Gene Regulation and Expression

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2008

Cell cycle progression requires the CDC-48(UFD-1/NPL-4) complex for efficient DNA replication

Mouysset, J., Deichsel, A., Moser, S., Hoege, C., Hyman, A. A., Gartner, A. & Hoppe, T., 2 Sep 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 35, p. 12879-12884 6 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity

Agostinho, M., Santos, V., Ferreira, F., Costa, R., Cardoso, J., Pinheiro, I., Rino, J., Jaffray, E., Hay, R. T. & Ferreira, J., 1 Apr 2008, In : Cancer Research. 68, 7, p. 2409-2418 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Correction: Human topoisomerase 2 alpha conjugates with SUMO-2 (vol 68, pg 2409, 2008)

Agostinho, M., Santos, V., Ferreira, F., Costa, R., Cardoso, J., Pinheiro, I., Rino, J., Jaffray, E., Hay, R. T. & Ferreira, J., 15 Apr 2008, In : Cancer Research. 68, 8, p. 3076-3076 1 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Discovery, in vivo activity and mechanism of action of a small-molecule p53 activator

Lain, S., Hollick, J. J., Campbell, J., Staples, O. D., Higgins, M., Aoubala, M., McCarthy, A., Appleyard, V., Murray, K. E., Baker, L., Thompson, A., Mathers, J., Holland, S. J., Stark, M. J. R., Pass, G., Woods, J., Lane, D. P. & Westwood, N. J., 6 May 2008, In : Cancer Cell. 13, 5, p. 454-463 10 p.

Research output: Contribution to journalArticle

366 Citations (Scopus)

Displacement affinity chromatography of protein phosphatase one (PP1) complexes

Moorhead, G. B. G., Trinkle-Mulcahy, L., Nimick, M., De Wever, V., Campbell, D. G., Gourlay, R., Lam, Y. W. & Lamond, A. I., 1 Jan 2008, In : BMC Biochemistry. 9, 1

Research output: Contribution to journalArticle

49 Citations (Scopus)

Dual-specificity phosphatases in the hypo-osmotic stress response of keratin-defective epithelial cell lines

Liovic, M., Lee, B., Tomic-Canic, M., D'Alessandro, M., Bolshakov, V. N. & Lane, E. B., 2008, In : Experimental Cell Research. 314, 10, p. 2066-2075 10 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine

Seifert, A., Allan, L. A. & Clarke, P. R., Dec 2008, In : FEBS Journal. 275, 24, p. 6268-6280 13 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

Germline survival and apoptosis

Gartner, A., Boag, P. R. & Blackwell, T. K., 1 Jan 2008, In : WormBook. p. 1-20 20 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes

Trinkle-Mulcahy, L., Boulon, S., Lam, Y. W., Urcia, R., Boisvert, F-M., Vandermoere, F., Morrice, N. A., Swift, S., Rothbauer, U., Leonhardt, H. & Lamond, A., 20 Oct 2008, In : Journal of Cell Biology. 183, 2, p. 223-239 17 p.

Research output: Contribution to journalArticle

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321 Citations (Scopus)
323 Downloads (Pure)

In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy

Matic, I., van Hagen, M., Schimmel, J., Macek, B., Ogg, S. C., Tatham, M. H., Hay, R. T., Lamond, A. I., Mann, M. & Vertegaal, A. C. O., 1 Jan 2008, In : Molecular & Cellular Proteomics. 7, 1, p. 132-144 13 p.

Research output: Contribution to journalArticle

197 Citations (Scopus)

MacroH2A allows ATP-dependent chromatin remodeling by SWI/SNF and ACF complexes but specifically reduces recruitment of SWI/SNF

Chang, E. Y., Ferreira, H., Somers, J., Nusinow, D. A., Owen-Hughes, T. & Narlikar, G. J., 23 Dec 2008, In : Biochemistry. 47, 51, p. 13726-13732 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo

Miles, W. O., Jaffray, E., Campbell, S. G., Takeda, S., Bayston, L. J., Basu, S. P., Li, M., Raftery, L. A., Ashe, M. P., Hay, R. T. & Ashe, H. L., 15 Sep 2008, In : Genes & Development. 22, 18, p. 2578-2590 13 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)

Deutsch, E. W., Ball, C. A., Berman, J. J., Bova, G. S., Brazma, A., Bumgarner, R. E., Campbell, D., Causton, H. C., Christiansen, J. H., Daian, F., Dauga, D., Davidson, D. R., Gimenez, G., Goo, Y. A., Grimmond, S., Henrich, T., Herrmann, B. G., Johnson, M. H., Korb, M., Mills, J. C. & 20 others, Oudes, A. J., Parkinson, H. E., Pascal, L. E., Pollet, N., Quackenbush, J., Ramialison, M., Ringwald, M., Salgado, D., Sansone, S-A., Sherlock, G., Stoeckert, C. J., Swedlow, J., Taylor, R. C., Walashek, L., Warford, A., Wilkinson, D. G., Zhou, Y., Zon, L. I., Liu, A. Y. & True, L. D., Mar 2008, In : Nature Biotechnology. 26, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

NF-kappa B is a critical regulator of the survival of rodent and human hepatic myofibroblasts

Watson, M. R., Wallace, K., Gieling, R. G., Manas, D. M., Jaffray, E., Hay, R. T., Mann, D. A. & Oakley, F., Apr 2008, In : Journal of Hepatology. 48, 4, p. 589-597 9 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Novel substrates and functions for the ubiquitin-like molecule NEDD8

Xirodimas, D. P., Oct 2008, In : Biochemical Society Transactions. 36, 5, p. 802-806 5 p.

Research output: Contribution to journalArticle

121 Citations (Scopus)

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

Brummer, T., Larance, M., Herrera Abreu, M. T., Lyons, R. J., Timpson, P., Emmerich, C. H., Fleuren, E. D. G., Lehrbach, G. M., Schramek, D., Guilhaus, M., James, D. E. & Daly, R. J., 3 Sep 2008, In : EMBO Journal. 27, 17, p. 2305-2316 12 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

Goehler, T., Munoz, I. M., Rouse, J. & Blow, J. J., 2008, In : DNA Repair. 7, 5, p. 775-787 13 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway

Martin, S. F., Tatham, M. H., Hay, R. T. & Samuel, I. D. W., Apr 2008, In : Protein Science. 17, 4, p. 777-784 8 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts

Bru, T., Clarke, C., McGrew, M. J., Sang, H. M., Wilmut, I. & Blow, J. J., 15 Aug 2008, In : Experimental Cell Research. 314, 14, p. 2634-2642 9 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Regulation of cyclin D1 RNA stability by SNIP1

Bracken, C. P., Wall, S. J., Barré, B., Panov, K. I., Ajuh, P. M. & Perkins, N. D., 15 Sep 2008, In : Cancer Research. 68, 18, p. 7621-8 8 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Regulation of hypoxia-inducible factor-1 alpha by NF-kappa B

van Uden, P., Kenneth, N. S. & Rocha, S., 15 Jun 2008, In : Biochemical Journal. 412, 3, p. 477-484 8 p.

Research output: Contribution to journalArticle

406 Citations (Scopus)

Regulation of the RelA (p65) transactivation domain

O'Shea, J. M. & Perkins, N. D., Aug 2008, In : Biochemical Society Transactions. 36, Pt 4, p. 603-8 6 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Reversible Accumulation of PEGylated Single-Walled Carbon Nanotubes in the Mammalian Nucleus

Cheng, J., Fernando, K. A. S., Veca, L. M., Sun, Y-P., Lamond, A. I., Lam, Y. W. & Cheng, S. H., Oct 2008, In : ACS Nano. 2, 10, p. 2085-2094 10 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Ribosomal proteins are targets for the NEDD8 pathway

Xirodimas, D. P., Sundqvist, A., Nakamura, A., Shen, L., Botting, C. & Hay, R. T., Mar 2008, In : EMBO Reports. 9, 3, p. 280-286 7 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

Tatham, M. H., Geoffroy, M-C., Shen, L., Plechanovova, A., Hattersley, N., Jaffray, E. G., Palvimo, J. J. & Hay, R. T., May 2008, In : Nature Cell Biology. 10, 5, p. 538-546 9 p.

Research output: Contribution to journalArticle

564 Citations (Scopus)

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

Richard, D. J., Bolderson, E., Cubeddu, L., Wadsworth, R. I. M., Savage, K., Sharma, G. G., Nicolette, M. L., Tsvetanov, S., McIlwraith, M. J., Pandita, R. K., Takeda, S., Hay, R. T., Gautier, J., West, S. C., Paull, T. T., Pandita, T. K., White, M. F. & Khanna, K. K., 29 May 2008, In : Nature. 453, 7195, p. 677-U13 6 p.

Research output: Contribution to journalArticle

161 Citations (Scopus)

Spatial mapping of splicing factor complexes involved in exon and intron definition

Ellis, J. D., Llères, D., Denegri, M., Lamond, A. & Cáceres, J., 1 Jun 2008, In : Chemtracts. 21, 6, p. 243-244 2 p.

Research output: Contribution to journalArticle

Spatial mapping of splicing factor complexes involved in exon and intron definition

Ellis, J. D., Lleres, D., Denegri, M., Lamond, A. I. & Caceres, J. F., 16 Jun 2008, In : Journal of Cell Biology. 181, 6, p. 921-934 14 p.

Research output: Contribution to journalArticle

Open Access
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37 Citations (Scopus)
318 Downloads (Pure)

Splicing factors facilitate RNAi-directed silencing in fission yeast

Bayne, E. H., Portoso, M., Kagansky, A., Kos-Braun, I. C., Urano, T., Ekwall, K., Alves, F., Rappsilber, J. & Allshire, R. C., 24 Oct 2008, In : Science. 322, 5901, p. 602-606 5 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Structure and function of ribosomal RNA gene chromatin

Birch, J. L. & Zomerdijk, J. C. B. M., Aug 2008, In : Biochemical Society Transactions. 36, p. 619-624 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
46 Citations (Scopus)

Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays

Karamanska, R., Clarke, J., Blixt, O., MacRae, J. I., Zhang, J. Q., Crocker, P. R., Laurent, N., Wright, A., Flitsch, S. L., Russell, D. A. & Field, R. A., Jan 2008, In : Glycoconjugate Journal. 25, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Targeting a nucleolar SUMO protease for degradation: a mechanism by which ARF induces SUMO conjugation

Xirodimas, D. P. & Lane, D. P., 1 Nov 2008, In : Cell Cycle. 7, 21, p. 3287-3288 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition

Khoudoli, G. A., Gillespie, P. J., Stewart, G., Andersen, J. S., Swedlow, J. R. & Blow, J. J., 3 Jun 2008, In : Current Biology. 18, 11, p. 838-843 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior

Lee, H., Cho, J. S., Lambacher, N., Lee, J., Lee, S-J., Lee, T. H., Gartner, A. & Koo, H-S., 30 May 2008, In : Journal of Biological Chemistry. 283, 22, p. 14988-14993 6 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

The GLUT4 code

Larance, M., Ramm, G. & James, D. E., 1 Feb 2008, In : Molecular Endocrinology. 22, 2, p. 226-233 8 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

The human intermediate filament database: Comprehensive information on a gene family involved in many human diseases

Szeverenyi, I., Cassidy, A. J., Chung, C. W., Lee, B. T. K., Common, J. E. A., Ogg, S. C., Chen, H., Sim, S. Y., Goh, W. L. R., Ng, K. W., Simpson, J. A., Chee, L. L., Eng, G. H., Li, B., Lunny, D. P., Chuon, D., Venkatesh, A., Khoo, K. H., McLean, W. H. I., Lim, Y. P. & 1 others, Lane, E. B., Mar 2008, In : Human Mutation. 29, 3, p. 351-360 10 p.

Research output: Contribution to journalArticle

218 Citations (Scopus)

The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle

Schimmel, J., Larsen, K. M., Matic, I., van Hagen, M., Cox, J., Mann, M., Andersen, J. S. & Vertegaal, A. C. O., 1 Nov 2008, In : Molecular & Cellular Proteomics. 7, 11, p. 2107-2122 16 p.

Research output: Contribution to journalArticle

118 Citations (Scopus)

Three-dimensional electron microscopy analysis of ndc10-1 mutant reveals an aberrant organization of the mitotic spindle and spindle pole body defects in Saccharomyces cerevisiae

Romao, M., Tanaka, K., Sibarita, J-B., Ly-Hartig, N. T. B., Tanaka, T. U. & Antony, C., Jul 2008, In : Journal of Structural Biology. 163, 1, p. 18-28 11 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Transcriptional profiling in C-elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

Greiss, S., Schumacher, B., Grandien, K., Rothblatt, J. & Gartner, A., 15 Jul 2008, In : BMC Genomics. 9, p. - 10 p., 334.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Using dialogical argument as an interface to complex debates

Wells, S. & Reed, C., 1 Sep 2008, In : IEEE Potentials. 27, 5, p. 26-30 5 p.

Research output: Contribution to journalArticle

2007

A cell cycle regulatory network controlling NF-B subunit activity and function

Barre, B. & Perkins, N., 2007, In : The EMBO Journal. 26, 23, p. 4841-4855 15 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)

Analysis of Nucleolar Protein Dynamics Reveals the Nuclear Degradation of Ribosomal Proteins

Lam, Y. W., Lamond, A. I., Mann, M. & Andersen, J. S., May 2007, In : Current Biology. 17, 9, p. 749-760 12 p.

Research output: Contribution to journalArticle

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242 Citations (Scopus)
284 Downloads (Pure)

A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase function and sorbic acid stress tolerance

Makrantoni, V., Dennison, P., Stark, M. J. R. & Coote, P. J., Dec 2007, In : Microbiology. 153, p. 4016-4026 11 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription

Gorski, J. J., Pathak, S., Panov, K., Kasciukovic, T., Panova, T., Russell, J. & Zomerdijk, J. C. B. M., Mar 2007, In : The EMBO Journal. 26, 6, p. 1560-1568 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Bod1, a novel kinetochore protein required for chromosome biorientation

Porter, I. M., McClelland, S. E., Khoudoli, G. A., Hunter, C. J., Andersen, J. S., McAinsh, A. D., Blow, J. J. & Swedlow, J. R., 15 Oct 2007, In : Journal of Cell Biology. 179, 2, p. 187-197 11 p.

Research output: Contribution to journalArticle

Open Access
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40 Citations (Scopus)
263 Downloads (Pure)

Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing

Jantsch, V., Tang, L., Pasierbek, P., Penkner, A., Nayak, S., Baudrimont, A., Schedl, T., Gartner, A. & Loidl, J., Dec 2007, In : Molecular Biology of the Cell. 18, 12, p. 4911-4920 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Characterization of a new SUMO-1 nuclear body (SNB) enriched in pCREB, CBP, c-Jun in neuron-like UR61 cells

Navascues, J., Bengoechea, R., Tapia, O., Vaqué, J. P., Lafarga, M. & Berciano, M. T., 2007, In : Chromosoma. 116, 5, p. 441-451 11 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Disease induced dynamics in host-parasitoid systems: chaos and coexistence

Preedy, K. F., Schofield, P. G., Chaplain, M. A. J. & Hubbard, S. F., 2007, In : Journal of the Royal Society Interface. 4, 14, p. 463-471 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress

Ge, X. Q., Jackson, D. A. & Blow, J. J., 15 Dec 2007, In : Genes & Development. 21, 24, p. 3331-3341 11 p.

Research output: Contribution to journalArticle

340 Citations (Scopus)