Gene Regulation and Expression

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2018

Expanded Interactome of the Intrinsically Disordered Protein Dss1

Schenstrøm, S. M., Rebula, C. A., Tatham, M. H., Hendus-Altenburger, R., Jourdain, I., Hay, R. T., Kragelund, B. B. & Hartmann-Petersen, R., 23 Oct 2018, In : Cell Reports. 25, 4, p. 862-870 9 p.

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2 Citations (Scopus)
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32 Citations (Scopus)
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Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

Shoaib, M., Walter, D., Gillespie, P. J., Izard, F., Fahrenkrog, B., Lleres, D., Lerdrup, M., Johansen, J. V., Hansen, K., Julien, E., Blow, J. J. & Sørensen, C. S., 12 Sep 2018, In : Nature Communications. 9, 1, p. 1-11 11 p., 3704.

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4 Citations (Scopus)
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Identification of Elg1 interaction partners and effects on post-replication chromatin re-formation

Gali, V. K., Dickerson, D., Katou, Y., Fujiki, K., Shirahige, K., Owen-Hughes, T., Kubota, T. & Donaldson, A. D., Nov 2018, In : PLoS Genetics. 14, 11, p. 1-20 20 p., e1007783.

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2 Citations (Scopus)
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Inhibitors against Fungal Cell Wall Remodeling Enzymes

Delso, I., Valero-Gonzalez, J., Gomollón-Bel, F., Castro-López, J., Fang, W., Navratilova, I., van Aalten, D. M. F., Tejero, T., Merino, P. & Hurtado-Guerrero, R., 22 Jan 2018, In : ChemMedChem. 13, 2, p. 128-132 5 p.

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1 Citation (Scopus)
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Killing with proficiency: integrated post-translational regulation of an offensive Type VI secretion system

Ostrowski, A., Cianfanelli, F. R., Porter, M., Mariano, G., Peltier, J., Wong, J. J., Swedlow, J. R., Trost, M. & Coulthurst, S. J., 27 Jul 2018, In : PLoS Pathogens. 14, 7, p. 1-25 25 p., e1007230.

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8 Citations (Scopus)
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LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Hong, Y., Sonneville, R., Wang, B., Scheidt, V., Meier, B., Woglar, A., Demetriou, S., Labib, K., Jantsch, V. & Gartner, A., 20 Feb 2018, In : Nature Communications. 9, p. 1-11 11 p., 728.

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11 Citations (Scopus)
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Live-cell imaging of marked chromosome regions reveals dynamics of mitotic chromosome resolution and compaction

Eykelenboom, J. K., Gierlinski, M., Yue, Z., Hegarat, N., Pollard, H., Fukagawa, T., Hochegger, H. & Tanaka, T. U., 17 May 2018, In : BioRxiv. 53 p.

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Mechanism of activation of the BNLF2a immune evasion gene of Epstein-Barr virus by Zta

Almohammed, R., Osborn, K., Ramasubramanyan, S., Perez-Fernandez, I. B. N., Godfrey, A., Mancini, E. J. & Sinclair, A. J., 1 Jun 2018, In : Journal of General Virology. 99, 6, p. 805-817 13 p., 001056.

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Morphological and genetic characterisation of the root system architecture of selected barley recombinant chromosome substitution lines using an integrated phenotyping approach

Canto, C. D. L. F., Kalogiros, D. I., Ptashnyk, M., George, T. S., Waugh, R., Bengough, A. G., Russell, J. & Dupuy, L. X., 14 Jun 2018, In : Journal of Theoretical Biology. 447, p. 84-97 14 p.

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2 Citations (Scopus)
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mRNA cap methyltransferase, RNMT-RAM, promotes RNA pol II-dependent transcription

Varshney, D., Lombardi, O., Schweikert, G., Dunn, S., Suska, O. & Cowling, V., May 2018, In : Cell Reports. 23, 5, p. 1530-1542 13 p.

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9 Citations (Scopus)
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Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

Meier, B., Volkova, N. V., Hong, Y., Schofield, P., Campbell, P. J., Gerstung, M. & Gartner, A., May 2018, In : Genome Research. 28, 5, p. 666-675 10 p.

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20 Citations (Scopus)
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Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

Offenburger, S-L., Jongsma, E. & Gartner, A., 18 Jan 2018, In : PLoS Genetics. 14, 1, p. 1-34 34 p., e1007106.

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6 Citations (Scopus)
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Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse

Mastromina, I., Verrier, L., Clara Silva, J., Storey, K. & Dale, J., 30 Jul 2018, In : Development. 145, 14, p. 1-14 14 p., dev161091.

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3 Citations (Scopus)
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O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry

Borodkin, V. S., Rafie, K., Selvan, N., Aristotelous, T., Navratilova, I., Ferenbach, A. T. & Van Aalten, D. M. F., 18 May 2018, In : ACS Chemical Biology. 13, 5, p. 1353-1360 8 p.

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3 Citations (Scopus)
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PAWS1controls cytoskeletal dynamics and cell migration through association with the SH3 adaptor CD2AP

Cummins, T. D., Wu, K. Z. L., Bozatzi, P., Dingwell, K. S., Macartney, T. J., Wood, N. T., Varghese, J., Gourlay, R., Campbell, D. G., Prescott, A., Griffis, E., Smith, J. C. & Sapkota, G. P., 10 Jan 2018, In : Journal of Cell Science. 131, 1, p. 1-12 12 p., jcs202390.

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12 Citations (Scopus)
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Phosphorylation of Parkin at Serine65 is essential for its activation in vivo

McWilliams, T. G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S. P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava Garriga, L., Prescott, A., Hassoun, S. M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D. A., Tamjar, J., Antico, O., Fears, K. & 11 others, Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S. B., Ganley, I., Suomalainen, A. & Muqit, M., 7 Nov 2018, In : Open Biology. 8, 11, p. 1-18 18 p., 181108.

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20 Citations (Scopus)
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PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ

Jonik-Nowak, B., Menneteau, T., Fesquet, D., Baldin, V., Bonne-Andrea, C., Méchali, F., Fabre, B., Boisguerin, P., de Rossi, S., Henriquet, C., Pugnière, M., Ducoux-Petit, M., Burlet-Schiltz, O., Lamond, A., Fort, P., Boulon, S., Bousquet, M-P. & Coux, O., 10 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 28, p. E6477-E6486 10 p., 201722299.

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10 Citations (Scopus)
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Positioning Europe for the EPITRANSCRIPTOMICS challenge

Jantsch, M., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J-Y., Balatsos, N., Dinnyes, A., Baranov, P., Kelly, V. & 40 others, Lamm, A., Rechavi, G., Pelizzola, M., Liepins, J., Holodnuka Kholodnyuk, I., Zammit, V., Ayers, D., Drablos, F., Dahl, J. A., Bujnicki, J., Jeronimo, C., Almeida, R., Neagu, M., Costache, M., Bankovic, J., Banovic, B., Kyselovic, J., Valor, L. M., Selbert, S., Pir, P., Demircan, T., Cowling, V., Schäfer, M., Rossmanith, W., Lafontaine, D., David, A., Carre, C., Lyko, F., Schaffrath, R., Schwartz, S., Verdel, A., Klungland, A., Purta, E., Timotijevic, G., Cardona, F., Davalos, A., Ballana, E., O Carroll, D., Ule, J. & Fray, R., 3 Jun 2018, In : RNA Biology. 15, 6, p. 829-831 8 p.

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9 Citations (Scopus)
156 Downloads (Pure)
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3 Citations (Scopus)
137 Downloads (Pure)

Proteomic analysis of the cell cycle of procylic form Trypanosoma brucei

Crozier, T. W. M., Tinti, M., Wheeler, R. J., Ly, T., Ferguson, M. A. J. & Lamond, A. I., 1 Jun 2018, In : Molecular & Cellular Proteomics. 17, 6, p. 1184-1195 12 p.

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7 Citations (Scopus)
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Publisher Correction: Image Data Resource: a bioimage data integration and publication platform

Williams, E., Moore, J., Li, S. W., Rustici, G., Tarkowska, A., Chessel, A., Leo, S., Antal, B., Ferguson, R. K., Sarkans, U., Brazma, A., Carazo Salas, R. E. & Swedlow, J. R., 4 Oct 2018, In : Nature Methods. 15, 11, p. 984-984 1 p.

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1 Citation (Scopus)

Requirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila

Clemente, G. D., Hannaford, M. R., Beati, H., Kapp, K., Januschke, J., Griffis, E. R. & Müller, H-A. J., Jun 2018, In : Journal of Developmental Biology. 6, 2, 23 p., 9.

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4 Citations (Scopus)
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RNF12 X-linked intellectual disability mutations disrupt E3 ligase activity and neural differentiation

Bustos, F., Segarra Fas, A., Chaugule, V. K., Brandenburg, L., Branigan, E., Toth, R., Macartney, T., Knebel, A., Hay, R., Walden, H. & Findlay, G., 8 May 2018, In : Cell Reports. 23, 6, p. 1599-1611 13 p.

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6 Citations (Scopus)
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Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron

Gray, K. M., Kaifer, K. A., Baillat, D., Wen, Y., Bonacci, T. R., Ebert, A. D., Raimer, A. C., Spring, A. M., Have, S. T., Glascock, J. J., Gupta, K., Van Duyne, G. D., Emanuele, M. J., Lamond, A. I., Wagner, E. J., Lorson, C. L. & Matera, A. G., 15 Jan 2018, In : Molecular Biology of the Cell. 29, 2, p. 96-110 15 p.

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12 Citations (Scopus)
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SINHCAF/FAM60A and SIN3A specifically repress HIF 2α expression

Biddlestone, J., Batie, M., Bandarra, D., Munoz, I. & Rocha, S., 29 Jun 2018, In : Biochemical Journal. 475, 12, p. 2073-2090 18 p.

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3 Citations (Scopus)
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Spindly is required for rapid migration of human cells

Conte, C., Baird, M. A., Davidson, M. W. & Griffis, E. R., 29 May 2018, In : Biology Open. 7, 5, 9 p., 033233 .

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3 Citations (Scopus)
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Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome

Sundaramoorthy, R., Hughes, A., El-Mkami, H., Norman, D. & Owen-Hughes, T., 6 Aug 2018, In : eLife. 2018, 7, p. 1-28 28 p., e35720.

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26 Citations (Scopus)
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Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity

Hepburn, L., McHugh, A., Fernandes, K., Boag, G., Proby, C., Leigh, I. & Saville, M., 1 May 2018, In : Oncotarget. 9, 33, p. 23029-23046 18 p.

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8 Citations (Scopus)
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The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1

Barini, E., Miccoli, A., Tinarelli, F., Mulholland, K., Kadri, H., Khanim, F., Stojanovski, L., Read, K. D., Burness, K., Blow, J. J., Mehellou, Y. & Muqit, M. M. K., 2 Mar 2018, In : ChemBioChem. 19, 5, p. 425-429 5 p.

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11 Citations (Scopus)
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The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Hong, Y., Velkova, M., Silva, N., Jagut, M., Scheidt, V., Labib, K., Jantsch, V. & Gartner, A., 7 Jun 2018, In : PLoS Genetics. 14, 6, p. 1-22 22 p., e1007453.

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4 Citations (Scopus)
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The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT: UDP-GlcNAc glycosylation and proteolysis activities

Kapuria, V., Röhrig, U. F., Waridel, P., Lammers, F., Borodkin, V. S., van Aalten, D. M. F., Zoete, V. & Herr, W., 16 Nov 2018, In : Journal of Biological Chemistry. 293, 46, p. 17754-17768 15 p.

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The Encyclopedia of Proteome Dynamics – A big data ecosystem for (prote)omics

Brenes Murillo, A., Afzal, V., Kent, R. & Lamond, A., 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1202-D1209 8 p.

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8 Citations (Scopus)
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The mRNA cap methyltransferase gene TbCMT1 is not essential in vitro but is a virulence factor in vivo for bloodstream form Trypanosoma brucei

Kelner, A., Tinti, M., Guther, M., Foth, B. J., Chappell, L., Berriman, M., Cowling, V. & Ferguson, M., 24 Jul 2018, In : PLoS ONE. 13, 7, p. 1-14 14 p., e0201263.

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2 Citations (Scopus)
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The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

Gundogdu, M., Llabres, S., Gorelik, A., Ferenbach, A., Zachariae, U. & Van Aalten, D., 17 May 2018, In : Cell Chemical Biology. 25, 5, p. 513-518.e4 10 p.

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11 Citations (Scopus)
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Thio-linked UDP-peptide conjugates as O-GlcNAc transferase inhibitors

Rafie, K., Gorelik, A., Trapannone, R., Borodkin, V. & Van Aalten, D., 20 Jun 2018, In : Bioconjugate Chemistry. 29, 6, p. 1834-1840 7 p.

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9 Citations (Scopus)
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TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway

D'Ignazio, L., Batie, M. & Rocha, S., 8 Aug 2018, In : Cells. 7, 8, p. 1-14 14 p., 102.

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UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies

Ghirardello, M., Perrone, D., Chinaglia, N., Sádaba, D., Delso, I., Tejero, T., Marchesi, E., Fogagnolo, M., Rafie, K., van Aalten, D. M. F. & Merino, P., 17 May 2018, In : Chemistry: a European Journal. 24, 28, p. 7264-7272 9 p.

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4 Citations (Scopus)
100 Downloads (Pure)

USP45 and Spindly are part of the same complex implicated in cell migration

Conte, C., Griffis, E., Hickson, I. D. & Perez-Oliva, A., 26 Sep 2018, In : Scientific Reports. 8, 1, 13 p., 14375.

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2 Citations (Scopus)
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Visualization of Biomedical Data

O'Donoghue, S. I., Baldi, B. F., Clark, S. J., Darling, A. E., Hogan, J. M., Kaur, S., Maier-Hein, L., McCarthy, D. J., Moore, W., Stenau, E., Swedlow, J., Vuong, J. & Procter, J., 20 Jul 2018, In : Annual Review of Biomedical Data Science. 1

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2017

A Functional Link Between Bir1 and the Saccharomyces cerevisiae Ctf19 Kinetochore Complex Revealed Through Quantitative Fitness Analysis

Makrantoni, V., Ciesiolka, A., Lawless, C., Fernius, J., Marston, A. L., Lydall, D. & Stark, M. J. R., 7 Sep 2017, In : G3 : Genes, Genomes, Genetics. 7, 9, p. 3203-3215 13 p.

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2 Citations (Scopus)
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A high quality Arabidopsis transcriptome for accurate transcript-level analysis of alternative splicing

Zhang, R., Calixto, C. P. G., Marquez, Y., Venhuizen, P., Tzioutziou, N. A., Guo, W., Spensley, M., Entizne, J. C., Lewandowska, D., ten Have, S., Frei dit Frey, N., Hirt, H., James, A. B., Nimmo, H. G., Barta, A., Kalyna, M. & Brown, J. W. S., 19 May 2017, In : Nucleic Acids Research. 45, 9, p. 5061-5073 13 p.

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68 Citations (Scopus)
201 Downloads (Pure)

ALADIN is Required for the Production of Fertile Mouse Oocytes

Carvalhal, S., Stevense, M., Koehler, K., Naumann, R., Huebner, A., Jessberger, R. & Griffis, E. R., 17 Sep 2017, In : Molecular Biology of the Cell. 28, 19, p. 2470-2478 9 p.

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6 Citations (Scopus)
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A mutant O-GlcNAcase enriches Drosophila developmental regulators

Selvan, N., Williamson, R., Mariappa, D., Campbell, D. G., Gourlay, R., Ferenbach, A. T., Aristotelous, T., Hopkins-Navratilova, I., Trost, M. & van Aalten, D. M. F., Aug 2017, In : Nature Chemical Biology. 13, 8, p. 882-887 8 p.

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19 Citations (Scopus)
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A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

Mishra, A., Oulès, B., Pisco, A. O., Ly, T., Liakath-Ali, K., Walko, G., Viswanathan, P., Tihy, M., Nijjhar, J., Dunn, S-J., Lamond, A. I. & Watt, F. M., 18 Oct 2017, In : eLife. 6, p. 1-20 20 p., e27356.

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11 Citations (Scopus)
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A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

Tatham, M. H., Cole, C., Scullion, P., Wilkie, R., Westwood, N. J., Stark, L. A. & Hay, R. T., 1 Feb 2017, In : Molecular & Cellular Proteomics. 16, 2, p. 310-326 17 p.

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21 Citations (Scopus)
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A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans

González-Huici, V., Wang, B. & Gartner, A., 1 Aug 2017, In : Genetics. 206, 4, p. 1853-1864 12 p.

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3 Citations (Scopus)
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A SUMO-Dependent Protein Network Regulates Chromosome Congression During Oocyte Meiosis

Pelisch, F., Tammsalu, T., Wang, B., Jaffray, E. G., Gartner, A. & Hay, R. T., 5 Jan 2017, In : Molecular Cell. 65, 1, p. 66-77 12 p.

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22 Citations (Scopus)
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Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway

González, A. E., Muñoz, V. C., Cavieres, V. A., Bustamante, H. A., Cornejo, V-H., Januário, Y. C., González, I., Hetz, C., daSilva, L. L., Rojas-Fernández, A., Hay, R. T., Mardones, G. A. & Burgos, P. V., Jun 2017, In : FASEB Journal. 31, 6, p. 2446-2459 14 p.

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18 Citations (Scopus)
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