Gene Regulation and Expression

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p53-Dependent subcellular proteome localization following DNA damage

Boisvert, F-M. & Lamond, A. I., Nov 2010, In : Proteomics. 10, 22, p. 4087-4097 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

p53 isoforms can regulate p53 transcriptional activity

Bourdon, J. C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K. & Lane, D. P., 15 Sep 2005, In : Genes & Development. 19, 18, p. 2122-2137 16 p.

Research output: Contribution to journalArticle

560 Citations (Scopus)

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1

Rocha, S., Martin, A. M., Meek, D. W. & Perkins, N. D., Jul 2003, In : Molecular and Cellular Biology. 23, 13, p. 4713-4727 15 p.

Research output: Contribution to journalArticle

181 Citations (Scopus)

P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA-dependent manner

Fox, A. H., Bond, C. S. & Lamond, A. I., 1 Nov 2005, In : Molecular Biology of the Cell. 16, 11, p. 5304-5315 12 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

Belotserkovskaya, R., Raga Gil, E., Lawrence, N., Butler, R., Clifford, G., Wilson, M. D. & Jackson, S. P., 10 Feb 2020, In : Nature Communications. 11, p. 1-11 11 p., 819.

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Paraspeckles

Fox, A. H. & Lamond, A. I., Jul 2010, In : Cold spring harbor perspectives in biology. 2, 7, p. - 14 p., a000687.

Research output: Contribution to journalArticle

147 Citations (Scopus)

Paraspeckles: a novel nuclear domain

Fox, A. H., Lam, Y. W., Leung, A. K. L., Lyon, C. E., Andersen, J., Mann, M. & Lamond, A. I., Jan 2002, In : Current Biology. 12, 1, p. 13-24 12 p.

Research output: Contribution to journalArticle

318 Citations (Scopus)

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

Kumar, A., Chaugule, V. K., Condos, T. E. C., Barber, K. R., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Shaw, G. S. & Walden, H., May 2017, In : Nature Structural & Molecular Biology. 24, 5, p. 475-483 9 p.

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39 Citations (Scopus)
265 Downloads (Pure)

PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

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12 Citations (Scopus)
153 Downloads (Pure)

PChopper: high throughput peptide prediction for MRM/SRM transition design

Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J., 15 Aug 2011, In : BMC Bioinformatics. 12, p. - 9 p., 338.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Glover, L., Marques, C., Suska, O. & Horn, D., Aug 2019, In : MBio. 10, 4, p. 1-17 17 p., e01252-19.

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5 Citations (Scopus)
74 Downloads (Pure)

Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors

Schor, I. E., Llères, D., Risso, G. J., Pawellek, A., Ule, J., Lamond, A. I. & Kornblihtt, A. R., 12 Nov 2012, In : PLoS ONE. 7, 11, 16 p., e48084.

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39 Citations (Scopus)
127 Downloads (Pure)

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

Moser, S. C., Bensaddek, D., Ortmann, B., Maure, J-F., Mudie, S., Blow, J. J., Lamond, A. I., Swedlow, J. R. & Rocha, S., 26 Aug 2013, In : Developmental Cell. 26, 4, p. 381-392 12 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
85 Citations (Scopus)

Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation

Fernandez-Alonso, R., Bustos, F., Budzyk, M., Kumar, P., Helbig, A. O., Hukelmann, J., Lamond, A. I., Lanner, F., Zhou, H., Petsalaki, E. & Findlay, G. M., 13 Mar 2020, In : Nature Communications. 11, 1, p. 1-13 13 p., 1357.

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1 Citation (Scopus)
20 Downloads (Pure)

Phosphorylated DegU Manipulates Cell Fate Differentiation in the Bacillus subtilis Biofilm

Marlow, V. L., Porter, M., Hobley, L., Kiley, T. B., Swedlow, J. R., Davidson, F. A. & Stanley-Wall, N. R., Jan 2014, In : Journal of Bacteriology. 196, 1, p. 16-27 10 p.

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22 Citations (Scopus)
139 Downloads (Pure)

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

Brummer, T., Larance, M., Herrera Abreu, M. T., Lyons, R. J., Timpson, P., Emmerich, C. H., Fleuren, E. D. G., Lehrbach, G. M., Schramek, D., Guilhaus, M., James, D. E. & Daly, R. J., 3 Sep 2008, In : EMBO Journal. 27, 17, p. 2305-2316 12 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Phosphorylation of Elp1 by Hrr25 is required for Elongator-dependent tRNA modification in yeast

Abdel-Fattah, W., Jablonowski, D., Di Santo, R., Thüring, K. L., Scheidt, V., Hammermeister, A., ten Have, S., Helm, M., Schaffrath, R. & Stark, M. J. R., 8 Jan 2015, In : PLoS Genetics. 11, 1, 16 p., e1004931.

Research output: Contribution to journalArticle

Open Access
24 Citations (Scopus)

Phosphorylation of histone H3 Thr-45 is linked to apoptosis

Hurd, P. J., Bannister, A. J., Halls, K., Dawson, M. A., Vermeulen, M., Olsen, J. V., Ismail, H., Somers, J., Mann, M., Owen-Hughes, T., Gout, I. & Kouzarides, T., 12 Jun 2009, In : Journal of Biological Chemistry. 284, 24, p. 16575-16583 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

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18 Citations (Scopus)
129 Downloads (Pure)

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae

Makrantoni, V., Corbishley, S., Rachidi, N., Morrice, N. A., Robinson, D. A. & Stark, M. J. R., 18 Feb 2014, In : PLoS ONE. 9, 2, 15 p., e89399.

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9 Citations (Scopus)
132 Downloads (Pure)

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

Sopko, R., Silva, E., Clayton, L., Gardano, L., Barrios-Rodiles, M., Wrana, J., Varelas, X., Arbouzova, N. I., Shaw, S., Saburi, S., Matakatsu, H., Blair, S. & McNeill, H., 14 Jul 2009, In : Current Biology. 19, 13, p. 1112-1117 6 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

Hutchins, J. R. A., Moore, W. J., Hood, F. E., Wilson, J. S. J., Andrews, P. D., Swedlow, J. R. & Clarke, P. R., Jun 2004, In : Current Biology. 14, 12, p. 1099-1104 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases

Mathur, S., Fletcher, A. J., Branigan, E., Hay, R. T. & Virdee, S., 16 Jan 2020, In : Cell Chemical Biology. 27, 1, p. 74-82.e6 16 p.

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Phylogeny and Function of the Invertebrate p53 Superfamily

Rutkowski, R., Hofmann, K. & Gartner, A., Jul 2010, In : Cold spring harbor perspectives in biology. 2, 7, p. - 13 p., a001131.

Research output: Contribution to journalArticle

60 Citations (Scopus)

PICH: A DNA Translocase Specially Adapted for Processing Anaphase Bridge DNA

Biebricher, A., Hirano, S., Enzlin, J. H., Wiechens, N., Streicher, W. W., Huttner, D., Wang, L. H. C., Nigg, E. A., Owen-Hughes, T., Liu, Y., Peterman, E., Wuite, G. J. L. & Hickson, I. D., 12 Sep 2013, In : Molecular Cell. 51, 5, p. 691-701 11 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

Zhou, X. Z., Kops, O., Werner, A., Lu, P-J., Shen, M., Stoller, G., Kullertz, G., Stark, M., Fischer, G. & Lu, K. P., 2000, In : Molecular Cell. 6, 4, p. 873-883 11 p.

Research output: Contribution to journalArticle

447 Citations (Scopus)

PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

Jonik-Nowak, B., Menneteau, T., Fesquet, D., Baldin, V., Bonne-Andrea, C., Méchali, F., Fabre, B., Boisguerin, P., de Rossi, S., Henriquet, C., Pugnière, M., Ducoux-Petit, M., Burlet-Schiltz, O., Lamond, A., Fort, P., Boulon, S., Bousquet, M-P. & Coux, O., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. E6477-E6486 10 p., 201722299.

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9 Citations (Scopus)
183 Downloads (Pure)

PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia

Mudie, S., Bandarra, D., Batie, M., Biddlestone, J., Moniz, S., Ortmann, B., Shmakova, A. & Rocha, S., 15 Dec 2014, In : Cell Cycle. 13, 24, p. 3878-3891 14 p.

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10 Citations (Scopus)
176 Downloads (Pure)

Plant SILAC: stable-isotope labelling with amino acids of Arabidopsis seedlings for quantitative proteomics

Lewandowska, D., ten Have, S., Hodge, K., Tillemans, V., Lamond, A. I. & Brown, J. W. S., 20 Aug 2013, In : PLoS ONE. 8, 8, e72207.

Research output: Contribution to journalArticle

23 Citations (Scopus)

PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation

Hands, K. J., Cuchet-Lourenco, D., Everett, R. D. & Hay, R. T., 15 Jan 2014, In : Journal of Cell Science. 127, 2, p. 365-375 11 p.

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25 Citations (Scopus)
235 Downloads (Pure)

PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53

Wimmer, P., Berscheminski, J., Blanchette, P., Groitl, P., Branton, P. E., Hay, R. T., Dobner, T. & Schreiner, S., 7 Jan 2016, In : Oncogene. 35, p. 69-82 14 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

PNAC: a protein nucleolar association classifier

Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J., 27 Jan 2011, In : BMC Genomics. 12, p. - 14 p., 74.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Poly(A)-specific ribonuclease regulates the processing of small-subunit rRNAs in human cells

Ishikawa, H., Yoshikawa, H., Izumikawa, K., Miura, Y., Taoka, M., Nobe, Y., Yamauchi, Y., Nakayama, H., Simpson, R. J., Isobe, T. & Takahashi, N., 7 Apr 2017, In : Nucleic Acids Research. 45, 6, p. 3437-3447 11 p.

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18 Citations (Scopus)
219 Downloads (Pure)

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

Ahel, D., Horejsi, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., Owen-Hughes, T. & Boulton, S. J., 4 Sep 2009, In : Science. 325, 5945, p. 1240-1243 4 p.

Research output: Contribution to journalArticle

345 Citations (Scopus)

Polypyrimidine Tract Binding Protein (hnRNP I) Is Possibly a Conserved Modulator of miRNA-Mediated Gene Regulation

Engels, B., Jannot, G., Remenyi, J., Simard, M. J. & Hutvagner, G., 9 Mar 2012, In : PLoS ONE. 7, 3, p. - 11 p., e33144.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Positioning Europe for the EPITRANSCRIPTOMICS challenge

Jantsch, M., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J-Y., Balatsos, N., Dinnyes, A., Baranov, P., Kelly, V. & 40 others, Lamm, A., Rechavi, G., Pelizzola, M., Liepins, J., Holodnuka Kholodnyuk, I., Zammit, V., Ayers, D., Drablos, F., Dahl, J. A., Bujnicki, J., Jeronimo, C., Almeida, R., Neagu, M., Costache, M., Bankovic, J., Banovic, B., Kyselovic, J., Valor, L. M., Selbert, S., Pir, P., Demircan, T., Cowling, V., Schäfer, M., Rossmanith, W., Lafontaine, D., David, A., Carre, C., Lyko, F., Schaffrath, R., Schwartz, S., Verdel, A., Klungland, A., Purta, E., Timotijevic, G., Cardona, F., Davalos, A., Ballana, E., O Carroll, D., Ule, J. & Fray, R., 3 Jun 2018, In : RNA Biology. 15, 6, p. 829-831 8 p.

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9 Citations (Scopus)
146 Downloads (Pure)

Potent and selective chemical probe of hypoxic signaling downstream of HIF-α hydroxylation via VHL inhibition

Frost, J., Galdeano, C., Soares, P., Gadd, M. S., Grzes, K. M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K. D., Cantrell, D. A., Rocha, S. & Ciulli, A., 4 Nov 2016, In : Nature Communications. 7, p. 1-12 12 p., 13312.

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54 Citations (Scopus)
141 Downloads (Pure)

ppGpp regulates the binding of two RNA polymerase molecules to the tyrT promoter

Travers, A. A., Lamond, A. I. & Mace, H. A. F., 25 Aug 1982, In : Nucleic Acids Research. 10, 16, p. 5043-5057 15 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

Nielsen, S. V., Stein, A., Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, L. J., Lindorff-Larsen, K. & Hartmann-Petersen, R., 19 Apr 2017, In : PLoS Genetics. 13, 4, 26 p., e1006739.

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27 Citations (Scopus)
189 Downloads (Pure)

Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning

Crozier, T. W. M., Tinti, M., Larance, M., Lamond, A. I. & Ferguson, M. A. J., 1 Dec 2017, In : Molecular & Cellular Proteomics. 16, 12, p. 2254-2267 14 p.

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6 Citations (Scopus)
167 Downloads (Pure)

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

Gillespie, P. J., Gambus, A. & Blow, J. J., Jun 2012, In : Methods. 57, 2, p. 203-13 11 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

Pao, K. C., Stanley, M., Han, C., Lai, Y. C., Murphy, P., Balk, K., Wood, N. T., Corti, O., Corvol, J. C., Muqit, M. M. K. & Virdee, S., May 2016, In : Nature Chemical Biology. 12, 5, p. 324-331 8 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling

Bowman, A., Ward, R., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., Jan 2010, In : Nucleic Acids Research. 38, 2, p. 695-707 13 p.

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31 Citations (Scopus)
140 Downloads (Pure)

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

Lamond, A. I., Sproat, B., Ryder, U. & Hamm, J., 28 Jul 1989, In : Cell. 58, 2, p. 383-390 8 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-B- and p53-regulated gene targets

McTavish, N., Copeland, L. A., Saville, M. K., Perkins, N. D. & Spruce, B. A., 2007, In : Cell Death & Differentiation. 14, 9, p. 1700-1710 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Prohibitin is required for transcriptional repression by the WT1-BASP1 complex

Toska, E., Shandilya, J., Goodfellow, S. J., Medler, K. F. & Roberts, S. G. E., 23 Oct 2014, In : Oncogene. 33, 43, p. 5100-5108 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Prostaglandin D2 synthase enzymes and PPARγ are co-expressed in mouse 3T3-L1 adipocytes and human tissues

Jowsey, I. R., Murdock, P. R., Moore, G. B. T., Murphy, G. J., Smith, S. A. & Hayes, J. D., 2003, In : Prostaglandins & Other Lipid Mediators. 70, 3-4, p. 267-84 18 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Protein A-calmodulin fusions: a novel approach for investigating calmodulin function in yeast

Stirling, D. A., Petrie, A., Pulford, D. J., Paterson, D. T. W. & Stark, M. J. R., 1992, In : Molecular Microbiology. 6, 6, p. 703-713 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

PROTEINCHALLENGE: Crowd sourcing in proteomics analysis and software development

Martin, S. F., Falkenberg, H., Dyrlund, T. F., Khoudoli, G. A., Mageean, C. J. & Linding, R., 2 Aug 2013, In : Journal of Proteomics. 88, p. 41-46 6 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)