Gene Regulation and Expression

  • United Kingdom

Research Output

Filter
Article
Article

Structural biology: Pivotal findings for a transcription machine

Zomerdijk, J., 2013, In : Nature. 502, 7473, p. 629-630 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural biology: Pivotal findings for a transcription machine

Zomerdijk, J., 31 Oct 2013, In : Nature. 502, 7473, p. 629-630 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural characterization of NETNES, a novel glycoconjugate in Trypanosoma cruzi epimastigotes

MacRae, J. I., Acosta-Serrano, A., Morrice, N. A., Mehlert, A. & Ferguson, M. A. J., 1 Apr 2005, In : Journal of Biological Chemistry. 280, 13, p. 12201-12211 11 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4

Xu, Y., Plechanovová, A., Simpson, P., Marchant, J., Leidecker, O., Kraatz, S., Hay, R. T. & Matthews, S. J., 27 Jun 2014, In : Nature Communications. 5, 12 p., 4217.

Research output: Contribution to journalArticle

Open Access
File
16 Citations (Scopus)
206 Downloads (Pure)

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E., Jan 2013, In : Nature Structural & Molecular Biology. 20, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

Sundaramoorthy, R., Hughes, A. L., Singh, V., Wiechens, N., Ryan, D. P., El-Mkami, H., Petoukhov, M., Svergun, D. I., Treutlein, B., Quack, S., Fischer, M., Michaelis, J., Bottcher, B., Norman, D. G. & Owen-Hughes, T., 13 Apr 2017, In : eLife. 6, 28 p., e22510.

Research output: Contribution to journalArticle

Open Access
File
29 Citations (Scopus)
154 Downloads (Pure)

Structure and function of ribosomal RNA gene chromatin

Birch, J. L. & Zomerdijk, J. C. B. M., Aug 2008, In : Biochemical Society Transactions. 36, p. 619-624 6 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

Blair, D. E., Schuettelkopf, A. W., MacRae, J. I., van Aalten, D. M. F. & Thornton, J. (ed.), 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 43, p. 15429-15434 6 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Structure-Based Design of a Macrocyclic PROTAC

Testa, A., Hughes, S. J., Lucas, X., Wright, J. E. & Ciulli, A., 19 Nov 2019, In : Angewandte Chemie International Edition. 9 p.

Research output: Contribution to journalArticle

Open Access
File
125 Downloads (Pure)

Structure-based exploration of cyclic dipeptide chitinase inhibitors

Houston, D. R., Synstad, B., Eijsink, V. G. H., Stark, M. J. R., Eggleston, I. M. & van Aalten, D. M. F., 2004, In : Journal of Medicinal Chemistry. 47, 23, p. 5713-20 8 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

Plechanovová, A., Jaffray, E. G., Tatham, M. H., Naismith, J. H. & Hay, R. T., 2012, In : Nature. 489, 7414, p. 115-120 5 p.

Research output: Contribution to journalArticle

267 Citations (Scopus)

Structure of PINK1 and mechanisms of Parkinson's disease associated mutations

Kumar, A., Tamjar, J., Waddell, A. D., Woodroof, H. I., Raimi, O. G., Shaw, A. M., Peggie, M., Muqit, M. M. K. & van Aalten, D. M. F., 9 Nov 2017, In : eLife. 6, p. 1-16 16 p., e29985.

Research output: Contribution to journalArticle

Open Access
File
28 Citations (Scopus)
186 Downloads (Pure)
46 Citations (Scopus)

Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, p. 1-28 28 p., e35720.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
134 Downloads (Pure)

Studying pre-mRNA splicing using antisense 2-OMe RNA oligonucleotides

Lamond, A. I., Barabino, S., Blencowe, B. J., Sproat, B. & Ryder, U., Jun 1990, In : Molecular Biology Reports. 14, 2-3, 1 p., 201.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei

Chaves, I., Zomerdijk, J., Dirks-Mulder, A., Dirks, R. W., Raap, A. K. & Borst, P., 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12328-12333 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

SUMO chain-induced dimerization activates RNF4

Rojas-Fernandez, A., Plechanovová, A., Hattersley, N., Jaffray, E., Tatham, M. H. & Hay, R. T., 20 Mar 2014, In : Molecular Cell. 53, 6, p. 880-92 13 p.

Research output: Contribution to journalArticle

Open Access
File
45 Citations (Scopus)
138 Downloads (Pure)

SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1

Jacobs, A-M., Nicol, S. M., Hislop, R. G., Jaffray, E. G., Hay, R. T. & Fuller-Pace, F. V., 30 Aug 2007, In : Oncogene. 26, 40, p. 5866-76 11 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

Wang, X. D., Lapi, E., Sullivan, A., Ratnayaka, I., Goldin, R., Hay, R. & Lu, X., Feb 2011, In : Cell Death & Differentiation. 18, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

SUMO protease SENP1 induces isomerization of the scissile peptide bond

Shen, L., Tatham, M. H., Dong, C., Zagorska, A., Naismith, J. H. & Hay, R. T., Dec 2006, In : Nature Structural & Molecular Biology. 13, 12, p. 1069-1077 9 p.

Research output: Contribution to journalArticle

87 Citations (Scopus)

SUMO-specific proteases: a twist in the tail

Hay, R. T., Aug 2007, In : Trends in Cell Biology. 17, 8, p. 370-6 7 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)

SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage

Yin, Y., Seifert, A., Chua, J. S., Maure, J-F., Golebiowski, F. & Hay, R. T., 1 Jun 2012, In : Genes & Development. 26, 11, p. 1196-1208 13 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri

Fritah, S., Lhocine, N., Golebiowski, F., Mounier, J., Andrieux, A., Jouvion, G., Hay, R. T., Sansonetti, P. & Dejean, A., Sep 2014, In : EMBO Reports. 15, 9, p. 965-972 8 p.

Research output: Contribution to journalArticle

Open Access
20 Citations (Scopus)

SUMOylation of the GTPase Rac1 is required for optimal cell migration

Castillo-Lluva, S., Tatham, M. H., Jones, R. C., Jaffray, E. G., Edmondson, R. D., Hay, R. T. & Malliri, A., Nov 2010, In : Nature Cell Biology. 12, 11, p. 1078-U70 21 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)
Open Access
File
2 Citations (Scopus)
93 Downloads (Pure)

Supercoiling response of a bacterial tRNA gene.

Lamond, A. I., 1 Feb 1985, In : EMBO Journal. 4, 2, p. 501-507 7 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Super-resolution video microscopy of live cells by structured illumination

Kner, P., Chhun, B. B., Griffis, E. R., Winoto, L. & Gustafsson, M. G. L., May 2009, In : Nature Methods. 6, 5, p. 339-342 4 p.

Research output: Contribution to journalArticle

452 Citations (Scopus)

Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays

Karamanska, R., Clarke, J., Blixt, O., MacRae, J. I., Zhang, J. Q., Crocker, P. R., Laurent, N., Wright, A., Flitsch, S. L., Russell, D. A. & Field, R. A., Jan 2008, In : Glycoconjugate Journal. 25, 1, p. 69-74 6 p.

Research output: Contribution to journalArticle

84 Citations (Scopus)

SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter

Gkikopoulos, T., Havas, K. M., Dewar, H. & Owen-Hughes, T., Aug 2009, In : Molecular and Cellular Biology. 29, 15, p. 4057-4066 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

SWI/SNF regulates the cellular response to hypoxia

Kenneth, N. S., Mudie, S., van Uden, P. & Rocha, S., 13 Feb 2009, In : Journal of Biological Chemistry. 284, 7, p. 4123-4131 9 p.

Research output: Contribution to journalArticle

77 Citations (Scopus)

Synthesis and applications of oligoribonucleotides with selected 2′-o-methylation using the 2′-o-[1-(2-fluorophenyl)-4-methoxypiperidin-4-yl] protecting group

Beijer, B., Sulston, I., Sproat, B. S., Rider, P., Lamond, A. I. & Neuner, P., 11 Sep 1990, In : Nucleic Acids Research. 18, 17, p. 5143-5151 9 p.

Research output: Contribution to journalArticle

44 Citations (Scopus)

Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization

Ahmad, Y., Boisvert, F-M., Lundberg, E., Uhlen, M. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

37 Citations (Scopus)

System-wide changes to SUMO modifications in response to heat shock

Golebiowski, F., Matic, I., Tatham, M. H., Cole, C., Yin, Y., Nakamura, A., Cox, J., Barton, G. J., Mann, M. & Hay, R. T., 26 May 2009, In : Science Signaling. 2, 72, 12 p., ra24.

Research output: Contribution to journalArticle

329 Citations (Scopus)

TAF1B Is a TFIIB-Like Component of the Basal Transcription Machinery for RNA Polymerase I

Naidu, S., Friedrich, J. K., Russell, J. & Zomerdijk, J. C. B. M., 16 Sep 2011, In : Science. 333, 6049, p. 1640-1642 3 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Tale of two transcription factors: NF-кB and HIF crosstalk

Bandarra, D. & Rocha, S., 2013, In : OA Molecular and Cell Biology. 1, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Open Access
File
150 Downloads (Pure)

Targeted knock-down of miR21 primary transcripts using snoMEN vectors induces apoptosis in human cancer cell lines

Ono, M., Ono, K., Avolio, F., Afzal, V., Bensaddek, D. & Lamond, A. I., 25 Sep 2015, In : PLoS ONE. 10, 9, 22 p., e0138668.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
390 Downloads (Pure)

Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly

Barabino, S. M. L., Blencowe, B. J., Ryder, U., Sproat, B. S. & Lamond, A. I., 19 Oct 1990, In : Cell. 63, 2, p. 293-302 10 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)

Targeting a critical step in fungal hexosamine biosynthesis

Lockhart, D., Stanley, M., Raimi, O., Robinson, D., Boldovjakova, D., Squair, D., Ferenbach, A., Fang, W. & van Aalten, D., 26 Jun 2020, In : Journal of Biological Chemistry. 295, 26, p. 8678-8691 15 p.

Research output: Contribution to journalArticle

Open Access
File
4 Downloads (Pure)

Targeting a nucleolar SUMO protease for degradation: a mechanism by which ARF induces SUMO conjugation

Xirodimas, D. P. & Lane, D. P., 1 Nov 2008, In : Cell Cycle. 7, 21, p. 3287-3288 2 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Targeting of RCC1 to chromosomes is required for proper mitotic spindle assembly in human cells

Moore, W. J., Zhang, C. & Clarke, P. R., Aug 2002, In : Current Biology. 12, 16, p. 1442-1447 6 p.

Research output: Contribution to journalArticle

85 Citations (Scopus)

Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast

Køhler, J. B., Tammsalu, T., Jørgensen, M. M., Steen, N., Hay, R. T. & Thon, G., 2015, In : Nature Communications. 6, p. 1-14 14 p., 8827.

Research output: Contribution to journalArticle

Open Access
File
14 Citations (Scopus)
114 Downloads (Pure)

Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
128 Downloads (Pure)

TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter

Friedrich, J. K., Panov, K. I., Cabart, P., Russell, J. & Zomerdijk, J. C. B. M., 2005, In : Journal of Biological Chemistry. 280, 33, p. 29551-29558 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

TDP-43 stabilises the processing intermediates of mitochondrial transcripts

Izumikawa, K., Nobe, Y., Yoshikawa, H., Ishikawa, H., Miura, Y., Nakayama, H., Nonaka, T., Hasegawa, M., Egawa, N., Inoue, H., Nishikawa, K., Yamano, K., Simpson, R. J., Taoka, M., Yamauchi, Y., Isobe, T. & Takahashi, N., 9 Aug 2017, In : Scientific Reports. 7, p. 1-14 14 p., 7709.

Research output: Contribution to journalArticle

Open Access
File
17 Citations (Scopus)
150 Downloads (Pure)

Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

Tatchell, K., Makrantoni, V., Stark, M. J. R. & Robinson, L. C., 8 Mar 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 3994-3999 6 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition

Khoudoli, G. A., Gillespie, P. J., Stewart, G., Andersen, J. S., Swedlow, J. R. & Blow, J. J., 3 Jun 2008, In : Current Biology. 18, 11, p. 838-843 6 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Ten quick tips for biocuration

Tang, Y. A., Pichler, K., Füllgrabe, A., Lomax, J., Malone, J., Munoz-Torres, M. C., Vasant, D. V., Williams, E. & Haendel, M., 2 May 2019, In : PLoS Computational Biology. 15, 5, p. 1-7 7 p., e1006906.

Research output: Contribution to journalArticle

Open Access
File
143 Downloads (Pure)

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle

Dewar, H., Tanaka, K., Nasmyth, K. & Tanaka, T. U., 2004, In : Nature. 428, 6978, p. 93-97 5 p.

Research output: Contribution to journalArticle

150 Citations (Scopus)

TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells

Rasmussen, K. D., Berest, I., Keβler, S., Nishimura, K., Simón-Carrasco, L., Vassiliou, G. S., Pedersen, M. T., Christensen, J., Zaugg, J. B. & Helin, K., Apr 2019, In : Genome Research. 29, 4, p. 564-575 12 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)
172 Downloads (Pure)

Tetrahymena telomerase contains an internal RNA template

Lamond, A. I., Jun 1989, In : Trends in Biochemical Sciences. 14, 6, p. 202-204 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)