Gene Regulation and Expression

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2011

Nuclear Speckles

Spector, D. L. & Lamond, A. I., Feb 2011, In : Cold spring harbor perspectives in biology. 3, 2, p. - 12 p., a000646.

Research output: Contribution to journalArticle

355 Citations (Scopus)

OMX: a new platform for multimodal, multichannel wide-field imaging

Dobbie, I. M., King, E., Parton, R. M., Carlton, P. M., Sedat, J. W., Swedlow, J. R. & Davis, I., 1 Aug 2011, In : Cold Spring Harbor Protocols. 6, 8, p. 899-909 11 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

PChopper: high throughput peptide prediction for MRM/SRM transition design

Afzal, V., Huang, J. T-J., Atrih, A. & Crowther, D. J., 15 Aug 2011, In : BMC Bioinformatics. 12, p. - 9 p., 338.

Research output: Contribution to journalArticle

4 Citations (Scopus)

PNAC: a protein nucleolar association classifier

Scott, M. S., Boisvert, F-M., Lamond, A. I. & Barton, G. J., 27 Jan 2011, In : BMC Genomics. 12, p. - 14 p., 74.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Purification and identification of endogenous polySUMO conjugates

Bruderer, R., Tatham, M. H., Plechanovova, A., Matic, I., Garg, A. K. & Hay, R. T., Feb 2011, In : EMBO Reports. 12, 2, p. 142-148 7 p.

Research output: Contribution to journalArticle

119 Citations (Scopus)

Quantitative Proteomic Analysis of Chromatin Reveals that Ctf18 Acts in the DNA Replication Checkpoint

Kubota, T., Hiraga, S., Yamada, K., Lamond, A. I. & Donaldson, A. D., Jul 2011, In : Molecular & Cellular Proteomics. 10, 7, p. - 14 p., M110.005561. .

Research output: Contribution to journalArticle

42 Citations (Scopus)

Quantitative proteomic analysis of the adipocyte plasma membrane

Prior, M. J., Larance, M., Lawrence, R. T., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J. R., La-Borde, P. J., Buckley, M., Kanazawa, H., Parton, R. G., Guilhaus, M. & James, D. E., 4 Nov 2011, In : Journal of Proteome Research. 10, 11, p. 4970-4982 13 p.

Research output: Contribution to journalArticle

25 Citations (Scopus)

Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation

Moore, H. M., Bai, B., Boisvert, F-M., Latonen, L., Rantanen, V., Simpson, J. C., Pepperkok, R., Lamond, A. I. & Laiho, M., Oct 2011, In : Molecular & Cellular Proteomics. 10, 10, p. - 15 p., M111.009241.

Research output: Contribution to journalArticle

76 Citations (Scopus)

Regulation of Caenorhabditis elegans p53/CEP-1-Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

Rutkowski, R., Dickinson, R., Stewart, G., Craig, A., Schimpl, M., Keyse, S. M. & Gartner, A., Aug 2011, In : PLoS Genetics. 7, 8, p. - 21 p., e1002238.

Research output: Contribution to journalArticle

48 Citations (Scopus)

RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle

Albert, B., Leger-Silvestre, I., Normand, C., Ostermaier, M. K., Perez-Fernandez, J., Panov, K. I., Zomerdijk, J. C. B. M., Schultz, P. & Gadal, O., 24 Jan 2011, In : Journal of Cell Biology. 192, 2, p. 277-293 17 p.

Research output: Contribution to journalArticle

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39 Citations (Scopus)
442 Downloads (Pure)

Simulated spectral states of active galactic nuclei and observational predictions

Sobolewska, M. A., Siemiginowska, A. & Gierliński, M., 11 May 2011, In : Monthly Notices of the Royal Astronomical Society. 413, 3, p. 2259-2268 10 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Spatio-temporal modelling of the Hes1 and p53-Mdm2 intracellular signalling pathways

Sturrock, M., Terry, A. J., Xirodimas, D. P., Thompson, A. M. & Chaplain, M. A. J., 21 Mar 2011, In : Journal of Theoretical Biology. 273, 1, p. 15-31 17 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

Stable-isotope labeling with amino acids in nematodes

Larance, M., Bailly, A. P., Pourkarimi, E., Hay, R. T., Buchanan, G., Coulthurst, S., Xirodimas, D. P., Gartner, A. & Lamond, A. I., Oct 2011, In : Nature Methods. 8, 10, p. 849-851 3 p.

Research output: Contribution to journalArticle

79 Citations (Scopus)

SUMO-modified nuclear cyclin D1 bypasses Ras-induced senescence

Wang, X. D., Lapi, E., Sullivan, A., Ratnayaka, I., Goldin, R., Hay, R. & Lu, X., Feb 2011, In : Cell Death & Differentiation. 18, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

TAF1B Is a TFIIB-Like Component of the Basal Transcription Machinery for RNA Polymerase I

Naidu, S., Friedrich, J. K., Russell, J. & Zomerdijk, J. C. B. M., 16 Sep 2011, In : Science. 333, 6049, p. 1640-1642 3 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Temperature-sensitive ipl1-2/Aurora B mutation is suppressed by mutations in TOR complex 1 via the Glc7/PP1 phosphatase

Tatchell, K., Makrantoni, V., Stark, M. J. R. & Robinson, L. C., 8 Mar 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 10, p. 3994-3999 6 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH

Melvin, A., Mudie, S. & Rocha, S., 1 Nov 2011, In : Molecular Biology of the Cell. 22, 21, p. 4171-4181 11 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains

Ryan, D. P., Sundaramoorthy, R., Martin, D., Singh, V. & Owen-Hughes, T., 6 Jul 2011, In : EMBO Journal. 30, 13, p. 2596-2609 14 p.

Research output: Contribution to journalArticle

Open Access
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72 Citations (Scopus)
119 Downloads (Pure)

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation

Bowman, A., Ward, R., Wiechens, N., Singh, V., El-Mkami, H., Norman, D. G. & Owen-Hughes, T., 18 Feb 2011, In : Molecular Cell. 41, 4, p. 398-408 11 p.

Research output: Contribution to journalArticle

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57 Citations (Scopus)
178 Downloads (Pure)

The Ndc80 Loop Region Facilitates Formation of Kinetochore Attachment to the Dynamic Microtubule Plus End

Maure, J-F., Komoto, S., Oku, Y., Mino, A., Pasqualato, S., Natsume, K., Clayton, L., Musacchio, A. & Tanaka, T. U., 8 Feb 2011, In : Current Biology. 21, 3, p. 207-213 7 p.

Research output: Contribution to journalArticle

66 Citations (Scopus)

The Opportunistic Pathogen Serratia marcescens Utilizes Type VI Secretion To Target Bacterial Competitors

Murdoch, S. L., Trunk, K., English, G., Fritsch, M. J., Pourkarimi, E. & Coulthurst, S. J., Nov 2011, In : Journal of Bacteriology. 193, 21, p. 6057-6069 13 p.

Research output: Contribution to journalArticle

129 Citations (Scopus)

The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans

Jannot, G., Bajan, S., Giguère, N. J., Bouasker, S., Banville, I. H., Piquet, S., Hutvagner, G. & Simard, M. J., Jun 2011, In : EMBO Reports. 12, 6, p. 581-586 6 p.

Research output: Contribution to journalArticle

Open Access
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47 Citations (Scopus)
163 Downloads (Pure)

The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration

Msaki, A., Sanchez, A. M., Koh, L. F., Barre, B., Rocha, S., Perkins, N. D. & Johnson, R. F., 1 Sep 2011, In : Molecular Biology of the Cell. 22, 17, p. 3032-3040 9 p.

Research output: Contribution to journalArticle

Open Access
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24 Citations (Scopus)
120 Downloads (Pure)

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events

Bach, M., Larance, M., James, D. E. & Ramm, G., 1 Dec 2011, In : Biochemical Journal. 440, 2, p. 283-291 9 p.

Research output: Contribution to journalArticle

113 Citations (Scopus)

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

Hattersley, N., Shen, L., Jaffray, E. G. & Hay, R. T., 1 Jan 2011, In : Molecular Biology of the Cell. 22, 1, p. 78-90 13 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4

Gkikopoulos, T., Singh, V., Tsui, K., Awad, S., Renshaw, M. J., Scholfield, P., Barton, G. J., Nislow, C., Tanaka, T. U. & Owen-Hughes, T., 18 May 2011, In : EMBO Journal. 30, 10, p. 1919-1927 9 p.

Research output: Contribution to journalArticle

Open Access
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33 Citations (Scopus)
127 Downloads (Pure)
2010

Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity

Hoehn, K. L., Turner, N., Swarbrick, M. M., Wilks, D., Preston, E., Phua, Y., Joshi, H., Furler, S. M., Larance, M., Hegarty, B. D., Leslie, S. J., Pickford, R., Hoy, A. J., Kraegen, E. W., James, D. E. & Cooney, G. J., 6 Jan 2010, In : Cell Metabolism. 11, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

111 Citations (Scopus)

Adenomatous polyposis coli and hypoxia-inducible factor-1 alpha have an antagonistic connection

Newton, I. P., Kenneth, N. S., Appleton, P. L., Nathke, I. & Rocha, S., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3630-3638 9 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Analysis of Human Small Nucleolar RNAs (snoRNA) and the Development of snoRNA Modulator of Gene Expression Vectors

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. & Lamond, A. I., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1569-1584 16 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

A Proteomic Screen for Nucleolar SUMO Targets Shows SUMOylation Modulates the Function of Nop5/Nop58

Westman, B. J., Verheggen, C., Hutten, S., Lam, Y. W., Bertrand, E. & Lamond, A. I., 27 Aug 2010, In : Molecular Cell. 39, 4, p. 618-631 14 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

A Quantitative Proteomics Analysis of Subcellular Proteome Localization and Changes Induced by DNA Damage

Boisvert, F-M., Lam, Y. W., Lamont, D. & Lamond, A. I., Mar 2010, In : Molecular & Cellular Proteomics. 9, 3, p. 457-470 14 p.

Research output: Contribution to journalArticle

128 Citations (Scopus)

Arsenic-induced SUMO-dependent recruitment of RNF4 into PML nuclear bodies

Geoffroy, M-C., Jaffray, E. G., Walker, K. J. & Hay, R. T., 1 Dec 2010, In : Molecular Biology of the Cell. 21, 23, p. 4227-4239 13 p.

Research output: Contribution to journalArticle

50 Citations (Scopus)

Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP

Fogarty, S., Hawley, S. A., Green, K. A., Saner, N., Mustard, K. J. & Hardie, D. G., 15 Feb 2010, In : Biochemical Journal. 426, p. 109-118 10 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Cell-Nonautonomous Regulation of C. elegans Germ Cell Death by kri-1

Ito, S., Greiss, S., Gartner, A. & Derry, W. B., 23 Feb 2010, In : Current Biology. 20, 4, p. 333-338 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Characterization and prediction of protein nucleolar localization sequences

Scott, M. S., Boisvert, F-M., McDowall, M. D., Lamond, A. I. & Barton, G. J., Nov 2010, In : Nucleic Acids Research. 38, 21, p. 7388-7399 12 p.

Research output: Contribution to journalArticle

91 Citations (Scopus)

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

Ge, X. Q. & Blow, J. J., 27 Dec 2010, In : Journal of Cell Biology. 191, 7, p. 1285-1297 13 p.

Research output: Contribution to journalArticle

Open Access
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126 Citations (Scopus)
140 Downloads (Pure)

Clusters, factories and domains: The complex structure of S-phase comes into focus

Gillespie, P. J. & Blow, J., 15 Aug 2010, In : Cell Cycle. 9, 16, p. 3218-3226 9 p.

Research output: Contribution to journalArticle

31 Citations (Scopus)

Compton scattering as the explanation of the peculiar X-ray properties of Cyg X-3

Zdziarski, A. A., Misra, R. & Gierliński, M., 21 Feb 2010, In : Monthly Notices of the Royal Astronomical Society. 402, 2, p. 767-775 9 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

Condensins Promote Chromosome Recoiling during Early Anaphase to Complete Sister Chromatid Separation

Renshaw, M. J., Ward, J. J., Kanemaki, M., Natsume, K., Nedelec, F. J. & Tanaka, T. U., 17 Aug 2010, In : Developmental Cell. 19, 2, p. 232-244 13 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Determinants of Myosin II Cortical Localization during Cytokinesis

Uehara, R., Goshima, G., Mabuchi, I., Vale, R. D., Spudich, J. A. & Griffis, E. R., 22 Jun 2010, In : Current Biology. 20, 12, p. 1080-1085 6 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice

Lleres, D., Denegri, M., Biggiogera, M., Ajuh, P. & Lamond, A. I., Jun 2010, In : EMBO Reports. 11, 6, p. 445-451 7 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

EPR distance measurements in deuterated proteins

Ward, R., Bowman, A., Sozudogru, E., El-Mkami, H., Owen-Hughes, T. & Norman, D. G., Nov 2010, In : Journal of Magnetic Resonance Imaging. 207, 1, p. 164-167 4 p.

Research output: Contribution to journalArticle

93 Citations (Scopus)

Establishment of a protein frequency library and its application in the reliable identification of specific protein interaction partners

Boulon, S., Ahmad, Y., Trinkle-Mulcahy, L., Verheggen, C., Cobley, A., Gregor, P., Bertrand, E., Whitehorn, M. & Lamond, A. I., May 2010, In : Molecular & Cellular Proteomics. 9, 5, p. 861-879 19 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)

Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3

Larance, M., Rowland, A. F., Hoehn, K. L., Humphreys, D. T., Preiss, T., Guilhaus, M. & James, D. E., Apr 2010, In : Molecular & Cellular Proteomics. 9, 4, p. 682-694 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

High-resolution whole-genome sequencing reveals that specific Chromatin Domains from most human chromosomes associate with nucleoli

van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. & Lamond, A. I., 1 Nov 2010, In : Molecular Biology of the Cell. 21, 21, p. 3735-3748 14 p.

Research output: Contribution to journalArticle

160 Citations (Scopus)

High-stringency tandem affinity purification of proteins conjugated to ubiquitin-like moieties

Golebiowski, F., Tatham, M. H., Nakamura, A. & Hay, R. T., 2010, In : Nature Protocols. 5, 5, p. 873-882 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

HSP90 and Its R2TP/Prefoldin-like Cochaperone Are Involved in the Cytoplasmic Assembly of RNA Polymerase II

Boulon, S., Pradet-Balade, B., Verheggen, C., Molle, D., Boireau, S., Georgieva, M., Azzag, K., Robert, M-C., Ahmad, Y., Neel, H., Lamond, A. I. & Bertrand, E., 24 Sep 2010, In : Molecular Cell. 39, 6, p. 912-924 13 p.

Research output: Contribution to journalArticle

158 Citations (Scopus)

HSP90 protein stabilizes unloaded Argonaute complexes and microscopic P-bodies in human cells

Johnston, M., Geoffroy, M-C., Sobala, A., Hay, R. & Hutvagner, G., 1 May 2010, In : Molecular Biology of the Cell. 21, 9, p. 1462-1469 8 p.

Research output: Contribution to journalArticle

106 Citations (Scopus)

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

MacKay, C., Declais, A-C., Lundin, C., Agostinho, A., Deans, A. J., MacArtney, T. J., Hofmann, K., Gartner, A., West, S. C., Helleday, T., Lilley, D. M. J. & Rouse, J., 9 Jul 2010, In : Cell. 142, 1, p. 65-76 12 p.

Research output: Contribution to journalArticle

201 Citations (Scopus)

IKK and NF-kappa B-mediated regulation of Claspin impacts on ATR checkpoint function

Kenneth, N. S., Mudie, S. & Rocha, S., 1 Sep 2010, In : EMBO Journal. 29, 17, p. 2966-2978 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)