Aalten, D., Nov 2019, In : Nature Structural & Molecular Biology. 26, 11, p. 1071-1077 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
6 Downloads (Pure)

Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells

Antoniou, M. N., Nicolas, A., Mesnage, R., Biserni, M., Rao, F. V. & Martin, C. V., 8 Aug 2019, In : BMC Research Notes. 12, p. 1-7 7 p., 494.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
57 Downloads (Pure)
Open Access
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61 Downloads (Pure)

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Batie, M., Frost, J., Frost, M., Wilson, J. W., Schofield, P. & Rocha, S., 15 Mar 2019, In : Science. 363, 6432, p. 1222-1226 5 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Popow, O., Paulo, J. A., Tatham, M., Volk, M., Rojas-Fernandez, A., Loyer, N., Newton, I., Januschke, J., Haigis, K. M. & Nathke, I., Sep 2019, In : Molecular Cancer Research. 17, 9, p. 1828-1841 14 p.

Research output: Contribution to journalArticle

Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator

Krutyhołowa, R., Hammermeister, A., Zabel, R., Abdel-Fattah, W., Reinhardt-Tews, A., Helm, M., Stark, M. J. R., Breunig, K. D., Schaffrath, R. & Glatt, S., 21 May 2019, In : Nucleic Acids Research. 47, 9, p. 4814-4830 17 p.

Research output: Contribution to journalArticle

Open Access
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Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

Eykelenboom, J., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T., 6 May 2019, In : Journal of Cell Biology. 218, 5, p. 1531-1552 22 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
99 Downloads (Pure)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

Research output: Contribution to journalArticle

Open Access
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LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Izumikawa, K., Ishikawa, H., Yoshikawa, H., Fujiyama, S., Watanabe, A., Aburatani, H., Tachikawa, H., Hayano, T., Miura, Y., Isobe, T., Simpson, R. J., Li, L., Min, J. & Takahashi, N., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. 10357-10372 16 p.

Research output: Contribution to journalArticle

Open Access
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Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations

Bueren-Calabuig, J., Bage, M., Cowling, V. & Pisliakov, A., 19 Sep 2019, In : Nucleic Acids Research. 47, 16, p. 8675-8692 18 p., gkz613.

Research output: Contribution to journalArticle

Open Access
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Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Fang, W., Sanz, A. B., Galan Bartual, S., Wang, B., Ferenbach, A., Farkaš, V., Hurtado-Guerrero, R., Arroyo, J. & van Aalten, D., 10 Apr 2019, In : Nature Communications. 10, 1, p. 1-10 10 p., 1669.

Research output: Contribution to journalArticle

Open Access
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86 Downloads (Pure)

Methods to analyze STUbL activity

Branigan, E., Plechanovová, A. & Hay, R. T., 2019, Methods in Enzymology. Hochstrasser, M. (ed.). Cambridge, MA: Elsevier, Vol. 618. p. 257-280 24 p. (Methods in Enzymology; vol. 618).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

mRNA cap regulation in mammalian cell function and fate

Galloway, A. & Cowling, V., Mar 2019, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1862, 3, p. 270-279 10 p.

Research output: Contribution to journalReview article

Open Access
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5 Citations (Scopus)
64 Downloads (Pure)
Open Access
6 Citations (Scopus)

Multiomics Analyses of HNF4α Protein Domain Function during Human Pluripotent Stem Cell Differentiation

Wang, Y., Tatham, M. H., Schmidt-Heck, W., Swann, C., Singh-Dolt, K., Meseguer-Ripolles, J., Lucendo-Villarin, B., Kunath, T., Rudd, T. R., Smith, A. J. H., Hengstler, J. G., Godoy, P., Hay, R. T. & Hay, D. C., 28 Jun 2019, In : iScience. 16, p. 206-217 12 p.

Research output: Contribution to journalArticle

Open Access
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3 Citations (Scopus)
66 Downloads (Pure)

Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates

Spatola, B. N., Lo, J. Y., Wang, B. & Curran, S. P., 13 Aug 2019, In : Scientific Reports. 9, 1, p. 1-11 11 p., 11783.

Research output: Contribution to journalArticle

Open Access
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57 Downloads (Pure)

Nucleosome remodelling: structural insights into ATP-dependent remodelling enzymes

Sundaramoorthy, R., Apr 2019, In : Essays in Biochemistry. 63, 1, p. 45-58 14 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Numerically Enhanced Stimulated Emission Depletion Microscopy with Adaptive Optics for Deep-Tissue Super-Resolved Imaging

Zdańkowski, P., Trusiak, M., McGloin, D. & Swedlow, J. R., 16 Dec 2019, In : ACS Nano. 12 p.

Research output: Contribution to journalArticle

Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells

Dunn, S., Lombardi, O., Lukoszek, R. & Cowling, V., Apr 2019, In : Open Biology. 9, 4, p. 1-15 15 p., 190052.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
87 Downloads (Pure)