Gene Regulation and Expression

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2'-O-alkyloligoribonucleotides: Synthesis and applications in studying rna splicing

Sproat, B. S., Iribarren, A., Beijer, B., Pieles, U. & Lamond, A. I., 1991, In : Nucleosides and Nucleotides. 10, 1-3, p. 25-36 12 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
7 Citations (Scopus)

2'-O-alkyloligoribonucleotides, synthesis and applications in molecular biology.

Sproat, B. S., Lamond, A. I., Garcia, R. G., Beijer, B., Pieles, U., Douglas, M., Bohmann, K., Carmo-Fonseco, M., Weston, S. & O'Loughlin, S., 1991, In : Nucleic acids symposium series. 24, p. 59-62 4 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

2'-O-alkyl oligoribonucleotides as antisense probes

Iribarren, A. M., Sproat, B. S., Neuner, P., Sulston, I., Ryder, U. & Lamond, A. I., 1 Oct 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 19, p. 7747-7751 5 p.

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100 Citations (Scopus)

2′-O-alkyl oligoribonucleotides as antisense probes

Iribarren, A. M., Sproat, B. S., Neuner, P., Sulston, I., Ryder, U. & Lamond, A. I., 1 Dec 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 19, p. 7752-7756 5 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

3D3/lyric: A novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus

Sutherland, H. G. E., Lam, Y. W., Briers, S., Lamond, A. I. & Bickmore, W. A., 10 Mar 2004, In : Experimental Cell Research. 294, 1, p. 94-105 12 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

6-hydroxydopamine (6-OHDA) Oxidative Stress Assay for Observing Dopaminergic Neuron Loss in Caenorhabditis elegans

Offenburger, S-L. & Gartner, A., 20 Sep 2018, In : Bio-Protocol. 8, 18, 12 p., e3025.

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6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

Offenburger, S-L., Ho, X. Y., Tachie-Menson, T., Coakley, S., Hilliard, M. A. & Gartner, A., 18 Jan 2018, In : PLoS Genetics. 14, 1, p. 1-27 27 p., e1007125.

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4 Citations (Scopus)
195 Downloads (Pure)

ABC50 promotes translation initiation in mammalian cells

Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G., 4 Sep 2009, In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

ABF1-binding sites promote efficient global genome nucleotide excision repair

Yu, S., Smirnova, J. B., Friedberg, E. C., Stillman, B., Akiyama, M., Owen-Hughes, T., Waters, R. & Reed, S. H., 9 Jan 2009, In : Journal of Biological Chemistry. 284, 2, p. 966-973 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Absolute SILAC-compatible expression strain allows SUMO-2 copy number determination in clinical samples

Matic, I., Jaffray, E. G., Oxenham, S. K., Groves, M. J., Barratt, C. L. R., Tauro, S., Stanley-Wall, N. R. & Hay, R. T., Oct 2011, In : Journal of Proteome Research. 10, 10, p. 4869-4875 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A call for public archives for biological image data

Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.

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8 Citations (Scopus)
115 Downloads (Pure)

Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

Reverón-Gómez, N., González-Aguilera, C., Stewart-Morgan, K. R., Petryk, N., Flury, V., Graziano, S., Johansen, J. V., Jakobsen, J. S., Alabert, C. & Groth, A., 18 Oct 2018, In : Molecular Cell. 72, 2, p. 239-249.e5

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29 Citations (Scopus)
117 Downloads (Pure)

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

Blow, J. J. & Nurse, P., 7 Sep 1990, In : Cell. 62, 5, p. 855-862 8 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)

A cell cycle regulatory network controlling NF-B subunit activity and function

Barre, B. & Perkins, N., 2007, In : The EMBO Journal. 26, 23, p. 4841-4855 15 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

Hutvagner, G., McLachlan, J., Pasquinelli, A. E., Balint, E., Tuschl, T. & Zamore, P. D., 2001, In : Science. 293, 5531, p. 834-838 5 p.

Research output: Contribution to journalArticle

1951 Citations (Scopus)

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

Di Cerbo, V., Mohn, F., Ryan, D. P., Montellier, E., Kacem, S., Tropberger, P., Kallis, E., Holzner, M., Hoerner, L., Feldmann, A., Richter, F. M., Bannister, A. J., Mittler, G., Michaelis, J., Khochbin, S., Feil, R., Schuebeler, D., Owen-Hughes, T., Daujat, S. & Schneider, R., 25 Mar 2014, In : eLife. 3, e01632.

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57 Citations (Scopus)
343 Downloads (Pure)

A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones

Allan, J., Fraser, R. M., Owen-Hughes, T., Docherty, K. & Singh, V., 15 Nov 2013, In : Journal of Molecular Biology. 425, 22, p. 4206-4222 17 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex

Di Santo, R., Bandau, S. & Stark, M. J. R., Jun 2014, In : Molecular Microbiology. 92, 6, p. 1227-1242 16 p.

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15 Citations (Scopus)
158 Downloads (Pure)

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

Gartner, A., Milstein, S., Ahmed, S., Hodgkin, J. & Hengartner, M. O., 2000, In : Molecular Cell. 5, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

368 Citations (Scopus)

Active repression of antiapoptotic gene expression by RelA(p65) NF-kB

Campbell, K. J., Rocha, S. & Perkins, N. D., Mar 2004, In : Molecular Cell. 13, 6, p. 853-865 13 p.

Research output: Contribution to journalArticle

331 Citations (Scopus)

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

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35 Citations (Scopus)
305 Downloads (Pure)

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., Leslie, S. J., Pickford, R., Hoy, A. J., Kraegen, E. W., James, D. E. & Cooney, G. J., 6 Jan 2010, In : Cell Metabolism. 11, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

Adenomatous polyposis coli and hypoxia-inducible factor-1 alpha have an antagonistic connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Nathke, I. & Rocha, S., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3630-3638 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing

Ajuh, P., Sleeman, J., Chusainow, J. & Lamond, A. I., 2001, In : Journal of Biological Chemistry. 276, 45, p. 42370-42381 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Advancing cell biology through proteomics in space and time (PROSPECTS)

Lamond, A. I., Uhlen, M., Horning, S., Makarov, A., Robinson, C. V., Serrano, L., Hartl, F. U., Baumeister, W., Werenskiold, A. K., Andersen, J. S., Vorm, O., Linial, M., Aebersold, R. & Mann, M., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

50 Citations (Scopus)

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation

Booth, A. J. R., Blanchard, G. B., Adams, R. J. & Röper, K., 9 Jun 2014, In : Developmental Cell. 29, 5, p. 562-576 15 p.

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39 Citations (Scopus)
159 Downloads (Pure)

A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis

Makrantoni, V., Ciesiolka, A., Lawless, C., Fernius, J., Marston, A. L., Lydall, D. & Stark, M. J. R., 7 Sep 2017, In : G3 : Genes, Genomes, Genetics. 7, 9, p. 3203-3215 13 p.

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2 Citations (Scopus)
140 Downloads (Pure)

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

Maculins, T., Carter, N., Dorval, T., Hudson, K., Nissink, J. W. M., Hay, R. T. & Alwan, H., 8 Jan 2016, In : Scientific Reports. 6, 18940.

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12 Citations (Scopus)
127 Downloads (Pure)

A glimpse into the spliceosome

Lamond, A. I., Jan 1993, In : Current Biology. 3, 1, p. 62-64 3 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A herpes simplex virus type 1 immediate-early gene product, IE63, regulates small nuclear ribonucleoprotein distribution

Phelan, A., Carmo-Fonseca, M., Mclauchlan, J., Lamond, A. I. & Clements, J. B., 1 Oct 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 9056-9060 5 p.

Research output: Contribution to journalArticle

120 Citations (Scopus)

A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

Zhang, R., Calixto, C. P. G., Marquez, Y., Venhuizen, P., Tzioutziou, N. A., Guo, W., Spensley, M., Entizne, J. C., Lewandowska, D., ten Have, S., Frei dit Frey, N., Hirt, H., James, A. B., Nimmo, H. G., Barta, A., Kalyna, M. & Brown, J. W. S., 19 May 2017, In : Nucleic Acids Research. 45, 9, p. 5061-5073 13 p.

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61 Citations (Scopus)
187 Downloads (Pure)

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A. & Labib, K., 7 Oct 2009, In : EMBO Journal. 28, 19, p. 2992-3004 13 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11

Piscitello, D., Varshney, D., Lilla, S., Vizioli, M. G., Reid, C., Gorbunova, V., Seluanov, A., Gillespie, D. A. & Adams, P. D., 25 Jan 2018, In : Oncogene. 37, 4, p. 427-438 12 p.

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14 Citations (Scopus)
163 Downloads (Pure)

ALADIN is Required for the Production of Fertile Mouse Oocytes

Carvalhal, S., Stevense, M., Koehler, K., Naumann, R., Huebner, A., Jessberger, R. & Griffis, E. R., 17 Sep 2017, In : Molecular Biology of the Cell. 28, 19, p. 2470-2478 9 p.

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6 Citations (Scopus)
135 Downloads (Pure)

ALDH2 mediates 5-nitrofuran activity in multiple species

Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K. L., Temperley, N. D., Johnson, S. L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E. M., Melton, D. W., Smith, T. K., Tyers, M., Westwood, N. J. & Patton, E. E., 27 Jul 2012, In : Chemistry & Biology. 19, 7, p. 883-892 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Alfalfa heat shock genes are differentially expressed during somatic embryogenesis

Györgyey, J., Gartner, A., Németh, K., Magyar, Z., Hirt, H., Heberle-Bors, E. & Dudits, D., 1 Jun 1991, In : Plant Molecular Biology. 16, 6, p. 999-1007 9 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)
91 Citations (Scopus)

Alteration of the growth-rate-dependent regulation of Escherichia coli tyrT expression by promoter mutations

Travers, A. A., Lamond, A. I. & Weeks, J. R., 5 May 1986, In : Journal of Molecular Biology. 189, 1, p. 251-255 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

A method for genetically installing site-specific acetylation in recombinant histories defines the effects of H3 K56 acetylation

Neumann, H., Hancock, S. M., Buning, R., Routh, A., Chapman, L., Somers, J., Owen-Hughes, T., van Noort, J., Rhodes, D. & Chin, J. W., 9 Oct 2009, In : Molecular Cell. 36, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

307 Citations (Scopus)

A microRNA in a multiple-turnover RNAi enzyme complex

Hutvagner, G. & Zamore, P. D., 2002, In : Science. 297, 5589, p. 2056-2060 5 p.

Research output: Contribution to journalArticle

1499 Citations (Scopus)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

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35 Citations (Scopus)
138 Downloads (Pure)

A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In : FEBS Letters.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A model for DNA replication showing how dormant origins safeguard against replication fork failure

Blow, J. J. & Ge, X. Q., Apr 2009, In : EMBO Reports. 10, 4, p. 406-412 7 p.

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64 Citations (Scopus)

A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1

Narayan, V., Halada, P., Hernychová, L., Chong, Y. P., Žáková, J., Hupp, T. R., Vojtesek, B. & Ball, K. L., 22 Apr 2011, In : Journal of Biological Chemistry. 286, 16, p. 14291-14303 13 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

A mutant O-GlcNAcase enriches Drosophila developmental regulators

Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In : Nature Chemical Biology. 13, 8, p. 882-887 8 p.

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17 Citations (Scopus)
156 Downloads (Pure)

A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation.

Lamond, A. I., Konarska, M. M. & Sharp, P. A., Aug 1987, In : Genes & Development. 1, 6, p. 532-543 12 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Analysis of Global RNA Synthesis at the Single Cell Level following Hypoxia

Biddlestone, J., Druker, J., Shmakova, A., Ferguson, G., Swedlow, J. R. & Rocha, S., 13 May 2014, In : JoVE: Journal of Visualized Experiments. 87, 7 p., e51420.

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2 Citations (Scopus)
148 Downloads (Pure)

Analysis of human protein replacement stable cell lines established using snoMEN-PR vector

Ono, M., Yamada, K., Endo, A., Avolio, F. & Lamond, A. I., 25 Apr 2013, In : PLoS ONE. 8, 4, 12 p., e62305.

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6 Citations (Scopus)
106 Downloads (Pure)

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)