Gene Regulation and Expression

  • United Kingdom

Research Output

Filter
Article
Open Access
File
30 Citations (Scopus)
150 Downloads (Pure)

Grow₂: The HIF system, energy homeostasis and the cell cycle

Moniz, S., Biddlestone, J. & Rocha, S., May 2014, In : Histology and Histopathology. 29, 5, p. 589-600 12 p.

Research output: Contribution to journalArticle

Open Access
14 Citations (Scopus)

H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex

Saredi, G., Huang, H., Hammond, C. M., Alabert, C., Bekker-Jensen, S., Forne, I., Reverón-Gómez, N., Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, N., Imhof, A., Patel, D. J. & Groth, A., 22 Jun 2016, In : Nature. 534, 7609, p. 714-718 5 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Having a direct look: analysis of DNA damage and repair mechanisms by next generation sequencing

Meier, B. & Gartner, A., 15 Nov 2014, In : Experimental Cell Research. 329, 1, p. 35-41 7 p.

Research output: Contribution to journalArticle

Open Access
File
4 Citations (Scopus)
151 Downloads (Pure)

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

Drakou, C. E., Malekkou, A., Hayes, J. M., Lederer, C. W., Leonidas, D. D., Oikonomakos, N. G., Lamond, A. I., Santama, N. & Zographos, S. E., Jan 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 1, p. 206-220 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Hepatic metastases in Hong Kong Chinese: evidence for an East-West difference in gastric cancer

Steele, R. J. C., Chung, S. C., Li, A. K. & Crofts, T. J., 1987, In : Annals of the Royal College of Surgeons of England. 69, 2, p. 61-63 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

Aillet, F., Lopitz-Otsoa, F., Egaña, I., Hjerpe, R., Fraser, P., Hay, R. T., Rodriguez, M. S. & Lang, V., 20 Dec 2012, In : PLoS ONE. 7, 12, e51672.

Research output: Contribution to journalArticle

39 Citations (Scopus)

HIF-1 alpha depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs

Culver, C., Melvin, A., Mudie, S. & Rocha, S., 15 Apr 2011, In : Cell Cycle. 10, 8, p. 1249-1260 12 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

HIF-1α, a novel piece in the NF-κB puzzle

Bandarra, D. & Rocha, S., 28 Apr 2015, In : Infammation and Cell Signaling. 2, 1, 4 p., e792.

Research output: Contribution to journalArticle

Open Access
File
157 Downloads (Pure)

HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

Bandarra, D., Biddlestone, J., Mudie, S., Müller, H. -A. J. & Rocha, S., Feb 2015, In : Disease Models & Mechanisms. 8, 2, p. 169-181 13 p.

Research output: Contribution to journalArticle

Open Access
30 Citations (Scopus)

HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6

D'Ignazio, L., Shakir, D., Batie, M., Muller, H. A. & Rocha, S., 24 Apr 2020, In : International Journal of Molecular Sciences. 21, 8, p. 1-19 19 p., 3000.

Research output: Contribution to journalArticle

Open Access
File
6 Downloads (Pure)

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

Durán, R. V., Mackenzie, E. D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., Bussolati, O., Rocha, S., Hall, M. N. & Gottlieb, E., 19 Sep 2013, In : Oncogene. 32, 38, p. 4549-4556 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Highly efficient chemical synthesis of 2′-O-methyloligoribonucleotides and tetrabiotinylated derivatives; novel probes that are resistant to degradation by RNA or DNA specific nucleases

Sproat, B. S., Lamond, A. I., Beijer, B., Neuner, P. & Ryder, U., 11 May 1989, In : Nucleic Acids Research. 17, 9, p. 3373-3386 14 p.

Research output: Contribution to journalArticle

202 Citations (Scopus)
27 Citations (Scopus)
Open Access
File
6 Citations (Scopus)
166 Downloads (Pure)

High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties

Golebiowski, F., Tatham, M. H., Nakamura, A. & Hay, R. T., 2010, In : Nature Protocols. 5, 5, p. 873-882 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

Hauer, M. H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. & Gasser, S. M., Feb 2017, In : Nature Structural & Molecular Biology. 24, 2, p. 99-107 13 p.

Research output: Contribution to journalArticle

Open Access
File
68 Citations (Scopus)
257 Downloads (Pure)

Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities

Bruno, M., Flaus, A., Stockdale, C., Rencurel, C., Ferreira, H. & Owen-Hughes, T., 2003, In : Molecular Cell. 12, 6, p. 1599-1606 8 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Shoaib, M., Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, M., Johansen, J. V., Hansen, K., Julien, E., Blow, J. J. & Sørensen, C. S., 12 Sep 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 3704.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
108 Downloads (Pure)

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms

Ferreira, H., Flaus, A. & Owen-Hughes, T., 30 Nov 2007, In : Journal of Molecular Biology. 374, 3, p. 563-579 17 p.

Research output: Contribution to journalArticle

File
95 Citations (Scopus)
194 Downloads (Pure)

Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability

Ferreira, H., Somers, J., Webster, R., Flaus, A. & Owen-Hughes, T., 2007, In : Molecular and Cellular Biology. 27, 11, p. 4037-48 12 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing

Leonard, D., Ajuh, P. M., Lamond, A. I. & Legerski, R. J., 5 Sep 2003, In : Biochemical and Biophysical Research Communications. 308, 4, p. 793-801 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. & Ciulli, A., 10 Oct 2017, In : Nature Communications. 8, p. 1-14 14 p., 830.

Research output: Contribution to journalArticle

Open Access
File
55 Citations (Scopus)
175 Downloads (Pure)

How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use?

Schurch, N. J., Schofield, P., Gierliński, M., Cole, C., Sherstnev, A., Singh, V., Wrobel, N., Gharbi, K., Simpson, G. G., Owen-Hughes, T., Blaxter, M. & Barton, G. J., Jun 2016, In : RNA: a Publication of the RNA Society. 22, 6, p. 839-851 13 p.

Research output: Contribution to journalArticle

Open Access
File
191 Citations (Scopus)
185 Downloads (Pure)

How to be a mitotic chromosome

Moser, S. C. & Swedlow, J. R., Apr 2011, In : Chromosome Research. 19, 3, p. 307-319 13 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
Open Access
File
67 Downloads (Pure)

hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters

Miller, G., Panov, K. I., Friedrich, J. K., Trinkle-Mulcahy, L., Lamond, A. I. & Zomerdijk, J. C. B. M., Mar 2001, In : The EMBO Journal. 20, 6, p. 1373-1382 10 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

Boulon, S., Pradet-Balade, B., Verheggen, C., Molle, D., Boireau, S., Georgieva, M., Azzag, K., Robert, M-C., Ahmad, Y., Neel, H., Lamond, A. I. & Bertrand, E., 24 Sep 2010, In : Molecular Cell. 39, 6, p. 912-924 13 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)

HSP90 protein stabilizes unloaded Argonaute complexes and microscopic P-bodies in human cells

Johnston, M., Geoffroy, M-C., Sobala, A., Hay, R. & Hutvagner, G., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1462-1469 8 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Human box C/D snoRNA processing conservation across multiple cell types

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I., Apr 2012, In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Human IFIT1 inhibits mRNA translation of rubulaviruses but not other members of the Paramyxoviridae family

Young, D. F., Andrejeva, J., Li, X., Inesta-Vaquera, F., Dong, C., Cowling, V. H., Goodbourn, S. & Randall, R. E., 15 Oct 2016, In : Journal of Virology. 90, 20, p. 9446-9456 11 p.

Research output: Contribution to journalArticle

Open Access
File
15 Citations (Scopus)
141 Downloads (Pure)

Human miRNA Precursors with Box H/ACA snoRNA Features

Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J., Sep 2009, In : PLoS Computational Biology. 5, 9, p. - 13 p., e1000507.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

Hiraga, S., Ly, T., Garzón, J., Hořejší, Z., Ohkubo, Y., Endo, A., Obuse, C., Boulton, S. J., Lamond, A. & Donaldson, A. D., 1 Mar 2017, In : EMBO Reports. 18, 3, p. 403-419 17 p.

Research output: Contribution to journalArticle

Open Access
File
42 Citations (Scopus)
119 Downloads (Pure)

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster

Bandarra, D., Biddlestone, J., Mudie, S., Muller, H. A. & Rocha, S., 2014, In : Bioscience Reports. 34, 4, p. 429-440 12 p., e00127.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
151 Downloads (Pure)

Hypoxia Induced NF-κB

D'Ignazio, L. & Rocha, S., 8 Mar 2016, In : Cells. 5, 1, 8 p., 10.

Research output: Contribution to journalArticle

Open Access
File
106 Downloads (Pure)

Hypoxia induces rapid changes to histone methylation and reprograms chromatin

Batie, M., Frost, J., Frost, M., Wilson, J. W., Schofield, P. & Rocha, S., 15 Mar 2019, In : Science. 363, 6432, p. 1222-1226 5 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Identification and characterization of the KlCMD1 gene encoding Kluyveromyces lactis calmodulin

Rayner, T. F. & Stark, M. J. R., 1998, In : Yeast. 14, 9, p. 869-875 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Identification and functional characterization of FMN2: a regulator of the cyclin-dependent kinase Inhibitor p21

Yamada, K., Ono, M., Perkins, N. D., Rocha, S. & Lamond, A. I., Mar 2013, In : Molecular Cell. 49, 5, p. 922-933 12 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., Nov 2018, In : PLoS Genetics. 14, 11, p. 1-20 20 p., e1007783.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
114 Downloads (Pure)

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Popow, O., Paulo, J. A., Tatham, M., Volk, M., Rojas-Fernandez, A., Loyer, N., Newton, I., Januschke, J., Haigis, K. M. & Nathke, I., Sep 2019, In : Molecular Cancer Research. 17, 9, p. 1828-1841 14 p.

Research output: Contribution to journalArticle

Identification of hnRNP P2 as TLS/FUS using electrospray mass spectrometry

Calvio, C., Neubauer, G., Mann, M. & Lamond, A. I., Sep 1995, In : RNA. 1, 7, p. 724-733 10 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Identification of hSRP1α as a functional receptor for nuclear localization sequences

Weis, K., Mattaj, I. W. & Lamond, A. I., 19 May 1995, In : Science. 268, 5213, p. 1049-1053 5 p.

Research output: Contribution to journalArticle

300 Citations (Scopus)

Identification of human miRNA precursors that resemble box C/D snoRNAs

Ono, M., Scott, M. S., Yamada, K., Avolio, F., Barton, G. J. & Lamond, A. I., May 2011, In : Nucleic Acids Research. 39, 9, p. 3879-3891 13 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J., 9 Jul 2010, In : Cell. 142, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs

Flaus, A., Martin, D. M. A., Barton, G. J. & Owen-Hughes, T., 2006, In : Nucleic Acids Research. 34, 10, p. 2887-905 19 p.

Research output: Contribution to journalArticle

File
407 Citations (Scopus)
140 Downloads (Pure)

Identification of novel inhibitors of UDP-Glc 4 '-epimerase, a validated drug target for African sleeping sickness

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J., 15 Nov 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of nucleolar associated chromatin loci reveals clues for nuclear architecture

van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 2009, In : Cellular Oncology. 31, 2, p. 105-106 2 p., O16.

Research output: Contribution to journalArticle

Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1

Ajuh, P. & Lamond, A. I., 1 Nov 2003, In : Nucleic Acids Research. 31, 21, p. 6104-6116 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin

Rowland, A. F., Larance, M., Hughes, W. E. & James, D. E., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4789-4800 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)