Gene Regulation and Expression

  • United Kingdom

Research Output

Filter
Article

Zooming in on Chromosome Dynamics

Eykelenboom, J. K. & Tanaka, T. U., 13 May 2020, In : Cell Cycle. 12 p.

Research output: Contribution to journalArticle

Open Access
File
5 Downloads (Pure)

Yeast Pescadillo is required for multiple activities during 60s ribosomal subunit synthesis

Oeffinger, M., Lueng, A., Lamond, A. & Tollervey, D., 21 May 2002, In : RNA. 8, 5, p. 626-636 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)
15 Citations (Scopus)

Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading

Jares, P. & Blow, J. J., 2000, In : Genes & Development. 14, 12, p. 1528-1540 13 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1

Poh, W. T., Chadha, G. S., Gillespie, P. J., Kaldis, P. & Blow, J. J., 8 Jan 2014, In : Open Biology. 4, January, 130138.

Research output: Contribution to journalArticle

Open Access
File
20 Citations (Scopus)
130 Downloads (Pure)

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

Davies, R. C., Calvio, C., Bratt, E., Larsson, S. H., Lamond, A. I. & Hastie, N. D., 15 Oct 1998, In : Genes and Development. 12, 20, p. 3217-3225 9 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)

Widespread arginine phosphorylation in human cells–a novel protein PTM revealed by mass spectrometry

Fu, S., Fu, C., Zhou, Q., Lin, R., Ouyang, H., Wang, M., Sun, Y., Liu, Y. & Zhao, Y., 18 Feb 2020, In : Science China Chemistry. 6 p.

Research output: Contribution to journalArticle

Why are patients with small cell lung cancer (SCLC) not given chemotherapy?

Khan, M. I., Brown, E. J., Lord, H., Allan, C., Sim, L., Buckle, F. & Rankin, E. M., Jan 2012, In : Lung Cancer. 75, p. S59-S59 1 p.

Research output: Contribution to journalArticle

What can we learn about quasars from αOX measurements in Galactic black hole binaries?

Sobolewska, M. A., Gierliński, M. & Siemiginowska, A., 11 Apr 2009, In : Monthly Notices of the Royal Astronomical Society. 394, 3, p. 1640-1648 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Web-based visualisation and analysis of 3D electron-microscopy data from EMDB and PDB

Lagerstedt, I., Moore, W. J., Patwardhan, A., Sanz-García, E., Best, C., Swedlow, J. R. & Kleywegt, G. J., 1 Jan 2013, In : Journal of Structural Biology. 184, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Visualization of the Serratia type VI secretion system reveals unprovoked attacks and dynamic assembly

Gerc, A. J., Diepold, A., Trunk, K., Porter, M., Rickman, C., Armitage, J. P., Stanley-Wall, N. R. & Coulthurst, S. J., 29 Sep 2015, In : Cell Reports. 12, 12, p. 2131-2142 12 p.

Research output: Contribution to journalArticle

Open Access
File
36 Citations (Scopus)
225 Downloads (Pure)

Visualization of Biomedical Data

O'Donoghue, S. I., Baldi, B. F., Clark, S. J., Darling, A. E., Hogan, J. M., Kaur, S., Maier-Hein, L., McCarthy, D. J., Moore, W., Stenau, E., Swedlow, J., Vuong, J. & Procter, J., 20 Jul 2018, In : Annual Review of Biomedical Data Science. 1

Research output: Contribution to journalArticle

Open Access

Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers

Stubbe, M., Mai, J., Paulus, C., Stubbe, H. C., Berscheminski, J., Karimi, M., Hofmann, S., Weber, E., Hadian, K., Hay, R., Groitl, P., Nevels, M., Dobner, T. & Schreiner, S., 17 Mar 2020, In : MBio. 11, 2, p. 1-21 21 p., e00049-20.

Research output: Contribution to journalArticle

Open Access
File
9 Downloads (Pure)

UV-induced fragmentation of Cajal bodies

Cioce, M., Boulon, S., Matera, A. G. & Lamond, A. I., 6 Nov 2006, In : Journal of Cell Biology. 175, 3, p. 401-413 13 p.

Research output: Contribution to journalArticle

Open Access
File
57 Citations (Scopus)
325 Downloads (Pure)

USP45 and Spindly are part of the same complex implicated in cell migration

Conte, C., Griffis, E., Hickson, I. D. & Perez-Oliva, A., 26 Sep 2018, In : Scientific Reports. 8, 1, 13 p., 14375.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
128 Downloads (Pure)

Using dialogical argument as an interface to complex debates

Wells, S. & Reed, C., 1 Sep 2008, In : IEEE Potentials. 27, 5, p. 26-30 5 p.

Research output: Contribution to journalArticle

Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts

Mattock, H., Jares, P., Zheleva, D. I., Lane, D. P., Warbrick, E. & Blow, J. J., 2001, In : Experimental Cell Research. 265, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator

Mehlgarten, C., Prochaska, H., Hammermeister, A., Abdel-Fattah, W., Wagner, M., Krutyhołowa, R., Jun, S. E., Kim, G-T., Glatt, S., Breunig, K. D., Stark, M. J. R. & Schaffrath, R., 5 Sep 2017, In : Toxins. 9, 9, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
File
7 Citations (Scopus)
171 Downloads (Pure)

Usability and user-centered design in scientific software development

Macaulay, C., Sloan, D., Jiang, X., Forbes, P., Loynton, S., Swedlow, J. R. & Gregor, P., 2009, In : IEEE Software. 26, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

Moreno, A., Carrington, J. T., Albergante, L., Al Mamun, M., Haagensen, E. J., Komseli, E-S., Gorgoulis, V. G., Newman, T. J. & Blow, J., 27 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 39, p. E5757-E5764 8 p.

Research output: Contribution to journalArticle

Open Access
File
44 Citations (Scopus)
341 Downloads (Pure)

Unlocking the nucleosome

Flaus, A. & Owen-Hughes, T., 20 Jan 2017, In : Science. 355, 6322, p. 245-246 2 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Unlocking the chromatin code by deciphering protein–DNA interactions

Bensaddek, D. & Lamond, A., Nov 2016, In : Molecular Systems Biology. 12, 11, p. 1-3 3 p., 887.

Research output: Contribution to journalArticle

Open Access
File
173 Downloads (Pure)

Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

Tatham, M. H., Kim, S., Jaffray, E., Song, J., Chen, Y. & Hay, R. T., Jan 2005, In : Nature Structural & Molecular Biology. 12, 1, p. 67-74 8 p.

Research output: Contribution to journalArticle

102 Citations (Scopus)

Ufd1-Npl4 recruit Cdc48 for disassembly of ubiquitylated CMG helicase at the end of chromosome replication

Maric, M., Mukherjee, P., Tatham, M. H., Hay, R. & Labib, K., 28 Mar 2017, In : Cell Reports. 18, 13, p. 3033-3042 10 p.

Research output: Contribution to journalArticle

Open Access
File
11 Citations (Scopus)
204 Downloads (Pure)

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies

Ghirardello, M., Perrone, D., Chinaglia, N., Sádaba, D., Delso, I., Tejero, T., Marchesi, E., Fogagnolo, M., Rafie, K., van Aalten, D. M. F. & Merino, P., 17 May 2018, In : Chemistry: a European Journal. 24, 28, p. 7264-7272 9 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
89 Downloads (Pure)

Ubiquitylation-dependent localization of PLK1 in mitosis

Beck, J., Maerki, S., Posch, M., Metzger, T., Persaud, A., Scheel, H., Hofmann, K., Rotin, D., Pedrioli, P., Swedlow, J. R., Peter, M. & Sumara, I., 2013, In : Nature Cell Biology. 15, 4, p. 430-439 10 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules

Krupina, K., Kleiss, C., Metzger, T., Fournane, S., Schmucker, S., Hofmann, K., Fischer, B., Paul, N., Porter, I. M., Raffelsberger, W., Poch, O., Swedlow, J. R., Brino, L. & Sumara, I., 11 Jan 2016, In : Developmental Cell. 36, 1, p. 63-78 16 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Ubiquitin-C-terminal hydrolases cleave isopeptide and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers

Bett, J. S., Ritorto, M. S., Ewan, R., Jaffray, E. G., Virdee, S., Chin, J. W., Knebel, A., Kurz, T., Trost, M., Tatham, M. H. & Hay, R. T., 15 Mar 2015, In : Biochemical Journal. 466, 3, p. 489-498 10 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J. J. & Rouse, J., 19 Feb 2016, In : Science. 351, 6275, p. 846-849 4 p.

Research output: Contribution to journalArticle

Open Access
58 Citations (Scopus)

UBF activates RNA polymerase I transcription by stimulating promoter escape

Panov, K. I., Friedrich, J. K., Russell, J. & Zomerdijk, J. C. B. M., 2006, In : The EMBO Journal. 25, 14, p. 3310-3322 13 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H. & Hay, R. T., 2013, In : Biochemical Journal. 453, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)
66 Citations (Scopus)

Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin

BUTLER, ANDREW. R., WHITE, JOHN. H., FOLAWIYO, YETUNDE., EDLIN, ANGELA., GARDINER, DONALD. & STARK, MICHAEL. J. R., Sep 1994, In : Molecular and Cellular Biology. 14, 9, p. 6306-6316 11 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Two distinct modes for propagation of histone PTMs across the cell cycle

Alabert, C., Barth, T. K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O., Imhof, A. & Groth, A., 15 Mar 2015, In : Genes and Development. 29, 6, p. 585-590 6 p.

Research output: Contribution to journalArticle

Open Access
File
140 Citations (Scopus)
93 Downloads (Pure)

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins

Gonsalvez, G. B., Tian, L., Ospina, J. K., Boisvert, F. M., Lamond, A. I. & Matera, A. G., 27 Aug 2007, In : Journal of Cell Biology. 178, 5, p. 733-740 8 p.

Research output: Contribution to journalArticle

Open Access
100 Citations (Scopus)

Two-dimensional liquid chromatography/tandem mass spectrometry analysis of Gradiflow fractionated native human plasma

Wasinger, V. C., Locke, V. L., Raftery, M. J., Larance, M., Rothemund, D., Liew, A., Bate, I. & Guilhaus, M., Aug 2005, In : Proteomics. 5, 13, p. 3397-3401 5 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Two cases of eosinophilic enteritis presenting as large bowel perforation and small bowel haemorrhage

Steele, R. J. C., Mok, S. D., Crofts, T. J. & Li, A. K., 1987, In : Australian and New Zealand Journal of Surgery. 57, 5, p. 335-336 2 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

tRNA-Derived RNA Fragments Associate with Human Multisynthetase Complex (MSC) and Modulate Ribosomal Protein Translation

Keam, S. P., Sobala, A., ten Have, S. & Hutvagner, G., 22 Nov 2016, In : Journal of Proteome Research. 16, 2, p. 413-420 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

Lionnard, L., Duc, P., Brennan, M. S., Kueh, A. J., Pal, M., Guardia, F., Mojsa, B., Damiano, M. A., Mora, S., Lassot, I., Ravichandran, R., Cochet, C., Aouacheria, A., Potts, P. R., Herold, M. J., Desagher, S. & Kucharczak, J., 24 Jul 2018, In : Cell Death and Differentiation.

Research output: Contribution to journalArticle

Open Access
File
5 Citations (Scopus)
228 Downloads (Pure)

Tratamiento exitoso de la necrosis isquémica del glande poscircuncisión con oxígeno hiperbárico y pentoxifilina intravenosa

Translated title of the contribution: Successful treatment of post circumcision glanular ischemia-necrosis with hyperbaric oxygen and intravenous pentoxifyllineElemen, L., Akay, A., Topçu, K. & Gürcan, N. I., 1 Mar 2012, In : Actas Urologicas Espanolas. 36, 3, p. 200-201 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis

Minshull, J., Blow, J. J. & Hunt, T., 24 Mar 1989, In : Cell. 56, 6, p. 947-956 10 p.

Research output: Contribution to journalArticle

275 Citations (Scopus)

Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis

Schumacher, B., Hanazawa, M., Lee, M-H., Nayak, S., Volkmann, K., Hofmann, R., Hengartner, M., Schedl, T. & Gartner, A., Feb 2005, In : Cell. 120, 3, p. 357-368 12 p.

Research output: Contribution to journalArticle

155 Citations (Scopus)

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

Carmo-Fonseca, M., Pepperkok, R., Carvalho, M. T. & Lamond, A. I., 1 Apr 1992, In : Journal of Cell Biology. 117, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

332 Citations (Scopus)

Transcriptional profiling of the LPS induced NF-kappaB response in macrophages

Sharif, O., Bolshakov, V. N., Raines, S., Newham, P. & Perkins, N. D., 2007, In : BMC Immunology. 8, p. 1

Research output: Contribution to journalArticle

225 Citations (Scopus)

Transcriptional profiling in C-elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

Greiss, S., Schumacher, B., Grandien, K., Rothblatt, J. & Gartner, A., 15 Jul 2008, In : BMC Genomics. 9, p. - 10 p., 334.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Toward a high-resolution view of nuclear dynamics

Trinkle-Mulcahy, L. & Lamond, A. I., 2007, In : Science. 318, 5855, p. 1402-1407 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Topoisomerase IIα promotes activation of RNA polymerase i transcription by facilitating pre-initiation complex formation

Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M., 19 Mar 2013, In : Nature Communications. 4, 1598.

Research output: Contribution to journalArticle

18 Citations (Scopus)

TOPALi v2: a rich graphical interface for evolutionary analyses of multiple alignments on HPC clusters and multi-core desktops

Milne, I., Lindner, D., Bayer, M., Husmeier, D., McGuire, G., Marshall, D. F. & Wright, F., 2009, In : Bioinformatics. 25, 1, p. 126-127 2 p.

Research output: Contribution to journalArticle

446 Citations (Scopus)

TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway

D'Ignazio, L., Batie, M. & Rocha, S., 8 Aug 2018, In : Cells. 7, 8, p. 1-14 14 p., 102.

Research output: Contribution to journalArticle

Open Access
File
114 Downloads (Pure)

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)