Gene Regulation and Expression

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1990

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei

Zomerdijk, J. C. B. M., Ouellette, M., ten Asbroek, A. L. M. A., Kieft, R., Bommer, A. M. M., Clayton, C. E. & Borst, P., 1990, In : EMBO Journal. 9, 9, p. 2791-2801 11 p.

Research output: Contribution to journalArticle

The trimethylguanosine cap is a nuclear targeting signal for snRNPs

Lamond, A. I., Dec 1990, In : Trends in Biochemical Sciences. 15, 12, p. 451-452 2 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)
1991

2'-O-alkyloligoribonucleotides: Synthesis and applications in studying rna splicing

Sproat, B. S., Iribarren, A., Beijer, B., Pieles, U. & Lamond, A. I., 1991, In : Nucleosides and Nucleotides. 10, 1-3, p. 25-36 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

2'-O-alkyloligoribonucleotides, synthesis and applications in molecular biology.

Sproat, B. S., Lamond, A. I., Garcia, R. G., Beijer, B., Pieles, U., Douglas, M., Bohmann, K., Carmo-Fonseco, M., Weston, S. & O'Loughlin, S., 1991, In : Nucleic acids symposium series. 24, p. 59-62 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Alfalfa heat shock genes are differentially expressed during somatic embryogenesis

Györgyey, J., Gartner, A., Németh, K., Magyar, Z., Hirt, H., Heberle-Bors, E. & Dudits, D., 1 Jun 1991, In : Plant Molecular Biology. 16, 6, p. 999-1007 9 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)
91 Citations (Scopus)

Analysis of the response of Saccharomyces cerevisiae cells to Kluyveromyces lactis toxin

Butler, A. R., White, J. H. & Stark, M. J. R., 1 Jul 1991, In : Journal of General Microbiology. 137, 7, p. 1749-1757 9 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Antigenic variation in Trypanosoma brucei: a telomeric expression site for variant-specific surface glycoprotein genes with novel features

Zomerdijk, J. C. B. M., Kieft, R., Duyndam, M., Shiels, P. G. & Borst, P., 1991, In : Nucleic Acids Research. 19, 7, p. 1359-1368 10 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts

Lamm, G. M., Blencowe, B. J., Sparoat, B. S., Iribarren, A. M., Ryder, U. & Lamond, A. I., 25 Jun 1991, In : Nucleic Acids Research. 19, 12, p. 3193-3198 6 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

ASF/SF2: a splice site selector

Lamond, A. I., 1991, In : Trends in Biochemical Sciences. 16, C, p. 452-453 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cell cycle control of DNA replication by p34cdc2

Blow, J. J., Aug 1991, In : Seminars in Cell & Developmental Biology. 2, 4, p. 243-250 8 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Efficient production of functional mRNA mediated by RNA polymerase I in Trypanosoma brucei

Zomerdijk, J. C. B. M., Kieft, R. & Borst, P., 1991, In : Nature. 353, 6346, p. 772-775 4 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)
52 Citations (Scopus)

In vivo detection of snRNP-rich organelles in the nuclei of mammalian cells

Carmo-Fonseca, M., Pepperkok, R., Sproat, B. S., Ansorge, W., Swanson, M. S. & Lamond, A. I., 5 Jul 1991, In : EMBO Journal. 10, 7, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

Kluyveromyces lactis toxin has an essential chitinase activity

BUTLER, A. R., O'DONNELL, R. W., MARTIN, V. J., GOODAY, G. W. & STARK, M. J. R., 15 Jul 1991, In : European Journal of Biochemistry. 199, 2, p. 483-488 6 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery

Carmo-Fonseca, M., Tollervey, D., Pepperkok, R., Barabino, S. M. L., Merdes, A., Brunner, C., Zamore, P. D., Green, M. R., Hurt, E. & Lamond, A. I., 1 Jan 1991, In : EMBO Journal. 10, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

Nuclear RNA processing

Lamond, A. I., Jun 1991, In : Current Opinion in Cell Biology. 3, 3, p. 493-501 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates

Norbury, C., Blow, J. & Nurse, P., Nov 1991, In : EMBO Journal. 10, 11, p. 3321-9 9 p.

Research output: Contribution to journalArticle

375 Citations (Scopus)

Site-directed ribose methylation identifies 2′-OH groups in polyadenylation substrates critical for AAUAAA recognition and poly(A) addition

Bardwell, V. J., Wickens, M., Bienroth, S., Keller, W., Sproat, B. S. & Lamond, A. I., 5 Apr 1991, In : Cell. 65, 1, p. 125-133 9 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)
1992

Antisense probes targeted to an internal domain in U2 snRNP specifically inhibit the second step of pre-mRNA splicing

Barabino, S. M. L., Sproat, B. S. & Lamond, A. I., 11 Sep 1992, In : Nucleic Acids Research. 20, 17, p. 4457-4464 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

A ribosomal RNA gene promoter at the telomere of a mini-chromosome in Trypanosoma brucei

Zomerdijk, J. C. B. M., Kieft, R. & Borst, P., 1992, In : Nucleic Acids Research. 20, 11, p. 2725-2734 10 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit

Zhang, M., Zamore, P. D., Carmo-Fonseca, M., Lamond, A. I. & Green, M. R., 15 Sep 1992, In : Proceedings of the National Academy of Sciences of the United States of America. 89, 18, p. 8769-8773 5 p.

Research output: Contribution to journalArticle

Open Access
161 Citations (Scopus)

DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts

Mahbubani, H. M., Paull, T., Elder, J. K. & Blow, J. J., 11 Apr 1992, In : Nucleic Acids Research. 20, 7, p. 1457-1462 6 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae

van Zyl, W., Huang, W., Sneddon, A. A., Stark, M., Camier, S., Werner, M., Marck, C., Sentenac, A. & Broach, J. R., Nov 1992, In : Molecular and Cellular Biology. 12, 11, p. 4946-4959 14 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

Kluyveromyces lactis killer system: ORF1 of pGKL2 has no function in immunity expression and is dispensable for killer plasmid replication and maintenance

Schaffrath, R., Stark, M. J. R., Gunge, N. & Meinhardt, F., Apr 1992, In : Current Genetics. 21, 4-5, p. 357-363 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Nuclease resistant ribozymes with high catalytic activity

Paolella, G., Sproat, B. S. & Lamond, A. I., 1 May 1992, In : EMBO Journal. 11, 5, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Protein A-calmodulin fusions: a novel approach for investigating calmodulin function in yeast

Stirling, D. A., Petrie, A., Pulford, D. J., Paterson, D. T. W. & Stark, M. J. R., 1992, In : Molecular Microbiology. 6, 6, p. 703-713 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Ser/thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

Mermoud, J. E., Cohen, P. & Lamond, A. I., 25 Oct 1992, In : Nucleic Acids Research. 20, 20, p. 5263-5269 7 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)

The regulation of chromosome replication

Blow, J. J., Jun 1992, In : Journal of Pathology. 167, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The use of field emission in-lens scanning electron microscopy to study the steps of assembly of the nuclear envelope in vitro

Goldberg, M. W., Blow, J. J. & Allen, T. D., May 1992, In : Journal of Structural Biology. 108, 3, p. 257-268 12 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

Carmo-Fonseca, M., Pepperkok, R., Carvalho, M. T. & Lamond, A. I., 1 Apr 1992, In : Journal of Cell Biology. 117, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

332 Citations (Scopus)
1993
7 Citations (Scopus)

A glimpse into the spliceosome

Lamond, A. I., Jan 1993, In : Current Biology. 3, 1, p. 62-64 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution

Phelan, A., Carmo-Fonseca, M., Mclauchlan, J., Lamond, A. I. & Clements, J. B., 1 Oct 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 9056-9060 5 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis - Evidence that the coiled body is a kinetic nuclear structure

Carmo-Fonseca, M., Ferreira, J. & Lamond, A. I., 26 Feb 1993, In : Journal of Cell Biology. 120, 4, p. 841-852 12 p.

Research output: Contribution to journalArticle

175 Citations (Scopus)

Both isoforms of protein phosphatase Z are essential for the maintenance of cell size and integrity in Saccharomyces cerevisiae in response to osmotic stress

Hughes, V., Müller, A., Stark, M. J. R. & Cohen, P. T. W., Aug 1993, In : European Journal of Biochemistry. 216, 1, p. 269-279 11 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Interaction of the human autoantigen p150 with splicing snRNPs

Blencowe, B. J., Carmo-Fonseca, M., Behrens, S. E., Luhrmann, R. & Lamond, A. I., 1 Jul 1993, In : Journal of Cell Science. 105, 3, p. 685-697 13 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Localisation of splicing snRNPs in mammalian cells

Lamond, A. I. & Carmo-Fonseca, M., 1 Aug 1993, In : Molecular Biology Reports. 18, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells

Bridge, E., Carmo-Fonseca, M., Lamond, A. & Pettersson, U., 1 Oct 1993, In : Journal of Virology. 67, 10, p. 5792-5802 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Nuclear organization of splicing snRNPs during differentiation of murine erythroleukemia cells in vitro

Antoniou, M., Carmo-Fonseca, M., Ferreira, J. & Lamond, A. I., 1 Dec 1993, In : Journal of Cell Biology. 123, 5, p. 1055-1068 14 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Secretion of β-lactamase from K. lactis using pEPS1, a convenient episomal vector designed for the secretion of foreign proteins

Macreadie, I. G., Castelli, L. A., Ward, A. C., Stark, M. J. R. & Azad, A. A., Mar 1993, In : Biotechnology Letters. 15, 3, p. 213-218 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The coiled body

Lamond, A. I. & Carmo-Fonseca, M., Jun 1993, In : Trends in Cell Biology. 3, 6, p. 198-203 6 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)
1994

Assembly of transcriptionally active RNA polymerase I initiation factor SL1 from recombinant subunits

Zomerdijk, J. C., Beckmann, H., Comai, L. & Tjian, R., 1994, In : Science. 266, 5193, p. 2015-2018 4 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Characterization of the S-adenosylmethionine decarboxylase (SAMDC) gene of potato

Arif, S. A. M., Taylor, M. A., George, L. A., Butler, A. R., Burch, L. R., Davies, H. V., Stark, M. J. R. & Kumar, A., Oct 1994, In : Plant Molecular Biology. 26, 1, p. 327-338 12 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei

Ferreira, J. A., Carmo-Fonseca, M. & Lamond, A. I., 1 Jul 1994, In : Journal of Cell Biology. 126, 1, p. 11-23 13 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Expression of reducing sugar accumulation in interspecific somatic hybrids of potato

Craig, A. L., Morrison, I., Baird, E., Waugh, R., Coleman, M., Davie, P. & Powell, W., 1 Apr 1994, In : Plant Cell Reports. 13, 7, p. 401-405 5 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Inositol trisphosphate metabolism in Saccharomyces cerevisiae - identification, purification and properties of Inositol 1,4,5-trisphosphae 6-kinase

ESTEVEZ, F., PULFORD, D., STARK, M. J. R., CARTER, A. N. & Downes, C. P., 15 Sep 1994, In : Biochemical Journal. 302, p. 709-716 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body

Stirling, D. A., Welch, K. A. & Stark, M. J. R., 1994, In : EMBO Journal. 13, 18, p. 4329-4342 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Novel solid-phase synthesis of branched oligoribonucleotides, including a substrate for the RNA debranching enzyme

Sproat, B. S., Beijer, B., Grøtli, M., Ryder, U., Morand, K. L. & Lamond, A. I., 1 Dec 1994, In : Journal of the Chemical Society, Perkin Transactions 1. 4, p. 419-431 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)