Gene Regulation and Expression

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2018

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei

Crozier, T. W. M., Tinti, M., Wheeler, R. J., Ly, T., Ferguson, M. A. J. & Lamond, A. I., 1 Jun 2018, In : Molecular & Cellular Proteomics. 17, 6, p. 1184-1195 12 p.

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6 Citations (Scopus)
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Publisher Correction: Image Data Resource: a bioimage data integration and publication platform

Williams, E., Moore, J., Li, S. W., Rustici, G., Tarkowska, A., Chessel, A., Leo, S., Antal, B., Ferguson, R. K., Sarkans, U., Brazma, A., Carazo Salas, R. E. & Swedlow, J. R., 4 Oct 2018, In : Nature Methods. 15, 11, p. 984-984 1 p.

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Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila

Clemente, G. D., Hannaford, M. R., Beati, H., Kapp, K., Januschke, J., Griffis, E. R. & Müller, H-A. J., Jun 2018, In : Journal of Developmental Biology. 6, 2, 23 p., 9.

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3 Citations (Scopus)
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RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation

Bustos, F., Segarra Fas, A., Chaugule, V. K., Brandenburg, L., Branigan, E., Toth, R., Macartney, T., Knebel, A., Hay, R., Walden, H. & Findlay, G., 8 May 2018, In : Cell Reports. 23, 6, p. 1599-1611 13 p.

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5 Citations (Scopus)
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Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron

Gray, K. M., Kaifer, K. A., Baillat, D., Wen, Y., Bonacci, T. R., Ebert, A. D., Raimer, A. C., Spring, A. M., Have, S. T., Glascock, J. J., Gupta, K., Van Duyne, G. D., Emanuele, M. J., Lamond, A. I., Wagner, E. J., Lorson, C. L. & Matera, A. G., 15 Jan 2018, In : Molecular Biology of the Cell. 29, 2, p. 96-110 15 p.

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9 Citations (Scopus)
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SINHCAF/FAM60A and SIN3A specifically repress HIF 2α expression

Biddlestone, J., Batie, M., Bandarra, D., Munoz, I. & Rocha, S., 29 Jun 2018, In : Biochemical Journal. 475, 12, p. 2073-2090 18 p.

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2 Citations (Scopus)
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Spindly is required for rapid migration of human cells

Conte, C., Baird, M. A., Davidson, M. W. & Griffis, E. R., 29 May 2018, In : Biology Open. 7, 5, 9 p., 033233 .

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2 Citations (Scopus)
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Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, p. 1-28 28 p., e35720.

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18 Citations (Scopus)
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Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

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7 Citations (Scopus)
107 Downloads (Pure)

The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Barini, E., Miccoli, A., Tinarelli, F., Mulholland, K., Kadri, H., Khanim, F., Stojanovski, L., Read, K. D., Burness, K., Blow, J. J., Mehellou, Y. & Muqit, M. M. K., 2 Mar 2018, In : ChemBioChem. 19, 5, p. 425-429 5 p.

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9 Citations (Scopus)
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The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

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4 Citations (Scopus)
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The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT: UDP-GlcNAc glycosylation and proteolysis activities

Kapuria, V., Röhrig, U. F., Waridel, P., Lammers, F., Borodkin, V. S., van Aalten, D. M. F., Zoete, V. & Herr, W., 16 Nov 2018, In : Journal of Biological Chemistry. 293, 46, p. 17754-17768 15 p.

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The Encyclopedia of Proteome Dynamics – A big data ecosystem for (prote)omics

Brenes Murillo, A., Afzal, V., Kent, R. & Lamond, A., 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1202-D1209 8 p.

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7 Citations (Scopus)
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The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

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2 Citations (Scopus)
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The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

Gundogdu, M., Llabres, S., Gorelik, A., Ferenbach, A., Zachariae, U. & Van Aalten, D., 17 May 2018, In : Cell Chemical Biology. 25, 5, p. 513-518.e4 10 p.

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8 Citations (Scopus)
141 Downloads (Pure)

Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors

Rafie, K., Gorelik, A., Trapannone, R., Borodkin, V. & Van Aalten, D., 20 Jun 2018, In : Bioconjugate Chemistry. 29, 6, p. 1834-1840 7 p.

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5 Citations (Scopus)
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TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway

D'Ignazio, L., Batie, M. & Rocha, S., 8 Aug 2018, In : Cells. 7, 8, p. 1-14 14 p., 102.

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TRIM17 and TRIM28 antagonistically regulate the ubiquitination and anti-apoptotic activity of BCL2A1

Lionnard, L., Duc, P., Brennan, M. S., Kueh, A. J., Pal, M., Guardia, F., Mojsa, B., Damiano, M. A., Mora, S., Lassot, I., Ravichandran, R., Cochet, C., Aouacheria, A., Potts, P. R., Herold, M. J., Desagher, S. & Kucharczak, J., 24 Jul 2018, In : Cell Death and Differentiation.

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5 Citations (Scopus)
212 Downloads (Pure)

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies

Ghirardello, M., Perrone, D., Chinaglia, N., Sádaba, D., Delso, I., Tejero, T., Marchesi, E., Fogagnolo, M., Rafie, K., van Aalten, D. M. F. & Merino, P., 17 May 2018, In : Chemistry: a European Journal. 24, 28, p. 7264-7272 9 p.

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3 Citations (Scopus)
76 Downloads (Pure)

USP45 and Spindly are part of the same complex implicated in cell migration

Conte, C., Griffis, E., Hickson, I. D. & Perez-Oliva, A., 26 Sep 2018, In : Scientific Reports. 8, 1, 13 p., 14375.

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1 Citation (Scopus)
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Visualization of Biomedical Data

O'Donoghue, S. I., Baldi, B. F., Clark, S. J., Darling, A. E., Hogan, J. M., Kaur, S., Maier-Hein, L., McCarthy, D. J., Moore, W., Stenau, E., Swedlow, J., Vuong, J. & Procter, J., 20 Jul 2018, In : Annual Review of Biomedical Data Science. 1

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2017

A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis

Makrantoni, V., Ciesiolka, A., Lawless, C., Fernius, J., Marston, A. L., Lydall, D. & Stark, M. J. R., 7 Sep 2017, In : G3 : Genes, Genomes, Genetics. 7, 9, p. 3203-3215 13 p.

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2 Citations (Scopus)
130 Downloads (Pure)

A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

Zhang, R., Calixto, C. P. G., Marquez, Y., Venhuizen, P., Tzioutziou, N. A., Guo, W., Spensley, M., Entizne, J. C., Lewandowska, D., ten Have, S., Frei dit Frey, N., Hirt, H., James, A. B., Nimmo, H. G., Barta, A., Kalyna, M. & Brown, J. W. S., 19 May 2017, In : Nucleic Acids Research. 45, 9, p. 5061-5073 13 p.

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54 Citations (Scopus)
179 Downloads (Pure)

ALADIN is Required for the Production of Fertile Mouse Oocytes

Carvalhal, S., Stevense, M., Koehler, K., Naumann, R., Huebner, A., Jessberger, R. & Griffis, E. R., 17 Sep 2017, In : Molecular Biology of the Cell. 28, 19, p. 2470-2478 9 p.

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6 Citations (Scopus)
127 Downloads (Pure)

A mutant O-GlcNAcase enriches Drosophila developmental regulators

Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In : Nature Chemical Biology. 13, 8, p. 882-887 8 p.

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17 Citations (Scopus)
148 Downloads (Pure)

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Mishra, A., Oulès, B., Pisco, A. O., Ly, T., Liakath-Ali, K., Walko, G., Viswanathan, P., Tihy, M., Nijjhar, J., Dunn, S-J., Lamond, A. I. & Watt, F. M., 18 Oct 2017, In : eLife. 6, p. 1-20 20 p., e27356.

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9 Citations (Scopus)
193 Downloads (Pure)

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

Tatham, M. H., Cole, C., Scullion, P., Wilkie, R., Westwood, N. J., Stark, L. A. & Hay, R. T., 1 Feb 2017, In : Molecular & Cellular Proteomics. 16, 2, p. 310-326 17 p.

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20 Citations (Scopus)
168 Downloads (Pure)

A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans

González-Huici, V., Wang, B. & Gartner, A., 1 Aug 2017, In : Genetics. 206, 4, p. 1853-1864 12 p.

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3 Citations (Scopus)
153 Downloads (Pure)

A SUMO-Dependent Protein Network Regulates Chromosome Congression During Oocyte Meiosis

Pelisch, F., Tammsalu, T., Wang, B., Jaffray, E. G., Gartner, A. & Hay, R. T., 5 Jan 2017, In : Molecular Cell. 65, 1, p. 66-77 12 p.

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19 Citations (Scopus)
287 Downloads (Pure)

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

González, A. E., Muñoz, V. C., Cavieres, V. A., Bustamante, H. A., Cornejo, V-H., Januário, Y. C., González, I., Hetz, C., daSilva, L. L., Rojas-Fernández, A., Hay, R. T., Mardones, G. A. & Burgos, P. V., Jun 2017, In : FASEB Journal. 31, 6, p. 2446-2459 14 p.

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17 Citations (Scopus)
217 Downloads (Pure)
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5 Citations (Scopus)
163 Downloads (Pure)
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190 Downloads (Pure)

Cell cycle RNA regulons coordinating early lymphocyte development

Galloway, A. & Turner, M., 2017, In : Wiley Interdisciplinary Reviews: RNA. 8, 5, p. 1-15 15 p., e1419.

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5 Citations (Scopus)
116 Downloads (Pure)

Characterisation of the biflavonoid hinokiflavone as a premRNA splicing modulator that inhibits SENP

Pawellek, A., Ryder, U., Tammsalu, T., King, L. J., Kreinin, H., Ly, T., Hay, R. T., Hartley, R. & Lamond, A., 8 Sep 2017, In : eLife. 6, e27402.

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7 Citations (Scopus)
134 Downloads (Pure)

c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production

Dunn, S., Lombardi, O. & Cowling, V., 20 Jan 2017, In : Biochemical Journal. 474, 3, p. 377-384 8 p.

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1 Citation (Scopus)
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Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., Danecek, P., Faulconbridge, A., Harrison, P. W., Kathuria, A., McCarthy, D. J., McCarthy, S. A., Meleckyte, R., Memari, Y., Moens, N., Soares, F. & 23 others, Mann, A., Streeter, I., Agu, C. A., Alderton, A., Nelson, R., Harper, S., Patel, M., White, A., Patel, S. R., Clarke, L., Halai, R., Kirton, C. M., Kolb-Kokocinski, A., Beales, P. L., Birney, E., Danovi, D., Lamond, A. I., Ouwehand, W. H., Vallier, L., Watt, F. M., Durbin, R., Stegle, O. & Gaffney, D. J., 15 Jun 2017, In : Nature. 546, 7658, p. 370-375 6 p.

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119 Citations (Scopus)
136 Downloads (Pure)
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4 Citations (Scopus)
153 Downloads (Pure)

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

Ugun-Klusek, A., Tatham, M. H., Elkharaz, J., Constantin-Teodosiu, D., Lawler, K., Mohamed, H., Paine, S. M. L., Anderson, G., John Mayer, R., Lowe, J., Ellen Billett, E. & Bedford, L., Jan 2017, In : Cell Death and Disease. 8, p. 1-12 12 p., e2531.

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12 Citations (Scopus)
146 Downloads (Pure)

Control of amino-acid transport coordinates metabolic reprogramming in T cell malignancy

Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. & Cantrell, D. A., 26 May 2017, In : Leukemia. 31, p. 2771-2779 9 p.

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11 Citations (Scopus)
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CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

Sonneville, R., Priego Moreno, S., Knebel, A., Johnson, C., Hastie, C. J., Gartner, A., Gambus, A. & Labib, K., 3 Apr 2017, In : Nature Cell Biology. 19, p. 468-479 11 p.

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23 Citations (Scopus)
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Cutting Edge: Building bridges between cellular and molecular structural biology

Patwardhan, A., Brandt, R., Butcher, S. J., Collinson, L., Gault, D., Grünewald, K., Hecksel, C., Huiskonen, J. T., Iudin, A., Jones, M. L., Korir, P. K., Koster, A. J., Lagerstedt, I., Lawson, C. L., Mastronarde, D., McCormick, M., Parkinson, H. E., Rosenthal, P. B., Saalfeld, S., Saibil, H. R. & 7 others, Sarntivijai, S., Solanes Valero, I., Subramaniam, S., Swedlow, J. R., Tudose, I., Winn, M. & Kleywegt, G. J., 24 Jul 2017, In : eLife. 6, p. 1-11 11 p., e25835.

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6 Citations (Scopus)
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Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry

Leney, A. C., Rafie, K., Van Aalten, D. M. F. & Heck, A. J. R., 18 Aug 2017, In : ACS Chemical Biology. 12, 8, p. 2078-2084 7 p.

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6 Citations (Scopus)
125 Downloads (Pure)

Effector-Decoy Pairs: Another Countermeasure Emerging during Host-Microbe Co-evolutionary Arms Races?

Cummins, M. & Huitema, E., 1 May 2017, In : Molecular Plant. 10, 5, p. 662-664 3 p.

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1 Citation (Scopus)
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Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates

Hauer, M. H., Seeber, A., Singh, V., Thierry, R., Sack, R., Amitai, A., Kryzhanovska, M., Eglinger, J., Holcman, D., Owen-Hughes, T. & Gasser, S. M., Feb 2017, In : Nature Structural & Molecular Biology. 24, 2, p. 99-107 13 p.

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65 Citations (Scopus)
232 Downloads (Pure)

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Maniaci, C., Hughes, S. J., Testa, A., Chen, W., Lamont, D. J., Rocha, S., Alessi, D. R., Romeo, R. & Ciulli, A., 10 Oct 2017, In : Nature Communications. 8, p. 1-14 14 p., 830.

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53 Citations (Scopus)
164 Downloads (Pure)

Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

Hiraga, S., Ly, T., Garzón, J., Hořejší, Z., Ohkubo, Y., Endo, A., Obuse, C., Boulton, S. J., Lamond, A. & Donaldson, A. D., 1 Mar 2017, In : EMBO Reports. 18, 3, p. 403-419 17 p.

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41 Citations (Scopus)
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KDM2 family members are regulated by HIF-1 in hypoxia.

Batie, M., Druker, J., D'Ignazio, L. & Rocha, S., 17 Mar 2017, In : Cells. 6, 1, p. 1-16 16 p., 8.

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Mechanisms mitigating problems with multiple kinetochores on one microtubule in early mitosis

Yue, Z., Komoto, S., Gierlinski, M., Pasquali, D., Kitamura, E. & Tanaka, T. U., 15 Jul 2017, In : Journal of Cell Science. 130, 14, p. 2266-2276 11 p.

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Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial

REMOVAL Trial Team, Petrie, J. R., Chaturvedi, N., Ford, I., Hramiak, I., Hughes, A. D., Jenkins, A. J., E. Klein, B., Klein, R., Ooi, T. C., Rossing, P., Sattar, N. & Stehouwer, C. D. A., 1 Apr 2017, In : Diabetes, Obesity and Metabolism. 19, 4, p. 509-516 8 p.

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13 Citations (Scopus)
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Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules

Vasileva, V., Gierlinski, M., Yue, Z., O'Reilly, N., Kitamura, E. & Tanaka, T. U., 26 Apr 2017, In : Journal of Cell Biology. 216, 6, p. 1809-1822 14 p.

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7 Citations (Scopus)
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