Gene Regulation and Expression

  • United Kingdom

Research Output

Filter
Article
Article

The Identification of Potential Therapeutic Targets for Cutaneous Squamous Cell Carcinoma

McHugh, A., Fernandes, K., Chinner, N., Ibrahim, A. F. M., Garg, A. K., Boag, G., Hepburn, L. A., Proby, C. M., Leigh, I. M. & Saville, M. K., 6 Nov 2019, In : Journal of Investigative Dermatology. 17 p.

Research output: Contribution to journalArticle

Open Access
File
56 Downloads (Pure)

The Image Data Resource: a bioimage data integration and publication platform

Williams, E., Moore, J., Li, S. W., Rustici, G., Tarkowska, A., Chessel, A., Leo, S., Antal, B., Ferguson, R. K., Sarkans, U., Brazma, A., Carzo Salas, R. E. & Swedlow, J. R., Aug 2017, In : Nature Methods. 14, 8, p. 775-781 7 p.

Research output: Contribution to journalArticle

Open Access
File
48 Citations (Scopus)
337 Downloads (Pure)

The Induction of Cyclooxygenase-2 mRNA in Macrophages Is Biphasic and Requires both CCAAT Enhancer-binding protein β (C/EBPβ) and C/EBPδ Transcription Factors

Caivano, M., Gorgoni, B., Cohen, P. & Poli, V., 28 Dec 2001, In : Journal of Biological Chemistry. 276, 52, p. 48693-48701 9 p.

Research output: Contribution to journalArticle

Open Access
134 Citations (Scopus)

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

Agger, K., Nishimura, K., Miyagi, S., Messling, J-E., Rasmussen, K. D. & Helin, K., 21 Aug 2019, In : Blood. 14 p.

Research output: Contribution to journalArticle

Open Access
File
1 Citation (Scopus)
174 Downloads (Pure)

The linear-plasmid-encoded toxin produced by the yeast Pichia acaciae : characterization and comparison with the toxin of Kluyveromyces lactis

McCracken, D. A., Martin, V. J., Stark, M. J. R. & Bolen, P. L., Feb 1994, In : Microbiology. 140, p. 425-431 7 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

The manganese cation disrupts membrane dynamics along the secretory pathway

Towler, M. C., Prescott, A. R., James, J., Lucocq, J. M. & Ponnambalam, S., 25 Aug 2000, In : Experimental Cell Research. 259, 1, p. 167-179 13 p.

Research output: Contribution to journalArticle

39 Citations (Scopus)

The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

Research output: Contribution to journalArticle

Open Access
File
2 Citations (Scopus)
113 Downloads (Pure)

The MRT-1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

Meier, B., Barber, L. J., Liu, Y., Shtessel, L., Boulton, S. J., Gartner, A. & Ahmed, S., 18 Nov 2009, In : EMBO Journal. 28, 22, p. 3549-3563 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

The multifunctional nucleolus

Boisvert, F-M., van Koningsbruggen, S., Navascués, J. & Lamond, A. I., 2007, In : Nature Reviews Molecular Cell Biology. 8, 7, p. 574-585 12 p.

Research output: Contribution to journalArticle

886 Citations (Scopus)

The "Mutated in Colorectal Cancer" Protein Is a Novel Target of the UV-Induced DNA Damage Checkpoint

Pangon, L., Sigglekow, N. D., Larance, M., Al-Sohaily, S., Mladenova, D. N., Selinger, C. I., Musgrove, E. A. & Kohonen-Corish, M. R. J., Sep 2010, In : Genes and Cancer. 1, 9, p. 917-926 10 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

The Ndc80 complex targets Bod1 to human mitotic kinetochores

Schleicher, K., Porter, M., ten Have, S., Sundaramoorthy, R., Porter, I. M. & Swedlow, J. R., 15 Nov 2017, In : Open Biology. 7, p. 1-14 14 p., 170099.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)
145 Downloads (Pure)

The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End

Maure, J-F., Komoto, S., Oku, Y., Mino, A., Pasqualato, S., Natsume, K., Clayton, L., Musacchio, A. & Tanaka, T. U., 8 Feb 2011, In : Current Biology. 21, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

68 Citations (Scopus)

The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway

Bailly, A., Perrin, A., Bou Malhab, L. J., Pion, E., Larance, M., Nagala, M., Smith, P., O'Donohue, M-F., Gleizes, P-E., Zomerdijk, J., Lamond, A. I. & Xirodimas, D. P., 28 Jan 2016, In : Oncogene. 35, 4, p. 415-426 12 p.

Research output: Contribution to journalArticle

Open Access
File
21 Citations (Scopus)
291 Downloads (Pure)

The NM23 family in development

Bilitou, A., Watson, J., Gartner, A. & Ohnuma, S., Sep 2009, In : Molecular and Cellular Biochemistry. 329, 1-2, p. 17-33 17 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans

Masoudi, N., Fancsalszky, L., Pourkarimi, E., Vellai, T., Alexa, A., Reményi, A., Gartner, A., Mehta, A. & Takács-Vellai, K., 15 Aug 2013, In : Development. 140, 16, p. 3486-3495 10 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

The nuclear ATPase/adenylate kinase hCINAP is recruited to perinucleolar caps generated upon RNA pol.II inhibition

Malekkou, A., Lederer, C. W., Lamond, A. I. & Santama, N., 19 Nov 2010, In : FEBS Letters. 584, 22, p. 4559-4564 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G

Ulke-Lemée, A., Trinkle-Mulcahy, L., Chaulk, S., Bernstein, N. K., Morrice, N., Glover, M., Lamond, A. I. & Moorhead, G. B. G., 1 Oct 2007, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1774, 10, p. 1339-1350 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

The nucleolus

Lyon, C. E. & Lamond, A. I., 1 May 2000, In : Current biology : CB. 10, 9, p. R323 1 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

The nucleolus

Lam, Y. W., Trinkle-Mulcahy, L. & Lamond, A. I., 2005, In : Journal of Cell Science. 118, 7, p. 1335-1337 3 p.

Research output: Contribution to journalArticle

Open Access
137 Citations (Scopus)

The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation

Carvalhal, S., Abreu Ribeiro, S., Arocena, M., Kasciukovic, T., Temme, A., Koehler, K., Huebner, A. & Griffis, E. R., 1 Oct 2015, In : Molecular Biology of the Cell. 26, 19, p. 3424-3438 15 p.

Research output: Contribution to journalArticle

Open Access
File
12 Citations (Scopus)
190 Downloads (Pure)

The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex

Platani, M., Santarella-Mellwig, R., Posch, M., Walczak, R., Swedlow, J. R. & Mattaj, I. W., 15 Dec 2009, In : Molecular Biology of the Cell. 20, 24, p. 5260-5275 16 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

Gundogdu, M., Llabres, S., Gorelik, A., Ferenbach, A., Zachariae, U. & Van Aalten, D., 17 May 2018, In : Cell Chemical Biology. 25, 5, p. 513-518.e4 10 p.

Research output: Contribution to journalArticle

Open Access
File
9 Citations (Scopus)
152 Downloads (Pure)

The open microscopy environment: informatics and quantitative analysis for biological microscopy

Swedlow, J. R., Allan, C., Burel, J-M., Linkert, M., Loranger, B., MacDonald, D., Moore, W. J., Patterson, A. J., Rueden, C., Tarkowska, A., Goldberg, I. G. & Eliceiri, K. W., Jul 2009, In : Microscopy and Microanalysis. 15, p. 1520-1521 2 p.

Research output: Contribution to journalArticle

The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging

Goldberg, I. G., Allan, C., Burel, J-M., Creager, D., Falconi, A., Hochheiser, H., Johnston, J., Mellen, J., Sorger, P. K. & Swedlow, J. R., 2005, In : Genome Biology. 6, 5, R47.

Research output: Contribution to journalArticle

151 Citations (Scopus)

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

Murdoch, S. L., Trunk, K., English, G., Fritsch, M. J., Pourkarimi, E. & Coulthurst, S. J., Nov 2011, In : Journal of Bacteriology. 193, 21, p. 6057-6069 13 p.

Research output: Contribution to journalArticle

133 Citations (Scopus)

The origin of CDK regulation

Li, A. & Blow, J. J., 2001, In : Nature Cell Biology. 3, 8, p. E182-E184 3 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro

Rocha, S., Campbell, K. J., Roche, K. C. & Perkins, N. D., Sep 2003, In : BMC Molecular Biology. 4, 9

Research output: Contribution to journalArticle

50 Citations (Scopus)

The p53 isoforms are differentially modified by Mdm2

Camus, S., Menendez, S., Fernandes, K., Kua, N., Liu, G., Xirodimas, D. P., Lane, D. P. & Bourdon, J-C., 15 Apr 2012, In : Cell Cycle. 11, 8, p. 1646-1655 10 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner

Wilson, B. J., Bates, G. J., Nicol, S. M., Gregory, D. J., Perkins, N. D. & Fuller-Pace, F. V., 6 Aug 2004, In : BMC Molecular Biology. 5, 15 p., 11.

Research output: Contribution to journalArticle

Open Access
File
105 Citations (Scopus)
68 Downloads (Pure)

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T., 15 Apr 2013, In : Biochemical Journal. 451, 2, p. 185-194 10 p., BJ20130026.

Research output: Contribution to journalArticle

29 Citations (Scopus)

The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages

Vosper, H., Patel, L., Graham, T. L., Khoudoli, G. A., Hill, A., Macphee, C. H., Pinto, I., Smith, S. A., Suckling, K. E., Wolf, C. R. & Palmer, C. N. A., Nov 2001, In : Journal of Biological Chemistry. 276, 47, p. 44258-44265 8 p.

Research output: Contribution to journalArticle

219 Citations (Scopus)

The peroxisome proliferator activated receptor δ is required for the differentiation of THP-1 monocytic cells by phorbol ester

Vosper, H., Khoudoli, G. A. & Palmer, C. N. A., 11 Dec 2003, In : Nuclear Receptor. 1, 10 p., 9.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
46 Downloads (Pure)

The PHD and Chromo Domains Regulate the ATPase Activity of the Human Chromatin Remodeler CHD4

Watson, A. A., Mahajan, P., Mertens, H. D. T., Deery, M. J., Zhang, W., Chen, Y., Edlich, C., Laue, E. D., Berridge, G., Burgess-Brown, N. A., Gileadi, O., Svergun, D. I., Pham, P., Du, X., Bartke, T., Kouzarides, T., Wiechens, N. & Owen-Hughes, T., 2012, In : Journal of Molecular Biology. 422, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)
16 Citations (Scopus)

The prevalence and origin of exoprotease-producing cells in the Bacillus subtilis biofilm

Marlow, V. L., Cianfanelli, F. R., Porter, M., Cairns, L. S., Dale, J. K. & Stanley-Wall, N. R., Jan 2014, In : Microbiology. 160, 1, p. 56-66 11 p.

Research output: Contribution to journalArticle

Open Access
File
19 Citations (Scopus)
161 Downloads (Pure)

The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei

Zomerdijk, J. C. B. M., Ouellette, M., ten Asbroek, A. L. M. A., Kieft, R., Bommer, A. M. M., Clayton, C. E. & Borst, P., 1990, In : EMBO Journal. 9, 9, p. 2791-2801 11 p.

Research output: Contribution to journalArticle

The Proteasomal Deubiquitinating Enzyme PSMD14 Regulates Macroautophagy by Controlling Golgi-to-ER Retrograde Transport

Bustamante, H. A., Cereceda, K., González, A. E., Valenzuela, G. E., Cheuquemilla, Y., Hernández, S., Arias-Muñoz, E., Cerda-Troncoso, C., Bandau, S., Soza, A., Kausel, G., Kerr, B., Mardones, G. A., Cancino, J., Hay, R. T., Rojas-Fernandez, A. & Burgos, P. V., 23 Mar 2020, In : Cells. 9, 3, p. 1-24 24 p., 777.

Research output: Contribution to journalArticle

Open Access
File
15 Downloads (Pure)

The regulation of chromosome replication

Blow, J. J., Jun 1992, In : Journal of Pathology. 167, 2, p. 175-179 5 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

The regulation of replication origin activation

Donaldson, A. D. & Blow, J. J., 1999, In : Current Opinion in Genetics & Development. 9, 1, p. 62-68 7 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)

The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins

Sun, W., Hola, M., Pedley, K., Tada, S., Blow, J. J., Todorov, I. T., Kearsey, S. E. & Brooks, R. F., 2000, In : Journal of Cell Science. 113 , 4, p. 683-695 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription

Nieduszynski, C. A., Blow, J. J. & Donaldson, A. D., 2005, In : Nucleic Acids Research. 33, 8, p. 2410-20 11 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

Jannot, G., Bajan, S., Giguère, N. J., Bouasker, S., Banville, I. H., Piquet, S., Hutvagner, G. & Simard, M. J., Jun 2011, In : EMBO Reports. 12, 6, p. 581-586 6 p.

Research output: Contribution to journalArticle

Open Access
File
49 Citations (Scopus)
171 Downloads (Pure)

The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin

Tada, S., Chong, J. P. J., Mahbubani, H. M. & Blow, J. J., 1999, In : Current Biology. 9, 4, p. 211-214 4 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

The RNA-binding proteins Zfp36l1 and Zfp36l2 enforce the Thymic β-selection checkpoint by limiting DNA damage response signaling and cell cycle progression

Vogel, K. U., Bell, L. S., Galloway, A., Ahlfors, H. & Turner, M., 1 Oct 2016, In : Journal of Immunology. 197, 7, p. 2673-2685 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation

Oehlmann, M., Score, A. J. & Blow, J. J., 2004, In : Journal of Cell Biology. 165, 2, p. 181-90 10 p.

Research output: Contribution to journalArticle

98 Citations (Scopus)

The role of cyclin synthesis, modification and destruction in the control of cell division

Minshull, J., Pines, J., Golsteyn, R., Standart, N., Mackie, S., Colman, A., Blow, J., Ruderman, J. V., Wu, M. & Hunt, T., Feb 1989, In : Journal of Cell Science. 1989, Supplement 12, p. 77-97 21 p.

Research output: Contribution to journalArticle

Open Access
File
108 Citations (Scopus)
121 Downloads (Pure)

The role of hypoxia in inflammatory disease (Review)

Biddlestone, J., Bandarra, D. & Rocha, S., 1 Apr 2015, In : International Journal of Molecular Medicine. 35, 4, p. 859-869 11 p.

Research output: Contribution to journalArticle

Open Access
70 Citations (Scopus)

The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

Msaki, A., Sanchez, A. M., Koh, L. F., Barre, B., Rocha, S., Perkins, N. D. & Johnson, R. F., 1 Sep 2011, In : Molecular Biology of the Cell. 22, 17, p. 3032-3040 9 p.

Research output: Contribution to journalArticle

Open Access
File
24 Citations (Scopus)
130 Downloads (Pure)

The role of the replication licensing system in cell proliferation and cancer

Shreeram, S. & Blow, J., 2003, In : Progress in Cell Cycle Research. 5, p. 287-293 7 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

The Saccharomyces cerevisiae gene SDS22 encodes a potential regulator of the mitotic function of yeast type 1 protein phosphatase

MACKELVIE, SARAH. H., ANDREWS, PAUL. D. & STARK, MICHAEL. J. R., Jul 1995, In : Molecular and Cellular Biology. 15, 7, p. 3777-3785 9 p.

Research output: Contribution to journalArticle

81 Citations (Scopus)