Gene Regulation and Expression

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2009

Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

Moser, S. C., von Elsner, S., Buessing, I., Alpi, A., Schnabel, R. & Gartner, A., Apr 2009, In : PLoS Genetics. 5, 4, p. - 15 p., e1000451.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

Colbert, J. D., Plechanovova, A. & Watts, C., Apr 2009, In : Traffic. 10, 4, p. 425-437 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Human miRNA Precursors with Box H/ACA snoRNA Features

Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J., Sep 2009, In : PLoS Computational Biology. 5, 9, p. - 13 p., e1000507.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Identification of nucleolar associated chromatin loci reveals clues for nuclear architecture

van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 2009, In : Cellular Oncology. 31, 2, p. 105-106 2 p., O16.

Research output: Contribution to journalArticle

In vivo imaging of mammalian cells: cell engineering and viability

Swedlow, J. R., Andrews, P. D. & Platani, M., 1 Jan 2009, In : Cold Spring Harbor Protocols. 4, 9

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vivo imaging of mammalian cells: image acquisition and analysis

Swedlow, J. R., Andrews, P. D. & Platani, M., 1 Jan 2009, In : Cold Spring Harbor Protocols. 4, 9

Research output: Contribution to journalArticle

2 Citations (Scopus)

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores

Keating, P., Rachidi, N., Tanaka, T. U. & Stark, M. J. R., 1 Dec 2009, In : Journal of Cell Science. 122, 23, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Iso-seco-tanapartholides: isolation, synthesis and biological evaluation

Makiyi, E. F., Frade, R. F. M., Lebl, T., Jaffray, E. G., Cobb, S. E., Harvey, A. L., Slawin, A. M. Z., Hay, R. T. & Westwood, N. J., Nov 2009, In : European Journal of Organic Chemistry. 33, p. 5711-5715 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Long distance PELDOR measurements on the histone core particle

Ward, R., Bowman, A., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., 4 Feb 2009, In : Journal of the American Chemical Society. 131, 4, p. 1348-+ 3 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Mutations of NFKBIA, encoding I kappa B alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases

Lake, A., Shield, L. A., Cordano, P., Chui, D. T. Y., Osborne, J., Crae, S., Wilson, K. S., Tosi, S., Knight, S. J. L., Gesk, S., Siebert, R., Hay, R. T. & Jarrett, R. F., 15 Sep 2009, In : International Journal of Cancer. 125, 6, p. 1334-1342 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions

Somers, J. & Owen-Hughes, T., May 2009, In : Nucleic Acids Research. 37, 8, p. 2504-2513 10 p.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
215 Downloads (Pure)

NOPdb: Nucleolar proteome database - 2008 Update

Ahmad, Y., Boisvert, F-M., Gregor, P., Cobley, A. & Lamond, A. I., Jan 2009, In : Nucleic Acids Research. 37, Suppl. 1, p. D181-D184 4 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Nucleosomes can invade DNA territories occupied by their neighbors

Engeholm, M., de Jager, M., Flaus, A., Brenk, R., van Noort, J. & Owen-Hughes, T., Feb 2009, In : Nature Structural & Molecular Biology. 16, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

p38 alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

Seifert, A. & Clarke, P. R., Nov 2009, In : Cellular Signalling. 21, 11, p. 1626-1633 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Phosphorylation of histone H3 Thr-45 is linked to apoptosis

Hurd, P. J., Bannister, A. J., Halls, K., Dawson, M. A., Vermeulen, M., Olsen, J. V., Ismail, H., Somers, J., Mann, M., Owen-Hughes, T., Gout, I. & Kouzarides, T., 12 Jun 2009, In : Journal of Biological Chemistry. 284, 24, p. 16575-16583 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

Sopko, R., Silva, E., Clayton, L., Gardano, L., Barrios-Rodiles, M., Wrana, J., Varelas, X., Arbouzova, N. I., Shaw, S., Saburi, S., Matakatsu, H., Blair, S. & McNeill, H., 14 Jul 2009, In : Current Biology. 19, 13, p. 1112-1117 6 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

Ahel, D., Horejsi, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., Owen-Hughes, T. & Boulton, S. J., 4 Sep 2009, In : Science. 325, 5945, p. 1240-1243 4 p.

Research output: Contribution to journalArticle

341 Citations (Scopus)

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET

Lleres, D., James, J., Swift, S., Norman, D. G. & Lamond, A. I., 16 Nov 2009, In : Journal of Cell Biology. 187, 4, p. 481-496 16 p.

Research output: Contribution to journalArticle

Open Access
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98 Citations (Scopus)
290 Downloads (Pure)

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

De Marco, V., Gillespie, P. J., Li, A., Karantzelis, N., Christodoulou, E., Klompmaker, R., van Gerwen, S., Fish, A., Petoukhov, M. V., Iliou, M. S., Lygerou, Z., Medema, R. H., Blow, J. J., Svergun, D. I., Taraviras, S. & Perrakis, A., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19807-19812 6 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation

Pion, E., Narayan, V., Eckert, M. & Ball, K. L., Oct 2009, In : Cellular Signalling. 21, 10, p. 1479-1487 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Super-resolution video microscopy of live cells by structured illumination

Kner, P., Chhun, B. B., Griffis, E. R., Winoto, L. & Gustafsson, M. G. L., May 2009, In : Nature Methods. 6, 5, p. 339-342 4 p.

Research output: Contribution to journalArticle

449 Citations (Scopus)

SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter

Gkikopoulos, T., Havas, K. M., Dewar, H. & Owen-Hughes, T., Aug 2009, In : Molecular and Cellular Biology. 29, 15, p. 4057-4066 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

SWI/SNF regulates the cellular response to hypoxia

Kenneth, N. S., Mudie, S., van Uden, P. & Rocha, S., 13 Feb 2009, In : Journal of Biological Chemistry. 284, 7, p. 4123-4131 9 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

System-wide changes to SUMO modifications in response to heat shock

Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T., 26 May 2009, In : Science Signaling. 2, 72, 12 p., ra24.

Research output: Contribution to journalArticle

327 Citations (Scopus)

The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

Meier, B., Barber, L. J., Liu, Y., Shtessel, L., Boulton, S. J., Gartner, A. & Ahmed, S., 18 Nov 2009, In : EMBO Journal. 28, 22, p. 3549-3563 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The NM23 family in development

Bilitou, A., Watson, J., Gartner, A. & Ohnuma, S., Sep 2009, In : Molecular and Cellular Biochemistry. 329, 1-2, p. 17-33 17 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex

Platani, M., Santarella-Mellwig, R., Posch, M., Walczak, R., Swedlow, J. R. & Mattaj, I. W., 15 Dec 2009, In : Molecular Biology of the Cell. 20, 24, p. 5260-5275 16 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

The open microscopy environment: informatics and quantitative analysis for biological microscopy

Swedlow, J. R., Allan, C., Burel, J-M., Linkert, M., Loranger, B., MacDonald, D., Moore, W. J., Patterson, A. J., Rueden, C., Tarkowska, A., Goldberg, I. G. & Eliceiri, K. W., Jul 2009, In : Microscopy and Microanalysis. 15, p. 1520-1521 2 p.

Research output: Contribution to journalArticle

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C., 15 Feb 2009, In : Development. 136, 4, p. 655-664 10 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

TOPALi v2: a rich graphical interface for evolutionary analyses of multiple alignments on HPC clusters and multi-core desktops

Milne, I., Lindner, D., Bayer, M., Husmeier, D., McGuire, G., Marshall, D. F. & Wright, F., 2009, In : Bioinformatics. 25, 1, p. 126-127 2 p.

Research output: Contribution to journalArticle

447 Citations (Scopus)

Usability and user-centered design in scientific software development

Macaulay, C., Sloan, D., Jiang, X., Forbes, P., Loynton, S., Swedlow, J. R. & Gregor, P., 2009, In : IEEE Software. 26, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

What can we learn about quasars from αOX measurements in Galactic black hole binaries?

Sobolewska, M. A., Gierliński, M. & Siemiginowska, A., 11 Apr 2009, In : Monthly Notices of the Royal Astronomical Society. 394, 3, p. 1640-1648 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2010

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., Leslie, S. J., Pickford, R., Hoy, A. J., Kraegen, E. W., James, D. E. & Cooney, G. J., 6 Jan 2010, In : Cell Metabolism. 11, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Adenomatous polyposis coli and hypoxia-inducible factor-1 alpha have an antagonistic connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Nathke, I. & Rocha, S., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3630-3638 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A Proteomic Screen for Nucleolar SUMO Targets Shows SUMOylation Modulates the Function of Nop5/Nop58

Westman, B. J., Verheggen, C., Hutten, S., Lam, Y. W., Bertrand, E. & Lamond, A. I., 27 Aug 2010, In : Molecular Cell. 39, 4, p. 618-631 14 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

A Quantitative Proteomics Analysis of Subcellular Proteome Localization and Changes Induced by DNA Damage

Boisvert, F-M., Lam, Y. W., Lamont, D. & Lamond, A. I., Mar 2010, In : Molecular & Cellular Proteomics. 9, 3, p. 457-470 14 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies

Geoffroy, M-C., Jaffray, E. G., Walker, K. J. & Hay, R. T., 1 Dec 2010, In : Molecular Biology of the Cell. 21, 23, p. 4227-4239 13 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G., 15 Feb 2010, In : Biochemical Journal. 426, p. 109-118 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1

Ito, S., Greiss, S., Gartner, A. & Derry, W. B., 23 Feb 2010, In : Current Biology. 20, 4, p. 333-338 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Characterization and prediction of protein nucleolar localization sequences

Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J., Nov 2010, In : Nucleic Acids Research. 38, 21, p. 7388-7399 12 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

Ge, X. Q. & Blow, J. J., 27 Dec 2010, In : Journal of Cell Biology. 191, 7, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

Open Access
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128 Citations (Scopus)
148 Downloads (Pure)

Clusters, factories and domains: The complex structure of S-phase comes into focus

Gillespie, P. J. & Blow, J., 15 Aug 2010, In : Cell Cycle. 9, 16, p. 3218-3226 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Compton scattering as the explanation of the peculiar X-ray properties of Cyg X-3

Zdziarski, A. A., Misra, R. & Gierliński, M., 21 Feb 2010, In : Monthly Notices of the Royal Astronomical Society. 402, 2, p. 767-775 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Condensins Promote Chromosome Recoiling during Early Anaphase to Complete Sister Chromatid Separation

Renshaw, M. J., Ward, J. J., Kanemaki, M., Natsume, K., Nedelec, F. J. & Tanaka, T. U., 17 Aug 2010, In : Developmental Cell. 19, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Determinants of Myosin II Cortical Localization during Cytokinesis

Uehara, R., Goshima, G., Mabuchi, I., Vale, R. D., Spudich, J. A. & Griffis, E. R., 22 Jun 2010, In : Current Biology. 20, 12, p. 1080-1085 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice

Lleres, D., Denegri, M., Biggiogera, M., Ajuh, P. & Lamond, A. I., Jun 2010, In : EMBO Reports. 11, 6, p. 445-451 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

EPR distance measurements in deuterated proteins

Ward, R., Bowman, A., Sozudogru, E., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., Nov 2010, In : Journal of Magnetic Resonance Imaging. 207, 1, p. 164-167 4 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners

Boulon, S., Ahmad, Y., Trinkle-Mulcahy, L., Verheggen, C., Cobley, A., Gregor, P., Bertrand, E., Whitehorn, M. & Lamond, A. I., May 2010, In : Molecular & Cellular Proteomics. 9, 5, p. 861-879 19 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3

Larance, M., Rowland, A. F., Hoehn, K. L., Humphreys, D. T., Preiss, T., Guilhaus, M. & James, D. E., Apr 2010, In : Molecular & Cellular Proteomics. 9, 4, p. 682-694 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)