Gene Regulation and Expression

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2004

DNA replication licensing in somatic and germ cells

Eward, K. L., Obermann, E. C., Shreeram, S., Loddo, M., Fanshawe, T., Williams, C., Jung, H-I., Prevost, A. T., Blow, J. J., Stoeber, K. & Williams, G. H., 2004, In : Journal of Cell Science. 117, Pt 24, p. 5875-86 12 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

Xirodimas, D. P., Saville, M. K., Bourdon, J. C., Hay, R. T. & Lane, D. P., 9 Jul 2004, In : Cell. 118, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

368 Citations (Scopus)

Mechanical stress induces profound remodelling of keratin filaments and cell junctions in epidermolysis bullosa simplex keratinocytes

Russell, D., Andrews, P. D., James, J. & Lane, E. B., Oct 2004, In : Journal of Cell Science. 117, 22, p. 5233-5243 11 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Multiple genetic pathways involving the Caenorhabditis elegans Bloom's syndrome genes him-6, rad-51, and top-3 are needed to maintain genome stability in the germ line

Wicky, C., Alpi, A., Passannante, M., Rose, A., Gartner, A. & Muller, F., 2004, In : Molecular and Cellular Biology. 24, 11, p. 5016-5027 12 p.

Research output: Contribution to journalArticle

53 Citations (Scopus)

Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing

Li, A. & Blow, J. J., 2004, In : Cell Cycle. 3, 4, p. 441-443 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination

Li, A. & Blow, J. J., Mar 2004, In : Nature Cell Biology. 6, 3, p. 260-267 8 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach

Khoudoli, G. A., Porter, I. M., Blow, J. J. & Swedlow, J. R., 9 Sep 2004, In : Proteome Science. 2, 1, 6.

Research output: Contribution to journalArticle

36 Citations (Scopus)

p14 arf promotes small ubiquitin-like modifier conjugation of Werners helicase

Woods, Y. L., Xirodimas, D. P., Prescott, A. R., Sparks, A., Lane, D. P. & Saville, M. K., 2004, In : Journal of Biological Chemistry. 279, 48, p. 50157-50166 10 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
85 Citations (Scopus)

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

Hutchins, J. R. A., Moore, W. J., Hood, F. E., Wilson, J. S. J., Andrews, P. D., Swedlow, J. R. & Clarke, P. R., Jun 2004, In : Current Biology. 14, 12, p. 1099-1104 6 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells

Leung, A. K. L., Gerlich, D., Miller, G., Lyon, C., Lam, Y. W., Lleres, D., Daigle, N., Zomerdijk, J., Ellenherg, J. & Lamond, A. I., 2004, In : Journal of Cell Biology. 166, 6, p. 787-800 14 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

Saville, M. K., Sparks, A., Xirodimas, D. P., Wardrop, J., Stevenson, L. F., Bourdon, J-C., Woods, Y. L. & Lane, D. P., 1 Oct 2004, In : Journal of Biological Chemistry. 279, 40, p. 42169-42181 13 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Sequence-specific inhibition of small RNA function

Hutvagner, G., Simard, M. J., Mello, C. C. & Zamore, P. D., 2004, In : PLoS Biology. 2, 4, p. e98

Research output: Contribution to journalArticle

533 Citations (Scopus)

Sin mutations alter inherent nucleosome mobility

Flaus, A., Rencurel, C., Ferreira, H., Wiechens, N. & Owen-Hughes, T., 2004, In : The EMBO Journal. 23, 2, p. 343-353 11 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F., 2004, In : Journal of Medicinal Chemistry. 47, 23, p. 5713-20 8 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

Dewar, H., Tanaka, K., Nasmyth, K. & Tanaka, T. U., 2004, In : Nature. 428, 6978, p. 93-97 5 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage

Pohler, E., Craig, A. L., Cotton, J., Lawrie, L., Dillon, J. F., Ross, P., Kernohan, N. & Hupp, T. R., 2004, In : Molecular & Cellular Proteomics. 3, 6, p. 534-547 14 p.

Research output: Contribution to journalArticle

115 Citations (Scopus)

The development of a CDK2-docking site peptide that inhibits p53 and sensitizes cells to death

Ferguson, M., Luciani, M. G., Finlan, L., Rankin, E. M., Ibbotson, S., Fersht, A. & Hupp, T. R., Jan 2004, In : Cell Cycle. 3, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner

Wilson, B. J., Bates, G. J., Nicol, S. M., Gregory, D. J., Perkins, N. D. & Fuller-Pace, F. V., 6 Aug 2004, In : BMC Molecular Biology. 5, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
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105 Citations (Scopus)
68 Downloads (Pure)

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation

Oehlmann, M., Score, A. J. & Blow, J. J., 2004, In : Journal of Cell Biology. 165, 2, p. 181-90 10 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

The STAT3 isoforms α and β have unique and specific functions

Maritano, D., Sugrue, M. L., Tininini, S., Dewilde, S., Strobl, B., Fu, X., Murray-Tait, V., Chiarle, R. & Poli, V., Apr 2004, In : Nature Immunology. 5, 4, p. 401-409 9 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

The yeast elongator histone acetylase requires Sit4-dependent dephosphorylation for toxin-target capacity

Jablonowski, D., Fichtner, L., Stark, M. J. R. & Schaffrath, R., 1 Mar 2004, In : Molecular Biology of the Cell. 15, 3, p. 1459-69 11 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa

Thomson, R. E., Bigley, A. L., Foster, J. R., Jowsey, I. R., Elcombe, C. R., Orton, T. C. & Hayes, J. D., May 2004, In : Journal of Histochemistry & Cytochemistry. 52, 5, p. 653-662 10 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
2003

An essential role for hGle1 nucleocytoplasmic shuttling in mRNA export

Kendirgi, F., Barry, D. M., Griffis, E. R., Powers, M. A. & Wente, S. R., 2003, In : Journal of Cell Biology. 160, 7, p. 1029-40 12 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

A new role for Ran in ensuring precise duplication of chromosomal DNA

Blow, J. J., 2003, In : Cell. 113, 1, p. 2-4 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Asymmetry in the assembly of the RNAi enzyme complex

Schwarz, D. S., Hutvagner, G., Du, T., Xu, Z., Aronin, N. & Zamore, P. D., 2003, In : Cell. 115, 2, p. 199-208 10 p.

Research output: Contribution to journalArticle

2024 Citations (Scopus)

Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase

Jowsey, I. R., Thomson, R. E., Orton, T. C., Elcombe, C. R. & Hayes, J. D., 2003, In : Biochemical Journal. 373, Pt 2, p. 559-69 11 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo

Sleeman, J. E., Trinkle-Mulcahy, L., Prescott, A. R., Ogg, S. C. & Lamond, A. I., 1 Apr 2003, In : Journal of Cell Science. 116, 10, p. 2039-2050 12 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Collection and characterisation of bacterial membrane proteins

Saidijam, M., Psakis, G., Clough, J. L., Meuller, J., Suzuki, S., Hoyle, C. J., Palmer, S. L., Morrison, S. M., Pos, M. K., Essenberg, R. C., Maiden, M. C. J., Abu-bakr, A., Baumberg, S. G., Neyfakh, A. A., Griffith, J. K., Stark, M. J., Ward, A., O'Reilly, J., Rutherford, N. G., Phillips-Jones, M. K. & 4 others, Henderson, P. J. F., von Heijne, G. (ed.), Rydstrom, J. (ed.) & Brzezinski, P. (ed.), 27 Nov 2003, In : FEBS Letters. 555, 1, p. 170-5 6 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Degradation ensures integrity

Li, A. & Blow, J. J., 2003, In : Nature. 423, 6942, p. 818-9 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dynamic properties of nucleosomes during thermal and ATP-driven mobilization

Flaus, A. & Owen-Hughes, T., 2003, In : Molecular and Cellular Biology. 23, 21, p. 7767-7779 13 p.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

Sutherland, C. M., Hawley, S. A., McCartney, R. R., Leech, A., Stark, M. J. R., Schmidt, M. C. & Hardie, D. G., 5 Aug 2003, In : Current Biology. 13, 15, p. 1299-1305 7 p.

Research output: Contribution to journalArticle

203 Citations (Scopus)

Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification

Fichtner, L., Jablonowski, D., Schierhorn, A., Kitamoto, H. K., Stark, M. J. R. & Schaffrath, R., Sep 2003, In : Molecular Microbiology. 49, 5, p. 1297-307 11 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)
51 Citations (Scopus)
27 Citations (Scopus)

Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities

Bruno, M., Flaus, A., Stockdale, C., Rencurel, C., Ferreira, H. & Owen-Hughes, T., 2003, In : Molecular Cell. 12, 6, p. 1599-1606 8 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing

Leonard, D., Ajuh, P. M., Lamond, A. I. & Legerski, R. J., 5 Sep 2003, In : Biochemical and Biophysical Research Communications. 308, 4, p. 793-801 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1

Ajuh, P. & Lamond, A. I., 1 Nov 2003, In : Nucleic Acids Research. 31, 21, p. 6104-6116 13 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Informatics and quantitative analysis in biological imaging

Swedlow, J. R., Goldberg, I., Brauner, E. & Sorger, P. K., Apr 2003, In : Science. 300, 5616, p. 100-102 3 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I

Rabitsch, K. P., Petronczki, M., Javerzat, J-P., Genier, S., Chwalla, B., Schleiffer, A., Tanaka, T. U. & Nasmyth, K., 2003, In : Developmental Cell. 4, 4, p. 535-48 14 p.

Research output: Contribution to journalArticle

156 Citations (Scopus)

Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes

Griffis, E. R., Xu, S. & Powers, M. A., 2003, In : Molecular Biology of the Cell. 14, 2, p. 600-10 11 p.

Research output: Contribution to journalArticle

123 Citations (Scopus)

P300 transcriptional repression is mediated by SUMO modification

Girdwood, D., Bumpass, D., Vaughan, O. A., Thain, A., Anderson, L. A., Snowden, A. W., Garcia-Wilson, E., Perkins, N. D. & Hay, R. T., Apr 2003, In : Molecular Cell. 11, 4, p. 1043-1054 12 p.

Research output: Contribution to journalArticle

360 Citations (Scopus)

p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor

Rocha, S., Campbell, K. J. & Perkins, N. D., Jul 2003, In : Molecular Cell. 12, 1, p. 15-25 11 p.

Research output: Contribution to journalArticle

169 Citations (Scopus)

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1

Rocha, S., Martin, A. M., Meek, D. W. & Perkins, N. D., Jul 2003, In : Molecular and Cellular Biology. 23, 13, p. 4713-4727 15 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Prostaglandin D2 synthase enzymes and PPARγ are co-expressed in mouse 3T3-L1 adipocytes and human tissues

Jowsey, I. R., Murdock, P. R., Moore, G. B. T., Murphy, G. J., Smith, S. A. & Hayes, J. D., 2003, In : Prostaglandins & Other Lipid Mediators. 70, 3-4, p. 267-84 18 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs

Carnegie, G. K., Sleeman, J. E., Morrice, N., Hastie, C. J., Peggie, M. W., Philp, A., Lamond, A. I. & Cohen, P. T. W., May 2003, In : Journal of Cell Science. 116, 10, p. 1905-1913 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro

Rocha, S., Campbell, K. J., Roche, K. C. & Perkins, N. D., Sep 2003, In : BMC Molecular Biology. 4, 9

Research output: Contribution to journalArticle

50 Citations (Scopus)

The peroxisome proliferator activated receptor δ is required for the differentiation of THP-1 monocytic cells by phorbol ester

Vosper, H., Khoudoli, G. A. & Palmer, C. N. A., 11 Dec 2003, In : Nuclear Receptor. 1, 10 p., 9.

Research output: Contribution to journalArticle

Open Access
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19 Citations (Scopus)
46 Downloads (Pure)

The role of the replication licensing system in cell proliferation and cancer

Shreeram, S. & Blow, J., 2003, In : Progress in Cell Cycle Research. 5, p. 287-293 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Time-lapse Imaging Reveals Dynamic Relocalization of PP1γ throughout the Mammalian Cell Cycle

Trinkle-Mulcahy, L., Andrews, P. D., Wickramasinghe, S., Sleeman, J., Prescott, A., Lam, Y. W., Lyon, C., Swedlow, J. R. & Lamond, A. I., 1 Jan 2003, In : Molecular Biology of the Cell. 14, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

114 Citations (Scopus)