Molecular and Clinical Medicine

Research Output 1976 2020

Filter
Article
2020

Ability of primary care health databases to assess medicinal products discussed by the European Union Pharmacovigilance Risk Assessment Committee

Flynn, R., Hedenmalm, K., Murray-Thomas, T., Pacurariu, A., Arlett, P., Shepherd, H., Myles, P. & Kurz, X., 12 Feb 2020, In : Clinical Pharmacology and Therapeutics. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Pharmacovigilance
European Union
Biomedical Research
Primary Health Care
Databases

A feasibility study of microwave therapy for precancerous actinic keratoses

Jackson, D. N., Hogarth, F. J., Sutherland, D., Holmes, E. M., Donnan, P. T. & Proby, C. M., 6 Feb 2020, In : British Journal of Dermatology.

Research output: Contribution to journalArticle

Actinic Keratosis
Feasibility Studies
Microwaves
Therapeutics
Randomized Controlled Trials
Oscillometry
Asthma
Airway Resistance
Electric Impedance
Vascular Resistance

Anti-inflammatory reliever therapy for asthma

Lipworth, B., Chan, R. & RuiWen Kuo, C., Jan 2020, In : Annals of Allergy, Asthma & Immunology. 124, 1, p. 13-15 3 p.

Research output: Contribution to journalArticle

Biomarkers of Aortopathy in Marfan Syndrome

Iskandar, Z., Mordi, I., Lang, C., Huang, J. & Choy, A., 23 Jan 2020, In : Cardiology in Review. 28, 2, p. 92-97 6 p.

Research output: Contribution to journalArticle

Marfan Syndrome
Biomarkers
Dissection
Patient Care
Cardiovascular System

Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial

Chalmers, J. R., Haines, R. H., Bradshaw, L. E., Montgomery, A. A., Thomas, K. S., Brown, S. J., Ridd, M. J., Lawton, S., Simpson, E. L., Cork, M. J., Sach, T. H., Flohr, C., Mitchell, E. J., Swinden, R., Tarr, S., Davies-Jones, S., Jay, N., Kelleher, M. M., Perkin, M. R., Boyle, R. J. & 1 others, Williams, H. C., 19 Feb 2020, In : Lancet. 11 p.

Research output: Contribution to journalArticle

Open Access
File
Emollients
Eczema
Randomized Controlled Trials
Skin Care
Control Groups
15 Downloads (Pure)

Development and initial validation of the bronchiectasis exacerbation and symptom tool (BEST)

Artaraz, A., Crichton, M. L., Finch, S., Abo-Leyah, H., Goeminne, P., Aliberti, S., Fardon, T. & Chalmers, J. D., 13 Jan 2020, In : Respiratory Research. 21, 1, p. 1-9 1 p., 18.

Research output: Contribution to journalArticle

Open Access
File
Bronchiectasis
Sputum
Cough
Chronic Obstructive Pulmonary Disease
Dyspnea

Distinct Pathological Pathways in Patients with Heart Failure and Diabetes

Tromp, J., Voors, A. A., Sharma, A., Ferreira, J. P., Ouwerkerk, W., Hillege, H. L., Arevalo Gomez, K., Dickstein, K., Anker, S. D., Metra, M., Lang, C., Ng, L. L., van der Harst, P., van Veldhuisen, D. J., van der Meer, P., Lam, C. S. P., Zannad, F. & Sama, I. E., 5 Feb 2020, In : JACC: Heart Failure. 8, 3, p. 234-242 9 p.

Research output: Contribution to journalArticle

Heart Failure
Biomarkers
Epidermal Growth Factor Receptor
Galectin 4
Neutrophils
13 Downloads (Pure)

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure

Kloosterman, M., Santema, B. T., Roselli, C., Nelson, C. P., Koekemoer, A., Romaine, S. P. R., Van Gelder, I. C., Lam, C. S. P., Artola, V. A., Lang, C., Ng, L. L., Metra, M., Anker, S. D., Filippatos, G. S., Dickstein, K., Ponikowski, P., van der Harst, P., Meer, P. V. D., Van Veldhuisen, D. J., Benjamin, E. J. & 3 others, Voors, A. A., Samani, N. J. & Rienstra, M., 9 Jan 2020, In : European Journal of Heart Failure. 9 p.

Research output: Contribution to journalArticle

Open Access
File
Atrial Fibrillation
Heart Failure
Single Nucleotide Polymorphism
Atrial Flutter
Genome-Wide Association Study
24 Downloads (Pure)

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Shah, S., Henry, A., Roselli, C., Lin, H., Sveinbjörnsson, G., Fatemifar, G., Hedman, Å. K., Wilk, J. B., Morley, M. P., Chaffin, M. D., Helgadottir, A., Verweij, N., Dehghan, A., Almgren, P., Andersson, C., Aragam, K. G., Ärnlöv, J., Backman, J. D., Biggs, M. L., Bloom, H. L. & 31 others, Brandimarto, J., Brown, M. R., Buckbinder, L., Carey, D. J., Chasman, D. I., Chen, X., Chen, X., Chung, J., Chutkow, W., Cook, J. P., Delgado, G. E., Denaxas, S., Doney, A. S., Dörr, M., Dudley, S. C., Dunn, M. E., Engström, G., Esko, T., Felix, S. B., Finan, C., Ford, I., Mordi, I. R., Morris, A. D., Morris, A. P., Palmer, C. N. A., Parry, H. M., Smith, N. L., Veluchamy, A., McMurray, J. J. V., Lang, C. C. & Lumbers, R. T., 9 Jan 2020, In : Nature Communications. 11, 1, p. 1-12 12 p., 163.

Research output: Contribution to journalArticle

Open Access
File
Mendelian Randomization Analysis
pathogenesis
genome
Heart Failure
Genes

Genome-wide association study of angioedema induced by angiotensin-converting enzyme inhibitor and angiotensin receptor blocker treatment

Rasmussen, E. R., Hallberg, P., Baranova, E. V., Eriksson, N., Karawajczyk, M., Johansson, C., Cavalli, M., Maroteau, C., Veluchamy, A., Islander, G., Hugosson, S., Terreehorst, I., Asselbergs, F. W., Norling, P., Johansson, H-E., Kohnke, H., Syvänen, A-C., Siddiqui, M. K., Lang, C., Magnusson, P. K. E. & 8 others, Yue, Q-Y., Wadelius, C., von Buchwald, C., Bygum, A., Alfirevic, A., Maitland-van der Zee, A. H., Palmer, C. N. A. & Wadelius, M., 21 Feb 2020, In : Pharmacogenomics Journal. 14 p.

Research output: Contribution to journalArticle

Open Access
File
Angioedema
Angiotensin Receptor Antagonists
Genome-Wide Association Study
Angiotensin-Converting Enzyme Inhibitors
Genome

Geographical differences in heart failure characteristics and treatment across Europe: results from the BIOSTAT-CHF study

Lombardi, C. M., Ferreira, J. P., Carubelli, V., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. & Metra, M., 29 Jan 2020, In : Clinical Research in Cardiology . 11 p.

Research output: Contribution to journalArticle

Heart Failure
Therapeutics
Slovenia
Serbia
Greece
6 Downloads (Pure)

Glycopyrrolate/formoterol fumarate metered dose inhaler improves lung function versus monotherapies in GOLD category a patients with COPD: Pooled data from the phase III PINNACLE studies

Martinez, F. J., Rabe, K. F., Lipworth, B. J., Arora, S., Jenkins, M., Martin, U. J. & Reisner, C., 2020, In : International Journal of COPD. 15, p. 99-106 8 p.

Research output: Contribution to journalArticle

Open Access
File
Glycopyrrolate
Metered Dose Inhalers
Chronic Obstructive Pulmonary Disease
Lung
Forced Expiratory Volume
Open Access
File
Hepatitis C
Pharmaceutical Preparations
Mortality
Polymerase Chain Reaction
Therapeutics
4 Downloads (Pure)

Higher doses of loop diuretics limit uptitration of angiotensin converting enzyme inhibitors in patients with heart failure and reduced ejection fraction

ter Maaten, J. M., Martens, P., Damman, K., Dickstein, K., Ponikowski, P., Lang, C., Ng, L. L., Anker, S. D., Samani, N. J., Filippatos, G. S., Cleland, J. G. F., Zannad, F., Hillege, H. L., van Veldhuisen, D. J., Metra, M., Voors, A. A. & Mullens, W., 30 Jan 2020, In : Clinical Research in Cardiology . 12 p.

Research output: Contribution to journalArticle

Open Access
File
Sodium Potassium Chloride Symporter Inhibitors
Angiotensin-Converting Enzyme Inhibitors
Heart Failure
Mineralocorticoid Receptor Antagonists
Hospitalization
12 Downloads (Pure)

Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands

Morales, D. R., Morant, S. V., MacDonald, T. M., Mackenzie, I. S., Doney, A. S. F., Mitchell, L., Bennie, M., Robertson, C., Hallas, J., Pottegard, A., Ernst, M. T., Wei, L., Nicholson, L., Morris, C., Herings, R. M. C., Overbeek, J. A., Smits, E. & Flynn, R. W. V., 3 Jan 2020, In : Pharmacoepidemiology and Drug Safety. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Diclofenac
Scotland
Denmark
England
Netherlands

International consensus guideline for reporting transmission electron microscopy results in the diagnosis of Primary Ciliary Dyskinesia (BEAT PCD TEM Criteria)

Shoemark, A., Boon, M., Brochhausen, C., Bukowy-Bieryllo, Z., Margherita De Santi, M., Goggin, P., Griffin, P., Hegele, R. G., Hirst, R. A., Leigh, M. W., Lupton, A., MacKenney, K., Omran, H., Pache, J-C., Pinto, A., Reinholt, F. P., Schroeder, J., Yiallouros, P. & Escudier, E., 14 Feb 2020, In : The European respiratory journal.

Research output: Contribution to journalArticle

Kartagener Syndrome
Transmission Electron Microscopy
Guidelines
Terminology
Electron Microscopy
7 Downloads (Pure)

Is bronchiectasis really a disease?

Shteinberg, M., Flume, P. A. & Chalmers, J. D., 29 Jan 2020, In : European Respiratory Review. 29, 155, p. 1-10 10 p., 190051.

Research output: Contribution to journalArticle

Open Access
File
Bronchiectasis
Signs and Symptoms
Clinical Trials
Inflammation
Phenotype
Bronchiectasis
Macrolides
Anti-Bacterial Agents
Health Care Costs
Therapeutics
Breast Neoplasms
Biopsy
Skin
Neoplasms
Logistic Models
2 Downloads (Pure)

Standardised clinical data from patients with primary ciliary dyskinesia: FOLLOW-PCD

Goutaki, M., Papon, J-F., Boon, M., Casaulta, C., Eber, E., Escudier, E., Halbeisen, F. S., Harris, A., Hogg, C., Honore, I., Jung, A., Karadag, B., Koerner-Rettberg, C., Legendre, M., Maitre, B., Nielsen, K. G., Rubbo, B., Rumman, N., Schofield, L., Shoemark, A. & 4 others, Thouvenin, G., Willkins, H., Lucas, J. S. & Kuehni, C. E., 10 Feb 2020, In : ERJ Open Research. 6, 1, p. 1-10 10 p., 00237.

Research output: Contribution to journalArticle

Open Access
File
Kartagener Syndrome
Research
Patient Advocacy
Standard of Care
Documentation

Statistical shape modelling provides a responsive measure of morphological change in knee osteoarthritis over 12 months

Gregory, J. S., Barr, R. J., Yoshida, K., Alesci, S., Reid, D. M. & Aspden, R. M., 14 Jan 2020, In : Rheumatology. 8 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Knee
Joints
Replacement Arthroplasties
Biomarkers
1 Citation (Scopus)

The year in cardiology: aorta and peripheral circulation

Heiss, C., Pitcher, A., Belch, J. J. F., De Carlo, M., Reinecke, H., Baumgartner, I., Mazzolai, L. & Aboyans, V., 21 Jan 2020, In : European Heart Journal. 41, 4, p. 501-508b 10 p.

Research output: Contribution to journalArticle

Peripheral Arterial Disease
Cardiology
Aorta
Lower Extremity
Arteries
99 Downloads (Pure)
Open Access
File
Type 2 Diabetes Mellitus
Cardiovascular Diseases
Diabetic Foot
Mortality
Diabetic Neuropathies
2019
16 Downloads (Pure)

A 2 × 2 factorial, randomised, open-label trial to determine the clinical and cost-effectiveness of hypertonic saline (HTS 6%) and carbocisteine for airway clearance versus usual care over 52 weeks in adults with bronchiectasis: a protocol for the CLEAR clinical trial

Bradley, J. M., Anand, R., O'Neill, B., Ferguson, K., Clarke, M., Carroll, M., Chalmers, J., De Soyza, A., Duckers, J., Hill, A. T., Loebinger, M. R., Copeland, F., Gardner, E., Campbell, C., Agus, A., McGuire, A., Boyle, R., McKinney, F., Dickson, N., McAuley, D. F. & 1 others, Elborn, S., 19 Dec 2019, In : Trials. 20, 1, p. 1-10 10 p., 747.

Research output: Contribution to journalArticle

Open Access
File
Bronchiectasis
Cost-Benefit Analysis
Clinical Trials
Standard of Care
Sputum
10 Citations (Scopus)
68 Downloads (Pure)

Accuracy of High-Speed Video Analysis to Diagnose Primary Ciliary Dyskinesia

Rubbo, B., Shoemark, A., Jackson, C. L., Hirst, R., Thompson, J., Hayes, J., Frost, E., Copeland, F., Hogg, C., O'Callaghan, C., Reading, I. & Lucas, J. S., 1 May 2019, In : Chest. 155, 5, p. 1008-1017 10 p.

Research output: Contribution to journalArticle

Open Access
File
Kartagener Syndrome
Video Microscopy
Routine Diagnostic Tests
Guidelines
Referral and Consultation
68 Downloads (Pure)

Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

Murchie, P., Masthoff, J., Walter, F. M., Rahman, K., Allan, J. L., Burrows, N., Proby, C., Lee, A. J., Johnston, M., Durrani, A., Depasquale, I., Brant, B., Neilson, A., Meredith, F., Treweek, S., Hall, S. & McDonald, A., 3 Jun 2019, In : Trials. 20, 1, p. 1-11 11 p., 318.

Research output: Contribution to journalArticle

Open Access
File
Aftercare
Melanoma
Self-Examination
Neoplasms
Skin
23 Downloads (Pure)

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Sakellaropoulos, T., Vougas, K., Narang, S., Koinis, F., Kotsinas, A., Polyzos, A., Moss, T. J., Piha-Paul, S., Zhou, H., Kardala, E., Damianidou, E., Alexopoulos, L. G., Aifantis, I., Townsend, P. A., Panayiotidis, M. I., Sfikakis, P., Bartek, J., Fitzgerald, R. C., Thanos, D., Mills Shaw, K. R. & 3 others, Petty, R., Tsirigos, A. & Gorgoulis, V. G., 10 Dec 2019, In : Cell Reports. 29, 11, p. 3367-3373.e4 12 p.

Research output: Contribution to journalArticle

Open Access
File
Learning systems
Learning
Workflow
Gene expression
Pharmaceutical Preparations

Adherence to once-daily and twice-daily direct acting antiviral therapy for hepatitis C infection among people with recent injection drug use or current opioid agonist therapy

Cunningham, E. B., Hajarizadeh, B., Amin, J., Litwin, A. H., Gane, E., Cooper, C., Lacombe, K., Hellard, M., Read, P., Powis, J., Dalgard, O., Bruneau, J., Matthews, G. V., Feld, J. J., Dillon, J. F., Shaw, D., Bruggmann, P., Conway, B., Fraser, C., Marks, P. & 2 others, Dore, G. J. & Grebely, J., 2 Nov 2019, In : Clinical Infectious Diseases.

Research output: Contribution to journalArticle

Hepatitis C
Opioid Analgesics
Antiviral Agents
Injections
Infection
4 Citations (Scopus)

A domestication history of dynamic adaptation and genomic deterioration in Sorghum

Smith, O., Nicholson, W., Kistler, L., Mace, E., Clapham, A., Rose, P., Stevens, C., Ware, R., Samavedam, S., Barker, G., Jordan, D., Fuller, D. Q. & Allaby, R. G., 8 Apr 2019, In : Nature Plants. 5, 4, p. 369-379 11 p.

Research output: Contribution to journalArticle

domestication
Sorghum (Poaceae)
deterioration
introgression
genomics
1 Citation (Scopus)
64 Downloads (Pure)

A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia

Huang, Y., Kee, C-S., Hocking, P. M., Williams, C., Yip, S. P. & Guggenheim, J. A., 1 Feb 2019, In : Investigative Ophthalmology & Visual Science. 60, 2, p. 559-569 11 p.

Research output: Contribution to journalArticle

Open Access
File
Genome-Wide Association Study
Myopia
Refractive Errors
Genetic Predisposition to Disease
Genetic Markers
4 Citations (Scopus)
26 Downloads (Pure)

Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients

Lanz, J., Bouwes Bavinck, J. N., Westhuis, M., Quint, K. D., Harwood, C. A., Nasir, S., Van-de-Velde, V., Proby, C. M., Ferrándiz, C., Genders, R. E., Del Marmol, V., Forchetti, G., Hafner, J., Vital, D. G. & Vital, D. G., 1 Jan 2019, In : JAMA Dermatology. 155, 1, p. 66-71 6 p.

Research output: Contribution to journalArticle

Open Access
File
Squamous Cell Carcinoma
Transplants
Neoplasms
Neoplasm Metastasis
Organ Transplantation
5 Citations (Scopus)

Airway Bacterial Load and Inhaled Antibiotic Response in Bronchiectasis

Sibila, O., Laserna, E., Shoemark, A., Keir, H. R., Finch, S., Rodrigo-Troyano, A., Perea, L., Lonergan, M., Goeminne, P. C. & Chalmers, J. D., 1 Jul 2019, In : American Journal of Respiratory and Critical Care Medicine. 200, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

Bronchiectasis
Bacterial Load
Anti-Bacterial Agents
Aztreonam
Quality of Life
2 Citations (Scopus)
104 Downloads (Pure)

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension

Gingles, C., Symon, R., Gandy, S., Struthers, A., Houston, G., MacDonald, T., Lang, C., Donnan, P. & George, J., Dec 2019, In : Journal of Hypertension. 37, 12, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

Open Access
File
Allopurinol
Hypertension
Placebos
Oxidative Stress
Left Ventricular Hypertrophy

A modified Delphi process to establish future research priorities in malignant oesophagogastric surgery

Wilson, M. S. J., Blencowe, N. S., Boyle, C., Knight, S. R., Petty, R., Vohra, R. S. & Underwood, T. J., 16 Dec 2019, In : Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland. 6 p.

Research output: Contribution to journalArticle

Research
Neoplasms
Genomics
Patient Care
Delivery of Health Care

A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

LifeLines Cohort Study, Sung, Y. J., de Las Fuentes, L., Winkler, T. W., Chasman, D. I., Bentley, A. R., Kraja, A. T., Ntalla, I., Warren, H. R., Guo, X., Schwander, K., Manning, A. K., Brown, M. R., Aschard, H., Feitosa, M. F., Franceschini, N., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D. & 40 others, Marten, J., Musani, S. K., Kilpeläinen, T. O., Richard, M. A., Aslibekyan, S., Bartz, T. M., Dorajoo, R., Li, C., Liu, Y., Rankinen, T., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Zhao, W., Zhou, Y., Matoba, N., Sofer, T., Alver, M., Amini, M., Boissel, M., Chai, J. F., Chen, X., Divers, J., Gandin, I., Gao, C., Giulianini, F., Goel, A., Harris, S. E., Hartwig, F. P., Connell, J. M., Smith, B. H., Rotter, J. I., Franks, P. W., Rice, K., Elliott, P., Caulfield, M. J., Gauderman, W. J., Munroe, P. B., Rao, D. C. & Morrison, A. C., 1 Aug 2019, In : Human Molecular Genetics. 28, 15, p. 2615-2633 19 p.

Research output: Contribution to journalArticle

Arterial Pressure
Smoking
Genome
Blood Pressure
Genes
5 Citations (Scopus)
25 Downloads (Pure)

A Multicenter, Randomized, Placebo-Controlled Trial of Atorvastatin for the Primary Prevention of Cardiovascular Events in Patients With Rheumatoid Arthritis: A multicenter, randomized, placebo controlled trial

Kitas, G. D., Nightingale, P., Armitage, J., Sattar, N., Belch, J. J. F. & Symmons, D. P. M., Sep 2019, In : Arthritis and Rheumatology. 71, 9, p. 1437-1449 13 p.

Research output: Contribution to journalArticle

Open Access
File
Primary Prevention
Rheumatoid Arthritis
Randomized Controlled Trials
Placebos
Risk Reduction Behavior
1 Citation (Scopus)
70 Downloads (Pure)

An Owner-Independent Investigation of Diabetes Alert Dog Performance

Wilson, C., Morant, S., Kane, S., Pesterfield, C., Guest, C. & Rooney, N. J., 27 Mar 2019, In : Frontiers in Veterinary Science. 6, p. 1-11 11 p., 91.

Research output: Contribution to journalArticle

Open Access
File
Dogs
Hypoglycemic Agents
Television
Glucose
Critical Care
2 Citations (Scopus)
124 Downloads (Pure)

Antimicrobial peptides, disease severity and exacerbations in bronchiectasis

Sibila, O., Perea, L., Cantó, E., Shoemark, A., Cassidy, D., Smith, A. H., Suarez-cuartin, G., Rodrigo-troyano, A., Keir, H. R., Oriano, M., Ong, S., Vidal, S., Blasi, F., Aliberti, S. & Chalmers, J. D., Sep 2019, In : Thorax. 74, 9, p. 835-842 8 p.

Research output: Contribution to journalArticle

Open Access
File
Secretory Leukocyte Peptidase Inhibitor
Bronchiectasis
Disease Progression
Peptides
Sputum
2 Citations (Scopus)

Anti-microbial Resistance In Atopic Dermatitis: Need for an Urgent Rethink

Harkins, C. P., Holden, M. T. G. & Irvine, A. D., 1 Mar 2019, In : Annals of Allergy, Asthma & Immunology. 122, 3, p. 236-240 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A point of care neutrophil elastase activity assay identifies bronchiectasis severity, airway infection and risk of exacerbation

Shoemark, A., Cant, E., Carreto, L., Smith, A., Oriano, M., Keir, H. R., Perea, L., Canto, E., Terranova, L., Vidal, S., Moffitt, K., Aliberti, S., Sibila, O. & Chalmers, J. D., 1 Jun 2019, In : European Respiratory Journal. 53, 6, 1900303.

Research output: Contribution to journalArticle

Point-of-Care Systems
Leukocyte Elastase
Bronchiectasis
Sputum
Infection
27 Downloads (Pure)
Open Access
File
Opiate Substitution Treatment
Hepatitis C
Primary Health Care
Motivation
Patient Acceptance of Health Care
15 Citations (Scopus)

Application of High-Sensitivity Troponin in Suspected Myocardial Infarction

Neumann, J. T., Twerenbold, R., Ojeda, F., Sörensen, N. A., Chapman, A. R., Shah, A. S. V., Anand, A., Boeddinghaus, J., Nestelberger, T., Badertscher, P., Mokhtari, A., Pickering, J. W., Troughton, R. W., Greenslade, J., Parsonage, W., Mueller-Hennessen, M., Gori, T., Jernberg, T., Morris, N., Liebetrau, C. & 34 others, Hamm, C., Katus, H. A., Münzel, T., Landmesser, U., Salomaa, V., Iacoviello, L., Ferrario, M. M., Giampaoli, S., Kee, F., Thorand, B., Peters, A., Borchini, R., Jørgensen, T., Söderberg, S., Sans, S., Tunstall-Pedoe, H., Kuulasmaa, K., Renné, T., Lackner, K. J., Worster, A., Body, R., Ekelund, U., Kavsak, P. A., Keller, T., Lindahl, B., Wild, P., Giannitsis, E., Than, M., Cullen, L. A., Mills, N. L., Mueller, C., Zeller, T., Westermann, D. & Blankenberg, S., 27 Jun 2019, In : New England Journal of Medicine. 380, 26, p. 2529-2540 12 p.

Research output: Contribution to journalArticle

Troponin
Myocardial Infarction
Troponin I
Hospital Emergency Service
Troponin T
5 Citations (Scopus)
16 Downloads (Pure)

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium

Brunner, F. J., Waldeyer, C., Ojeda, F., Salomaa, V., Kee, F., Sans, S., Thorand, B., Giampaoli, S., Brambilla, P., Tunstall-Pedoe, H., Moitry, M., Iacoviello, L., Veronesi, G., Grassi, G., Mathiesen, E. B., Söderberg, S., Linneberg, A., Brenner, H., Amouyel, P., Ferrières, J. & 20 others, Tamosiunas, A., Nikitin, Y. P., Drygas, W., Melander, O., Jöckel, K-H., Leistner, D. M., Shaw, J. E., Panagiotakos, D. B., Simons, L. A., Kavousi, M., Vasan, R. S., Dullaart, R. P. F., Wannamethee, S. G., Risérus, U., Shea, S., de Lemos, J. A., Omland, T., Kuulasmaa, K., Landmesser, U. & Blankenberg, S., 14 Dec 2019, In : Lancet. 394, 10215, p. 2173-2183 11 p.

Research output: Contribution to journalArticle

Open Access
File
Cardiovascular Diseases
Cholesterol
Population
Risk Reduction Behavior
Lipids

A randomised, factorial trial to reduce arterial stiffness independently of blood pressure: Proof of concept? The 'VaSera' trial testing dietary nitrate and spironolactone

Mills, C. E., Govoni, V., Faconti, L., Casagrande, M-L., Morant, S. V., Crickmore, H., Iqbal, F., Maskell, P., Masani, A., Nanino, E., Webb, A. J. & Cruickshank, J. K., 13 Dec 2019, In : British Journal of Clinical Pharmacology. 35 p.

Research output: Contribution to journalArticle

Spironolactone
Vascular Stiffness
Doxazosin
Nitrates
Blood Pressure
11 Citations (Scopus)
63 Downloads (Pure)

A Randomized Controlled Trial of Metformin on Left Ventricular Hypertrophy in Patients with Coronary Artery Disease without Diabetes: The MET-REMODEL Trial

Mohan, M., Al-Talabany, S., McKinnie, A., Mordi, I., Singh, J., Gandy, S., Baig, F., Hussain, M. S. ., Bhalraam, U., Khan, F., Choy, A., Matthew, S., Houston, G., Struthers, A., George, J. & Lang, C. C., 1 Nov 2019, In : European Heart Journal. 40, 41, p. 3409-3417 9 p.

Research output: Contribution to journalArticle

Open Access
File
Metformin
Left Ventricular Hypertrophy
Coronary Artery Disease
Randomized Controlled Trials
Insulin Resistance
15 Citations (Scopus)
53 Downloads (Pure)

A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects

Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., Sahakian, B. J., Zrinzo, L., Hariz, M. & Joyce, E. M., 1 May 2019, In : Biological Psychiatry. 85, 9, p. 726-734 9 p.

Research output: Contribution to journalArticle

Open Access
File
Anterior Thalamic Nuclei
Subthalamic Nucleus
Deep Brain Stimulation
Obsessive-Compulsive Disorder
Capsules
41 Downloads (Pure)

Are baseline ultrasound and mammographic features associated with rates of pathological completes response in patients receiving neoadjuvant chemotherapy for breast cancer?

Savaridas, S. L., Sim, Y. T., Vinnicombe, S. J., Purdie, C. A., Thompson, A. M. & Evans, A., 21 Oct 2019, In : Cancer Imaging. 19, 1, p. 1-7 7 p., 67.

Research output: Contribution to journalArticle

Open Access
File
Breast Neoplasms
Drug Therapy
Calcinosis
Neoplasms
Biopsy
Periapical Tissue
Primary Health Care
Hospitalization
Periapical Abscess
Tooth
24 Downloads (Pure)

A Retrospective Observational Study to Determine Baseline Characteristics and Early Prescribing Patterns for Patients Receiving Alirocumab in UK Clinical Practice

Reynolds, T., Carey, P., George, J., Konidaris, G., Narayanan, D., Ramachandran, S., Saunders, L., Viljoen, A. & Ferns, G., Dec 2019, In : Drugs - real world outcomes. 6, 4, p. 205-213 9 p.

Research output: Contribution to journalArticle

Open Access
File
Observational Studies
Retrospective Studies
LDL Cholesterol
Lipids
Hydroxymethylglutaryl-CoA Reductase Inhibitors