Gene Regulation and Expression

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Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

Parker, M. T., Knop, K., Sherwood, A. V., Schurch, N. J., Mackinnon, K., Gould, P. D., Hall, A. J. W., Barton, G. J. & Simpson, G. G., 14 Jan 2020, In : eLife. 9, p. 1-35 35 p., e49658.

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7 Citations (Scopus)
55 Downloads (Pure)

Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components

Alabert, C., Bukowski-Wills, J. C., Lee, S. B., Kustatscher, G., Nakamura, K., De Lima Alves, F., Menard, P., Mejlvang, J., Rappsilber, J. & Groth, A., 23 Feb 2014, In : Nature Cell Biology. 16, 3, p. 281-291 11 p.

Research output: Contribution to journalArticle

162 Citations (Scopus)

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects

Hain, D., Bettencourt, B. R., Okamura, K., Csorba, T., Meyer, W., Jin, Z., Biggerstaff, J., Siomi, H., Hutvagner, G., Lai, E. C., Welte, M. & Muller, H. -A. J., 16 Dec 2010, In : PLoS ONE. 5, 12, p. - 14 p., e15264.

Research output: Contribution to journalArticle

25 Citations (Scopus)

NDK-1, the homolog of NM23-H1/H2 regulates cell migration and apoptotic engulfment in C. elegans

Fancsalszky, L., Monostori, E., Farkas, Z., Pourkarimi, E., Masoudi, N., Hargitai, B., Bosnar, M. H., Deželjin, M., Zsákai, A., Vellai, T., Mehta, A. & Takács-Vellai, K., 21 Mar 2014, In : PLoS ONE. 9, 3, 12 p., e92687.

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19 Citations (Scopus)
93 Downloads (Pure)

Near real-time processing of proteomics data using Hadoop.

Hillman, C., Ahmad, Y., Whitehorn, M. & Cobley, A., 14 Mar 2014, In : Big Data. 2, 1, p. 44-49 5 p.

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5 Citations (Scopus)
254 Downloads (Pure)

Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing

Li, A. & Blow, J. J., 2004, In : Cell Cycle. 3, 4, p. 441-443 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

New Apex in Proteome Analysis

Ly, T. & Lamond, A. I., 28 Jun 2017, In : Cell Systems. 4, 6, p. 581-582 2 p.

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159 Downloads (Pure)

New histone supply regulates replication fork speed and PCNA unloading

Mejlvang, J., Feng, Y., Alabert, C., Neelsen, K. J., Jasencakova, Z., Zhao, X., Lees, M., Sandelin, A., Pasero, P., Lopes, M. & Groth, A., 6 Jan 2014, In : Journal of Cell Biology. 204, 1, p. 29-43 15 p.

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74 Citations (Scopus)
104 Downloads (Pure)

NF-kappa B controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

Mauro, C., Leow, S. C., Anso, E., Rocha, S., Thotakura, A. K., Tornatore, L., Moretti, M., De Smaele, E., Beg, A. A., Tergaonkar, V., Chandel, N. S. & Franzoso, G., Oct 2011, In : Nature Cell Biology. 13, 10, p. 1272-U234 18 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

NF-kappa B is a critical regulator of the survival of rodent and human hepatic myofibroblasts

Watson, M. R., Wallace, K., Gieling, R. G., Manas, D. M., Jaffray, E., Hay, R. T., Mann, D. A. & Oakley, F., Apr 2008, In : Journal of Hepatology. 48, 4, p. 589-597 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

NF-κB and HIF crosstalk in immune responses

D'Ignazio, L., Bandarra, D. & Rocha, S., Feb 2016, In : FEBS Journal. 283, 3, p. 413-424 12 p.

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85 Citations (Scopus)
136 Downloads (Pure)

Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination

Li, A. & Blow, J. J., Mar 2004, In : Nature Cell Biology. 6, 3, p. 260-267 8 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

NOPdb: Nucleolar proteome database

Leung, A. K. L., Trinkle-Mulcahy, L., Lam, Y. W., Andersen, J. S., Mann, M. & Lamond, A. I., 1 Jan 2006, In : Nucleic Acids Research. 34, Database Suppl. 1, p. D218-D220 3 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

NOPdb: Nucleolar proteome database - 2008 Update

Ahmad, Y., Boisvert, F-M., Gregor, P., Cobley, A. & Lamond, A. I., Jan 2009, In : Nucleic Acids Research. 37, Suppl. 1, p. D181-D184 4 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Notch and Hedgehog in the thymus/parathyroid common primordium: crosstalk in organ formation

Figueiredo, M., Silva, J. C., Santos, A. S., Proa, V., Alcobia, I., Zilhão, R., Cidadão, A. & Neves, H., 15 Oct 2016, In : Developmental Biology. 418, 2, p. 268-282 5 p.

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8 Citations (Scopus)
142 Downloads (Pure)

Novel interactions of Saccharomyces cerevisiae type 1 protein phosphatase identified by single-step affinity purification and mass spectrometry

Walsh, E. P., Lamont, D. J., Beattie, K. A. & Stark, M. J. R., 2002, In : Biochemistry. 41, 7, p. 2409-2420 12 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Novel solid-phase synthesis of branched oligoribonucleotides, including a substrate for the RNA debranching enzyme

Sproat, B. S., Beijer, B., Grøtli, M., Ryder, U., Morand, K. L. & Lamond, A. I., 1 Dec 1994, In : Journal of the Chemical Society, Perkin Transactions 1. 4, p. 419-431 13 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Novel substrates and functions for the ubiquitin-like molecule NEDD8

Xirodimas, D. P., Oct 2008, In : Biochemical Society Transactions. 36, 5, p. 802-806 5 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Nuclear and cytoplasmic WDR-23 isoforms mediate differential effects on GEN-1 and SKN-1 substrates

Spatola, B. N., Lo, J. Y., Wang, B. & Curran, S. P., 13 Aug 2019, In : Scientific Reports. 9, 1, p. 1-11 11 p., 11783.

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Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. & Hammarton, T. C., 14 May 2010, In : Journal of Biological Chemistry. 285, 20, p. 15356-15368 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells

Bridge, E., Carmo-Fonseca, M., Lamond, A. & Pettersson, U., 1 Oct 1993, In : Journal of Virology. 67, 10, p. 5792-5802 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Nuclear organization of splicing snRNPs during differentiation of murine erythroleukemia cells in vitro

Antoniou, M., Carmo-Fonseca, M., Ferreira, J. & Lamond, A. I., 1 Dec 1993, In : Journal of Cell Biology. 123, 5, p. 1055-1068 14 p.

Research output: Contribution to journalArticle

Open Access
45 Citations (Scopus)

Nuclear processes controlled by molecular machines

Fox, A. H. & Lamond, A. I., 23 May 2002, In : Genome Biology. 3, 6, p. 4016.1-4016.3 3 p., 4016.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nuclear RNA processing

Lamond, A. I., Jun 1991, In : Current Opinion in Cell Biology. 3, 3, p. 493-501 9 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Nuclear Speckles

Spector, D. L. & Lamond, A. I., Feb 2011, In : Cold spring harbor perspectives in biology. 3, 2, p. - 12 p., a000646.

Research output: Contribution to journalArticle

362 Citations (Scopus)

Nuclear structure and the control of DNA replication in the Xenopus embryo

Blow, J. J., Sheehan, M. A., Watson, J. V. & Laskey, R. A., 1989, In : Journal of Cell Science. Supplement. 12, p. 183-195 13 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Nuclease resistant ribozymes with high catalytic activity

Paolella, G., Sproat, B. S. & Lamond, A. I., 1 May 1992, In : EMBO Journal. 11, 5, p. 1913-1919 7 p.

Research output: Contribution to journalArticle

140 Citations (Scopus)

Nuclei act as independent and integrated units of replication in a Xenopus cell-free DNA replication system

Blow, J. J. & Watson, J. V., Jul 1987, In : EMBO Journal. 6, 7, p. 1997-2002 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Nucleolar proteome dynamics

Andersen, J. S., Lam, Y. W., Leung, A. K. L., Ong, S. E., Lyon, C. E., Lamond, A. I. & Mann, M., 6 Jan 2005, In : Nature. 433, 7021, p. 77-83 7 p.

Research output: Contribution to journalArticle

844 Citations (Scopus)
36 Citations (Scopus)

Nucleosomes can invade DNA territories occupied by their neighbors

Engeholm, M., de Jager, M., Flaus, A., Brenk, R., van Noort, J. & Owen-Hughes, T., Feb 2009, In : Nature Structural & Molecular Biology. 16, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

Numerically Enhanced Stimulated Emission Depletion Microscopy with Adaptive Optics for Deep-Tissue Super-Resolved Imaging

Zdańkowski, P., Trusiak, M., McGloin, D. & Swedlow, J. R., 28 Jan 2020, In : ACS Nano. 14, 1, p. 394-405 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Nup98 is a mobile nucleoporin with transcription-dependent dynamics

Griffis, E. R., Altan, N., Lippincott-Schwartz, J. & Powers, M. A., 2002, In : Molecular Biology of the Cell. 13, 4, p. 1282-97 16 p.

Research output: Contribution to journalArticle

186 Citations (Scopus)

Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes

Griffis, E. R., Xu, S. & Powers, M. A., 2003, In : Molecular Biology of the Cell. 14, 2, p. 600-10 11 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

O-GlcNAcase contributes to cognitive function in Drosophila

Muha, V., Fenckova, M., Ferenbach, A., Catinozzi, M., Eidhof, I., Storkebaum, E., Schenck, A. & van Aalten, D., 26 Jun 2020, In : Journal of Biological Chemistry. 295, 26, p. 8636-8646 12 p.

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O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry

Borodkin, V. S., Rafie, K., Selvan, N., Aristotelous, T., Navratilova, I., Ferenbach, A. T. & Van Aalten, D. M. F., 18 May 2018, In : ACS Chemical Biology. 13, 5, p. 1353-1360 8 p.

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2 Citations (Scopus)
137 Downloads (Pure)

Oligoasthenoteratozoospermia and Infertility in Mice Deficient for miR-34b/c and miR-449 Loci

Comazzetto, S., Di Giacomo, M., Rasmussen, K. D., Much, C., Azzi, C., Perlas, E., Morgan, M. & O'Carroll, D., 16 Oct 2014, In : PLoS Genetics. 10, 10

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62 Citations (Scopus)
105 Downloads (Pure)

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

Hjerpe, R., Aillet, F., Lopitz-Otsoa, F., Lang, V., Torres-Ramos, M., Farras, R., Hay, R. T. & Rodriguez, M. S., May 2010, In : International Journal of Biochemistry & Cell Biology. 42, 5, p. 725-735 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

OMERO: flexible, model-driven data management for experimental biology

Allan, C., Burel, J-M., Moore, J., Blackburn, C., Linkert, M., Loynton, S., MacDonald, D., Moore, W. J., Neves, C., Patterson, A., Porter, M., Tarkowska, A., Loranger, B., Avondo, J., Lagerstedt, I., Lianas, L., Leo, S., Hands, K., Hay, R. T., Patwardhan, A. & 4 others, Best, C., Kleywegt, G. J., Zanetti, G. & Swedlow, J. R., 1 Mar 2012, In : Nature Methods. 9, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)

OMX: a new platform for multimodal, multichannel wide-field imaging

Dobbie, I. M., King, E., Parton, R. M., Carlton, P. M., Sedat, J. W., Swedlow, J. R. & Davis, I., 1 Aug 2011, In : Cold Spring Harbor Protocols. 6, 8, p. 899-909 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells

Dunn, S., Lombardi, O., Lukoszek, R. & Cowling, V., Apr 2019, In : Open Biology. 9, 4, p. 1-15 15 p., 190052.

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1 Citation (Scopus)
101 Downloads (Pure)

On the connection between RNAi and heterochromatin at centromeres

Lejeune, E., Bayne, E. H. & Allshire, R. C., 1 Jan 2010, In : Cold Spring Harbor Symposia on Quantitative Biology. 75, p. 275-283 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

'Open minded' cells: how cells can change fate

Costa, S. & Shaw, P., Mar 2007, In : Trends in Cell Biology. 17, 3, p. 101-6 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach

Khoudoli, G. A., Porter, I. M., Blow, J. J. & Swedlow, J. R., 9 Sep 2004, In : Proteome Science. 2, 1, 6.

Research output: Contribution to journalArticle

36 Citations (Scopus)

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2

Xirodimas, D. P., Chisholm, J., Desterro, J. M. S., Lane, D. P., Hay, R. T. & Celis, J. (ed.), 2002, In : FEBS Letters. 528, 1-3, p. 207-211 5 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K., 2004, In : Journal of Biological Chemistry. 279, 48, p. 50157-50166 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

P300 transcriptional repression is mediated by SUMO modification

Girdwood, D., Bumpass, D., Vaughan, O. A., Thain, A., Anderson, L. A., Snowden, A. W., Garcia-Wilson, E., Perkins, N. D. & Hay, R. T., Apr 2003, In : Molecular Cell. 11, 4, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

362 Citations (Scopus)

p38 alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

Seifert, A. & Clarke, P. R., Nov 2009, In : Cellular Signalling. 21, 11, p. 1626-1633 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor

Rocha, S., Campbell, K. J. & Perkins, N. D., Jul 2003, In : Molecular Cell. 12, 1, p. 15-25 11 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

p53-dependent repression of polo-like kinase-1 (PLK1)

McKenzie, L., King, S., Marcar, L., Nicol, S., Dias, S., Schumm, K., Robertson, P., Bourdon, J-C., Perkins, N., Fuller-Pace, F. & Meek, D. W., 15 Oct 2010, In : Cell Cycle. 9, 20, p. 4200-4212 13 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)