Gene Regulation and Expression

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2010

Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3

Larance, M., Rowland, A. F., Hoehn, K. L., Humphreys, D. T., Preiss, T., Guilhaus, M. & James, D. E., Apr 2010, In : Molecular & Cellular Proteomics. 9, 4, p. 682-694 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

Research output: Contribution to journalArticle

164 Citations (Scopus)

High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties

Golebiowski, F., Tatham, M. H., Nakamura, A. & Hay, R. T., 2010, In : Nature Protocols. 5, 5, p. 873-882 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

Boulon, S., Pradet-Balade, B., Verheggen, C., Molle, D., Boireau, S., Georgieva, M., Azzag, K., Robert, M-C., Ahmad, Y., Neel, H., Lamond, A. I. & Bertrand, E., 24 Sep 2010, In : Molecular Cell. 39, 6, p. 912-924 13 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)

HSP90 protein stabilizes unloaded Argonaute complexes and microscopic P-bodies in human cells

Johnston, M., Geoffroy, M-C., Sobala, A., Hay, R. & Hutvagner, G., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1462-1469 8 p.

Research output: Contribution to journalArticle

107 Citations (Scopus)

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J., 9 Jul 2010, In : Cell. 142, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function

Kenneth, N. S., Mudie, S. & Rocha, S., 1 Sep 2010, In : EMBO Journal. 29, 17, p. 2966-2978 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain

Möller, A., Pion, E., Narayan, V. & Ball, K. L., 3 Dec 2010, In : Journal of Biological Chemistry. 285, 49, p. 38348-38361 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Involvement of the nuclear cap-binding protein complex in alternative splicing in Arabidopsis thaliana

Raczynska, K. D., Simpson, C. G., Ciesiolka, A., Szewc, L., Lewandowska, D., McNicol, J., Szweykowska-Kulinska, Z., Brown, J. W. S. & Jarmolowski, A., 2010, In : Nucleic Acids Research. 38, 1, p. 265-278 14 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases

Jaqaman, K., King, E. M., Amaro, A. C., Winter, J. R., Dorn, J. F., Elliott, H. L., Mchedlishvili, N., McClelland, S. E., Porter, I. M., Posch, M., Toso, A., Danuser, G., McAinsh, A. D., Meraldi, P. & Swedlow, J. R., 8 Mar 2010, In : Journal of Cell Biology. 188, 5, p. 665-679 15 p.

Research output: Contribution to journalArticle

Open Access
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87 Citations (Scopus)
200 Downloads (Pure)

Kinetochores Generate Microtubules with Distal Plus Ends: Their Roles and Limited Lifetime in Mitosis

Kitamura, E., Tanaka, K., Komoto, S., Kitamura, Y., Antony, C. & Tanaka, T. U., 16 Feb 2010, In : Developmental Cell. 18, 2, p. 248-259 12 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

LigaSure compared with ligatures and endoclips in experimental appendectomy: How safe is it?

Elemen, L., Tugay, M., Akay, A., Yazir, Y., Ceylan, S., Aydin, S. & Yanar, K., 2010, In : Pediatric Surgery International. 26, 5, p. 539-545 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Live-cell analysis of kinetochore-microtubule interaction in budding yeast

Tanaka, K., Kitamura, E. & Tanaka, T. U., 2010, In : Methods (San Diego, Calif.). 51, 2, p. 206-13 8 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Live-cell imaging RNAi screen identifies PP2A-B55 alpha and importin-beta 1 as key mitotic exit regulators in human cells

Schmitz, M. H. A., Held, M., Janssens, V., Hutchins, J. R. A., Hudecz, O., Ivanova, E., Goris, J., Trinkle-Mulcahy, L., Lamond, A. I., Poser, I., Hyman, A. A., Mechtler, K., Peters, J-M. & Gerlich, D. W., Sep 2010, In : Nature Cell Biology. 12, 9, p. 886-893 8 p.

Research output: Contribution to journalArticle

215 Citations (Scopus)

Mechanism of Hypoxia-Induced NF-kappa B

Culver, C., Sundqvist, A., Mudie, S., Melvin, A., Xirodimas, D. & Rocha, S., 10 Oct 2010, In : Molecular and Cellular Biology. 30, 20, p. 4901-4921 21 p.

Research output: Contribution to journalArticle

127 Citations (Scopus)

Methylation of H3K4 is required for inheritance of active transcriptional states

Muramoto, T., Mueller, I., Thomas, G., Melvin, A. & Chubb, J. R., 9 Mar 2010, In : Current Biology. 20, 5, p. 397-406 10 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Microtubule assembly by the Apc protein is regulated by importin-beta-RanGTP

Dikovskaya, D., Li, Z., Newton, I. P., Davidson, I., Hutchins, J. R. A., Kalab, P., Clarke, P. R. & Nathke, I. S., 1 Mar 2010, In : Journal of Cell Science. 123, 5, p. 736-746 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Modelling contact spread of infection in host-parasitoid systems: Vertical transmission of pathogens can cause chaos

Preedy, K. F., Schofield, P. G., Liu, S., Matzavinos, A., Chaplain, M. A. J. & Hubbard, S. F., 7 Feb 2010, In : Journal of Theoretical Biology. 262, 3, p. 441-451 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects

Hain, D., Bettencourt, B. R., Okamura, K., Csorba, T., Meyer, W., Jin, Z., Biggerstaff, J., Siomi, H., Hutvagner, G., Lai, E. C., Welte, M. & Muller, H. -A. J., 16 Dec 2010, In : PLoS ONE. 5, 12, p. - 14 p., e15264.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Nuclear DBF-2-related Kinases Are Essential Regulators of Cytokinesis in Bloodstream Stage Trypanosoma brucei

Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. & Hammarton, T. C., 14 May 2010, In : Journal of Biological Chemistry. 285, 20, p. 15356-15368 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Oligomerization conditions Mdm2-mediated efficient p53 polyubiquitylation but not its proteasomal degradation

Hjerpe, R., Aillet, F., Lopitz-Otsoa, F., Lang, V., Torres-Ramos, M., Farras, R., Hay, R. T. & Rodriguez, M. S., May 2010, In : International Journal of Biochemistry & Cell Biology. 42, 5, p. 725-735 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

On the connection between RNAi and heterochromatin at centromeres

Lejeune, E., Bayne, E. H. & Allshire, R. C., 1 Jan 2010, In : Cold Spring Harbor Symposia on Quantitative Biology. 75, p. 275-283 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

p53-dependent repression of polo-like kinase-1 (PLK1)

McKenzie, L., King, S., Marcar, L., Nicol, S., Dias, S., Schumm, K., Robertson, P., Bourdon, J-C., Perkins, N., Fuller-Pace, F. & Meek, D. W., 15 Oct 2010, In : Cell Cycle. 9, 20, p. 4200-4212 13 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

p53-Dependent subcellular proteome localization following DNA damage

Boisvert, F-M. & Lamond, A. I., Nov 2010, In : Proteomics. 10, 22, p. 4087-4097 11 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Paraspeckles

Fox, A. H. & Lamond, A. I., Jul 2010, In : Cold spring harbor perspectives in biology. 2, 7, p. - 14 p., a000687.

Research output: Contribution to journalArticle

144 Citations (Scopus)

Phylogeny and Function of the Invertebrate p53 Superfamily

Rutkowski, R., Hofmann, K. & Gartner, A., Jul 2010, In : Cold spring harbor perspectives in biology. 2, 7, p. - 13 p., a001131.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Probing the (H3-H4)(2) histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling

Bowman, A., Ward, R., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., Jan 2010, In : Nucleic Acids Research. 38, 2, p. 695-707 13 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
135 Downloads (Pure)

Proteomics Analysis of the Nucleolus in Adenovirus-infected Cells

Lam, Y. W., Evans, V. C., Heesom, K. J., Lamond, A. I. & Matthews, D. A., 2010, In : Molecular & Cellular Proteomics. 9, 1, p. 117-130 14 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Regulation of miRNA transcription in macrophages in response to Candida albicans

Monk, C. E., Hutvagner, G. & Arthur, J. S. C., 27 Oct 2010, In : PLoS ONE. 5, 10, p. - 12 p., e13669.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins

Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. & Arthur, J. S. C., 1 Jun 2010, In : Biochemical Journal. 428, 2, p. 281-291 11 p.

Research output: Contribution to journalArticle

152 Citations (Scopus)

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels

Thomson, A. M., Gillespie, P. J. & Blow, J. J., 25 Jan 2010, In : Journal of Cell Biology. 188, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

Open Access
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45 Citations (Scopus)
257 Downloads (Pure)

RRP1B Targets PP1 to Mammalian Cell Nucleoli and Is Associated with Pre-60S Ribosomal Subunits

Chamousset, D., De Wever, V., Moorhead, G. B., Chen, Y., Boisvert, F-M., Lamond, A. I. & Trinkle-Mulcahy, L., 1 Dec 2010, In : Molecular Biology of the Cell. 21, 23, p. 4212-4226 15 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis

Posch, M., Khoudoli, G. A., Swift, S., King, E. M., DeLuca, J. G. & Swedlow, J. R., 4 Oct 2010, In : Journal of Cell Biology. 191, 1, p. 61-74 14 p.

Research output: Contribution to journalArticle

Open Access
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86 Citations (Scopus)
275 Downloads (Pure)

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

Li, X., Vadrevu, S., Dunlop, A., Day, J., Advant, N., Troeger, J., Klussmann, E., Jaffray, E., Hay, R. T., Adams, D. R., Houslay, M. D. & Baillie, G. S., 15 May 2010, In : Biochemical Journal. 428, p. 55-65 11 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif

Matic, I., Schimmel, J., Hendriks, I. . A., van Santen, M. A., van de Rijke, F., van Dam, H., Gnad, F., Mann, M. & Vertegaal, A. C. O., 27 Aug 2010, In : Molecular Cell. 39, 4, p. 641-652 12 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)

Spatial regulation and organization of DNA replication within the nucleus

Natsume, T. & Tanaka, T. U., Jan 2010, In : Chromosome Research. 18, 1, p. 7-17 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity

Bayne, E. H., White, S. A., Kagansky, A., Bijos, D. A., Sanchez-Pulido, L., Hoe, K-L., Kim, D-U., Park, H-O., Ponting, C. P., Rappsilber, J. & Allshire, R. C., 5 Mar 2010, In : Cell. 140, 5, p. 666-677 12 p.

Research output: Contribution to journalArticle

131 Citations (Scopus)

SUMOylation of the GTPase Rac1 is required for optimal cell migration

Castillo-Lluva, S., Tatham, M. H., Jones, R. C., Jaffray, E. G., Edmondson, R. D., Hay, R. T. & Malliri, A., Nov 2010, In : Nature Cell Biology. 12, 11, p. 1078-U70 21 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

The Caenorhabditis elegans Homolog of Gen1/Yen1 Resolvases Links DNA Damage Signaling to DNA Double-Strand Break Repair

Bailly, A. P., Freeman, A., Hall, J., Declais, A-C., Alpi, A., Lilley, D. M. J., Ahmed, S. & Gartner, A., Jul 2010, In : PLoS Genetics. 6, 7, p. - 16 p., e1001025.

Research output: Contribution to journalArticle

62 Citations (Scopus)

The Caenorhabditis elegans Werner Syndrome Protein functions upstream of ATR and ATM in response to DNA Replication Inhibition and Double-Strand DNA Breaks

Lee, S-J., Gartner, A., Hyun, M., Ahn, B. & Koo, H-S., Jan 2010, In : PLoS Genetics. 6, 1, p. - 11 p., e1000801.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The "Mutated in Colorectal Cancer" Protein Is a Novel Target of the UV-Induced DNA Damage Checkpoint

Pangon, L., Sigglekow, N. D., Larance, M., Al-Sohaily, S., Mladenova, D. N., Selinger, C. I., Musgrove, E. A. & Kohonen-Corish, M. R. J., Sep 2010, In : Genes and Cancer. 1, 9, p. 917-926 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition

Malekkou, A., Lederer, C. W., Lamond, A. I. & Santama, N., 19 Nov 2010, In : FEBS Letters. 584, 22, p. 4559-4564 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The serine/arginine-rich protein SF2/ASF regulates protein sumoylation

Pelisch, F., Gerez, J., Druker, J., Schor, I. E., Munoz, M. J., Risso, G., Petrillo, E., Westman, B. J., Lamond, A. I., Arzt, E. & Srebrow, A., 14 Sep 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 37, p. 16119-16124 6 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

The Snf2 Homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme

Awad, S., Ryan, D., Prochasson, P., Owen-Hughes, T. & Hassan, A. H., 26 Mar 2010, In : Journal of Biological Chemistry. 285, 13, p. 9477-9484 8 p.

Research output: Contribution to journalArticle

Open Access
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43 Citations (Scopus)
148 Downloads (Pure)
2009

ABC50 promotes translation initiation in mammalian cells

Paytubi, S., Wang, X., Lam, Y. W., Izquierdo, L., Hunter, M. J., Jan, E., Hundal, H. S. & Proud, C. G., 4 Sep 2009, In : Journal of Biological Chemistry. 284, 36, p. 24061-24073 13 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

ABF1-binding sites promote efficient global genome nucleotide excision repair

Yu, S., Smirnova, J. B., Friedberg, E. C., Stillman, B., Akiyama, M., Owen-Hughes, T., Waters, R. & Reed, S. H., 9 Jan 2009, In : Journal of Biological Chemistry. 284, 2, p. 966-973 8 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome

Gambus, A., van Deursen, F., Polychronopoulos, D., Foltman, M., Jones, R. C., Edmondson, R. D., Calzada, A. & Labib, K., 7 Oct 2009, In : EMBO Journal. 28, 19, p. 2992-3004 13 p.

Research output: Contribution to journalArticle

171 Citations (Scopus)

A method for genetically installing site-specific acetylation in recombinant histories defines the effects of H3 K56 acetylation

Neumann, H., Hancock, S. M., Buning, R., Routh, A., Chapman, L., Somers, J., Owen-Hughes, T., van Noort, J., Rhodes, D. & Chin, J. W., 9 Oct 2009, In : Molecular Cell. 36, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

307 Citations (Scopus)

A model for DNA replication showing how dormant origins safeguard against replication fork failure

Blow, J. J. & Ge, X. Q., Apr 2009, In : EMBO Reports. 10, 4, p. 406-412 7 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Analysis of small RNA in fission yeast; centromeric siRNAs are potentially generated through a structured RNA

Djupedal, I., Kos-Braun, I. C., Mosher, R. A., Soderholm, N., Simmer, F., Hardcastle, T. J., Fender, A., Heidrich, N., Kagansky, A., Bayne, E., Wagner, E. G. H., Baulcombe, D. C., Allshire, R. C. & Ekwall, K., 16 Dec 2009, In : EMBO Journal. 28, 24, p. 3832-3844 13 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)