Molecular and Clinical Medicine

Research Output

2020

Ability of primary care health databases to assess medicinal products discussed by the European Union Pharmacovigilance Risk Assessment Committee

Flynn, R., Hedenmalm, K., Murray-Thomas, T., Pacurariu, A., Arlett, P., Shepherd, H., Myles, P. & Kurz, X., 12 Feb 2020, In : Clinical Pharmacology and Therapeutics. 107, 4, p. 957-965 9 p.

Research output: Contribution to journalArticle

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A case series and literature review on patients with rhinological complications secondary to the use of cocaine and levamisole

Green, R. J., Gardiner, Q., Vinod, K., Oparka, R. & Ross, P. D., 20 May 2020, In : Journal of Laryngology and Otology. 7 p.

Research output: Contribution to journalArticle

A feasibility study of microwave therapy for precancerous actinic keratosis

Jackson, D. N., Hogarth, F. J., Sutherland, D., Holmes, E. M., Donnan, P. T. & Proby, C. M., 6 Feb 2020, In : British Journal of Dermatology. 9 p.

Research output: Contribution to journalArticle

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Airwave oscillometry and patient reported outcomes in persistent asthma

RuiWen Kuo, C. & Lipworth, B., 3 Jan 2020, In : Annals of Allergy, Asthma & Immunology. 124, 3, p. 289-290 2 p.

Research output: Contribution to journalLetter

Allergic burden and response to dupilumab

Lipworth, B., Chan, R. & Kuo, C., Feb 2020, In : Journal of Allergy and Clinical Immunology: In Practice. 8, 2, p. 822 1 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)

A network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure

Sama, I. E., Woolley, R. J., Nauta, J. F., Romaine, S. P. R., Tromp, J., Ter Maaten, J. M., van der Meer, P., Lam, C. S. P., Samani, N. J., Ng, L. L., Metra, M., Dickstein, K., Anker, S. D., Zannad, F., Lang, C. C., Cleland, J. G. F., van Veldhuisen, D. J., Hillege, H. L. & Voors, A. A., 3 Apr 2020, In : European Journal of Heart Failure. 13 p.

Research output: Contribution to journalArticle

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Anti-inflammatory reliever therapy for asthma

Lipworth, B., Chan, R. & RuiWen Kuo, C., Jan 2020, In : Annals of Allergy, Asthma & Immunology. 124, 1, p. 13-15 3 p.

Research output: Contribution to journalArticle

A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The 'VaSera' trial testing dietary nitrate and spironolactone

Mills, C. E., Govoni, V., Faconti, L., Casagrande, M-L., Morant, S. V., Crickmore, H., Iqbal, F., Maskell, P., Masani, A., Nanino, E., Webb, A. J. & Cruickshank, J. K., 17 Apr 2020, In : British Journal of Clinical Pharmacology. 86, 5, p. 891-902 12 p.

Research output: Contribution to journalArticle

A rational approach to e-cigarettes: challenging ERS policy on tobacco harm reduction

Britton, J., George, J., Bauld, L., Agrawal, S., Moxham, J., Arnott, D., McNeill, A. & Hopkinson, N. S. ., 7 May 2020, In : European Respiratory Journal. 55, 5, p. 1-8 8 p., 2000166.

Research output: Contribution to journalArticle

ASPIRE-3-PREVENT: a cross-sectional survey of preventive care after a coronary event across the UK

Jennings, C. S., Kotseva, K., Bassett, P., Adamska, A., Wood, D. & ASPIRE-3-PREVENT Investigators, 29 Apr 2020, In : Open Heart. 7, 1, p. 1-10 10 p., e001196.

Research output: Contribution to journalArticle

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Assessment of a causal relationship between body mass index and atopic dermatitis

Budu-Aggrey, A., Watkins, S. H., Brumpton, B., Løset, M., Tyrrell, J., Modalsli, E. H., Vie, G. Å., Palmer, T., Fritsche, L. G., Nielsen, J. B., Romundstad, P. R., Davey Smith, G., Åsvold, B. O., Paternoster, L. & Brown, S., 17 May 2020, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access

Biomarkers of Aortopathy in Marfan Syndrome

Iskandar, Z., Mordi, I., Lang, C., Huang, J. & Choy, A., 1 Mar 2020, In : Cardiology in Review. 28, 2, p. 92-97 6 p.

Research output: Contribution to journalArticle

Bring the Sunshine Indoors: Easy Dosimetry for Indoor Daylight Photodynamic Therapy

O'Mahoney, P. & Eadie, E., Mar 2020, In : Photochemistry and Photobiology. 96, 2, p. 434-436 3 p.

Research output: Contribution to journalArticle

Chronotherapy in hypertension: the devil is in the details

Guthrie, G., TIME study Steering Committee, Poulter, N., Macdonald, T., Ford, I., Mackenzie, I., Findlay, E., Williams, B., Brown, M., Lang, C. & Webb, D., 21 Apr 2020, In : European Heart Journal. 41, 16, p. 1606-1607 2 p.

Research output: Contribution to journalComment/debate

Circulating plasma concentrations of ACE2 in men and women with heart failure and effects of renin-angiotensin-aldosterone-inhibitors

Sama, I. E., Ravera, A., Santema, B. T., van Goor, H., ter Maaten, J. M., Cleland, J. G. F., Rienstra, M., Friedrich, A. W., Samani, N. J., Ng, L. L., Dickstein, K., Lang, C. C., Filippatos, G., Anker, S. D., Ponikowski, P., Metra, M., van Veldhuisen, D. J. & Voors, A. A., 14 May 2020, In : European Heart Journal. 41, 19, p. 1810-1817 8 p.

Research output: Contribution to journalArticle

Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure

BIOSTAT consortium, Kobayashi, M., ter Maaten, J. M., Stienen, S., Voors, A. A., Duarte, K., Lamiral, Z., Girerd, N., Rossignol, P., Zannad, F. & Ferreira, J. P., 13 Mar 2020, In : ESC Heart Failure. p. 1-11 11 p.

Research output: Contribution to journalArticle

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Clinical Role of CA125 in Worsening Heart Failure: A BIOSTAT-CHF Study Subanalysis

Núñez, J., Bayés-Genís, A., Revuelta-López, E., Ter Maaten, J. M., Miñana, G., Barallat, J., Cserkóová, A., Bodi, V., Fernández-Cisnal, A., Núñez, E., Sanchis, J., Lang, C., Ng, L. L., Metra, M. & Voors, A. A., May 2020, In : JACC: Heart Failure. 8, 5, p. 386-397 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Comparison of Cardiovascular Risk Factors in European Population Cohorts for Predicting Atrial Fibrillation and Heart Failure, Their Subsequent Onset, and Death

Schrage, B., Geelhoed, B., Niiranen, T. J., Gianfagna, F., Vishram-Nielsen, J. K. K., Costanzo, S., Söderberg, S., Ojeda, F. M., Vartiainen, E., Donati, M. B., Magnussen, C., Di Castelnuovo, A., Camen, S., Kontto, J., Koenig, W., Blankenberg, S., de Gaetano, G., Linneberg, A., Jørgensen, T., Zeller, T. & 6 others, Kuulasmaa, K., Tunstall-Pedoe, H., Hughes, M., Iacoviello, L., Salomaa, V. & Schnabel, R. B., 5 May 2020, In : Journal of the American Heart Association. 9, 9, p. 1-26 26 p., e015218.

Research output: Contribution to journalArticle

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Corrigendum to 'Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia' [European Journal of Vascular & Endovascular Surgery 58/1S (2019) 1-109]

Conte, M. S., Bradbury, A. W., Kolh, P., White, J. V., Dick, F., Fitridge, R., Mills, J. L., Ricco, J-B., Suresh, K. R., Murad, M. H., Aboyans, V., Aksoy, M., Alexandrescu, V-A., Armstrong, D., Azuma, N., Belch, J., Bergoeing, M., Bjorck, M., Chakfé, N., Cheng, S. & 30 others, Dawson, J., Debus, E. S., Dueck, A., Duval, S., Eckstein, H. H., Ferraresi, R., Gambhir, R., Garguilo, M., Geraghty, P., Goode, S., Gray, B., Guo, W., Gupta, P. C., Hinchliffe, R., Jetty, P., Komori, K., Lavery, L., Liang, W., Lookstein, R., Menard, M., Misra, S., Miyata, T., Moneta, G., Munoa Prado, J. A., Munoz, A., Paolini, J. E., Patel, M., Pomposelli, F., Powell, R. & Robless, P., Mar 2020, In : European Journal of Vascular and Endovascular Surgery. 59, 3, p. 492-493 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Cost-utility of an online education platform and diabetes personal health record: analysis over ten years

Cunningham, S., Stoddart, A., Wild, S., Conway, N. & Wake, D., 2020.

Research output: Contribution to conferencePoster

CT imaging prior to transcatheter aortic valve implantation in the UK

Harries, I., Weir-Mccall, J. R., Williams, M. C., Shambrook, J., Roditi, G., Bull, R., Morgan-Hughes, G. J., Nicol, E. D. & Moss, A. J., 6 Apr 2020, In : Open Heart. 7, 1, p. 1-7 7 p., e001233.

Research output: Contribution to journalArticle

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Cystic fibrosis lung disease and bronchiectasis

Chalmers, J. D., Jan 2020, In : The Lancet Respiratory Medicine. 8, 1, p. 12-14 3 p.

Research output: Contribution to journalComment/debate

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Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Flohr, C., Mitchell, E. J., Swinden, R., Tarr, S., Davies-Jones, S., Jay, N., Kelleher, M. M., Perkin, M. R., Boyle, R. J. & 1 others, Williams, H. C., 21 Mar 2020, In : Lancet. 395, 10228, p. 962-972 11 p.

Research output: Contribution to journalArticle

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Dapagliflozin Versus Placebo on Left Ventricular Remodeling in Patients With Diabetes and Heart Failure: The REFORM Trial

Singh, J. S. S., Mordi, I. R., Vickneson, K., Fathi, A., Donnan, P. T., Mohan, M., Choy, A. M. J., Gandy, S., George, J., Khan, F., Pearson, E. R., Houston, J. G., Struthers, A. D. & Lang, C. C., 3 Apr 2020, In : Diabetes Care. dc192187.

Research output: Contribution to journalArticle

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Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST)

Artaraz, A., Crichton, M. L., Finch, S., Abo-Leyah, H., Goeminne, P., Aliberti, S., Fardon, T. & Chalmers, J. D., 13 Jan 2020, In : Respiratory Research. 21, 1, p. 1-9 1 p., 18.

Research output: Contribution to journalArticle

Open Access
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Development and Reporting of Prediction Models: Guidance for Authors From Editors of Respiratory, Sleep, and Critical Care Journals

Leisman, D. E., Harhay, M. O., Lederer, D. J., Abramson, M., Adjei, A. A., Bakker, J., Ballas, Z. K., Barreiro, E., Bell, S. C., Bellomo, R., Bernstein, J. A., Branson, R. D., Brusasco, V., Chalmers, J. D., Chokroverty, S., Citerio, G., Collop, N. A., Cooke, C. R., Crapo, J. D., Donaldson, G. & 19 others, Fitzgerald, D. A., Grainger, E., Hale, L., Herth, F. J., Kochanek, P. M., Marks, G., Moorman, J. R., Ost, D. E., Schatz, M., Sheikh, A., Smyth, A. R., Stewart, I., Stewart, P. W., Swenson, E. R., Szymusiak, R., Teboul, J-L., Vincent, J-L., Wedzicha, J. A. & Maslove, D. M., May 2020, In : Critical Care Medicine. 48, 5, p. 623-633 11 p.

Research output: Contribution to journalArticle

Open Access
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Distinct Pathological Pathways in Patients with Heart Failure and Diabetes

Tromp, J., Voors, A. A., Sharma, A., Ferreira, J. P., Ouwerkerk, W., Hillege, H. L., Arevalo Gomez, K., Dickstein, K., Anker, S. D., Metra, M., Lang, C., Ng, L. L., van der Harst, P., van Veldhuisen, D. J., van der Meer, P., Lam, C. S. P., Zannad, F. & Sama, I. E., Mar 2020, In : JACC: Heart Failure. 8, 3, p. 234-242 9 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function: a randomised controlled trial

Witham, M. D., Clarke, C. L., Hutcheon, A., Gingles, C., Gandy, S., Priba, L., Nicholas, R. S., Cavin, I., Sumukadas, D., Struthers, A. D. & George, J., 21 Apr 2020, In : Age and Ageing. 8 p., afaa061.

Research output: Contribution to journalArticle

Open Access
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Elevated levels of interleukin-6 and CRP predict the need for mechanical ventilation in COVID-19

Herold, T., Jurinovic, V., Arnreich, C., Lipworth, B. J., Hellmuth, J. C., von Bergwelt-Baildon, M., Klein, M. & Weinberger, T., 18 May 2020, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
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Feasibility of a trial to evaluate nicotinamide for chemoprevention of skin cancers in organ transplant recipients in the UK

Gollins, C. E., Shah, A., Sinha, K., Khan, S., Paul, N., Meeajun, B., Abbott, R. A., Blasdale, C., Cooper, H., Harwood, C. A., Ismail, F., Lear, J. T., Mackintosh, L., McCormack, S., Perrett, C. M., Proby, C. M., Durack, A., Patalay, R. & Matin, R. N., 7 Apr 2020, In : British Journal of Dermatology. 4 p.

Research output: Contribution to journalLetter

Genetic background influences tumour development in heterozygous Men1 knockout mice

Lines, K. E., Javid, M., Reed, A. A., Walls, G. V., Stevenson, M., Simon, M., Kooblall, K. G., Piret, S. E., Christie, P. T., Newey, P. J., Mallon, A-M. & Thakker, R. V., Apr 2020, In : Endocrine Connections. 9, 5, p. 426–437 12 p.

Research output: Contribution to journalArticle

Open Access
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Genetic Risk and Atrial Fibrillation in Patients with Heart Failure

Kloosterman, M., Santema, B. T., Roselli, C., Nelson, C. P., Koekemoer, A., Romaine, S. P. R., Van Gelder, I. C., Lam, C. S. P., Artola, V. A., Lang, C., Ng, L. L., Metra, M., Anker, S. D., Filippatos, G. S., Dickstein, K., Ponikowski, P., van der Harst, P., Meer, P. V. D., Van Veldhuisen, D. J., Benjamin, E. J. & 3 others, Voors, A. A., Samani, N. J. & Rienstra, M., 9 Jan 2020, In : European Journal of Heart Failure. 9 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
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Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects

Brown, S. J., Elias, M. S. & Bradley, M., 15 May 2020, In : Acta Dermato-Venereologica.

Research output: Contribution to journalReview article

Genetics of Skeletal Disorders

Hannan, F. M., Newey, P. J., Whyte, M. P. & Thakker, R. V., 13 Mar 2020, In : Handbook of experimental pharmacology.

Research output: Contribution to journalArticle

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., Bloom, H. L. & 31 others, Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In : Nature Communications. 11, p. 1-12 12 p., 163.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)
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Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment

Rasmussen, E. R., Hallberg, P., Baranova, E. V., Eriksson, N., Karawajczyk, M., Johansson, C., Cavalli, M., Maroteau, C., Veluchamy, A., Islander, G., Hugosson, S., Terreehorst, I., Asselbergs, F. W., Norling, P., Johansson, H-E., Kohnke, H., Syvänen, A-C., Siddiqui, M. K., Lang, C., Magnusson, P. K. E. & 8 others, Yue, Q-Y., Wadelius, C., von Buchwald, C., Bygum, A., Alfirevic, A., Maitland-van der Zee, A. H., Palmer, C. N. A. & Wadelius, M., 21 Feb 2020, In : Pharmacogenomics Journal. 14 p.

Research output: Contribution to journalArticle

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Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study

Lombardi, C. M., Ferreira, J. P., Carubelli, V., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. & Metra, M., 29 Jan 2020, In : Clinical Research in Cardiology . 11 p.

Research output: Contribution to journalArticle

Glycopyrrolate/formoterol fumarate metered dose inhaler for maintenance-naïve patients with chronic obstructive pulmonary disease: a post-hoc analysis of the randomized PINNACLE trials

Zheng, J., Xu, J-F., Jenkins, M., Assam, P. N., Wang, L. & Lipworth, B. J., 12 Mar 2020, In : Respiratory Research. 21, 1, p. 1-10 10 p., 69.

Research output: Contribution to journalArticle

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Glycopyrrolate/formoterol fumarate metered dose inhaler improves lung function versus monotherapies in GOLD category a patients with COPD: Pooled data from the phase III PINNACLE studies

Martinez, F. J., Rabe, K. F., Lipworth, B. J., Arora, S., Jenkins, M., Martin, U. J. & Reisner, C., 2020, In : International Journal of COPD. 15, p. 99-106 8 p.

Research output: Contribution to journalArticle

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Happy Birthday Bronchiectasis: 200 Years of Targeting Mucus

Chalmers, J. D. & Sibila, O., 15 Mar 2020, In : American Journal of Respiratory and Critical Care Medicine. 201, 6, p. 639-640 2 p.

Research output: Contribution to journalEditorial

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Heart failure treatment up‐titration and outcome and age: an analysis of BIOSTAT‐CHF

Mordi, I. R., Ouwerkerk, W., Anker, S. D., Cleland, J. G., Dickstein, K., Metra, M., Ng, L. L., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. A. & Lang, C. C., 25 Mar 2020, In : European Journal of Heart Failure. 10 p.

Research output: Contribution to journalArticle

Open Access
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Hepatitis C reinfection after successful antiviral treatment among people who inject drugs: A meta-analysis

Hajarizadeh, B., Cunningham, E. B., Valerio, H., Martinello, M., Law, M., Janjua, N., Midgard, H., Dalgard, O., Dillon, J., Hickman, M., Bruneau, J., Dore, G. J. & Grebely, J., Apr 2020, In : Journal of Hepatology. 72, 4, p. 643-657 15 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Higher doses of loop diuretics limit uptitration of angiotensin converting enzyme inhibitors in patients with heart failure and reduced ejection fraction

ter Maaten, J. M., Martens, P., Damman, K., Dickstein, K., Ponikowski, P., Lang, C., Ng, L. L., Anker, S. D., Samani, N. J., Filippatos, G. S., Cleland, J. G. F., Zannad, F., Hillege, H. L., van Veldhuisen, D. J., Metra, M., Voors, A. A. & Mullens, W., 30 Jan 2020, In : Clinical Research in Cardiology . 12 p.

Research output: Contribution to journalArticle

Open Access
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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

Fan, Y., Tonelli, F., Padmanabhan, S., Baptista, M., Riley, L., Smith, D., Marras, C., Howden, A., Alessi, D. & Sammler, E., 22 Mar 2020, In : JoVE: Journal of Visualized Experiments. 157, e58956.

Research output: Contribution to journalArticle