Molecular and Clinical Medicine

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2020
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Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects

Brown, S. J., Elias, M. S. & Bradley, M., 15 May 2020, In : Acta Dermato-Venereologica.

Research output: Contribution to journalReview article

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Birch, J. L., Coull, B. J., Spender, L. C., Watt, C., Willison, A., Syed, N., Chalmers, A. J., Hossain-Ibrahim, M. K. & Inman, G. J., 19 Apr 2020, In : Cellular Signalling. 72, p. 1-12 12 p., 109638.

Research output: Contribution to journalReview article

Optimising outcomes in chronic heart failure

Mordi, I. R. & Szwejkowski, B. R., 22 Feb 2020, In : The Practitioner. 263, 1823, p. 21-25 5 p.

Research output: Contribution to journalReview article

Preventing foot ulceration in diabetes: systematic review and meta-analyses of RCT data

Crawford, F., Nicolson, D. J., Amanna, A. E., Martin, A., Gupta, S., Leese, G. P., Heggie, R., Chappell, F. M. & McIntosh, H. H., Jan 2020, In : Diabetologia. 63, 1, p. 49-64 16 p.

Research output: Contribution to journalReview article

Open Access
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47 Downloads (Pure)

Primary ciliary dyskinesia in the genomics age

Lucas, J. S., Davis, S. D., Omran, H. & Shoemark, A., Feb 2020, In : The Lancet Respiratory Medicine. 8, 2, p. 202-216 15 p.

Research output: Contribution to journalReview article

Open Access
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4 Citations (Scopus)
5 Downloads (Pure)
2019

A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults

Crichton, M. L., Aliberti, S. & Chalmers, J. D., 31 Mar 2019, In : European Respiratory Review. 28, 151, p. 1-14 14 p., 180108.

Research output: Contribution to journalReview article

Open Access
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3 Citations (Scopus)
125 Downloads (Pure)

Benefit: Risk Profile of Budesonide in Obstructive Airways Disease

Tashkin, D. P., Lipworth, B. & Brattsand, R., Nov 2019, In : Drugs. 79, 16, p. 1757-1775 19 p.

Research output: Contribution to journalReview article

Open Access
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80 Downloads (Pure)

Bronchiectasis insanity: Doing the same thing over and over again and expecting different results?

Metersky, M. & Chalmers, J., 15 Mar 2019, In : F1000Research. 8, p. 1-7 7 p., 293.

Research output: Contribution to journalReview article

Open Access
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1 Citation (Scopus)
96 Downloads (Pure)

Challenges in severe community-acquired pneumonia: a point-of-view review

Torres, A., Chalmers, J. D., Dela Cruz, C. S., Dominedò, C., Kollef, M., Martin-Loeches, I., Niederman, M. & Wunderink, R. G., Feb 2019, In : Intensive Care Medicine. 45, 2, p. 159-171 13 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Clinical Genetic Testing in Endocrinology: Current Concepts and Contemporary Challenges

Newey, P. J., Nov 2019, In : Clinical Endocrinology. 91, 5, p. 587-607 21 p.

Research output: Contribution to journalReview article

Deep brain stimulation: current challenges and future directions

Lozano, A. M., Lipsman, N., Bergman, H., Brown, P., Chabardes, S., Chang, J. W., Matthews, K., McIntyre, C. C., Schlaepfer, T. E., Schulder, M., Temel, Y., Volkmann, J. & Krauss, J. K., Mar 2019, In : Nature Reviews Neurology. 15, 3, p. 148-160 13 p.

Research output: Contribution to journalReview article

32 Citations (Scopus)

Exercise-based cardiac rehabilitation for adults with heart failure

Long, L., Mordi, I. R., Bridges, C., Sagar, V. A., Davies, E. J., Coats, A. J. S., Dalal, H., Rees, K., Singh, S. J. & Taylor, R. S., 29 Jan 2019, In : Cochrane Database of Systematic Reviews. 2019, 1, 184 p., CD003331.

Research output: Contribution to journalReview article

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38 Citations (Scopus)
32 Downloads (Pure)

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance

Løset, M., Brown, S. J., Saunes, M. & Hveem, K., Aug 2019, In : Dermatology . 235, 5, p. 355-364 10 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Healthcare-associated pneumonia: is there any reason to continue to utilize this label in 2019?

Ewig, S., Kolditz, M., Pletz, M. W. & Chalmers, J., Oct 2019, In : Clinical Microbiology and Infection. 25, 10, p. 1173-1179 7 p.

Research output: Contribution to journalReview article

3 Citations (Scopus)

Keratinocyte Carcinomas: Current concepts and future research priorities

Nagarajan, P., Asgari, M. M., Green, A. C., Guhan, S. M., Arron, S. T., Proby, C., Rollison, D. E., Harwood, C. A. & Ewart Toland, A., 15 Apr 2019, In : Clinical Cancer Research. 25, 8, p. 2379-2391 13 p.

Research output: Contribution to journalReview article

Open Access
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10 Citations (Scopus)
98 Downloads (Pure)

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases

ARIA Study Group, MASK Study Group, Bousquet, J. J., Schünemann, H. J., Togias, A., Erhola, M., Hellings, P. W., Zuberbier, T., Agache, I., Ansotegui, I. J., Anto, J. M., Bachert, C., Becker, S., Bedolla-Barajas, M., Bewick, M., Bosnic-Anticevich, S., Bosse, I., Boulet, L. P., Bourrez, J. M., Brusselle, G. & 32 others, Chavannes, N., Costa, E., Cruz, A. A., Czarlewski, W., Fokkens, W. J., Fonseca, J. A., Gaga, M., Haahtela, T., Illario, M., Klimek, L., Kuna, P., Kvedariene, V., Le, L. T. T., Larenas-Linnemann, D., Laune, D., Lourenço, O. M., Menditto, E., Mullol, J., Okamoto, Y., Papadopoulos, N., Pham-Thi, N., Picard, R., Pinnock, H., Roche, N., Roller-Wirnsberger, R. E., Rolland, C., Samolinski, B., Sheikh, A., Williams, S., Lipworth, B., Mair, A. & Price, D., 9 Sep 2019, In : Clinical and Translational Allergy. 9, 1, p. 1-15 15 p., 44.

Research output: Contribution to journalReview article

Open Access
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5 Citations (Scopus)
81 Downloads (Pure)

Non-Invasive Imaging in Diabetic Cardiomyopathy

Mordi, I. R., 16 Apr 2019, In : Journal of Cardiovascular Development and Disease. 6, 2, p. 1-11 11 p., 18.

Research output: Contribution to journalReview article

Open Access
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76 Downloads (Pure)

Scottish consensus statement on the role of FeNO in adult asthma

Kuo, C. R., Spears, M., Haughney, J., Smith, A., Miller, J., Bradshaw, T., Murray, L., Williamson, P. & Lipworth, B., Aug 2019, In : Respiratory Medicine. 155, p. 54-57 4 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Single-inhaler triple therapy in patients with chronic obstructive pulmonary disease: a systematic review

Langham, S., Lewis, J., Pooley, N., Embleton, N., Langham, J., Han, M. K. & Chalmers, J. D., 4 Nov 2019, In : Respiratory Research. 20, p. 1-13 13 p., 242.

Research output: Contribution to journalReview article

Open Access
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69 Downloads (Pure)

Sperm defects in primary ciliary dyskinesia and related causes of male infertility

Sironen, A., Shoemark, A., Patel, M., Loebinger, M. R. & Mitchison, H. M., 28 Nov 2019, In : Cellular and Molecular Life Sciences. 20 p.

Research output: Contribution to journalReview article

Open Access
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43 Downloads (Pure)

The Adverse Effects of Topical Photodynamic Therapy: a consensus review and approach to management

Ibbotson, S. H., Wong, T. H., Morton, C. A., Collier, N. J., Haylett, A. K., McKenna, K. E., Mallipeddi, R., Moseley, H., Rhodes, L. E., Seukeran, D. C., Mohd Mustapa, M. F. & Exton, L. S., Apr 2019, In : British Journal of Dermatology. 180, 4, p. 715-729 15 p.

Research output: Contribution to journalReview article

Open Access
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7 Citations (Scopus)
97 Downloads (Pure)
Open Access
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1 Citation (Scopus)
42 Downloads (Pure)

Treatment approaches in immunosuppressed patients with advanced cutaneous squamous cell carcinoma

Willenbrink, T. J., Jambusaria-Pahlajani, A., Arron, S., Seckin, D., Harwood, C. A. & Proby, C. M., Dec 2019, In : Journal of the European Academy of Dermatology and Venereology. 33, S8, p. 57-60 4 p.

Research output: Contribution to journalReview article

We know DAAs work, so now what? Simplifying models of care to enhance the hepatitis C cascade

Lazarus, J. V., Pericàs, J. M., Picchio, C., Cernosa, J., Hoekstra, M., Luhmann, N., Maticic, M., Read, P., Robinson, E. M. & Dillon, J. F., Nov 2019, In : Journal of Internal Medicine. 286, 5, p. 503-525 23 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Whole-body magnetic resonance angiography

Weir-McCall, J. R., Bonnici-Mallia, M., Ramkumar, P. G., Nath, A. F. & Houston, J. G., Jan 2019, In : Clinical Radiology. 74, 1, p. 3-12 10 p.

Research output: Contribution to journalReview article

Open Access
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1 Citation (Scopus)
80 Downloads (Pure)
2018

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

Flume, P. A., Chalmers, J. D. & Olivier, K. N., 8 Sep 2018, In : The Lancet. 392, 10150, p. 880-890 11 p.

Research output: Contribution to journalReview article

Open Access
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42 Citations (Scopus)
195 Downloads (Pure)

A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk

McDonnell, M. J., O'Toole, D., Ward, C., Pearson, J. P., Lordan, J. L., De Soyza, A., Loebinger, M., Chalmers, J. D., Laffey, J. G. & Rutherford, R. M., Aug 2018, In : Respiratory Medicine. 141, p. 132-143 12 p.

Research output: Contribution to journalReview article

Open Access
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6 Citations (Scopus)
121 Downloads (Pure)

Bronchiectasis

Chalmers, J. D., Chang, A. B., Chotirmall, S. H., Dhar, R. & McShane, P. J., 15 Nov 2018, In : Nature reviews. Disease primers. 4, 1, 1 p., 45.

Research output: Contribution to journalReview article

12 Citations (Scopus)

Bronchiectasis: new therapies and new perspectives

Chalmers, J. D. & Chotirmall, S. H., Sep 2018, In : The Lancet Respiratory Medicine. 6, 9, p. 715-726 12 p.

Research output: Contribution to journalReview article

Open Access
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51 Citations (Scopus)
348 Downloads (Pure)

Burden of pneumococcal community-acquired pneumonia in adults across Europe: A literature review

Torres, A., Cillóniz, C., Blasi, F., Chalmers, J. D., Gaillat, J., Dartois, N., Schmitt, H-J. & Welte, T., Apr 2018, In : Respiratory Medicine. 137, p. 6-13 8 p.

Research output: Contribution to journalReview article

18 Citations (Scopus)

Cardioprotective signalling: Past, present and future

Jovanović, A., 15 Aug 2018, In : European Journal of Pharmacology. 833, p. 314-319 6 p.

Research output: Contribution to journalReview article

11 Citations (Scopus)

Caveolae and the cardiac myocyte

Norman, R., Fuller, W. & Calaghan, S., 1 Feb 2018, In : Current Opinion in Physiology. 1, p. 59-67 9 p.

Research output: Contribution to journalReview article

2 Citations (Scopus)

Challenges and recent progress in drug discovery for tropical diseases

De Rycker, M., Baragaña, B., Duce, S. L. & Gilbert, I. H., 25 Jul 2018, In : Nature. 559, 7715, p. 498-506 9 p.

Research output: Contribution to journalReview article

Open Access
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27 Citations (Scopus)
200 Downloads (Pure)

Continuous versus intermittent antibiotics for bronchiectasis

Donovan, T., Felix, L. M., Chalmers, J. D., Milan, S. J., Mathioudakis, A. G. & Spencer, S., 3 Jun 2018, In : Cochrane Database of Systematic Reviews. 2018, 6, p. 1-30 30 p., CD012733.

Research output: Contribution to journalReview article

Open Access
File
4 Citations (Scopus)
102 Downloads (Pure)

Conventional and combination topical photodynamic therapy for basal cell carcinoma: systematic review and meta-analysis

Collier, N. J., Haylett, A. K., Wong, T. H., Morton, C. A., Ibbotson, S. H., McKenna, K. E., Mallipeddi, R., Moseley, H., Seukeran, D., Ward, K. A., Mohd Mustapa, M. F., Exton, L. S., Green, A. C. & Rhodes, L. E., 3 Dec 2018, In : British Journal of Dermatology. 179, 6, p. 1277-1296 20 p.

Research output: Contribution to journalReview article

Open Access
File
12 Citations (Scopus)
149 Downloads (Pure)

Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK

Williams, R., Alexander, G., Armstrong, I., Baker, A., Bhala, N., Camps-Walsh, G., Cramp, M. E., de Lusignan, S., Day, N., Dhawan, A., Dillon, J., Drummond, C., Dyson, J., Foster, G., Gilmore, I., Hudson, M., Kelly, D., Langford, A., McDougall, N., Meier, P. & 14 others, Moriarty, K., Newsome, P., O'Grady, J., Pryke, R., Rolfe, L., Rice, P., Rutter, H., Sheron, N., Taylor, A., Thompson, J., Thorburn, D., Verne, J., Wass, J. & Yeoman, A., 17 Mar 2018, In : Lancet. 391, 10125, p. 1097-1107 11 p.

Research output: Contribution to journalReview article

Open Access
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50 Citations (Scopus)
382 Downloads (Pure)

Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis

Chandrasekaran, R., Mac Aogáin, M., Chalmers, J. D., Elborn, S. J. & Chotirmall, S. H., 22 May 2018, In : BMC Pulmonary Medicine. 18, 1, p. 1-14 14 p., 83.

Research output: Contribution to journalReview article

Open Access
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31 Citations (Scopus)
162 Downloads (Pure)

Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation

Howie, J., Wypijewski, K. J., Plain, F., Tulloch, L., Fraser, N. J. & Fuller, W., 4 Mar 2018, In : Critical Reviews in Biochemistry and Molecular Biology . 53, 2, p. 175-191 17 p.

Research output: Contribution to journalReview article

Open Access
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3 Citations (Scopus)
150 Downloads (Pure)

Impaired hypoglycaemia awareness in type 1 diabetes: lessons from the lab

McNeilly, A. D. & McCrimmon, R. J., 1 Apr 2018, In : Diabetologia. 61, 4, p. 743-750 8 p.

Research output: Contribution to journalReview article

Open Access
File
1 Citation (Scopus)
176 Downloads (Pure)
Open Access
File
22 Citations (Scopus)
131 Downloads (Pure)

Iron Therapy in Heart Failure: Ready for Primetime?

Mordi, I., Tee, A. & Lang, C., 6 May 2018, In : Cardiac Failure Review. 4, 1, p. 28-32 5 p.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)

Macrolide antibiotics for bronchiectasis

Kelly, C., Chalmers, J. D., Crossingham, I., Relph, N., Felix, L. M., Evans, D. J., Milan, S. J. & Spencer, S., 15 Mar 2018, In : Cochrane Database of Systematic Reviews. 2018, 3, p. 1-79 79 p., CD012406.

Research output: Contribution to journalReview article

Open Access
File
29 Citations (Scopus)
224 Downloads (Pure)

Non-tuberculous mycobacterial pulmonary infections

Chalmers, J. D., Aksamit, T., Carvalho, A. C. C., Rendon, A. & Franco, I., 1 Mar 2018, In : Pulmonology. 24, 2, p. 120-131 12 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
92 Downloads (Pure)

Pharmacogenetics and target identification in diabetes

Pearson, E. R., 1 Jun 2018, In : Current Opinion in Genetics & Development. 50, p. 68-73 6 p.

Research output: Contribution to journalReview article

Open Access
File
5 Citations (Scopus)
171 Downloads (Pure)

Relationship between diet and ankylosing spondylitis: a systematic review

Macfarlane, T., Abbood, H. M., Pathan, E., Gordon, K., Hinz, J. & Macfarlane, G. J., Mar 2018, In : European Journal of Rheumatology. 5, 1, p. 45-52 8 p.

Research output: Contribution to journalReview article

Open Access
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140 Downloads (Pure)

Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning

Klauschen, F., Müller, K-R., Binder, A., Bockmayr, M., Hägele, M., Seegerer, P., Wienert, S., Pruneri, G., de Maria, S., Badve, S., Michiels, S., Nielsen, T. O., Adams, S., Savas, P., Symmans, F., Willis, S., Gruosso, T., Park, M., Haibe-Kains, B., Gallas, B. & 12 others, Thompson, A. M., Cree, I., Sotiriou, C., Solinas, C., Hewitt, S. M., Preusser, M., Rimm, D., Viale, G., Loi, S., Loibl, S., Salgado, R. & Denkert, C., 1 Oct 2018, In : Seminars in Cancer Biology. 52, Part 2, p. 151-157 7 p.

Research output: Contribution to journalReview article

19 Citations (Scopus)

Systematic Review: Non A-E, seronegative or indeterminate hepatitis; what is this deadly disease?

Brennan, P., Donnelly, M. C. & Simpson, K. J., Apr 2018, In : Alimentary Pharmacology & Therapeutics. 47, 8, p. 1079-1091 13 p.

Research output: Contribution to journalReview article

Open Access
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6 Citations (Scopus)
155 Downloads (Pure)

Systematic review and meta-analysis of genetic risk factors for neuropathic pain

Veluchamy, A., Hébert, H. L., Meng, W., Palmer, C. N. A. & Smith, B. H., May 2018, In : Pain. 159, 5, p. 825-848 24 p.

Research output: Contribution to journalReview article

Open Access
File
12 Citations (Scopus)
226 Downloads (Pure)

The new 8th edition of TNM staging and its implications for skin cancer: a review by the British Association of Dermatologists and the Royal College of Pathologists, U.K.

Keohane, S. G., Proby, C. M., Newlands, C., Motley, R. J., Nasr, I., Mohd Mustapa, M. F. & Slater, D. N., Oct 2018, In : British Journal of Dermatology. 179, 4, p. 824-828 5 p.

Research output: Contribution to journalReview article

Open Access
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9 Citations (Scopus)
356 Downloads (Pure)