Gene Regulation and Expression

  • United Kingdom

Research Output

Filter
Article
2013
147 Citations (Scopus)

Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts

Newman, T. J., Mamun, M. A., Nieduszynski, C. A. & Blow, J. J., Nov 2013, In : Nucleic Acids Research. 41, 21, p. 9705-9718 14 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans

Akay, A., Craig, A., Lehrbach, N., Larance, M., Pourkarimi, E., Wright, J. E., Lamond, A., Miska, E. & Gartner, A., Nov 2013, In : Open Biology. 3, 130151.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Small RNAs derived from the 5' end of tRNA can inhibit protein translation in human cells

Sobala, A. & Hutvagner, G., Apr 2013, In : RNA Biology. 10, 4, p. 553-563 11 p.

Research output: Contribution to journalArticle

124 Citations (Scopus)

Stochastic association of neighboring replicons creates replication factories in budding yeast

Saner, N., Karschau, J., Natsume, T., Gierlinski, M., Retkute, R., Hawkins, M., Nieduszynski, C. A., Blow, J. J., de Moura, A. P. S. & Tanaka, T. U., 2013, In : Journal of Cell Biology. 202, 7, p. 1001-1012 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Stress Response: Anything that Doesn't Kill You Makes You Stronger

Gartner, A. & Akay, A., 18 Nov 2013, In : Current Biology. 23, 22, p. R1012-R1014 3 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Structural biology: Pivotal findings for a transcription machine

Zomerdijk, J., 31 Oct 2013, In : Nature. 502, 7473, p. 629-630 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural biology: Pivotal findings for a transcription machine

Zomerdijk, J., 2013, In : Nature. 502, 7473, p. 629-630 2 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Structural plasticity of histones H3–H4 facilitates their allosteric exchange between RbAp48 and ASF1

Zhang, W., Yyl, M., Ward, R., Sobott, F., Maman, J., Murthy, A., Watson, A., Fedorov, O., Bowman, A., Owen-Hughes, T., El Mkami, H., Murzina, N., Norman, D. G. & Laue, E., Jan 2013, In : Nature Structural & Molecular Biology. 20, 1, p. 29-35 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Tale of two transcription factors: NF-кB and HIF crosstalk

Bandarra, D. & Rocha, S., 2013, In : OA Molecular and Cell Biology. 1, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Open Access
File
128 Downloads (Pure)

TfR1 interacts with the IKK complex and is involved in IKK-NF-kappaB signalling

Kenneth, N. S., Mudie, S., Naron, S. & Rocha, S., 2013, In : Biochemical Journal. 449, p. 275-284

Research output: Contribution to journalArticle

20 Citations (Scopus)

The amidation step of Diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network

Uthman, S., Baer, C., Scheidt, V., Liu, S., Ten Have, S., Giorgini, F., Stark, M. J. R. & Schaffrath, R., 2013, In : PLoS Genetics. 9, 2, e1003334.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing

Caillat, C., Pefani, D-E., Gillespie, P. J., Taraviras, S., Blow, J. J., Lygerou, Z. & Perrakis, A., Nov 2013, In : Journal of Biological Chemistry. 288, 44, p. 31624-31634 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans

Masoudi, N., Fancsalszky, L., Pourkarimi, E., Vellai, T., Alexa, A., Reményi, A., Gartner, A., Mehta, A. & Takács-Vellai, K., 15 Aug 2013, In : Development. 140, 16, p. 3486-3495 10 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability

Bett, J. S., Ibrahim, A. F. M., Garg, A. K., Kelly, V., Pedrioli, P., Rocha, S. & Hay, R. T., 15 Apr 2013, In : Biochemical Journal. 451, 2, p. 185-194 10 p., BJ20130026.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

Saunders, S. P., Goh, C. S. M., Brown, S. J., Palmer, C. N. A., Porter, R. M., Cole, C., Campbell, L. E., Gierlinski, M., Barton, G. J., Schneider, G., Balmain, A., Prescott, A. R., Weidinger, S., Baurecht, H., Kabesch, M., Gieger, C., Lee, Y-A., Tavendale, R., Mukhopadhyay, S., Turner, S. W. & 14 others, Madhok, V. B., Sullivan, F. M., Relton, C., Burn, J., Meggitt, S., Smith, C. H., Allen, M. A., Barker, J. N. W. N., Reynolds, N. J., Cordell, H. J., Irvine, A. D., McLean, W. H. I., Sandilands, A. & Fallon, P. G., Nov 2013, In : Journal of Allergy and Clinical Immunology. 132, 5, p. 1121-1129 9 p.

Research output: Contribution to journalArticle

73 Citations (Scopus)

Topoisomerase IIα promotes activation of RNA polymerase i transcription by facilitating pre-initiation complex formation

Ray, S., Panova, T., Miller, G., Volkov, A., Porter, A. C. G., Russell, J., Panov, K. I. & Zomerdijk, J. C. B. M., 19 Mar 2013, In : Nature Communications. 4, 1598.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Ube2W conjugates ubiquitin to α-amino groups of protein N-termini

Tatham, M. H., Plechanovova, A., Jaffray, E. G., Salmen, H. & Hay, R. T., 2013, In : Biochemical Journal. 453, 1, p. 137-145 9 p.

Research output: Contribution to journalArticle

55 Citations (Scopus)

Ubiquitylation-dependent localization of PLK1 in mitosis

Beck, J., Maerki, S., Posch, M., Metzger, T., Persaud, A., Scheel, H., Hofmann, K., Rotin, D., Pedrioli, P., Swedlow, J. R., Peter, M. & Sumara, I., 2013, In : Nature Cell Biology. 15, 4, p. 430-439 10 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Web-based visualisation and analysis of 3D electron-microscopy data from EMDB and PDB

Lagerstedt, I., Moore, W. J., Patwardhan, A., Sanz-García, E., Best, C., Swedlow, J. R. & Kleywegt, G. J., 1 Jan 2013, In : Journal of Structural Biology. 184, 2, p. 173-181 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2012

Advancing cell biology through proteomics in space and time (PROSPECTS)

Lamond, A. I., Uhlen, M., Horning, S., Makarov, A., Robinson, C. V., Serrano, L., Hartl, F. U., Baumeister, W., Werenskiold, A. K., Andersen, J. S., Vorm, O., Linial, M., Aebersold, R. & Mann, M., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

50 Citations (Scopus)

ALDH2 mediates 5-nitrofuran activity in multiple species

Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K. L., Temperley, N. D., Johnson, S. L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E. M., Melton, D. W., Smith, T. K., Tyers, M., Westwood, N. J. & Patton, E. E., 27 Jul 2012, In : Chemistry & Biology. 19, 7, p. 883-892 10 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

A quantitative proteomic analysis of lung epithelial (A549) cells infected with 2009 pandemic influenza A virus using stable isotope labelling with amino acids in cell culture

Dove, B. K., Surtees, R., Bean, T. J. H., Munday, D., Wise, H. M., Digard, P., Carroll, M. W., Ajuh, P., Barr, J. N. & Hiscox, J. A., May 2012, In : Proteomics. 12, 9, p. 1431-1436 6 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

A quantitative spatial proteomics analysis of proteome turnover in human cells

Boisvert, F-M., Ahmad, Y., Gierlinski, M., Charrière, F., Lamont, D., Scott, M., Barton, G. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3, M111.011429.

Research output: Contribution to journalArticle

210 Citations (Scopus)

ATP-independent cooperative binding of yeast Isw1a to bare and nucleosomal DNA

De Cian, A., Praly, E., Ding, F., Singh, V., Lavelle, C., Le Cam, E., Croquette, V., Pietrement, O. & Bensimon, D., 2012, In : PLoS ONE. 7, 2, p. - 13 p., e31845.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway

Larance, M., Kirkwood, K. J., Xirodimas, D. P., Lundberg, E., Uhlen, M. & Lamond, A. I., 1 Mar 2012, In : Molecular & Cellular Proteomics. 11, 3

Research output: Contribution to journalArticle

17 Citations (Scopus)

Cnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore

Bock, L. J., Pagliuca, C., Alfieri, C., Golfieri, C., Dal Maschio, M., De Wulf, P., Kobayashi, N., Oku, Y., Tanaka, T. U., Grove, R. A., Shrestha, K., Hazbun, T. R., Oldani, A. & Bermejo, R., 2012, In : Nature Cell Biology. 14, 6, p. 614-624 11 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Cytosolic entry of shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active hrd1p

Li, S., Spooner, R. A., Hampton, R. Y., Lord, J. M. & Roberts, L. M., 2012, In : PLoS ONE. 7, 7, e41119.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

McIntosh, D. & Blow, J. J., Oct 2012, In : Cold spring harbor perspectives in biology. 4, 10, 10 p., 012955.

Research output: Contribution to journalArticle

63 Citations (Scopus)

Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction

Pourkarimi, E., Greiss, S. & Gartner, A., Mar 2012, In : Cell Death & Differentiation. 19, 3, p. 406-415 10 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth

Huart, A-S., MacLaine, N. J., Narayan, V. & Hupp, T. R., 20 Aug 2012, In : PLoS ONE. 7, 8, e43391.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Family with Sequence Similarity 60A (FAM60A) Protein Is a Cell Cycle-fluctuating Regulator of the SIN3-HDAC1 Histone Deacetylase Complex

Munoz, I. M., Macartney, T., Sanchez-Pulido, L., Ponting, C. P., Rocha, S. & Rouse, J., 21 Sep 2012, In : Journal of Biological Chemistry. 287, 39, p. 32346-53 8 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)

hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: Structural and functional studies

Drakou, C. E., Malekkou, A., Hayes, J. M., Lederer, C. W., Leonidas, D. D., Oikonomakos, N. G., Lamond, A. I., Santama, N. & Zographos, S. E., Jan 2012, In : Proteins: Structure, Function, and Bioinformatics. 80, 1, p. 206-220 15 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)

Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity

Aillet, F., Lopitz-Otsoa, F., Egaña, I., Hjerpe, R., Fraser, P., Hay, R. T., Rodriguez, M. S. & Lang, V., 20 Dec 2012, In : PLoS ONE. 7, 12, e51672.

Research output: Contribution to journalArticle

38 Citations (Scopus)
27 Citations (Scopus)

Human box C/D snoRNA processing conservation across multiple cell types

Scott, M. S., Ono, M., Yamada, K., Endo, A., Barton, G. J. & Lamond, A. I., Apr 2012, In : Nucleic Acids Research. 40, 8, p. 3676-3688 13 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

Influence of the nuclear membrane, active transport, and cell shape on the Hes1 and p53-Mdm2 pathways: insights from spatio-temporal modelling

Sturrock, M., Terry, A. J., Xirodimas, D. P., Thompson, A. M. & Chaplain, M. A. J., Jul 2012, In : Bulletin of Mathematical Biology. 74, 7, p. 1531-1579 49 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Inhibition of Pre-mRNA Splicing by a Synthetic Blom7α-Interacting Small RNA

Löscher, M., Schosserer, M., Dausse, E., Lee, K., Ajuh, P. M., Grillari-Voglauer, R., Lamond, A. I., Toulmé, J. J. & Grillari, J., 29 Oct 2012, In : PLoS ONE. 7, 10, 9 p., e47497.

Research output: Contribution to journalArticle

Open Access

Innovation in biological microscopy: current status and future directions

Swedlow, J. R., 1 Jan 2012, In : BioEssays.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Isolation of human mitotic protein phosphatase complexes: identification of a complex between protein phosphatase 1 and the RNA helicase Ddx21

de Wever, V., Lloyd, D. C., Nasa, I., Nimick, M., Trinkle-Mulcahy, L., Gourlay, R., Morrice, N. & Moorhead, G. B. G., 2012, In : PLoS ONE. 7, 6, e39510.

Research output: Contribution to journalArticle

5 Citations (Scopus)

LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis

Liu, B., Du, H., Rutkowski, R., Gartner, A. & Wang, X., 2012, In : Science. 337, 6092, p. 351-354 4 p.

Research output: Contribution to journalArticle

62 Citations (Scopus)

Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulation

Muramoto, T., Cannon, D., Gierlinski, M., Corrigan, A., Barton, G. J. & Chubb, J. R., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 19, p. 7350-7355 6 p.

Research output: Contribution to journalArticle

74 Citations (Scopus)

Making sense of transcribing chromatin

Owen-Hughes, T. & Gkikopoulos, T., 1 Jan 2012, In : Current Opinion in Cell Biology.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Micrococcal Nuclease Does Not Substantially Bias Nucleosome Mapping

Allan, J., Fraser, R. M., Owen-Hughes, T. & Keszenman-Pereyra, D., 30 Mar 2012, In : Journal of Molecular Biology. 417, 3, p. 152-164 13 p.

Research output: Contribution to journalArticle

File
52 Citations (Scopus)
202 Downloads (Pure)

Modulation of activation-associated host cell gene expression by the apicomplexan parasite Theileria annulata

Durrani, Z., Weir, W., Pillai, S., Kinnaird, J. & Shiels, B., 2012, In : Cellular Microbiology.

Research output: Contribution to journalArticle

16 Citations (Scopus)

OMERO: flexible, model-driven data management for experimental biology

Allan, C., Burel, J-M., Moore, J., Blackburn, C., Linkert, M., Loynton, S., MacDonald, D., Moore, W. J., Neves, C., Patterson, A., Porter, M., Tarkowska, A., Loranger, B., Avondo, J., Lagerstedt, I., Lianas, L., Leo, S., Hands, K., Hay, R. T., Patwardhan, A. & 4 others, Best, C., Kleywegt, G. J., Zanetti, G. & Swedlow, J. R., 1 Mar 2012, In : Nature Methods. 9, 3, p. 245-253 9 p.

Research output: Contribution to journalArticle

190 Citations (Scopus)

Perturbation of Chromatin Structure Globally Affects Localization and Recruitment of Splicing Factors

Schor, I. E., Llères, D., Risso, G. J., Pawellek, A., Ule, J., Lamond, A. I. & Kornblihtt, A. R., 12 Nov 2012, In : PLoS ONE. 7, 11, 16 p., e48084.

Research output: Contribution to journalArticle

Open Access
File
38 Citations (Scopus)
112 Downloads (Pure)

Polypyrimidine Tract Binding Protein (hnRNP I) Is Possibly a Conserved Modulator of miRNA-Mediated Gene Regulation

Engels, B., Jannot, G., Remenyi, J., Simard, M. J. & Hutvagner, G., 9 Mar 2012, In : PLoS ONE. 7, 3, p. - 11 p., e33144.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins

Gillespie, P. J., Gambus, A. & Blow, J. J., Jun 2012, In : Methods. 57, 2, p. 203-13 11 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

Arabi, A., Ullah, K., Branca, R. M. M., Johansson, J., Bandarra, D., Haneklaus, M., Fu, J., Ariës, I., Nilsson, P., Den Boer, M. L., Pokrovskaja, K., Grandér, D., Xiao, G., Rocha, S., Lehtiö, J. & Sangfelt, O., 2012, In : Nature Communications. 3, 976.

Research output: Contribution to journalArticle

53 Citations (Scopus)