Gene Regulation and Expression

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2012

Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction

Pourkarimi, E., Greiss, S. & Gartner, A., Mar 2012, In : Cell Death & Differentiation. 19, 3, p. 406-415 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth

Huart, A-S., MacLaine, N. J., Narayan, V. & Hupp, T. R., 20 Aug 2012, In : PLoS ONE. 7, 8, e43391.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J., 21 Sep 2012, In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

Drakou, C. E., Malekkou, A., Hayes, J. M., Lederer, C. W., Leonidas, D. D., Oikonomakos, N. G., Lamond, A. I., Santama, N. & Zographos, S. E., Jan 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 1, p. 206-220 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

Aillet, F., Lopitz-Otsoa, F., Egaña, I., Hjerpe, R., Fraser, P., Hay, R. T., Rodriguez, M. S. & Lang, V., 20 Dec 2012, In : PLoS ONE. 7, 12, e51672.

Research output: Contribution to journalArticle

41 Citations (Scopus)
28 Citations (Scopus)

Human box C/D snoRNA processing conservation across multiple cell types

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I., Apr 2012, In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling

Sturrock, M., Terry, A. J., Xirodimas, D. P., Thompson, A. M. & Chaplain, M. A. J., Jul 2012, In : Bulletin of Mathematical Biology. 74, 7, p. 1531-1579 49 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Inhibition of Pre-mRNA Splicing by a Synthetic Blom7α-Interacting Small RNA

Löscher, M., Schosserer, M., Dausse, E., Lee, K., Ajuh, P. M., Grillari-Voglauer, R., Lamond, A. I., Toulmé, J. J. & Grillari, J., 29 Oct 2012, In : PLoS ONE. 7, 10, 9 p., e47497.

Research output: Contribution to journalArticle

Open Access

Innovation in biological microscopy: current status and future directions

Swedlow, J. R., 1 Jan 2012, In : BioEssays.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21

de Wever, V., Lloyd, D. C., Nasa, I., Nimick, M., Trinkle-Mulcahy, L., Gourlay, R., Morrice, N. & Moorhead, G. B. G., 2012, In : PLoS ONE. 7, 6, e39510.

Research output: Contribution to journalArticle

6 Citations (Scopus)

LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis

Liu, B., Du, H., Rutkowski, R., Gartner, A. & Wang, X., 2012, In : Science. 337, 6092, p. 351-354 4 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Making sense of transcribing chromatin

Owen-Hughes, T. & Gkikopoulos, T., 1 Jan 2012, In : Current Opinion in Cell Biology.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Micrococcal Nuclease Does Not Substantially Bias Nucleosome Mapping

Allan, J., Fraser, R. M., Owen-Hughes, T. & Keszenman-Pereyra, D., 30 Mar 2012, In : Journal of Molecular Biology. 417, 3, p. 152-164 13 p.

Research output: Contribution to journalArticle

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52 Citations (Scopus)
225 Downloads (Pure)

Modulation of activation-associated host cell gene expression by the apicomplexan parasite Theileria annulata

Durrani, Z., Weir, W., Pillai, S., Kinnaird, J. & Shiels, B., 2012, In : Cellular Microbiology.

Research output: Contribution to journalArticle

16 Citations (Scopus)

OMERO: flexible, model-driven data management for experimental biology

Allan, C., Burel, J-M., Moore, J., Blackburn, C., Linkert, M., Loynton, S., MacDonald, D., Moore, W. J., Neves, C., Patterson, A., Porter, M., Tarkowska, A., Loranger, B., Avondo, J., Lagerstedt, I., Lianas, L., Leo, S., Hands, K., Hay, R. T., Patwardhan, A. & 4 others, Best, C., Kleywegt, G. J., Zanetti, G. & Swedlow, J. R., 1 Mar 2012, In : Nature Methods. 9, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

202 Citations (Scopus)

Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors

Schor, I. E., Llères, D., Risso, G. J., Pawellek, A., Ule, J., Lamond, A. I. & Kornblihtt, A. R., 12 Nov 2012, In : PLoS ONE. 7, 11, 16 p., e48084.

Research output: Contribution to journalArticle

Open Access
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40 Citations (Scopus)
136 Downloads (Pure)

Polypyrimidine Tract Binding Protein (hnRNP I) Is Possibly a Conserved Modulator of miRNA-Mediated Gene Regulation

Engels, B., Jannot, G., Remenyi, J., Simard, M. J. & Hutvagner, G., 9 Mar 2012, In : PLoS ONE. 7, 3, p. - 11 p., e33144.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

Gillespie, P. J., Gambus, A. & Blow, J. J., Jun 2012, In : Methods. 57, 2, p. 203-13 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Arabi, A., Ullah, K., Branca, R. M. M., Johansson, J., Bandarra, D., Haneklaus, M., Fu, J., Ariës, I., Nilsson, P., Den Boer, M. L., Pokrovskaja, K., Grandér, D., Xiao, G., Rocha, S., Lehtiö, J. & Sangfelt, O., 2012, In : Nature Communications. 3, 976.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Quantitative proteomic analysis of yeast DNA replication proteins

Kubota, T., Stead, D. A., Hiraga, S., ten Have, S. & Donaldson, A. D., 2012, In : Methods (San Diego, Calif.). 57, 2, p. 196-202 7 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Raf1 is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification

Buscaino, A., White, S. A., Houston, D. R., Lejeune, E., Simmer, F., de Lima Alves, F., Diyora, P. T., Bayne, E. H., Rappsilber, J., Allshire, R. C. & Urano, T., 2012, In : PLoS Genetics. 8, 2, e1002499.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Relationships between climate, water resources, land use and diffuse pollution and the significance of uncertainty in climate change

Dunn, S. M., Brown, I., Sample, J. & Post, H., 20 Apr 2012, In : Journal of Hydrology. 434-435, p. 19-35 17 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation

Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. & Blow, J. J., 15 May 2012, In : Journal of Cell Science. 125, 10, p. 2436-2445 10 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Scale integration: the structure and dynamics of macromolecular assemblies, cells and tissues

Swedlow, J. & Danuser, G., 1 Feb 2012, In : Current Opinion in Cell Biology. 24, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Software tools, data structures, and interfaces for microscope imaging

Stuurman, N. & Swedlow, J. R., 1 Jan 2012, In : Cold Spring Harbor Protocols. 7, 1, p. 50-61 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

Plechanovová, A., Jaffray, E. G., Tatham, M. H., Naismith, J. H. & Hay, R. T., 2012, In : Nature. 489, 7414, p. 115-120 5 p.

Research output: Contribution to journalArticle

267 Citations (Scopus)

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

Yin, Y., Seifert, A., Chua, J. S., Maure, J-F., Golebiowski, F. & Hay, R. T., 1 Jun 2012, In : Genes & Development. 26, 11, p. 1196-1208 13 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)

Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization

Ahmad, Y., Boisvert, F-M., Lundberg, E., Uhlen, M. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

37 Citations (Scopus)

The adenomatous polyposis Coli protein contributes to normal compaction of mitotic chromatin

Dikovskaya, D., Khoudoli, G., Newton, I. P., Chadha, G. S., Klotz, D., Visvanathan, A., Lamond, A., Swedlow, J. R. & Nathke, I. S., 2012, In : PLoS ONE. 7, 6, e38102.

Research output: Contribution to journalArticle

8 Citations (Scopus)

The dynamics of replication licensing in live Caenorhabditis elegans embryos

Sonneville, R., Querenet, M., Craig, A., Gartner, A. & Blow, J. J., 23 Jan 2012, In : Journal of Cell Biology. 196, 2, p. 233-246 14 p.

Research output: Contribution to journalArticle

Open Access
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48 Citations (Scopus)
186 Downloads (Pure)

The Function of Snodprot in the Cerato-Platanin Family from Dactylellina cionopaga in Nematophagous Fungi

Yu, H., Duan, J., Wang, B. & Jiang, X., 2012, In : Bioscience biotechnology and biochemistry. 76, 10, p. 1835-1842 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1

Mocquet, V., Neusiedler, J., Rende, F., Cluet, D., Robin, J-P., Terme, J-M., Dodon, M. D., Wittmann, J., Morris, C., Le Hir, H., Ciminale, V. & Jalinot, P., 2012, In : Journal of Virology. 86, 14, p. 7530-7543 14 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

The p53 isoforms are differentially modified by Mdm2

Camus, S., Menendez, S., Fernandes, K., Kua, N., Liu, G., Xirodimas, D. P., Lane, D. P. & Bourdon, J-C., 15 Apr 2012, In : Cell Cycle. 11, 8, p. 1646-1655 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

Watson, A. A., Mahajan, P., Mertens, H. D. T., Deery, M. J., Zhang, W., Chen, Y., Edlich, C., Laue, E. D., Berridge, G., Burgess-Brown, N. A., Gileadi, O., Svergun, D. I., Pham, P., Du, X., Bartke, T., Kouzarides, T., Wiechens, N. & Owen-Hughes, T., 2012, In : Journal of Molecular Biology. 422, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions

Leidecker, O., Matic, I., Mahata, B., Pion, E. & Xirodimas, D. P., 15 Mar 2012, In : Cell Cycle. 11, 6, p. 1142-1150 9 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Tratamiento exitoso de la necrosis isquémica del glande poscircuncisión con oxígeno hiperbárico y pentoxifilina intravenosa

Translated title of the contribution: Successful treatment of post circumcision glanular ischemia-necrosis with hyperbaric oxygen and intravenous pentoxifyllineElemen, L., Akay, A., Topçu, K. & Gürcan, N. I., 1 Mar 2012, In : Actas Urologicas Espanolas. 36, 3, p. 200-201 2 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Why are patients with small cell lung cancer (SCLC) not given chemotherapy?

Khan, M. I., Brown, E. J., Lord, H., Allan, C., Sim, L., Buckle, F. & Rankin, E. M., Jan 2012, In : Lung Cancer. 75, p. S59-S59 1 p.

Research output: Contribution to journalArticle

2011

Absolute SILAC-compatible expression strain allows SUMO-2 copy number determination in clinical samples

Matic, I., Jaffray, E. G., Oxenham, S. K., Groves, M. J., Barratt, C. L. R., Tauro, S., Stanley-Wall, N. R. & Hay, R. T., Oct 2011, In : Journal of Proteome Research. 10, 10, p. 4869-4875 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1

Narayan, V., Halada, P., Hernychová, L., Chong, Y. P., Žáková, J., Hupp, T. R., Vojtesek, B. & Ball, K. L., 22 Apr 2011, In : Journal of Biological Chemistry. 286, 16, p. 14291-14303 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

An evolutionarily conserved, alternatively spliced, intron in the p68/DDX5 DEAD-box RNA helicase gene encodes a novel miRNA

Moore, H. C., Johnston, M., Nicol, S. M., Bourdon, J-C., Thompson, A. M., Hutvagner, G. & Fuller-Pace, F. V., Apr 2011, In : RNA: a Publication of the RNA Society. 17, 4, p. 555-562 8 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

An intranucleolar body associated with rDNA

Hutten, S., Prescott, A., James, J., Riesenberg, S., Boulon, S., Lam, Y. W. & Lamond, A. I., Oct 2011, In : Chromosoma. 120, 5, p. 481-499 19 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis

Vilas-Boas, F., Fior, R., Swedlow, J. R., Storey, K. G. & Henrique, D., 31 Aug 2011, In : BMC Molecular Biology. 9, p. - 16 p., 58.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Antagonistic crosstalk between APC and HIF-1 alpha

Nathke, I. & Rocha, S., 15 May 2011, In : Cell Cycle. 10, 10, p. 1545-1547 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization

Gkikopoulos, T., Schofield, P., Singh, V., Pinskaya, M., Mellor, J., Smolle, M., Workman, J. L., Barton, G. J. & Owen-Hughes, T., 23 Sep 2011, In : Science. 333, 6050, p. 1758-1760 3 p.

Research output: Contribution to journalArticle

176 Citations (Scopus)

A role for SUMOylation in snoRNP biogenesis revealed by quantitative proteomics

Westman, B. J. & Lamond, A. I., 1 Jan 2011, In : Nucleus. 2, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

A Screen for Novel Phosphoinositide 3-kinase Effector Proteins

Dixon, M. J., Gray, A., Boisvert, F-M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. & Batty, I. H., Apr 2011, In : Molecular & Cellular Proteomics. 10, 4, p. - 13 p., 003178.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication

Kundu, L. R., Seki, M., Watanabe, N., Murofushi, H., Furukohri, A., Waga, S., Score, A. J., Blow, J. J., Horikoshi, M., Enomoto, T. & Tada, S., Jun 2011, In : Biochimica et Biophysica Acta. Molecular Cell Research. 1813, 6, p. 1129-1136 8 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

CDC-48/p97 Coordinates CDT-1 Degradation with GINS Chromatin Dissociation to Ensure Faithful DNA Replication

Franz, A., Orth, M., Pirson, P. A., Sonneville, R., Blow, J. J., Gartner, A., Stemmann, O. & Hoppe, T., 7 Oct 2011, In : Molecular Cell. 44, 1, p. 85-96 12 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)