Gene Regulation and Expression

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Kinetochore-microtubule error correction is driven by differentially regulated interaction modes

Kalantzaki, M., Kitamura, E., Zhang, T., Mino, A., Novák, B. & Tanaka, T. U., Apr 2015, In : Nature Cell Biology. 17, 4, p. 421-433 13 p.

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31 Citations (Scopus)
276 Downloads (Pure)

Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae

Kitamura, E., Tanaka, K., Kitamura, Y. & Tanaka, T. U., 15 Dec 2007, In : Genes & Development. 21, 24, p. 3319-3330 12 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I

Rabitsch, K. P., Petronczki, M., Javerzat, J-P., Genier, S., Chwalla, B., Schleiffer, A., Tanaka, T. U. & Nasmyth, K., 2003, In : Developmental Cell. 4, 4, p. 535-48 14 p.

Research output: Contribution to journalArticle

156 Citations (Scopus)

Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment

Natsume, T., Müller, C. A., Katou, Y., Retkute, R., Gierlinski, M., Araki, H., Blow, J. J., Shirahige, K., Nieduszynski, C. A. & Tanaka, T. U., 6 Jun 2013, In : Molecular Cell. 50, 5, p. 661-674 14 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Kinetochores Generate Microtubules with Distal Plus Ends: Their Roles and Limited Lifetime in Mitosis

Kitamura, E., Tanaka, K., Komoto, S., Kitamura, Y., Antony, C. & Tanaka, T. U., 16 Feb 2010, In : Developmental Cell. 18, 2, p. 248-259 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Kluyveromyces lactis killer system: ORF1 of pGKL2 has no function in immunity expression and is dispensable for killer plasmid replication and maintenance

Schaffrath, R., Stark, M. J. R., Gunge, N. & Meinhardt, F., Apr 1992, In : Current Genetics. 21, 4-5, p. 357-363 7 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Kluyveromyces lactis toxin does not inhibit yeast adenylyl cyclase

White, J. H., Butler, A. R. & Stark, M. J. R., 19 Oct 1989, In : Nature. 341, 6243, p. 666-668 3 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Kluyveromyces lactis toxin has an essential chitinase activity

BUTLER, A. R., O'DONNELL, R. W., MARTIN, V. J., GOODAY, G. W. & STARK, M. J. R., 15 Jul 1991, In : European Journal of Biochemistry. 199, 2, p. 483-488 6 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator

Jablonowski, D., Frohloff, F., Fichtner, L., Stark, M. J. R. & Schaffrath, R., Nov 2001, In : Molecular Microbiology. 42, 4, p. 1095-105 11 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

Kti12, a PSTK-like tRNA dependent ATPase essential for tRNA modification by Elongator

Krutyhołowa, R., Hammermeister, A., Zabel, R., Abdel-Fattah, W., Reinhardt-Tews, A., Helm, M., Stark, M. J. R., Breunig, K. D., Schaffrath, R. & Glatt, S., 21 May 2019, In : Nucleic Acids Research. 47, 9, p. 4814-4830 17 p.

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1 Citation (Scopus)
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LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis

Liu, B., Du, H., Rutkowski, R., Gartner, A. & Wang, X., 2012, In : Science. 337, 6092, p. 351-354 4 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

Large-scale isolation of Cajal bodies from HeLa cells

Lam, Y. W., Lyon, C. E. & Lamond, A. I., Jul 2002, In : Molecular Biology of the Cell. 13, 7, p. 2461-2473 13 p.

Research output: Contribution to journalArticle

Open Access
65 Citations (Scopus)

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

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9 Citations (Scopus)
187 Downloads (Pure)

Length-dependent anisotropic scaling of spindle shape

Young, S., Besson, S. & Welburn, J. P. I., 15 Dec 2014, In : Open Biology. 3, 12, p. 1217-1223 7 p.

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13 Citations (Scopus)
121 Downloads (Pure)

LigaSure compared with ligatures and endoclips in experimental appendectomy: How safe is it?

Elemen, L., Tugay, M., Akay, A., Yazir, Y., Ceylan, S., Aydin, S. & Yanar, K., 2010, In : Pediatric Surgery International. 26, 5, p. 539-545 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

LimsPortal and BonsaiLIMS: development of a lab information management system for translational medicine

Bath, T. G., Bozdag, S., Afzal, V. & Crowther, D., 15 Sep 2011, In : Source code for biology and medicine. 6, p. 9

Research output: Contribution to journalArticle

6 Citations (Scopus)

Live-cell analysis of kinetochore-microtubule interaction in budding yeast

Tanaka, K., Kitamura, E. & Tanaka, T. U., 2010, In : Methods (San Diego, Calif.). 51, 2, p. 206-13 8 p.

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21 Citations (Scopus)

Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

Eykelenboom, J. K., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T. U., 17 May 2018, In : BioRxiv. 53 p.

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Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories

Kitamura, E., Blow, J. J. & Tanaka, T. U., 2006, In : Cell. 125, 7, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Live-cell imaging RNAi screen identifies PP2A-B55 alpha and importin-beta 1 as key mitotic exit regulators in human cells

Schmitz, M. H. A., Held, M., Janssens, V., Hutchins, J. R. A., Hudecz, O., Ivanova, E., Goris, J., Trinkle-Mulcahy, L., Lamond, A. I., Poser, I., Hyman, A. A., Mechtler, K., Peters, J-M. & Gerlich, D. W., Sep 2010, In : Nature Cell Biology. 12, 9, p. 886-893 8 p.

Research output: Contribution to journalArticle

217 Citations (Scopus)

Live imaging of marked chromosome regions reveals their dynamic resolution and compaction in mitosis

Eykelenboom, J., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T., 6 May 2019, In : Journal of Cell Biology. 218, 5, p. 1531-1552 22 p.

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6 Citations (Scopus)
115 Downloads (Pure)

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Localisation of splicing snRNPs in mammalian cells

Lamond, A. I. & Carmo-Fonseca, M., 1 Aug 1993, In : Molecular Biology Reports. 18, 2, p. 127-133 7 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

Locus-specific proteomics by TChP: targeted chromatin purification

Pourfarzad, F., Aghajanirefah, A., de Boer, E., Ten Have, S., Bryn van Dijk, T., Kheradmandkia, S., Stadhouders, R., Thongjuea, S., Soler, E., Gillemans, N., von Lindern, M., Demmers, J., Philipsen, S. & Grosveld, F., 15 Aug 2013, In : Cell Reports. 4, 3, p. 589-600 12 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Long distance PELDOR measurements on the histone core particle

Ward, R., Bowman, A., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., 4 Feb 2009, In : Journal of the American Chemical Society. 131, 4, p. 1348-+ 3 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Muha, V., Williamson, R., Hills, R., McNeilly, A., McWilliams, T. G., Alonso, J., Schimpl, M., Leney, A. C., Heck, A. J. R., Sutherland, C., Read, K., McCrimmon, R., Brooks, S. P. & van Aalten, D., 27 Nov 2019, In : Open Biology. 9, 11, p. 1-15 15 p.

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1 Citation (Scopus)
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Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J. & Helin, K., 1 May 2015, In : Genes and Development. 29, 9, p. 910-922 13 p.

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114 Citations (Scopus)
76 Downloads (Pure)

Loss of ubiquitin E2 Ube2w rescues hypersensitivity of Rnf4 mutant cells to DNA damage

Maure, J. F., Moser, S. C., Jaffray, E. G., Alpi, A. F. & Hay, R. T., 17 May 2016, In : Scientific Reports. 6, 10 p., 26178.

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3 Citations (Scopus)
144 Downloads (Pure)

LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA

Izumikawa, K., Ishikawa, H., Yoshikawa, H., Fujiyama, S., Watanabe, A., Aburatani, H., Tachikawa, H., Hayano, T., Miura, Y., Isobe, T., Simpson, R. J., Li, L., Min, J. & Takahashi, N., 4 Nov 2019, In : Nucleic Acids Research. 47, 19, p. 10357-10372 16 p.

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MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF

Chang, E. Y., Ferreira, H., Somers, J., Nusinow, D. A., Owen-Hughes, T. & Narlikar, G. J., 23 Dec 2008, In : Biochemistry. 47, 51, p. 13726-13732 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Maintenance of distinct melanocyte populations in the interfollicular epidermis

Glover, J. D., Knolle, S., Wells, K. L., Liu, D., Jackson, I. J., Mort, R. L. & Headon, D. J., 1 Jul 2015, In : Pigment Cell and Melanoma Research. 28, 4, p. 476-480 5 p.

Research output: Contribution to journalArticle

Open Access
16 Citations (Scopus)

Making sense of transcribing chromatin

Owen-Hughes, T. & Gkikopoulos, T., 1 Jan 2012, In : Current Opinion in Cell Biology.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Mammalian nuclei become licensed for DNA replication during late telophase

Dimitrova, D. S., Prokhorova, T. A., Blow, J. J., Todorov, I. T. & Gilbert, D. M., 2002, In : Journal of Cell Science. 115, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery

Carmo-Fonseca, M., Tollervey, D., Pepperkok, R., Barabino, S. M. L., Merdes, A., Brunner, C., Zamore, P. D., Green, M. R., Hurt, E. & Lamond, A. I., 1 Jan 1991, In : EMBO Journal. 10, 1, p. 195-206 12 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

Mannosyl-diinositolphospho-ceramide, the major yeast plasma membrane sphingolipid, governs toxicity of Kluyveromyces lactis zymocin

Zink, S., Mehlgarten, C., Kitamoto, H. K., Nagase, J., Jablonowski, D., Dickson, R. C., Stark, M. J. R. & Schaffrath, R., May 2005, In : Eukaryotic Cell. 4, 5, p. 879-89 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Mapping U2 snRNP-pre-mRNA interactions using biotinylated oligonucleotides made of 2'-OMe RNA

Barabino, S. M. L., Sproat, B. S., Ryder, U., Blencowe, B. J. & Lamond, A. I., 1 Dec 1989, In : EMBO Journal. 8, 13, p. 4171-4178 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins

Zachariae, W., Shevchenko, A., Andrews, P. D., Ciosk, R., Galova, M., Stark, M. J. R., Mann, M. & Nasmyth, K., 1998, In : Science. 279, 5354, p. 1216-1219 4 p.

Research output: Contribution to journalArticle

285 Citations (Scopus)

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

Neubauer, G., King, A., Rappsilber, J., Calvio, C., Watson, M., Ajuh, P., Sleeman, J., Lamond, A. & Mann, M., Sep 1998, In : Nature Genetics. 20, 1, p. 46-50 5 p.

Research output: Contribution to journalArticle

402 Citations (Scopus)

Mass spectrometry-based immuno-precipitation proteomics - The user's guide

ten Have, S., Boulon, S., Ahmad, Y. & Lamond, A. I., Mar 2011, In : Proteomics. 11, 6, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)
16 Citations (Scopus)

Mating-type locus control of killer toxins from Kluyveromyces lactis and Pichia acaciae

Klassen, R., Jablonowski, D., Stark, M. J. R., Schaffrath, R. & Meinhardt, F., May 2006, In : FEMS Yeast Research. 6, 3, p. 404-13 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

MCM2-7 Form Double Hexamers at Licensed Origins in Xenopus Egg Extract

Gambus, A., Khoudoli, G. A., Jones, R. C. & Blow, J. J., 1 Apr 2011, In : Journal of Biological Chemistry. 286, 13, p. 11855-11864 10 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation

Gambus, A. & Blow, J. J., 15 Apr 2013, In : Cell Cycle. 12, 8, p. 1225-1232 8 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

Xirodimas, D. P., Saville, M. K., Bourdon, J. C., Hay, R. T. & Lane, D. P., 9 Jul 2004, In : Cell. 118, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

370 Citations (Scopus)

Measuring tubulin content in Toxoplasma gondii: A comparison of laser-scanning confocal and wide-field fluorescence microscopy

Swedlow, J. R., Hu, K., Andrews, P. D., Roos, D. S. & Murray, J. M., 19 Feb 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 4, p. 2014-2019 6 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes

Russell, D., Andrews, P. D., James, J. & Lane, E. B., Oct 2004, In : Journal of Cell Science. 117, 22, p. 5233-5243 11 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta

Almohammed, R., Osborn, K., Ramasubramanyan, S., Perez-Fernandez, I. B. N., Godfrey, A., Mancini, E. J. & Sinclair, A. J., 1 Jun 2018, In : Journal of General Virology. 99, 6, p. 805-817 13 p., 001056.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
141 Downloads (Pure)

Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: Insights from accelerated molecular dynamics simulations

Bueren-Calabuig, J., Bage, M., Cowling, V. & Pisliakov, A., 19 Sep 2019, In : Nucleic Acids Research. 47, 16, p. 8675-8692 18 p., gkz613.

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Mechanism of Hypoxia-Induced NF-kappa B

Culver, C., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D. & Rocha, S., 10 Oct 2010, In : Molecular and Cellular Biology. 30, 20, p. 4901-4921 21 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Mechanism of hypoxia-induced NFκB

Melvin, A., Mudie, S. & Rocha, S., 2011, In : Cell Cycle. 10, 6, p. 879-882 4 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)