Molecular and Clinical Medicine

2023

Use of AI and access to banked bio samples for the detection and diagnosis of patients with heart failure from electronic health records: a population cohort study

Oo, M. M., Gao, C., Cole, C., Hummel, Y., Guignard-Duff, M., Jefferson, E., Hare, J., Voors, A., de Boer, R., Lam, C. S. P., Tromp, J. & Lang, C. C., 14 Feb 2023, In: Scottish Medical Journal. 68, 1, p. NP5-NP10 6 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2022

EFFECT OF LEUCINE SUPPLEMENTATION ON PHYSICAL PERFORMANCE, MUSCLE MASS AND QUALITY OF LIFE IN OLDER PEOPLE WITH SARCOPENIA

Witham, M., Adamson, S., Avenell, A., Band, M., Donnan, P., George, J., Hapca, A., Hume, C., Kemp, P. R., McKenzie, E., Pilvinyte, K., Smith, K., Struthers, A. & Sumukadas, D., 8 Mar 2022, In: Age and Ageing. 51, 1, p. i5-i7 2 p., 667.

Research output: Contribution to journal › Meeting abstract › peer-review

EFFECT OF PERINDOPRIL ON PHYSICAL PERFORMANCE, MUSCLE MASS AND QUALITY OF LIFE IN OLDER PEOPLE WITH SARCOPENIA: RESULTS

Witham, M., Adamson, S., Avenell, A., Band, M., Donnan, P., George, J., Hapca, A., Hume, C., Kemp, P. R., McKenzie, E., Pilvinyte, K., Smith, K., Struthers, A. & Sumukadas, D., 8 Mar 2022, In: Age and Ageing. 51, 1, 2 p., 666.

Research output: Contribution to journal › Meeting abstract › peer-review

Prepare to Succeed: Real-World Image Datasets for Artificial Intelligence in Skin Cancer Triage

Chin, G. X. M., Suveges, T., Carse, J., Butt, S., Muthiah, S., Morton, C., Trucco, E., Proby, C., McKenna, S. & Fleming, C., 5 Jul 2022, In: British Journal of Dermatology. 187, S1, p. 125 1 p., BT13.

Research output: Contribution to journal › Meeting abstract › peer-review

2021

Automated data capture from echocardiography reports to enhance heart failure population research

Mordi, I., Tee, A., Elder, D., Parry, H., Shearer, F., Dawson, A., Mohan, P., Currie, P., George, J., Choy, A-M., Doney, A. & Lang, C., 1 Aug 2021, In: Scottish Medical Journal. 64, 3, p. 51 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Characterization of LRP10 Expression in Lewy Body Disorders and AND IPSC-Derived Brain Cells

Grochowska, M., Carreras Mascaro, A., Boumeester, V., Natale, D., Breedveld, G., Geut, H., van Cappellen, W., Boon, A., Kievit, A., Sammler, E., Parchi, P., Cortelli, P., Alessi, D., van de Berg, W., Bonifati, V. & Mandemakers, W., 2021, In: Movement Disorders. 36, Supplement 1, p. S3334 1 p., 781.

Research output: Contribution to journal › Meeting abstract › peer-review

Correlating LRRK2 activation status in peripheral blood to urine BMPs in monogenic and idiopathic Parkinson’s disease

Gomes, S., Garrido, A., Tonelli, F., Tolosa, E., Marti, M., Anderson, D., Pratuseviciute, N., Hsieh, F., Bruecke, T., Koenig, T., Hotzy, C., Ruiz-Martínez, J., Bergareche-Yarza, A., Mondragón Rezola, E., Vinagre Aragón, A., Croitoru, I., Gorostidi Pagola, A., Markinez, L. P., Valldeoriola, F., Merchant, K. M., & 4 othersPadmanabhan, S., Zimprich, A., Alessi, D. & Sammler, E., 2021, In: Movement Disorders. 36, Supplement 1, p. S333-S334 2 p., 780.

Research output: Contribution to journal › Meeting abstract › peer-review

2020

1690P Development of a model to predict hospital admission and severe outcome in cancer patients with COVID-19

Lee, R., Zhou, C., Shotton, R., Tivey, A., Dickens, E., Huddar, P., Mckenzie, H., Boyce, H., Maynard, A., Rowe, M. P., Khan, S., Eastlake, L., Angelakas, A., Baxter, M., Copson, E., Horsley, L., Thomas, A., Wilson, C., Cooksley, T. & Armstrong, A., Sept 2020, In: Annals of Oncology. 31, Supplement 4, p. S999 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

PATIENT-REPORTED OUTCOME MEASURES AND USER EXPERIENCE FOLLOWING SIX MONTHS' ENROLMENT IN A DIABETES DIGITAL HEALTH SERVICE: MYDIABETESMYWAY: INFORMATICS IN THE SERVICE OF MEDICINE; TELEMEDICINE, SOFTWARE AND OTHER TECHNOLOGIES

Shields, C., Nutt, R., Wake, D., Brodie, D., Cunningham, S., Benson, T., Bickerton, A. & Conway, N., 18 Feb 2020, In: Diabetes Technology & Therapeutics. 22, S1, p. A163-A164 469/ Abstract ID 422.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

7 Citations (Scopus)

Real-world survival in advanced gastro-oesophagealadenocarcinoma with best supportive care

Cavanagh, K., Baxter, M. & Petty, R., 1 Sept 2020, In: Annals of Oncology. 31, Supplement 4, S914.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

2019

ADRB2 haplotypes and risk of exacerbations in asthmatic children and young adults treated with long-acting beta 2-agonists: A meta-analysis in the PiCA consortium

Karimi, L., Vijverberg, S. J., Engelkes, M., Hernandez-Pacheco, N., Farzan, N., Soares, P., Francis, B. R., Pino-Yanes, M., Eng, C., Mukhopadhyay, S., Schieck, M., Kabesch, M., Burchard, E. G., Palmer, C. N. A., Turner, S. W., Janssens, H. M., Maitland-Van Der Zee, A-H. & Verhamme, K. M. C., 21 Nov 2019, In: European Respiratory Journal. 54, 63, PA5388.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Chemotherapy for frail and elderly patients (pts) with advanced gastroesophageal cancer (aGOAC): Quality of Life (QoL) results from the GO2 phase III trial

Hall, P. S., Swinson, D., Lord, S., Handforth, C., Cairns, D., Marshall, H., Petty, R., Bennett, M., Velikova, G. & Seymour, M. T., Oct 2019, In: Annals of Oncology. 30, p. v879-v880 mdz394.037.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

9 Citations (Scopus)

Lowering Uric Acid in Normouricaemic Hypertensive Patients Has an Adverse Effect on Left Ventricular Hypertrophy Regression: Mechanistic Proof of the Urate Paradox

Gingles, C., Symon, R., Gandy, S. J., Struthers, A. D., Houston, G., Macdonald, T. M., Lang, C. C., Donnan, P. T. & George, J., 1 Jul 2019, In: Journal of Hypertension. 37, p. e57

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

10 Citations (Scopus)

Meta-analysis of inhaled corticosteroids response in children with asthma

Hernandez-Pacheco, N., Vijverberg, S. J., Gorenjak, M., Flores, C., Francis, B., Farzan, N., Corrales, A., Karimi, L., Maroteau, C., Schieck, M., Repnik, K., Perez-Mendez, L., Soares, P., Berce, V., Tavendale, R., Sardon, O., Corcuera, P., Korta, J., Mukhopadhyay, S., Pirmohamed, M., & 8 othersMc Verhamme, K., Kabesch, M., Hawcutt, D. B., Turner, S., Palmer, C. N., Potocnik, U., Maitland-Van Der Zee, A. H. & Pino-Yanes, M., 28 Sept 2019, In: European Respiratory Journal. 54, 63, PA5434.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

My Diabetes My Way: clinical outcomes impact and user experiences for an electronic personal health record for diabetes

Cunningham, S., Pokrajac, A., Allardice, B., Brillante, M., Wilson, L. & Wake, D., 1 Mar 2019, In: Future Healthcare Journal. 6, Suppl 1, p. 13-13

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Optimizing Chemotherapy for Frail and/or Elderly Patients With Advanced Gastroesophageal Cancer (Agoac): the Go2 Phase Iii Trial

Swinson, D., Hall, P. S., Lord, S. R., Marshall, H., Ruddock, S., Allmark, C., Cairns, D., Waters, J. S., Wadsley, J., Falk, S., Roy, R., Jospeh, M., Nicoll, J., Kamposioras, K., Tillett, T., Cummings, S., Grumett, S. A., Stokes, Z., Waddell, T., Chatterjee, A., & 4 othersGarcia-Alonso, A., Khan, M., Petty, R. & Seymour, M. T., Nov 2019, In: Journal of Geriatric Oncology. 10, 6 Supp. 1, p. S8 1 p., KO2.

Research output: Contribution to journal › Meeting abstract › peer-review

Optimizing chemotherapy for frail and elderly patients (pts) with advanced gastroesophageal cancer (aGOAC): The GO2 phase III trial.

Hall, P. S., Swinson, D., Waters, J. S., Wadsley, J., Falk, S., Roy, R., Tillett, T., Nicoll, J., Cummings, S., Grumett, S. A., Kamposioras, K., Garcia, A., Allmark, C., Marshall, H., Ruddock, S., Katona, E., Velikova, G., Petty, R. D., Grabsch, H. I. & Seymour, M. T., 20 May 2019, In: Journal of Clinical Oncology. 37, 15, p. 4006 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Real-world experience of trifluridine/tipiracil in patients with metastatic colorectal cancer: A multicenter United Kingdom study

Stavraka, C., Pouptsis, A., Kabuubi, P., Angelis, V., Baxter, M., Barrie, A., Costa, A., Nizam, A., De Naurois, J., Mikropoulos, C., Hill, M., Graham, J., Harris, V., Bridgewater, J. & Ross, P., 1 Feb 2019, In: Journal of Clinical Oncology. 37, 4, p. 668-668 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

69 Citations (Scopus)

Research into the effect of sodium-glucose linked transporter inhibition in left ventricular remodelling in patients with heart failure and diabetes mellitus (REFORM Trial)

Singh, J. S., Mordi, I., Fathi, A., Vickneson, K., Donnan, P. T., Mohan, M., Choy, A. M., Gandy, S. J., Pearson, E. R., Houston, J. G., Struthers, A. D. & Lang, C. C., Nov 2019, In: Scottish Medical Journal. 64, 4, p. NP64-NP65

Research output: Contribution to journal › Meeting abstract › peer-review

Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland

Deciphering Developmental Disorders (DDD) Study, Cacciottolo, T. M., Perikari, A., van der Klaauw, A., Henning, E., Stadler, L. K. J., Keogh, J., Farooqi, I. S., Tenin, G., Keavney, B., Ryan, E., Budd, R., Bewley, M., Coelho, P., Rumsey, W., Sanchez, Y., McCafferty, J., Dockrell, D., Walmsley, S., Whyte, M., & 31 othersLiu, Y., Choy, M-K., Tenin, G., Abraham, S., Black, G., Keavney, B., Watkins, S., Robertson, K., Collison, D., Rush, C., Marshall, J., McGowan, R., Fraser, R., Gandhi, S., Cooper, C., Howden, A., Hukelmann, J. L., Cantrell, D. A., Mordi, I., Forteath, C., Wong, A., Mohan, M., Palmer, C., Doney, A., Rena, G., Lang, C., Gray, E. H., Williams, R., Williams, S., Hughes, J. & Davies, J., 5 Sept 2019, In: QJM : an International Journal of Medicine. 112, 9, p. 724-729 6 p., 9.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

1 Citation (Scopus)

Trifluridine/tipiracil in metastatic colorectal cancer: An updated multicentre real-world analysis on efficacy, safety and predictive factors

Stavraka, C., Pouptsis, A., Synowiec, A., Aggelis, V., Satterthwaite, L., Khan, S., Chauhan, M., Holden, C. E., Young, S., Karampera, C., Martinou, M., Mills-Baldock, T., Baxter, M., Eccles, B. K., Iveson, T. J., Shiu, K., Hill, M. E., Abdel-raouf, S., Thomas, A. & Ross, P. J., 1 Oct 2019, In: Annals of Oncology. 30, 5, 2 p., mdz246.077.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Urinary desmosine, a biomarker of elastin degradation is significantly elevated and associated with maximum aortic root size and aortic Z-scores in patients with bicuspid aortic valve

Iskandar, Z., Huang, J., Miller, L., Chin, C., Mordi, I., Mcwilliam, C., Goudie, D., Berg, J., Neagoie, A., Lang, C. & Choy, A-M., 26 May 2019, In: Heart. 105, Supplement 6, p. A103-A104 2 p., 126.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

2018

65 The novel plasma biomarker desmosine, a marker of elastin breakdown, is an independent predictor of abdominal aortic aneurysm events independent of aneurysm size

Mordi, I., Forsythe, R., Bown, M., Lang, C., Newby, D. E., Gellatly, C., Chin, C. W. L., McBride, O., Saratzis, A., Iskandar, Z., Chalmers, R., Huang, J. & Choy, A., Jun 2018, In: Heart. 104, Suppl 6, p. A58-59 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

15 Citations (Scopus)

6 Metformin regresses left ventricular hypertrophy in normotensive patients with coronary artery disease without type 2 diabetes mellitus – the met-remodel trial

Mohan, M., Al-talabany, S., Mckinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M., Bhalraam, U., Khan, F., Choy, A. M., Houston, G., George, J., Struthers, A. & Lang, C., 1 Jun 2018, In: Heart. 104, Issue Suppl 6, p. A6.1-A6

Research output: Contribution to journal › Meeting abstract › peer-review

The novel biomarker plasma desmosine, a marker of elastin breakdown, is an independent predictor of abdominal aortic aneurysm events independent of aneurysm size

Mordi, I., Forsythe, R., Bown, M., Lang, C., Newby, D. E., Gellatly, C., Chin, C. W. L., McBride, O., Saratzis, A., Iskandar, Z., Chalmers, R., Huang, J. & Choy, A., Aug 2018, In: European Heart Journal. 39, Suppl 1, p. 1253-1254 ehy566.P6040.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Using a weighted genetic risk core to investigate the clinical impact of genetically determined Systolic Blood Pressure in a Large Prospective Cohort

Doney, A., Flynn, R., Man, T., Palmer, C., Donnelly, L., Morant, S., Mackenzie, I. & MacDonald, T., Oct 2018, In: Journal of Human Hypertension. 32, 10, p. 707-707

Research output: Contribution to journal › Meeting abstract › peer-review

2017

Early HTA in Pharmacogenomics: A Case Example in Cardiovascular Drugs

Baranova, E. V., Geenen, J. W., Asselbergs, F. W., Palmer, C. N., de Boer, A., Maitland-van der Zee, A-H. & Hövels, A. M., Aug 2017, In: Pharmacoepidemiology and Drug Safety. 26, S2, p. 264-265 2 p., 436.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Genome-Wide Association Study of Asthma Exacerbations in European Children Treated with Inhaled Corticosteroids

Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., Soares, P., Karimi, L., Tavendale, R., Berce, V., Repnik, K., Verhamme, K. M. C., Potocnik, U., Mukhopadhyay, S., Pirmohamed, M., Palmer, C. N., Turner, S. W., Hawcutt, D. B., Kabesch, M., Pino-Yanes, M., & 1 othersMaitland-van der Zee, A-H., 22 Aug 2017, In: Pharmacoepidemiology and Drug Safety. 26, p. 25-26

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Homozygous status for the Arg16 variant is associated with increased prescribing of controller asthma medication and increased asthma-related prescribing cost

Soares, P., Fidler, K., Tavendale, R., Turner, S., Lipworth, B., Bremner, S., Palmer, C. N. A. & Mukhopadhyay, S., Dec 2017, In: Clinical and Experimental Allergy. 47, 12, p. 1681-1682 2 p., O.010.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

Interventions to Enhance Medication Adherence in Older Heart Failure Patients - A Systematic Review

Fulton, R., Kroll, T., McMurdo, M., Molloy, G. J. & Witham, M., 16 May 2017, In: Age and Ageing. 46, Supplement 1, p. i25 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

2016

LATE-BREAKING ABSTRACT: Real life impact of long acting beta-2-agonist withdrawal in controlled step 3 asthma patients

Jabbal, S., Manoharan, A., Anderson, W. & Lipworth, B., 8 Nov 2016, In: European Respiratory Journal. 48, Suppl60

Research output: Contribution to journal › Meeting abstract

Patterns of early atherosclerosis formation and cardiac remodelling in healthy adults of south asian and european descent

Weir-McCall, J., Cassidy, D., Belch, J., Gandy, S., Houston, G., Lambert, M., Littleford, R., Rowland, J., Struthers, A. & Khan, F., May 2016, In: Heart. 102, Suppl 5, 014.

Research output: Contribution to journal › Meeting abstract › peer-review

Prevalence, pattern and significance of late gadolinium enhancement in a healthy asymptomatic cohort.

Weir-McCall, J., Fitzgerald, K., Papagiorcopulo, C., Gandy, S. J., Lambert, M., Belch, J., Cavin, I., Littleford, R., MacFarlane, J. A., Matthew, S. Z., Nicholas, R. S., Struthers, A., Sullivan, F., Waugh, S. A., White, R. D. & Houston, J. G., May 2016, In: Heart. 102, Suppl 5, 015.

Research output: Contribution to journal › Meeting abstract › peer-review

Ultra-Widefield Ophthalmic Imaging for Biomarker Discovery in Hypertension

Robertson, G., Peto, T., Williams, M., Dhillon, B., Houston, J., Newby, D. E., van Beek, E. J. R., Trucco, E., Fleming, A., van Hemert, J. & MacGillivray, T., Sept 2016, In: Investigative Ophthalmology & Visual Science. 57, 12, p. 1680 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

13 Citations (Scopus)

2015

Heart Rate is not Related to Survival in Patients with Heart Failure and Atrial Fibrillation

Hawkey, S., Levin, D., Mohan, M., Baig, F., Iskandar, Z., Rutherford, L., Lang, C. & Choy, A., Jun 2015, In: Heart. 101, Supplement 4, p. A15-16 28.

Research output: Contribution to journal › Meeting abstract › peer-review

Inferior Vena Cava Dilatation Predicts Mortality and Worsening Renal Function in Patients With Chronic Heart Failure

Iqbal, A. H. M., Soujeri, B., Hawkey, S., Levin, D., Iskandar, Z., Stewart, G., Sloan, J. & Lang, C., 26 Sept 2015, In: Journal of Cardiac Failure. 21, 8, Supplement, p. S70 151.

Research output: Contribution to journal › Meeting abstract › peer-review

2014

Treatment with allopurinol and oxypurinol promotes osteoblast differentiation and increases bone formation

Orriss, I., Arnett, T., George, J. & Witham, M., 2014, In: Bone Abstracts. 3, PP120.

Research output: Contribution to journal › Meeting abstract › peer-review

2013

Allopurinol reduces left ventricular mass in patients with type ii diabetes and left ventricular hypertrophy

Szwejkowski, B. R., Gandy, S., Rekhraj, S., Houston, G., George, J., Lang, C. C., Morris, A. D. & Struthers, A. D., 2013, In: Journal of the American College of Cardiology. 61, 10 Supplement, p. E1256 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2012

Allopurinol use associated with greater functional gains in older rehabilitation patients: a retrospective cohort study

Beveridge, L. A., Ramage, L., McMurdo, M. E. T., George, J. & Witham, M., 2012, In: Age and Ageing. 41, Suppl. 2, p. 65 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Automated data capture from echocardiography reports to enhance heart failure population research

Elder, D. H. J., Shearer, F., Dawson, A., Pradeep, M., Parry, H., Currie, P., Pringle, S. D., George, J., Choy, A. & Lang, C. C., 2012, In: Heart. 98, Suppl. 1, p. A10-A10 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

High admission Barthel scores do not predict lack of benefit from inpatient rehabilitation

Tan, S. C., Ramage, L., McMurdo, M. E. T. & Witham, M., 2012, In: Age and Ageing. 41, Suppl. 2, p. 69 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

2011

Robust neutralising activity and activation of neutrophil cytotoxic responses mediated by antibodies targeting the HTLV-1 envelope glycoprotein

Kuo, C., Tulloch, L. & Brighty, D. W., 6 Jun 2011, In: Retrovirology. 8, Supplement 1, 1 p., A170.

Research output: Contribution to journal › Meeting abstract › peer-review

Open Access

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102 Downloads (Pure)

2008

Role of chronic inflammation in sporadic colorectal neoplasia

McLean, M. H., Drew, J. E., Mayer, C. D., Farquharson, A. J., Barrera, L. N., Fyfe, N., Murray, G., Hold, G. L., Mowat, N. A. & El-Omar, E. M., 1 Apr 2008, In: Gastroenterology. 134, 4, Supplement 1, p. A-293-A-294 2 p., S1996.

Research output: Contribution to journal › Meeting abstract › peer-review

2005

Electron microscopy of yeast and bacterial V-ATPases

Nicholson, W., 2005, In: Biophysical Journal. 88, 1, p. 599A 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Using the demand-control model of job strain to predict caregiver burden: a longitudinal study

Molloy, G., Johnston, D., Johnston, M., Witham, M., Struthers, A. & McMurdo, M., 2005, In: Psychology and Health. 20, Suppl. 1, p. 176-177 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Molecular and Clinical Medicine

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