Gene Regulation and Expression

  • United Kingdom

Research Output

Filter
Article
2009

Blom7 alpha Is a Novel Heterogeneous Nuclear Ribonucleoprotein K Homology Domain Protein Involved in Pre-mRNA Splicing That Interacts with SNEVPrp19-Pso4

Grillari, J., Löscher, M., Denegri, M., Lee, K., Fortschegger, K., Eisenhaber, F., Ajuh, P., Lamond, A. I., Katinger, H. & Grillari-Voglauer, R., 16 Oct 2009, In : Journal of Biological Chemistry. 284, 42, p. 29193-29204 12 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Building a scientific data grid with DIGS

Beckett, M. G., Allton, C. R., Davies, C. T. H., Davis, I., Flynn, J. M., Grant, E. J., Hamilton, R. S., Irving, A. C., Kenway, R. D., Ostrowski, R. H., Perry, J. T., Swedlow, J. R. & Trew, A., 28 Jun 2009, In : Philosophical Transactions of the Royal Society A - Mathematical Physical and Engineering Sciences. 367, 1897, p. 2471-2481 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cell fate decisions are specified by the dynamic ERK interactome

von Kriegsheim, A., Baiocchi, D., Birtwistle, M., Sumpton, D., Bienvenut, W., Morrice, N., Yamada, K., Lamond, A., Kalna, G., Orton, R., Gilbert, D. & Kolch, W., Dec 2009, In : Nature Cell Biology. 11, 12, p. 1458-1464 7 p.

Research output: Contribution to journalArticle

191 Citations (Scopus)

Characterization of SENP7, a SUMO-2/3-specific isopeptidase

Shen, L. N., Geoffroy, M-C., Jaffray, E. G. & Hay, R. T., 15 Jul 2009, In : Biochemical Journal. 421, p. 223-230 8 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery

Narayan, V., Eckert, M., Zylicz, A., Zylicz, M. & Ball, K. L., 18 Sep 2009, In : Journal of Biological Chemistry. 284, 38, p. 25889-25899 11 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Detection of protein SUMOylation in vivo

Tatham, M. H., Rodriguez, M. S., Xirodimas, D. P. & Hay, R. T., 2009, In : Nature Protocols. 4, 9, p. 1363-1371 9 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Distinct subsets of Sit4 holophosphatases are required for inhibition of saccharomyces cerevisiae growth by rapamycin and zymocin

Jablonowski, D., Taeubert, J-E., Baer, C., Stark, M. J. R. & Schaffrath, R., Nov 2009, In : Eukaryotic Cell. 8, 11, p. 1637-1647 11 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Dynamic localisation of Ran GTPase during the cell cycle

Hutchins, J. R. A., Moore, W. J. & Clarke, P. R., 18 Sep 2009, In : BMC Cell Biology. 10, p. - 10 p., 66.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells

Vale, R. D., Spudich, J. A. & Griffis, E. R., 7 Sep 2009, In : Journal of Cell Biology. 186, 5, p. 727-738 12 p.

Research output: Contribution to journalArticle

Open Access
File
47 Citations (Scopus)
196 Downloads (Pure)

Efficient chromosome biorientation and the tension checkpoint in saccharomyces cerevisiae both require Bir1

Makrantoni, V. & Stark, M. J. R., 15 Aug 2009, In : Molecular and Cellular Biology. 29, 16, p. 4552-4562 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Elongator function depends on antagonistic regulation by casein kinase Hrr25 and protein phosphatase Sit4

Mehlgarten, C., Jablonowski, D., Breunig, K. D., Stark, M. J. R. & Schaffrath, R., Sep 2009, In : Molecular Microbiology. 73, 5, p. 869-881 13 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

FACT facilitates chromatin transcription by RNA polymerases I and III

Birch, J. L., Tan, B. C-M., Panov, K. I., Panova, T. B., Andersen, J. S., Owen-Hughes, T. A., Russell, J., Lee, S-C. & Zomerdijk, J. C. B. M., 8 Apr 2009, In : EMBO Journal. 28, 7, p. 854-865 12 p.

Research output: Contribution to journalArticle

65 Citations (Scopus)

Filtering of deep sequencing data reveals the existence of abundant Dicer-dependent small RNAs derived from tRNAs

Cole, C., Sobala, A., Lu, C., Thatcher, S. R., Bowman, A., Brown, J. W. S., Green, P. J., Barton, G. J. & Hutvagner, G., Dec 2009, In : RNA: a Publication of the RNA Society. 15, 12, p. 2147-2160 14 p.

Research output: Contribution to journalArticle

333 Citations (Scopus)

Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

Moser, S. C., von Elsner, S., Buessing, I., Alpi, A., Schnabel, R. & Gartner, A., Apr 2009, In : PLoS Genetics. 5, 4, p. - 15 p., e1000451.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

Colbert, J. D., Plechanovova, A. & Watts, C., Apr 2009, In : Traffic. 10, 4, p. 425-437 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Human miRNA Precursors with Box H/ACA snoRNA Features

Scott, M. S., Avolio, F., Ono, M., Lamond, A. I. & Barton, G. J., Sep 2009, In : PLoS Computational Biology. 5, 9, p. - 13 p., e1000507.

Research output: Contribution to journalArticle

134 Citations (Scopus)

Identification of nucleolar associated chromatin loci reveals clues for nuclear architecture

van Koningsbruggen, S., Martin, D. M. A., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 2009, In : Cellular Oncology. 31, 2, p. 105-106 2 p., O16.

Research output: Contribution to journalArticle

In vivo imaging of mammalian cells: cell engineering and viability

Swedlow, J. R., Andrews, P. D. & Platani, M., 1 Jan 2009, In : Cold Spring Harbor Protocols. 4, 9

Research output: Contribution to journalArticle

1 Citation (Scopus)

In vivo imaging of mammalian cells: image acquisition and analysis

Swedlow, J. R., Andrews, P. D. & Platani, M., 1 Jan 2009, In : Cold Spring Harbor Protocols. 4, 9

Research output: Contribution to journalArticle

2 Citations (Scopus)

Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores

Keating, P., Rachidi, N., Tanaka, T. U. & Stark, M. J. R., 1 Dec 2009, In : Journal of Cell Science. 122, 23, p. 4375-4382 8 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Iso-seco-tanapartholides: isolation, synthesis and biological evaluation

Makiyi, E. F., Frade, R. F. M., Lebl, T., Jaffray, E. G., Cobb, S. E., Harvey, A. L., Slawin, A. M. Z., Hay, R. T. & Westwood, N. J., Nov 2009, In : European Journal of Organic Chemistry. 33, p. 5711-5715 5 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Long distance PELDOR measurements on the histone core particle

Ward, R., Bowman, A., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., 4 Feb 2009, In : Journal of the American Chemical Society. 131, 4, p. 1348-+ 3 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Mutations of NFKBIA, encoding I kappa B alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases

Lake, A., Shield, L. A., Cordano, P., Chui, D. T. Y., Osborne, J., Crae, S., Wilson, K. S., Tosi, S., Knight, S. J. L., Gesk, S., Siebert, R., Hay, R. T. & Jarrett, R. F., 15 Sep 2009, In : International Journal of Cancer. 125, 6, p. 1334-1342 9 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions

Somers, J. & Owen-Hughes, T., May 2009, In : Nucleic Acids Research. 37, 8, p. 2504-2513 10 p.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
213 Downloads (Pure)

NOPdb: Nucleolar proteome database - 2008 Update

Ahmad, Y., Boisvert, F-M., Gregor, P., Cobley, A. & Lamond, A. I., Jan 2009, In : Nucleic Acids Research. 37, Suppl. 1, p. D181-D184 4 p.

Research output: Contribution to journalArticle

183 Citations (Scopus)

Nucleosomes can invade DNA territories occupied by their neighbors

Engeholm, M., de Jager, M., Flaus, A., Brenk, R., van Noort, J. & Owen-Hughes, T., Feb 2009, In : Nature Structural & Molecular Biology. 16, 2, p. 151-158 8 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)

p38 alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

Seifert, A. & Clarke, P. R., Nov 2009, In : Cellular Signalling. 21, 11, p. 1626-1633 8 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

Phosphorylation of histone H3 Thr-45 is linked to apoptosis

Hurd, P. J., Bannister, A. J., Halls, K., Dawson, M. A., Vermeulen, M., Olsen, J. V., Ismail, H., Somers, J., Mann, M., Owen-Hughes, T., Gout, I. & Kouzarides, T., 12 Jun 2009, In : Journal of Biological Chemistry. 284, 24, p. 16575-16583 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

Sopko, R., Silva, E., Clayton, L., Gardano, L., Barrios-Rodiles, M., Wrana, J., Varelas, X., Arbouzova, N. I., Shaw, S., Saburi, S., Matakatsu, H., Blair, S. & McNeill, H., 14 Jul 2009, In : Current Biology. 19, 13, p. 1112-1117 6 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

Ahel, D., Horejsi, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., Owen-Hughes, T. & Boulton, S. J., 4 Sep 2009, In : Science. 325, 5945, p. 1240-1243 4 p.

Research output: Contribution to journalArticle

340 Citations (Scopus)

Quantitative analysis of chromatin compaction in living cells using FLIM-FRET

Lleres, D., James, J., Swift, S., Norman, D. G. & Lamond, A. I., 16 Nov 2009, In : Journal of Cell Biology. 187, 4, p. 481-496 16 p.

Research output: Contribution to journalArticle

Open Access
File
98 Citations (Scopus)
288 Downloads (Pure)

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

De Marco, V., Gillespie, P. J., Li, A., Karantzelis, N., Christodoulou, E., Klompmaker, R., van Gerwen, S., Fish, A., Petoukhov, M. V., Iliou, M. S., Lygerou, Z., Medema, R. H., Blow, J. J., Svergun, D. I., Taraviras, S. & Perrakis, A., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19807-19812 6 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Role of the IRF-1 enhancer domain in signalling polyubiquitination and degradation

Pion, E., Narayan, V., Eckert, M. & Ball, K. L., Oct 2009, In : Cellular Signalling. 21, 10, p. 1479-1487 9 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Super-resolution video microscopy of live cells by structured illumination

Kner, P., Chhun, B. B., Griffis, E. R., Winoto, L. & Gustafsson, M. G. L., May 2009, In : Nature Methods. 6, 5, p. 339-342 4 p.

Research output: Contribution to journalArticle

449 Citations (Scopus)

SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter

Gkikopoulos, T., Havas, K. M., Dewar, H. & Owen-Hughes, T., Aug 2009, In : Molecular and Cellular Biology. 29, 15, p. 4057-4066 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

SWI/SNF regulates the cellular response to hypoxia

Kenneth, N. S., Mudie, S., van Uden, P. & Rocha, S., 13 Feb 2009, In : Journal of Biological Chemistry. 284, 7, p. 4123-4131 9 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

System-wide changes to SUMO modifications in response to heat shock

Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T., 26 May 2009, In : Science Signaling. 2, 72, 12 p., ra24.

Research output: Contribution to journalArticle

327 Citations (Scopus)

The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

Meier, B., Barber, L. J., Liu, Y., Shtessel, L., Boulton, S. J., Gartner, A. & Ahmed, S., 18 Nov 2009, In : EMBO Journal. 28, 22, p. 3549-3563 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The NM23 family in development

Bilitou, A., Watson, J., Gartner, A. & Ohnuma, S., Sep 2009, In : Molecular and Cellular Biochemistry. 329, 1-2, p. 17-33 17 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex

Platani, M., Santarella-Mellwig, R., Posch, M., Walczak, R., Swedlow, J. R. & Mattaj, I. W., 15 Dec 2009, In : Molecular Biology of the Cell. 20, 24, p. 5260-5275 16 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

The open microscopy environment: informatics and quantitative analysis for biological microscopy

Swedlow, J. R., Allan, C., Burel, J-M., Linkert, M., Loranger, B., MacDonald, D., Moore, W. J., Patterson, A. J., Rueden, C., Tarkowska, A., Goldberg, I. G. & Eliceiri, K. W., Jul 2009, In : Microscopy and Microanalysis. 15, p. 1520-1521 2 p.

Research output: Contribution to journalArticle

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

Yin, Y., Bangs, F., Paton, I. R., Prescott, A., James, J., Davey, M. G., Whitley, P., Genikhovich, G., Technau, U., Burt, D. W. & Tickle, C., 15 Feb 2009, In : Development. 136, 4, p. 655-664 10 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

TOPALi v2: a rich graphical interface for evolutionary analyses of multiple alignments on HPC clusters and multi-core desktops

Milne, I., Lindner, D., Bayer, M., Husmeier, D., McGuire, G., Marshall, D. F. & Wright, F., 2009, In : Bioinformatics. 25, 1, p. 126-127 2 p.

Research output: Contribution to journalArticle

446 Citations (Scopus)

Usability and user-centered design in scientific software development

Macaulay, C., Sloan, D., Jiang, X., Forbes, P., Loynton, S., Swedlow, J. R. & Gregor, P., 2009, In : IEEE Software. 26, 1, p. 96-102 7 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

What can we learn about quasars from αOX measurements in Galactic black hole binaries?

Sobolewska, M. A., Gierliński, M. & Siemiginowska, A., 11 Apr 2009, In : Monthly Notices of the Royal Astronomical Society. 394, 3, p. 1640-1648 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2008

Argonaute proteins: key players in RNA silencing

Hutvagner, G. & Simard, M. J., Jan 2008, In : Nature Reviews Molecular Cell Biology. 9, 1, p. 22-32 11 p.

Research output: Contribution to journalArticle

777 Citations (Scopus)

ATP-dependent looping of DNA by ISWI

Lia, G., Indrieri, M., Owen-Hughes, T., Finzi, L., Podesta, A., Milani, P. & Dunlap, D., Sep 2008, In : Journal of Biophotonics. 1, 4, p. 280-286 7 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3

Baer, C., Zabel, R., Liu, S., Stark, M. J. R. & Schaffrath, R., Sep 2008, In : Molecular Microbiology. 69, 5, p. 1221-1233 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis

Greiss, S., Hall, J., Ahmed, S. & Gartner, A., 15 Oct 2008, In : Genes & Development. 22, 20, p. 2831-2842 12 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

CaMKII-mediated phosphorylation of the myosin motor Myo1c is required for insulin-stimulated GLUT4 translocation in adipocytes

Yip, M. F., Ramm, G., Larance, M., Hoehn, K. L., Wagner, M. C., Guilhaus, M. & James, D. E., 5 Nov 2008, In : Cell Metabolism. 8, 5, p. 384-398 15 p.

Research output: Contribution to journalArticle

80 Citations (Scopus)