Gene Regulation and Expression

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2007

ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing

Gillespie, P. J., Khoudoli, G. A., Stewart, G., Swedlow, J. R. & Blow, J. J., 9 Oct 2007, In : Current Biology. 17, 19, p. 1657-62 6 p.

Research output: Contribution to journalArticle

94 Citations (Scopus)

Evaluating performance in three-dimensional fluorescence microscopy

Murray, J. M., Appleton, P. L., Swedlow, J. R. & Waters, J. C., Dec 2007, In : Journal of Microscopy. 228, 3, p. 390-405 16 p.

Research output: Contribution to journalArticle

Open Access
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85 Citations (Scopus)
248 Downloads (Pure)

FRG1P-mediated aggregation of proteins involved in pre-mRNA processing

van Koningsbruggen, S., Straasheijm, K. R., Sterrenburg, E., de Graaf, N., Dauwerse, H. G., Frants, R. R. & van der Maarel, S. M., 2007, In : Chromosoma. 116, 1, p. 53-64 12 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Gene regulation under low oxygen: holding your breath for transcription

Rocha, S., Aug 2007, In : Trends in Biochemical Sciences. 32, 8, p. 389-97 9 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)

Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms

Ferreira, H., Flaus, A. & Owen-Hughes, T., 30 Nov 2007, In : Journal of Molecular Biology. 374, 3, p. 563-579 17 p.

Research output: Contribution to journalArticle

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95 Citations (Scopus)
198 Downloads (Pure)

Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability

Ferreira, H., Somers, J., Webster, R., Flaus, A. & Owen-Hughes, T., 2007, In : Molecular and Cellular Biology. 27, 11, p. 4037-48 12 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D., Jan 2007, In : Nature Reviews Molecular Cell Biology. 8, 1, p. 49-62 14 p.

Research output: Contribution to journalArticle

1657 Citations (Scopus)

Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores

King, E., Rachidi, N., Morrice, N., Hardwick, K. G. & Stark, M. J. R., 2007, In : Genes & Development. 21, 10, p. 1163-1168 6 p.

Research output: Contribution to journalArticle

58 Citations (Scopus)

Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae

Kitamura, E., Tanaka, K., Kitamura, Y. & Tanaka, T. U., 15 Dec 2007, In : Genes & Development. 21, 24, p. 3319-3330 12 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord

Wilcock, A. C., Swedlow, J. R. & Storey, K. G., 15 May 2007, In : Development. 134, 10, p. 1943-54 12 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Molecular mechanisms of microtubule-dependent kinetochore transport toward spindle poles

Tanaka, K., Kitamura, E., Kitamura, Y. & Tanaka, T. U., 2007, In : Journal of Cell Biology. 178, 2, p. 269-81 13 p.

Research output: Contribution to journalArticle

116 Citations (Scopus)

Mps1 kinase promotes sister-kinetochore bi-orientation by a tension-dependent mechanism

Maure, J-F., Kitamura, E. & Tanaka, T. U., 18 Dec 2007, In : Current Biology. 17, 24, p. 2175-2182 8 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

'Open minded' cells: how cells can change fate

Costa, S. & Shaw, P., Mar 2007, In : Trends in Cell Biology. 17, 3, p. 101-6 6 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-B- and p53-regulated gene targets

McTavish, N., Copeland, L. A., Saville, M. K., Perkins, N. D. & Spruce, B. A., 2007, In : Cell Death & Differentiation. 14, 9, p. 1700-1710 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Pyrosequencing positions nucleosomes precisely

Owen-Hughes, T. & Engeholm, M., 27 Jun 2007, In : Genome Biology. 8, 6, p. 217

Research output: Contribution to journalArticle

2 Citations (Scopus)

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

Fox, G. C., Shafiq, M., Briggs, D. C., Knowles, P. P., Collister, M., Didmon, M. J., Makrantoni, V., Dickinson, R. J., Hanrahan, S., Totty, N., Stark, M. J. R., Keyse, S. M. & McDonald, N. Q., 2007, In : Nature. 447, 7143, p. 487-492 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1

Roche, K. C., Rocha, S., Bracken, C. P. & Perkins, N. D., 5 Jul 2007, In : Oncogene. 26, 31, p. 4523-30 8 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Screening and characterization of microbial inhibitors against eukaryotic protein phosphatases (PP1 and PP2A)

Ong, S. M., Voo, L. Y. C., Lai, N. S., Stark, M. J. R. & Ho, C. C., Mar 2007, In : Journal of Applied Microbiology. 102, 3, p. 680-92 13 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore

Griffis, E. R., Stuurman, N. & Vale, R. D., 2007, In : Journal of Cell Biology. 177, 6, p. 1005-15 11 p.

Research output: Contribution to journalArticle

138 Citations (Scopus)

SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1

Jacobs, A-M., Nicol, S. M., Hislop, R. G., Jaffray, E. G., Hay, R. T. & Fuller-Pace, F. V., 30 Aug 2007, In : Oncogene. 26, 40, p. 5866-76 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

SUMO-specific proteases: a twist in the tail

Hay, R. T., Aug 2007, In : Trends in Cell Biology. 17, 8, p. 370-6 7 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)

The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

Miranda-Saavedra, D., Stark, M. J. R., Packer, J. C., Vivares, C. P., Doerig, C. & Barton, G. J., 2007, In : BMC Genomics. 8, 309.

Research output: Contribution to journalArticle

48 Citations (Scopus)

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Stevenson, L. F., Sparks, A., Allende-Vega, N., Xirodimas, D. P., Lane, D. & Saville, M. K., 2007, In : The EMBO Journal. 26, 4, p. 976-986 11 p.

Research output: Contribution to journalArticle

178 Citations (Scopus)

The elusive determinants of replication origins

Costa, S. & Blow, J. J., 2007, In : EMBO Reports. 8, 4, p. 332-4 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The multifunctional nucleolus

Boisvert, F-M., van Koningsbruggen, S., Navascués, J. & Lamond, A. I., 2007, In : Nature Reviews Molecular Cell Biology. 8, 7, p. 574-585 12 p.

Research output: Contribution to journalArticle

886 Citations (Scopus)

The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G

Ulke-Lemée, A., Trinkle-Mulcahy, L., Chaulk, S., Bernstein, N. K., Morrice, N., Glover, M., Lamond, A. I. & Moorhead, G. B. G., 1 Oct 2007, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 10, p. 1339-1350 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The STAT3 oncogene as a predictive marker of drug resistance

Barré, B., Vigneron, A., Perkins, N., Roninson, I. B., Gamelin, E. & Coqueret, O., 2007, In : Trends in Molecular Medicine. 13, 1, p. 4-11 8 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

The tagged microarray marker (TAM) method for high-throughput detection of single nucleotide and indel polymorphisms

Jing, R., Bolshakov, V. & Flavell, A. J., 2007, In : Nature Protocols. 2, 1, p. 168-177 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

Toward a high-resolution view of nuclear dynamics

Trinkle-Mulcahy, L. & Lamond, A. I., 2007, In : Science. 318, 5855, p. 1402-1407 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Transcriptional profiling of the LPS induced NF-kappaB response in macrophages

Sharif, O., Bolshakov, V. N., Raines, S., Newham, P. & Perkins, N. D., 2007, In : BMC Immunology. 8, p. 1

Research output: Contribution to journalArticle

227 Citations (Scopus)

Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins

Gonsalvez, G. B., Tian, L., Ospina, J. K., Boisvert, F. M., Lamond, A. I. & Matera, A. G., 27 Aug 2007, In : Journal of Cell Biology. 178, 5, p. 733-740 8 p.

Research output: Contribution to journalArticle

Open Access
100 Citations (Scopus)
2006

Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes

Stockdale, C., Flaus, A., Ferreira, H. & Owen-Hughes, T., 2006, In : Journal of Biological Chemistry. 281, 24, p. 16279-88 10 p.

Research output: Contribution to journalArticle

Open Access
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127 Citations (Scopus)
165 Downloads (Pure)

A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160

Ramm, G., Larance, M., Guilhaus, M. & James, D. E., 29 Sep 2006, In : Journal of Biological Chemistry. 281, 39, p. 29174-29180 7 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription

Panova, T. B., Panov, K. I., Russell, J. & Zomerdijk, J. C. B. M., 2006, In : Molecular and Cellular Biology. 26, 16, p. 5957-5968 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation

Campbell, K. J., Witty, J. M., Rocha, S. & Perkins, N. D., Jan 2006, In : Cancer Research. 66, 2, p. 929-935 7 p.

Research output: Contribution to journalArticle

Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis

Vagnarelli, P., Hudson, D. F., Ribeiro, S. A., Trinkle-Mulcahy, L., Spence, J. M., Lai, F., Farr, C. J., Lamond, A. I. & Earnshaw, W. C., 1 Oct 2006, In : Nature Cell Biology. 8, 10, p. 1133-1142 10 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision

Davidson, I. F., Li, A. & Blow, J. J., Nov 2006, In : Molecular Cell. 24, 3, p. 433-443 11 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

Direct observation of DNA distortion by the RSC complex

Lia, G., Praly, E., Ferreira, H., Stockdale, C., Tse-Dinh, Y. C., Dunlap, D., Croquette, V., Bensimon, D. & Owen-Hughes, T., Feb 2006, In : Molecular Cell. 21, 3, p. 417-425 9 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics

Vertegaal, A. C. O., Andersen, J. S., Ogg, S. C., Hay, R. T., Mann, M. & Lamond, A. I., 1 Dec 2006, In : Molecular and Cellular Proteomics. 5, 12, p. 2298-2310 13 p.

Research output: Contribution to journalArticle

Open Access
220 Citations (Scopus)

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress

Woodward, A. M., Göhler, T., Luciani, M. G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D. A. & Blow, J. J., 2006, In : Journal of Cell Biology. 173, 5, p. 673-83 11 p.

Research output: Contribution to journalArticle

236 Citations (Scopus)

Identification of multiple distinct Snf2 subfamilies with conserved structural motifs

Flaus, A., Martin, D. M. A., Barton, G. J. & Owen-Hughes, T., 2006, In : Nucleic Acids Research. 34, 10, p. 2887-905 19 p.

Research output: Contribution to journalArticle

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408 Citations (Scopus)
141 Downloads (Pure)

Identification of novel inhibitors of UDP-Glc 4 '-epimerase, a validated drug target for African sleeping sickness

Urbaniak, M. D., Tabudravu, J. N., Msaki, A., Matera, K. M., Brenk, R., Jaspars, M. & Ferguson, M. A. J., 15 Nov 2006, In : Bioorganic & Medicinal Chemistry Letters. 16, 22, p. 5744-5747 4 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories

Kitamura, E., Blow, J. J. & Tanaka, T. U., 2006, In : Cell. 125, 7, p. 1297-1308 12 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Mating-type locus control of killer toxins from Kluyveromyces lactis and Pichia acaciae

Klassen, R., Jablonowski, D., Stark, M. J. R., Schaffrath, R. & Meinhardt, F., May 2006, In : FEMS Yeast Research. 6, 3, p. 404-13 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Modelling the spatio-temporal dynamics of multi-species host-parasitoid interactions: heterogeneous patterns and ecological implications

Pearce, I. G., Chaplain, M. A. J., Schofield, P. G., Anderson, A. R. A. & Hubbard, S. F., 2006, In : Journal of Theoretical Biology. 241, 4, p. 876-886 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

NOPdb: Nucleolar proteome database

Leung, A. K. L., Trinkle-Mulcahy, L., Lam, Y. W., Andersen, J. S., Mann, M. & Lamond, A. I., 1 Jan 2006, In : Nucleic Acids Research. 34, Database Suppl. 1, p. D218-D220 3 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

Regulating the licensing of DNA replication origins in metazoa

DePamphilis, M. L., Blow, J. J., Ghosh, S., Saha, T., Noguchi, K. & Vassilev, A., Jun 2006, In : Current Opinion in Cell Biology. 18, 3, p. 231-9 9 p.

Research output: Contribution to journalArticle

136 Citations (Scopus)

Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

Schumm, K., Rocha, S., Caamano, J. & Perkins, N. D., Oct 2006, In : The EMBO Journal. 25, 20, p. 4820-4832 13 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)

Repo-Man recruits PP1γ to chromatin and is essential for cell viability

Trinkle-Mulcahy, L., Andersen, J., Lam, Y. W., Moorhead, G., Mann, M. & Lamond, A. I., 27 Feb 2006, In : Journal of Cell Biology. 172, 5, p. 679-692 14 p.

Research output: Contribution to journalArticle

Open Access
181 Citations (Scopus)

RNA polymerase I-specific subunit CAST/hPAF49 has a role in the activation of transcription by upstream binding factor

Panov, K. I., Panova, T. B., Gadal, O., Nishiyama, K., Saito, T., Russell, J. & Zomerdijk, J. C. B. M., Jul 2006, In : Molecular and Cellular Biology. 26, 14, p. 5436-5448 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)