Gene Regulation and Expression

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2011

Comparative proteomic analysis identifies a role for SUMO in protein quality control

Tatham, M. H., Matic, I., Mann, M. & Hay, R. T., 21 Jun 2011, In : Science Signaling. 4, 178, p. - 12 p., rs4.

Research output: Contribution to journalArticle

126 Citations (Scopus)

Comparison of bipolar electrosurgical devices with ligatures and endoclips in the rat appendicitis model

Elemen, L., Yazir, Y., Akay, A., Boyacioǧlu, Z., Ceyran, B. & Ceylan, S., 2011, In : Journal of Pediatric Surgery. 46, 10, p. 1923-1929 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

DNA repair factor APLF is a histone chaperone

Mehrotra, P. V., Ahel, D., Ryan, D. P., Weston, R., Wiechens, N., Kraehenbuehl, R., Owen-Hughes, T. & Ahel, I., 7 Jan 2011, In : Molecular Cell. 41, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP

Narayan, V., Pion, E., Landré, V., Müller, P. & Ball, K. L., 7 Jan 2011, In : Journal of Biological Chemistry. 286, 1, p. 607-619 13 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Erratum: Further insights into the mechanism of hypoxia-induced NFκB (Cell Cycle (2011) 10 (879-82))

Melvin, A., Mudie, S. & Rocha, S., 2011, In : Cell Cycle. 10, 12, p. 2041 1 p.

Research output: Contribution to journalArticle

Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity

Sasaki, T., Li, A., Gillespie, P. J., Blow, J. J. & Gilbert, D. M., Sep 2011, In : Nucleus. 2, 5, p. 455-464

Research output: Contribution to journalArticle

4 Citations (Scopus)

Evolutionary conserved regulation of HIF-1 beta by NF-kappa B

van Uden, P., Kenneth, N. S., Webster, R., Muller, H. A., Mudie, S. & Rocha, S., Jan 2011, In : PLoS Genetics. 7, 1, p. - 15 p., e1001285.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Exo70, a subunit of the exocyst complex, interacts with SNEVhPrp19/hPso4 and is involved in pre-mRNA splicing

Dellago, H., Löscher, M., Ajuh, P., Ryder, U., Kaisermayer, C., Grillari-Voglauer, R., Fortschegger, K., Gross, S., Gstraunthaler, A., Borth, N., Eisenhaber, F., Lamond, A. I. & Grillari, J., 15 Aug 2011, In : Biochemical Journal. 438, p. 81-91 11 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

From snoRNA to miRNA: Dual function regulatory non-coding RNAs

Scott, M. S. & Ono, M., 1 Nov 2011, In : Biochimie. 93, 11, p. 1987-1992 6 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

Functional interactions between ubiquitin E2 enzymes and TRIM proteins

Napolitano, L. M., Jaffray, E. G., Hay, R. T. & Meroni, G., 1 Mar 2011, In : Biochemical Journal. 434, p. 309-319 11 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

HIF-1 alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs

Culver, C., Melvin, A., Mudie, S. & Rocha, S., 15 Apr 2011, In : Cell Cycle. 10, 8, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

How to be a mitotic chromosome

Moser, S. C. & Swedlow, J. R., Apr 2011, In : Chromosome Research. 19, 3, p. 307-319 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Identification of human miRNA precursors that resemble box C/D snoRNAs

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I., May 2011, In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin

Rowland, A. F., Larance, M., Hughes, W. E. & James, D. E., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4789-4800 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Kinetochore-Dependent Microtubule Rescue Ensures Their Efficient and Sustained Interactions in Early Mitosis

Gandhi, S. R., Gierlinski, M., Mino, A., Tanaka, K., Kitamura, E., Clayton, L. & Tanaka, T. U., 15 Nov 2011, In : Developmental Cell. 21, 5, p. 920-933 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

LimsPortal and BonsaiLIMS: development of a lab information management system for translational medicine

Bath, T. G., Bozdag, S., Afzal, V. & Crowther, D., 15 Sep 2011, In : Source code for biology and medicine. 6, p. 9

Research output: Contribution to journalArticle

6 Citations (Scopus)

Mass spectrometry-based immuno-precipitation proteomics - The user's guide

ten Have, S., Boulon, S., Ahmad, Y. & Lamond, A. I., Mar 2011, In : Proteomics. 11, 6, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

Gambus, A., Khoudoli, G. A., Jones, R. C. & Blow, J. J., 1 Apr 2011, In : Journal of Biological Chemistry. 286, 13, p. 11855-11864 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Mechanism of hypoxia-induced NFκB

Melvin, A., Mudie, S. & Rocha, S., 2011, In : Cell Cycle. 10, 6, p. 879-882 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Mechanism of ubiquitylation by dimeric RING ligase RNF4

Plechanovova, A., Jaffray, E. G., McMahon, S. A., Johnson, K. A., Navratilova, I., Naismith, J. H. & Hay, R. T., Sep 2011, In : Nature Structural & Molecular Biology. 18, 9, p. 1052-1059 8 p.

Research output: Contribution to journalArticle

100 Citations (Scopus)

NF-kappa B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., De Smaele, E., Beg, A. A., Tergaonkar, V., Chandel, N. S. & Franzoso, G., Oct 2011, In : Nature Cell Biology. 13, 10, p. 1272-U234 18 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Nuclear Speckles

Spector, D. L. & Lamond, A. I., Feb 2011, In : Cold spring harbor perspectives in biology. 3, 2, p. - 12 p., a000646.

Research output: Contribution to journalArticle

374 Citations (Scopus)

OMX: a new platform for multimodal, multichannel wide-field imaging

Dobbie, I. M., King, E., Parton, R. M., Carlton, P. M., Sedat, J. W., Swedlow, J. R. & Davis, I., 1 Aug 2011, In : Cold Spring Harbor Protocols. 6, 8, p. 899-909 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

PChopper: high throughput peptide prediction for MRM/SRM transition design

Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J., 15 Aug 2011, In : BMC Bioinformatics. 12, p. - 9 p., 338.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PNAC: a protein nucleolar association classifier

Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J., 27 Jan 2011, In : BMC Genomics. 12, p. - 14 p., 74.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Purification and identification of endogenous polySUMO conjugates

Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. & Hay, R. T., Feb 2011, In : EMBO Reports. 12, 2, p. 142-148 7 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Quantitative Proteomic Analysis of Chromatin Reveals that Ctf18 Acts in the DNA Replication Checkpoint

Kubota, T., Hiraga, S., Yamada, K., Lamond, A. I. & Donaldson, A. D., Jul 2011, In : Molecular & Cellular Proteomics. 10, 7, p. - 14 p., M110.005561. .

Research output: Contribution to journalArticle

43 Citations (Scopus)

Quantitative proteomic analysis of the adipocyte plasma membrane

Prior, M. J., Larance, M., Lawrence, R. T., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J. R., La-Borde, P. J., Buckley, M., Kanazawa, H., Parton, R. G., Guilhaus, M. & James, D. E., 4 Nov 2011, In : Journal of Proteome Research. 10, 11, p. 4970-4982 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation

Moore, H. M., Bai, B., Boisvert, F-M., Latonen, L., Rantanen, V., Simpson, J. C., Pepperkok, R., Lamond, A. I. & Laiho, M., Oct 2011, In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p., M111.009241.

Research output: Contribution to journalArticle

79 Citations (Scopus)

Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. & Gartner, A., Aug 2011, In : PLoS Genetics. 7, 8, p. - 21 p., e1002238.

Research output: Contribution to journalArticle

48 Citations (Scopus)

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K. I., Zomerdijk, J. C. B. M., Schultz, P. & Gadal, O., 24 Jan 2011, In : Journal of Cell Biology. 192, 2, p. 277-293 17 p.

Research output: Contribution to journalArticle

Open Access
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41 Citations (Scopus)
470 Downloads (Pure)

Simulated spectral states of active galactic nuclei and observational predictions

Sobolewska, M. A., Siemiginowska, A. & Gierliński, M., 11 May 2011, In : Monthly Notices of the Royal Astronomical Society. 413, 3, p. 2259-2268 10 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways

Sturrock, M., Terry, A. J., Xirodimas, D. P., Thompson, A. M. & Chaplain, M. A. J., 21 Mar 2011, In : Journal of Theoretical Biology. 273, 1, p. 15-31 17 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Stable-isotope labeling with amino acids in nematodes

Larance, M., Bailly, A. P., Pourkarimi, E., Hay, R. T., Buchanan, G., Coulthurst, S., Xirodimas, D. P., Gartner, A. & Lamond, A. I., Oct 2011, In : Nature Methods. 8, 10, p. 849-851 3 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

Wang, X. D., Lapi, E., Sullivan, A., Ratnayaka, I., Goldin, R., Hay, R. & Lu, X., Feb 2011, In : Cell Death & Differentiation. 18, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

TAF1B Is a TFIIB-Like Component of the Basal Transcription Machinery for RNA Polymerase I

Naidu, S., Friedrich, J. K., Russell, J. & Zomerdijk, J. C. B. M., 16 Sep 2011, In : Science. 333, 6049, p. 1640-1642 3 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

Tatchell, K., Makrantoni, V., Stark, M. J. R. & Robinson, L. C., 8 Mar 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 3994-3999 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH

Melvin, A., Mudie, S. & Rocha, S., 1 Nov 2011, In : Molecular Biology of the Cell. 22, 21, p. 4171-4181 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T., 6 Jul 2011, In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

Research output: Contribution to journalArticle

Open Access
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76 Citations (Scopus)
145 Downloads (Pure)

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation

Bowman, A., Ward, R., Wiechens, N., Singh, V., El-Mkami, H., Norman, D. G. & Owen-Hughes, T., 18 Feb 2011, In : Molecular Cell. 41, 4, p. 398-408 11 p.

Research output: Contribution to journalArticle

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57 Citations (Scopus)
197 Downloads (Pure)

The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End

Maure, J-F., Komoto, S., Oku, Y., Mino, A., Pasqualato, S., Natsume, K., Clayton, L., Musacchio, A. & Tanaka, T. U., 8 Feb 2011, In : Current Biology. 21, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

69 Citations (Scopus)

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

Murdoch, S. L., Trunk, K., English, G., Fritsch, M. J., Pourkarimi, E. & Coulthurst, S. J., Nov 2011, In : Journal of Bacteriology. 193, 21, p. 6057-6069 13 p.

Research output: Contribution to journalArticle

134 Citations (Scopus)

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

Jannot, G., Bajan, S., Giguère, N. J., Bouasker, S., Banville, I. H., Piquet, S., Hutvagner, G. & Simard, M. J., Jun 2011, In : EMBO Reports. 12, 6, p. 581-586 6 p.

Research output: Contribution to journalArticle

Open Access
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50 Citations (Scopus)
182 Downloads (Pure)

The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

Msaki, A., Sanchez, A. M., Koh, L. F., Barre, B., Rocha, S., Perkins, N. D. & Johnson, R. F., 1 Sep 2011, In : Molecular Biology of the Cell. 22, 17, p. 3032-3040 9 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
140 Downloads (Pure)

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Bach, M., Larance, M., James, D. E. & Ramm, G., 1 Dec 2011, In : Biochemical Journal. 440, 2, p. 283-291 9 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

Hattersley, N., Shen, L., Jaffray, E. G. & Hay, R. T., 1 Jan 2011, In : Molecular Biology of the Cell. 22, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T., 18 May 2011, In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

Research output: Contribution to journalArticle

Open Access
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33 Citations (Scopus)
151 Downloads (Pure)
2010

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., Leslie, S. J., Pickford, R., Hoy, A. J., Kraegen, E. W., James, D. E. & Cooney, G. J., 6 Jan 2010, In : Cell Metabolism. 11, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)

Adenomatous polyposis coli and hypoxia-inducible factor-1 alpha have an antagonistic connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Nathke, I. & Rocha, S., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3630-3638 9 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)