Gene Regulation and Expression

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2001

Sit4p protein phosphatase is required for sensitivity of Saccharomyces cerevisiae to Kluyveromyces lactis zymocin

Jablonowski, D., Butler, A. R., Fichtner, L., Gardiner, D., Schaffrath, R. & Stark, M. J. R., Dec 2001, In : Genetics. 159, 4, p. 1479-1489 11 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

snRNP protein expression enhances the formation of Cajal bodies containing p80-coilin and SMN

Sleeman, J. E., Ajuh, P. & Lamond, A. I., 1 Dec 2001, In : Journal of Cell Science. 114, 24, p. 4407-4419 13 p.

Research output: Contribution to journalArticle

126 Citations (Scopus)

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

Schumacher, B., Hofmann, K., Boulton, S. & Gartner, A., Oct 2001, In : Current Biology. 11, 21, p. 1722-1727 6 p.

Research output: Contribution to journalArticle

253 Citations (Scopus)

The human oesophageal squamous epithelium exhibits a novel type of heat shock protein response

Yagui-Beltran, A., Craig, A. L., Lawrie, L., Thompson, D., Pospisilova, S., Johnston, D., Kernohan, N., Hopwood, D., Dillon, J. F. & Hupp, T. R., Oct 2001, In : European Journal of Biochemistry. 268, 20, p. 5343-5355 13 p.

Research output: Contribution to journalArticle

36 Citations (Scopus)

The Induction of Cyclooxygenase-2 mRNA in Macrophages Is Biphasic and Requires both CCAAT Enhancer-binding protein β (C/EBPβ) and C/EBPδ Transcription Factors

Caivano, M., Gorgoni, B., Cohen, P. & Poli, V., 28 Dec 2001, In : Journal of Biological Chemistry. 276, 52, p. 48693-48701 9 p.

Research output: Contribution to journalArticle

Open Access
134 Citations (Scopus)

The origin of CDK regulation

Li, A. & Blow, J. J., 2001, In : Nature Cell Biology. 3, 8, p. E182-E184 3 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages

Vosper, H., Patel, L., Graham, T. L., Khoudoli, G. A., Hill, A., Macphee, C. H., Pinto, I., Smith, S. A., Suckling, K. E., Wolf, C. R. & Palmer, C. N. A., Nov 2001, In : Journal of Biological Chemistry. 276, 47, p. 44258-44265 8 p.

Research output: Contribution to journalArticle

219 Citations (Scopus)

The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations

Van Hoof, C., Janssens, V., De Baere, I., Stark, M. J. R., de Winde, J. H., Winderickx, J., Thevelein, J. M., Merlevede, W. & Goris, J., 2001, In : Experimental Cell Research. 264, 2, p. 372-387 16 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

Use of peptides from p21 (Waf1/Cip1) to investigate PCNA function in Xenopus egg extracts

Mattock, H., Jares, P., Zheleva, D. I., Lane, D. P., Warbrick, E. & Blow, J. J., 2001, In : Experimental Cell Research. 265, 2, p. 242-251 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)
15 Citations (Scopus)
2000

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

Gartner, A., Milstein, S., Ahmed, S., Hodgkin, J. & Hengartner, M. O., 2000, In : Molecular Cell. 5, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

368 Citations (Scopus)

A novel 'two-component' protein containing histidine kinase and response regulator domains required for sporulation in Aspergillus nidulans

Appleyard, M. V. C. L., McPheat, W. L. & Stark, M. J. R., 2000, In : Current Genetics. 37, 6, p. 364-372 9 p.

Research output: Contribution to journalArticle

47 Citations (Scopus)

A recQ family DNA helicase gene from Aspergillus nidulans

Appleyard, M. V. C. L., McPheat, W. L. & Stark, M. J. R., 2000, In : Mitochondrial DNA. 11, 3-4, p. 315-319 5 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cell cycle: a new check on issuing the licence

Blow, J. J. & Tada, S., 2000, In : Nature. 404, 6778, p. 560-561 2 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Dynamic, Rho1p-dependent localization of Pkc1p to sites of polarized growth

Andrews, P. D. & Stark, M. J. R., 2000, In : Journal of Cell Science. 113, 15, p. 2685-2693 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Editorial overview

Blow, J. J., 2000, In : Current Opinion in Cell Biology. 12, 6, p. 655-657 3 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Evaluation of the CaMAL2 promoter for regulated expression of genes in Candida albicans

Backen, A. C., Broadbent, I. D., Fetherston, R. W., Rosamond, J. D. C., Schnell, N. F. & Stark, M. J. R., 2000, In : Yeast. 16, 12, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Fa1p is a 171 kDa protein essential for axonemal microtubule severing in Chlamydomonas

Finst, R. J., Kim, P. J., Griffis, E. R. & Quarmby, L. M., 2000, In : Journal of Cell Science. 113, 11, p. 1963-71 9 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry

Ajuh, P., Kuster, B., Panov, K., Zomerdijk, J. C. B. M., Mann, M. & Lamond, A. I., 2000, In : EMBO Journal. 19, 23, p. 6569-6581 13 p.

Research output: Contribution to journalArticle

149 Citations (Scopus)

Interaction of Xenopus Cdc2 x cyclin A1 with the origin recognition complex

Romanowski, P., Marr, J., Madine, M. A., Rowles, A., Blow, J. J., Gautier, J. & Laskey, R. A., 2000, In : Journal of Biological Chemistry. 275, 6, p. 4239-4243 5 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

In vivo analysis of Cajal body movement, separation, and joining in live human cells

Platani, M., Goldberg, I., Swedlow, J. R. & Lamond, A. I., 31 Dec 2000, In : Journal of Cell Biology. 151, 7, p. 1561-1574 14 p.

Research output: Contribution to journalArticle

Open Access
194 Citations (Scopus)
36 Citations (Scopus)

Pin1-dependent prolyl isomerization regulates dephosphorylation of Cdc25C and tau proteins

Zhou, X. Z., Kops, O., Werner, A., Lu, P-J., Shen, M., Stoller, G., Kullertz, G., Stark, M., Fischer, G. & Lu, K. P., 2000, In : Molecular Cell. 6, 4, p. 873-883 11 p.

Research output: Contribution to journalArticle

444 Citations (Scopus)

Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity

Prokhorova, T. A. & Blow, J. J., 2000, In : Journal of Biological Chemistry. 275, 4, p. 2491-2498 8 p.

Research output: Contribution to journalArticle

89 Citations (Scopus)

The Cdc7/Dbf4 protein kinase: target of the S phase checkpoint?

Jares, P., Donaldson, A. & Blow, J. J., 2000, In : EMBO Reports. 1, 4, p. 319-322 4 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

The manganese cation disrupts membrane dynamics along the secretory pathway

Towler, M. C., Prescott, A. R., James, J., Lucocq, J. M. & Ponnambalam, S., 25 Aug 2000, In : Experimental Cell Research. 259, 1, p. 167-179 13 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The nucleolus

Lyon, C. E. & Lamond, A. I., 1 May 2000, In : Current biology : CB. 10, 9, p. R323 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins

Sun, W., Hola, M., Pedley, K., Tada, S., Blow, J. J., Todorov, I. T., Kearsey, S. E. & Brooks, R. F., 2000, In : Journal of Cell Science. 113 , 4, p. 683-695 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)
66 Citations (Scopus)

Xenopus cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading

Jares, P. & Blow, J. J., 2000, In : Genes & Development. 14, 12, p. 1528-1540 13 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)
1999

An extreme cytoplasmic bottleneck in the modern European cultivated potato (Solanum tuberosum) is not reflected in decreased levels of nuclear diversity

Provan, J., Powell, W., Dewar, H., Bryan, G., Machray, G. C. & Waugh, R., 22 Mar 1999, In : Proceedings of the Royal Society B: Biological Sciences. 266, 1419, p. 633-639 7 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins

Rowles, A., Tada, S. & Blow, J. J., 1999, In : Journal of Cell Science. 112 , 12, p. 2011-2018 8 p.

Research output: Contribution to journalArticle

142 Citations (Scopus)

Control of the terminal step of intracellular membrane fusion by protein phosphatase 1

Peters, C., Andrews, P. D., Stark, M. J. R., Cesaro-Tadic, S., Glatz, A., Podtelejnikov, A., Mann, M. & Mayer, A., 1999, In : Science. 285, 5430, p. 1084-1087 4 p.

Research output: Contribution to journalArticle

135 Citations (Scopus)

Purification and depletion of RNP particles by antisense affinity chromatography.

Blencowe, B. J. & Lamond, A. I., 1999, In : Methods in Molecular Biology (Clifton, N.J.). 118, p. 275-287 13 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p

Sassoon, I., Severin, F. F., Andrews, P. D., Taba, M-R., Kaplan, K. B., Ashford, A. J., Stark, M. J. R., Sorger, P. K. & Hyman, A. A., 1999, In : Genes & Development. 13, 5, p. 545-555 11 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)

Saying a firm 'no' to DNA re-replication

Blow, J. J. & Prokhorova, T. A., 1999, In : Nature Cell Biology. 1, 7, p. E175-E177 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

The regulation of replication origin activation

Donaldson, A. D. & Blow, J. J., 1999, In : Current Opinion in Genetics & Development. 9, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin

Tada, S., Chong, J. P. J., Mahbubani, H. M. & Blow, J. J., 1999, In : Current Biology. 9, 4, p. 211-214 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)
1998

Cloning and characterization of hSRP1γ, a tissue-specific nuclear transport factor

Nachury, M. V., Ryder, U. W., Lamond, A. I. & Weis, K., 20 Jan 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 2, p. 582-587 6 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Dynamic interactions between splicing snRNPs, coiled bodies and nucleoli revealed using snRNP protein fusions to the green fluorescent protein

Sleeman, J., Lyon, C. E., Platani, M., Kreivi, J. P. & Lamond, A. I., 15 Sep 1998, In : Experimental Cell Research. 243, 2, p. 290-304 15 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Identification and characterization of the KlCMD1 gene encoding Kluyveromyces lactis calmodulin

Rayner, T. F. & Stark, M. J. R., 1998, In : Yeast. 14, 9, p. 869-875 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins

Zachariae, W., Shevchenko, A., Andrews, P. D., Ciosk, R., Galova, M., Stark, M. J. R., Mann, M. & Nasmyth, K., 1998, In : Science. 279, 5354, p. 1216-1219 4 p.

Research output: Contribution to journalArticle

283 Citations (Scopus)

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

Neubauer, G., King, A., Rappsilber, J., Calvio, C., Watson, M., Ajuh, P., Sleeman, J., Lamond, A. & Mann, M., Sep 1998, In : Nature Genetics. 20, 1, p. 46-50 5 p.

Research output: Contribution to journalArticle

401 Citations (Scopus)

Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class Sigma glutathione S-transferase

Thomson, A. M., Meyer, D. J. & Hayes, J. D., 15 Jul 1998, In : Biochemical Journal. 333 ( Pt 2), p. 317-25 9 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

Subnuclear localization of the active variant surface glycoprotein gene expression site in Trypanosoma brucei

Chaves, I., Zomerdijk, J., Dirks-Mulder, A., Dirks, R. W., Raap, A. K. & Borst, P., 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 21, p. 12328-12333 6 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

Davies, R. C., Calvio, C., Bratt, E., Larsson, S. H., Lamond, A. I. & Hastie, N. D., 15 Oct 1998, In : Genes and Development. 12, 20, p. 3217-3225 9 p.

Research output: Contribution to journalArticle

193 Citations (Scopus)
1997
50 Citations (Scopus)

Inhibition of protein dephosphorylation results in the accumulation of splicing snRNPs and coiled bodies within the nucleolus

Lyon, C. E., Bohmann, K., Sleeman, J. & Lamond, A. I., 10 Jan 1997, In : Experimental Cell Research. 230, 1, p. 84-93 10 p.

Research output: Contribution to journalArticle

104 Citations (Scopus)