Gene Regulation and Expression

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2014
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11 Citations (Scopus)
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Grow₂: The HIF system, energy homeostasis and the cell cycle

Moniz, S., Biddlestone, J. & Rocha, S., May 2014, In : Histology and Histopathology. 29, 5, p. 589-600 12 p.

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Open Access
15 Citations (Scopus)

Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing

Meier, B. & Gartner, A., 15 Nov 2014, In : Experimental Cell Research. 329, 1, p. 35-41 7 p.

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4 Citations (Scopus)
161 Downloads (Pure)

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster

Bandarra, D., Biddlestone, J., Mudie, S., Muller, H. A. & Rocha, S., 2014, In : Bioscience Reports. 34, 4, p. 429-440 12 p., e00127.

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16 Citations (Scopus)
162 Downloads (Pure)

Identification of small molecule inhibitors of pre-mRNA splicing

Pawellek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I., 12 Dec 2014, In : Journal of Biological Chemistry. 289, 50, p. 34683-34698 16 p.

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39 Citations (Scopus)
262 Downloads (Pure)

Length-dependent anisotropic scaling of spindle shape

Young, S., Besson, S. & Welburn, J. P. I., 15 Dec 2014, In : Open Biology. 3, 12, p. 1217-1223 7 p.

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Open Access
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15 Citations (Scopus)
126 Downloads (Pure)
Open Access
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3 Citations (Scopus)
183 Downloads (Pure)

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

Hamilton, D. L., Philp, A., MacKenzie, M. G., Patton, A., Towler, M. C., Gallagher, I. J., Bodine, S. C. & Baar, K., 15 Aug 2014, In : American Journal of Physiology, Endocrinology and Metabolism. 307, 4, p. E365-E373 9 p.

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Open Access
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23 Citations (Scopus)
152 Downloads (Pure)

Monitoring Keap1-Nrf2 interactions in single live cells

Baird, L., Swift, S., Llères, D. & Dinkova-Kostova, A. T., 1 Nov 2014, In : Biotechnology Advances. 32, 6, p. 1133-1144 12 p.

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Open Access
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79 Citations (Scopus)
350 Downloads (Pure)

Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

Alabert, C., Bukowski-Wills, J. C., Lee, S. B., Kustatscher, G., Nakamura, K., De Lima Alves, F., Menard, P., Mejlvang, J., Rappsilber, J. & Groth, A., 23 Feb 2014, In : Nature Cell Biology. 16, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

NDK-1, the homolog of NM23-H1/H2 regulates cell migration and apoptotic engulfment in C. elegans

Fancsalszky, L., Monostori, E., Farkas, Z., Pourkarimi, E., Masoudi, N., Hargitai, B., Bosnar, M. H., Deželjin, M., Zsákai, A., Vellai, T., Mehta, A. & Takács-Vellai, K., 21 Mar 2014, In : PLoS ONE. 9, 3, 12 p., e92687.

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20 Citations (Scopus)
98 Downloads (Pure)

Near real-time processing of proteomics data using Hadoop.

Hillman, C., Ahmad, Y., Whitehorn, M. & Cobley, A., 14 Mar 2014, In : Big Data. 2, 1, p. 44-49 5 p.

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5 Citations (Scopus)
266 Downloads (Pure)

New histone supply regulates replication fork speed and PCNA unloading

Mejlvang, J., Feng, Y., Alabert, C., Neelsen, K. J., Jasencakova, Z., Zhao, X., Lees, M., Sandelin, A., Pasero, P., Lopes, M. & Groth, A., 6 Jan 2014, In : Journal of Cell Biology. 204, 1, p. 29-43 15 p.

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Open Access
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76 Citations (Scopus)
113 Downloads (Pure)

Oligoasthenoteratozoospermia and Infertility in Mice Deficient for miR-34b/c and miR-449 Loci

Comazzetto, S., Di Giacomo, M., Rasmussen, K. D., Much, C., Azzi, C., Perlas, E., Morgan, M. & O'Carroll, D., 16 Oct 2014, In : PLoS Genetics. 10, 10

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Open Access
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63 Citations (Scopus)
114 Downloads (Pure)

Phosphorylated DegU Manipulates Cell Fate Differentiation in the Bacillus subtilis Biofilm

Marlow, V. L., Porter, M., Hobley, L., Kiley, T. B., Swedlow, J. R., Davidson, F. A. & Stanley-Wall, N. R., Jan 2014, In : Journal of Bacteriology. 196, 1, p. 16-27 10 p.

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Open Access
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23 Citations (Scopus)
149 Downloads (Pure)

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae

Makrantoni, V., Corbishley, S., Rachidi, N., Morrice, N. A., Robinson, D. A. & Stark, M. J. R., 18 Feb 2014, In : PLoS ONE. 9, 2, 15 p., e89399.

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Open Access
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9 Citations (Scopus)
141 Downloads (Pure)

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

Mudie, S., Bandarra, D., Batie, M., Biddlestone, J., Moniz, S., Ortmann, B., Shmakova, A. & Rocha, S., 15 Dec 2014, In : Cell Cycle. 13, 24, p. 3878-3891 14 p.

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Open Access
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10 Citations (Scopus)
190 Downloads (Pure)

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation

Hands, K. J., Cuchet-Lourenco, D., Everett, R. D. & Hay, R. T., 15 Jan 2014, In : Journal of Cell Science. 127, 2, p. 365-375 11 p.

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Open Access
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26 Citations (Scopus)
244 Downloads (Pure)

Prohibitin is required for transcriptional repression by the WT1-BASP1 complex

Toska, E., Shandilya, J., Goodfellow, S. J., Medler, K. F. & Roberts, S. G. E., 23 Oct 2014, In : Oncogene. 33, 43, p. 5100-5108 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Proteome-wide identification of SUMO2 modification sites

Tammsalu, T., Matic, I., Jaffray, E. G., Ibrahim, A. F. M., Tatham, M. H. & Hay, R. T., 29 Apr 2014, In : Science Signaling. 7, 323, 10 p., rs2.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control

Bizarro, J., Charron, C., Boulon, S., Westman, B., Pradet-Balade, B., Vandermoere, F., Chagot, M-E., Hallais, M., Ahmad, Y., Leonhardt, H., Lamond, A., Manival, X., Branlant, C., Charpentier, B., Verheggen, C. & Bertrand, E., 24 Nov 2014, In : Journal of Cell Biology. 207, 4, p. 463-480 18 p.

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Open Access
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32 Citations (Scopus)
260 Downloads (Pure)

Proteomic Selection of Immunodiagnostic Antigens for Trypanosoma congolense

Fleming, J. R., Sastry, L., Crozier, T. W. M., Napier, G. B., Sullivan, L. & Ferguson, M. A. J., 2014, In : PLoS Neglected Tropical Diseases. 8, 6, e2936.

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Open Access
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6 Citations (Scopus)
372 Downloads (Pure)

Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma

Fernández-Barral, A., Orgaz, J. L., Baquero, P., Ali, Z., Moreno, A., Tiana, M., Gómez, V., Riveiro-Falkenbach, E., Cañadas, C., Zazo, S., Bertolotto, C., Davidson, I., Rodríguez-Peralto, J. L., Palmero, I., Rojo, F., Jensen, L. D., Del Peso, L. & Jiménez, B., 2014, In : Neoplasia. 16, 6, p. 529-542 14 p.

Research output: Contribution to journalArticle

Open Access
18 Citations (Scopus)

siRNA screening to identify ubiquitin and ubiquitin-like system regulators of biological pathways in cultured mammalian cells

Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Rocha, S. & Hay, R. T., 24 May 2014, In : JoVE: Journal of Visualized Experiments. 87, 10 p., e51572.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Sp100 isoform-specific regulation of human adenovirus 5 gene expression

Berscheminski, J., Wimmer, P., Brun, J., Ip, W. H., Groitl, P., Horlacher, T., Jaffray, E., Hay, R. T., Dobner, T. & Schreiner, S., Jun 2014, In : Journal of Virology. 88, 11, p. 6076-6092 17 p.

Research output: Contribution to journalArticle

Open Access
26 Citations (Scopus)

Stochasticity in the symmetric division of plant cells: when the exceptions are the rule

Besson, S. & Dumais, J., 9 Oct 2014, In : Frontiers in Plant Science. 5, October, p. 538

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
123 Downloads (Pure)

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

Xu, Y., Plechanovová, A., Simpson, P., Marchant, J., Leidecker, O., Kraatz, S., Hay, R. T. & Matthews, S. J., 27 Jun 2014, In : Nature Communications. 5, 12 p., 4217.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
221 Downloads (Pure)

SUMO chain-induced dimerization activates RNF4

Rojas-Fernandez, A., Plechanovová, A., Hattersley, N., Jaffray, E., Tatham, M. H. & Hay, R. T., 20 Mar 2014, In : Molecular Cell. 53, 6, p. 880-92 13 p.

Research output: Contribution to journalArticle

Open Access
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46 Citations (Scopus)
150 Downloads (Pure)

Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri

Fritah, S., Lhocine, N., Golebiowski, F., Mounier, J., Andrieux, A., Jouvion, G., Hay, R. T., Sansonetti, P. & Dejean, A., Sep 2014, In : EMBO Reports. 15, 9, p. 965-972 8 p.

Research output: Contribution to journalArticle

Open Access
21 Citations (Scopus)

Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity

Lang, V., Pallara, C., Zabala, A., Lobato-Gil, S., Lopitz-Otsoa, F., Farrás, R., Hjerpe, R., Torres-Ramos, M., Zabaleta, L., Blattner, C., Hay, R. T., Barrio, R., Carracedo, A., Fernandez-Recio, J., Rodríguez, M. S. & Aillet, F., 2014, In : Molecular Oncology. 8, 5, p. 1026-1042 17 p.

Research output: Contribution to journalArticle

Open Access
10 Citations (Scopus)

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans

Masoudi, N., Ibanez-Cruceyra, P., Offenburger, S-L., Holmes, A. & Gartner, A., 4 Dec 2014, In : PLoS Genetics. 10, 12, 15 p., e1004767.

Research output: Contribution to journalArticle

Open Access
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15 Citations (Scopus)
160 Downloads (Pure)

The contribution of dormant origins to genome stability: from cell biology to human genetics

Alver, R. C., Chadha, G. S. & Blow, J. J., Jul 2014, In : DNA Repair. 19, p. 182-189 8 p.

Research output: Contribution to journalArticle

Open Access
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50 Citations (Scopus)
223 Downloads (Pure)

The double loop mattress suture

Biddlestone, J., Samuel, M., Creagh, T. & Ahmad, T., 2014, In : Wound Repair and Regeneration. 22, 3, p. 415-423 9 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
178 Downloads (Pure)

The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei

Lilley, A. C., Major, L., Young, S., Stark, M. J. R. & Smith, T. K., May 2014, In : Molecular Microbiology. 92, 3, p. 453-470 18 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
197 Downloads (Pure)

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution

Bowman, A., Hammond, C. M., Stirling, A., Ward, R., Shang, W., El-Mkami, H., Robinson, D. A., Svergun, D. I., Norman, D. G. & Owen-Hughes, T., 2014, In : Nucleic Acids Research. 42, 9, p. 6038-6051 13 p.

Research output: Contribution to journalArticle

Open Access
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25 Citations (Scopus)
214 Downloads (Pure)

The prevalence and origin of exoprotease-producing cells in the Bacillus subtilis biofilm

Marlow, V. L., Cianfanelli, F. R., Porter, M., Cairns, L. S., Dale, J. K. & Stanley-Wall, N. R., Jan 2014, In : Microbiology. 160, 1, p. 56-66 11 p.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
175 Downloads (Pure)

The spatial effect of protein deuteration on nitroxide spin-label relaxation: implications for EPR distance measurement

El Mkami, H., Ward, R., Bowman, A., Owen-Hughes, T. & Norman, D. G., Nov 2014, In : Journal of Magnetic Resonance . 248, p. 36-41 6 p.

Research output: Contribution to journalArticle

Open Access
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9 Citations (Scopus)
177 Downloads (Pure)

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

Poh, W. T., Chadha, G. S., Gillespie, P. J., Kaldis, P. & Blow, J. J., 8 Jan 2014, In : Open Biology. 4, January, 130138.

Research output: Contribution to journalArticle

Open Access
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21 Citations (Scopus)
140 Downloads (Pure)
2013

A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones

Allan, J., Fraser, R. M., Owen-Hughes, T., Docherty, K. & Singh, V., 15 Nov 2013, In : Journal of Molecular Biology. 425, 22, p. 4206-4222 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Analysis of human protein replacement stable cell lines established using snoMEN-PR vector

Ono, M., Yamada, K., Endo, A., Avolio, F. & Lamond, A. I., 25 Apr 2013, In : PLoS ONE. 8, 4, 12 p., e62305.

Research output: Contribution to journalArticle

Open Access
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6 Citations (Scopus)
116 Downloads (Pure)

A role for paralog-specific sumoylation in histone deacetylase 1 stability

Citro, S., Jaffray, E., Hay, R. T., Seiser, C. & Chiocca, S., 2013, In : Journal of Molecular Cell Biology. 5, 6, p. 416-427 12 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

BC-box protein domain-related mechanism for VHL protein degradation

Pozzebon, M. E., Varadaraj, A., Mattoscio, D., Jaffray, E. G., Miccolo, C., Galimberti, V., Tommasino, M., Hay, R. T. & Chiocca, S., 5 Nov 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 45, p. 18168-18173 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Bod1 regulates protein phosphatase 2A at mitotic kinetochores

Porter, I., Schleicher, K., Porter, M. & Swedlow, J., 25 Oct 2013, In : Nature Communications. 4, 2677.

Research output: Contribution to journalArticle

45 Citations (Scopus)

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

Hobley, L., Ostrowski, A., Rao, F. V., Bromley, K. M., Porter, M., Prescott, A. R., Macphee, C. E., van Aalten, D. M. F. & Stanley-Wall, N. R., 13 Aug 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33, p. 13600-13605 6 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

CENP-A confers a reduction in height on octameric nucleosomes

Miell, M. D. D., Barysz, H. M., Rappsilber, J., Allshire, R. C., Fuller, C. J., Straight, A. F., Guse, A., Downes, A. & Owen-Hughes, T., 2013, In : Nature Structural & Molecular Biology.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Characterization of Native Protein Complexes and Protein Isoform Variation Using Size-fractionation-based Quantitative Proteomics

Kirkwood, K. J., Ahmad, Y., Larance, M. & Lamond, A. I., 1 Dec 2013, In : Molecular & Cellular Proteomics. 12, 12, p. 3851-3873 23 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Cleaning up the masses: Exclusion lists to reduce contamination with HPLC-MS/MS

Hodge, K., Ten Have, S., Hutton, L. & Lamond, A. I., 2 Aug 2013, In : Journal of Proteomics. 88, p. 92-103 12 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Clinical proteomics stretch goals: EuPA 2012 roundtable report

O'Neil, S. E., Palviainen, M. J., Ten Have, S., Filiou, M., Gonzalez, A., Hodge, K., Surinova, S., Penque, D. & Baker, M. S., 2 Aug 2013, In : Journal of Proteomics. 88, p. 37-40 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases

Agostinho, A., Meier, B., Sonneville, R., Jagut, M., Woglar, A., Blow, J., Jantsch, V. & Gartner, A., 18 Jul 2013, In : PLoS Genetics. 9, 7, e1003591.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Correlative imaging of fluorescent proteins in resin-embedded plant material

Bell, K., Mitchell, S., Paultre, D., Posch, M. & Oparka, K., Apr 2013, In : Plant Physiology. 161, 4, p. 1595-1603 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)