Gene Regulation and Expression

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Identification of novel inhibitors of UDP-Glc 4 '-epimerase, a validated drug target for African sleeping sickness

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J., 15 Nov 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Identification of nucleolar associated chromatin loci reveals clues for nuclear architecture

van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 2009, In : Cellular Oncology. 31, 2, p. 105-106 2 p., O16.

Research output: Contribution to journalArticle

Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1

Ajuh, P. & Lamond, A. I., 1 Nov 2003, In : Nucleic Acids Research. 31, 21, p. 6104-6116 13 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Identification of RhoGAP22 as an Akt-dependent regulator of cell motility in response to insulin

Rowland, A. F., Larance, M., Hughes, W. E. & James, D. E., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4789-4800 12 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Identification of RNF168 as a PML nuclear body regulator

Shire, K., Wong, A. I., Tatham, M. H., Anderson, O. F., Ripsman, D., Gulstene, S., Moffat, J., Hay, R. T. & Frappier, L., 1 Feb 2016, In : Journal of Cell Science. 129, 3, p. 580-591 12 p.

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9 Citations (Scopus)
157 Downloads (Pure)

Identification of small molecule inhibitors of pre-mRNA splicing

Pawellek, A., McElroy, S., Samatov, T., Mitchell, L., Woodland, A., Ryder, U., Gray, D., Lührmann, R. & Lamond, A. I., 12 Dec 2014, In : Journal of Biological Chemistry. 289, 50, p. 34683-34698 16 p.

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38 Citations (Scopus)
254 Downloads (Pure)

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

Trinkle-Mulcahy, L., Boulon, S., Lam, Y. W., Urcia, R., Boisvert, F-M., Vandermoere, F., Morrice, N. A., Swift, S., Rothbauer, U., Leonhardt, H. & Lamond, A., 20 Oct 2008, In : Journal of Cell Biology. 183, 2, p. 223-239 17 p.

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322 Citations (Scopus)
332 Downloads (Pure)

IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function

Kenneth, N. S., Mudie, S. & Rocha, S., 1 Sep 2010, In : EMBO Journal. 29, 17, p. 2966-2978 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae

van Zyl, W., Huang, W., Sneddon, A. A., Stark, M., Camier, S., Werner, M., Marck, C., Sentenac, A. & Broach, J. R., Nov 1992, In : Molecular and Cellular Biology. 12, 11, p. 4946-4959 14 p.

Research output: Contribution to journalArticle

141 Citations (Scopus)

Inevitability and containment of replication errors for eukaryotic genome lengths spanning Megabase to Gigabase

Al Mamun, M., Albergante, L., Moreno, A., Carrington, J. T., Blow, J. & Newman, T. J., 27 Sep 2016, In : Proceedings of the National Academy of Sciences. 113, 39, p. E5765-E5774 10 p.

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13 Citations (Scopus)
449 Downloads (Pure)

Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling

Sturrock, M., Terry, A. J., Xirodimas, D. P., Thompson, A. M. & Chaplain, M. A. J., Jul 2012, In : Bulletin of Mathematical Biology. 74, 7, p. 1531-1579 49 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Influenza virus NS1 protein alters the subnuclear localization of cellular splicing components

Fortes, P., Lamond, A. I. & Ortin, J., 1 Apr 1995, In : Journal of General Virology. 76, 4, p. 1001-1007 7 p.

Research output: Contribution to journalArticle

46 Citations (Scopus)

Informatics and quantitative analysis in biological imaging

Swedlow, J. R., Goldberg, I., Brauner, E. & Sorger, P. K., Apr 2003, In : Science. 300, 5616, p. 100-102 3 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Inhibition of autophagy in mitotic animal cells

Eskelinen, E-L., Prescott, A. R., Cooper, J., Brachmann, S. M., Wang, L., Tang, X., Backer, J. M. & Lucocq, J. M., 2002, In : Traffic. 3, 12, p. 878-893 16 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

Inhibition of Pre-mRNA Splicing by a Synthetic Blom7α-Interacting Small RNA

Löscher, M., Schosserer, M., Dausse, E., Lee, K., Ajuh, P. M., Grillari-Voglauer, R., Lamond, A. I., Toulmé, J. J. & Grillari, J., 29 Oct 2012, In : PLoS ONE. 7, 10, 9 p., e47497.

Research output: Contribution to journalArticle

Open Access

Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus

Lyon, C. E., Bohmann, K., Sleeman, J. & Lamond, A. I., 10 Jan 1997, In : Experimental Cell Research. 230, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Inhibitors against Fungal Cell Wall Remodeling Enzymes

Delso, I., Valero-Gonzalez, J., Gomollón-Bel, F., Castro-López, J., Fang, W., Navratilova, I., van Aalten, D. M. F., Tejero, T., Merino, P. & Hurtado-Guerrero, R., 22 Jan 2018, In : ChemMedChem. 13, 2, p. 128-132 5 p.

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1 Citation (Scopus)
153 Downloads (Pure)

Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs

Blow, J. J. & Laskey, R. A., 21 Nov 1986, In : Cell. 47, 4, p. 577-587 11 p.

Research output: Contribution to journalArticle

431 Citations (Scopus)

Innovation in biological microscopy: current status and future directions

Swedlow, J. R., 1 Jan 2012, In : BioEssays.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Inositol trisphosphate metabolism in Saccharomyces cerevisiae - identification, purification and properties of Inositol 1,4,5-trisphosphae 6-kinase

ESTEVEZ, F., PULFORD, D., STARK, M. J. R., CARTER, A. N. & Downes, C. P., 15 Sep 1994, In : Biochemical Journal. 302, p. 709-716 8 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Insights into Diphthamide, key Diphtheria Toxin effector

Abdel-Fattah, W., Scheidt, V., Uthman, S., Stark, M. J. R. & Schaffrath, R., 3 May 2013, In : Toxins. 5, 5, p. 958-968 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D., Jan 2007, In : Nature Reviews Molecular Cell Biology. 8, 1, p. 49-62 14 p.

Research output: Contribution to journalArticle

1676 Citations (Scopus)

Interaction of the human autoantigen p150 with splicing snRNPs

Blencowe, B. J., Carmo-Fonseca, M., Behrens, S. E., Luhrmann, R. & Lamond, A. I., 1 Jul 1993, In : Journal of Cell Science. 105, 3, p. 685-697 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Interaction of U-box E3 ligase SNEV with PSMB4, the β7 subunit of the 20 S proteasome

Löscher, M., Fortschegger, K., Ritter, G., Wostry, M., Voglauer, R., Schmid, J. A., Watters, S., Rivett, A. J., Ajuh, P. M., Lamond, A. I., Katinger, H. & Grillari, J., 1 Jun 2005, In : Biochemical Journal. 388, 2, p. 593-603 11 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex

Romanowski, P., Marr, J., Madine, M. A., Rowles, A., Blow, J. J., Gautier, J. & Laskey, R. A., 2000, In : Journal of Biological Chemistry. 275, 6, p. 4239-4243 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Interaction with calmodulin is required for the function of Spc110p, an essential component of the yeast spindle pole body

Stirling, D. A., Welch, K. A. & Stark, M. J. R., 1994, In : EMBO Journal. 13, 18, p. 4329-4342 14 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Inter-replicon transposition of Tn1/3 occurs in two sequential genetically separable steps

Kitts, P. A., Lamond, A. & Sherratt, D. J., 18 Feb 1982, In : Nature. 295, 5850, p. 626-628 3 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain

Möller, A., Pion, E., Narayan, V. & Ball, K. L., 3 Dec 2010, In : Journal of Biological Chemistry. 285, 49, p. 38348-38361 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
52 Citations (Scopus)

Intricate macrophage-colorectal cancer cell communication in response to radiation

Pinto, A. T., Pinto, M. L., Velho, S., Pinto, M. T., Cardoso, A. P., Figueira, R., Monteiro, A., Marques, M., Seruca, R., Barbosa, M. A., Mareel, M., Oliveira, M. J. & Rocha, S., 11 Aug 2016, In : PLoS ONE. 11, 8, p. 1-20 20 p., e0160891.

Research output: Contribution to journalArticle

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11 Citations (Scopus)
166 Downloads (Pure)
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77 Downloads (Pure)

In vivo analysis of Cajal body movement, separation, and joining in live human cells

Platani, M., Goldberg, I., Swedlow, J. R. & Lamond, A. I., 31 Dec 2000, In : Journal of Cell Biology. 151, 7, p. 1561-1574 14 p.

Research output: Contribution to journalArticle

Open Access
195 Citations (Scopus)
Open Access
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43 Citations (Scopus)
686 Downloads (Pure)

In vivo detection of snRNP-rich organelles in the nuclei of mammalian cells

Carmo-Fonseca, M., Pepperkok, R., Sproat, B. S., Ansorge, W., Swanson, M. S. & Lamond, A. I., 5 Jul 1991, In : EMBO Journal. 10, 7, p. 1863-1873 11 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy

Matic, I., van Hagen, M., Schimmel, J., Macek, B., Ogg, S. C., Tatham, M. H., Hay, R. T., Lamond, A. I., Mann, M. & Vertegaal, A. C. O., 1 Jan 2008, In : Molecular & Cellular Proteomics. 7, 1, p. 132-144 13 p.

Research output: Contribution to journalArticle

198 Citations (Scopus)

In vivo imaging of mammalian cells: cell engineering and viability

Swedlow, J. R., Andrews, P. D. & Platani, M., 1 Jan 2009, In : Cold Spring Harbor Protocols. 4, 9

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vivo imaging of mammalian cells: image acquisition and analysis

Swedlow, J. R., Andrews, P. D. & Platani, M., 1 Jan 2009, In : Cold Spring Harbor Protocols. 4, 9

Research output: Contribution to journalArticle

2 Citations (Scopus)

In vivo labelling of intermediates in the discontinuous synthesis of mRNAs in Trypanosoma brucei

Laird, P. W., Zomerdijk, J. C. B. M., de Korte, D. & Borst, P., 1987, In : EMBO Journal. 6, 4, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana

Raczynska, K. D., Simpson, C. G., Ciesiolka, A., Szewc, L., Lewandowska, D., McNicol, J., Szweykowska-Kulinska, Z., Brown, J. W. S. & Jarmolowski, A., 2010, In : Nucleic Acids Research. 38, 1, p. 265-278 14 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Ionizing radiation modulates human macrophages towards a pro-inflammatory phenotype preserving their pro-invasive and pro-angiogenic capacities

Teresa Pinto, A., Laranjeiro Pinto, M., Patrícia Cardoso, A., Monteiro, C., Teixeira Pinto, M., Filipe Maia, A., Castro, P., Figueira, R., Monteiro, A., Marques, M., Mareel, M., Dos Santos, S. G., Seruca, R., Adolfo Barbosa, M., Rocha, S. & JoséOliveira, M., 6 Jan 2016, In : Scientific Reports. 6, 18765.

Research output: Contribution to journalArticle

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51 Citations (Scopus)
142 Downloads (Pure)

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores

Keating, P., Rachidi, N., Tanaka, T. U. & Stark, M. J. R., 1 Dec 2009, In : Journal of Cell Science. 122, 23, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores

King, E., Rachidi, N., Morrice, N., Hardwick, K. G. & Stark, M. J. R., 2007, In : Genes & Development. 21, 10, p. 1163-1168 6 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21

de Wever, V., Lloyd, D. C., Nasa, I., Nimick, M., Trinkle-Mulcahy, L., Gourlay, R., Morrice, N. & Moorhead, G. B. G., 2012, In : PLoS ONE. 7, 6, e39510.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Iso-seco-tanapartholides: isolation, synthesis and biological evaluation

Makiyi, E. F., Frade, R. F. M., Lebl, T., Jaffray, E. G., Cobb, S. E., Harvey, A. L., Slawin, A. M. Z., Hay, R. T. & Westwood, N. J., Nov 2009, In : European Journal of Organic Chemistry. 33, p. 5711-5715 5 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

KDM2 family members are regulated by HIF-1 in hypoxia.

Batie, M., Druker, J., D'Ignazio, L. & Rocha, S., 17 Mar 2017, In : Cells. 6, 1, p. 1-16 16 p., 8.

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Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system

Ostrowski, A., Cianfanelli, F. R., Porter, M., Mariano, G., Peltier, J., Wong, J. J., Swedlow, J. R., Trost, M. & Coulthurst, S. J., 27 Jul 2018, In : PLoS Pathogens. 14, 7, p. 1-25 25 p., e1007230.

Research output: Contribution to journalArticle

Open Access
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8 Citations (Scopus)
141 Downloads (Pure)

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases

Jaqaman, K., King, E. M., Amaro, A. C., Winter, J. R., Dorn, J. F., Elliott, H. L., Mchedlishvili, N., McClelland, S. E., Porter, I. M., Posch, M., Toso, A., Danuser, G., McAinsh, A. D., Meraldi, P. & Swedlow, J. R., 8 Mar 2010, In : Journal of Cell Biology. 188, 5, p. 665-679 15 p.

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91 Citations (Scopus)
214 Downloads (Pure)

Kinetochore capture and bi-orientation on the mitotic spindle

Tanaka, T. U., Stark, M. J. R. & Tanaka, K., 2005, In : Nature Reviews Molecular Cell Biology. 6, 12, p. 929-42 14 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)

Kinetochore-Dependent Microtubule Rescue Ensures Their Efficient and Sustained Interactions in Early Mitosis

Gandhi, S. R., Gierlinski, M., Mino, A., Tanaka, K., Kitamura, E., Clayton, L. & Tanaka, T. U., 15 Nov 2011, In : Developmental Cell. 21, 5, p. 920-933 14 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)