Molecular Cell and Developmental Biology

Projects

Projects per year 2004 2010 2012 2013 2014 2015 2016 2017 2018 2031

• 32 Active
• 59 Not started
• 230 Finished

Projects per year

Search results

• Finished

  Modelling O-GlcNAc Transferase Intellectual Disability in Drosophila (PhD Studentship)

  van Aalten, D. (Investigator)

  1/01/23 → 30/06/23

  Project: Research

  • Intellectual Disability 100%
  • O-GlcNAc Transferase 100%
  • Transferase 100%
  • Conveyor 33%
  • Pluripotent Stem Cells 33%

• RNA Modifications in Frontotemporal Dementia and Motor Neuron Disease (Bridge Fund)

  McGurk, L. (Investigator)

  1/01/23 → 3/05/24

  Project: Research

• GPU-Based Machine Learning System For Fundamental Biological Research

  Barton, G. (Investigator), Gilbert, I. (Investigator), Lamond, A. (Investigator), Owen-Hughes, T. (Investigator), Pisliakov, A. (Investigator), Schweikert, G. (Investigator), Sknepnek, R. (Investigator), Swedlow, J. (Investigator), Weijer, K. (Investigator) & Zachariae, U. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/08/21 → 31/07/22

  Project: Research

  • Biological Research 100%
  • Dundee 100%
  • Life Sciences 50%

• Proteomic Characterisation of the Polarised Membrane Trafficking Machinery During Epithelial to Mesenchymal Transition

  Maib, H. (Investigator) & Murray, D. (Investigator)

  1/06/21 → 31/01/22

  Project: Research

• Next Generation Data Formats for BioImaging (Technology Development)

  Swedlow, J. (Investigator)

  1/04/21 → 30/06/24

  Project: Research

  • Biological Research 100%
  • Dundee 100%
  • Life Sciences 50%

• Understanding the Proliferation-Quiescence Switch Using Quantitative Cellular Biochemistry (Sir Henry Dale Fellowship) (Transfer from University of Edinburgh)

  Ly, T. (Investigator)

  1/12/20 → 12/08/24

  Project: Research

  • Cell Cycle 100%
  • Cyclin-dependent Kinase 4 (CDK4) 60%
  • Phosphorylation 52%
  • Cyclin-dependent Kinase 1 (CDK1) 50%
  • Cks1 48%

• A Fully Integrated FLIM-FRET System For Imaging Dynamic Protein - Protein Interactions And Protein Turnover In Single Live Cells And Model Organisms

  Appleton, P. (Investigator), Dinkova-Kostova, A. (Investigator), Hiom, K. (Investigator), Januschke, J. (Investigator), MacDonald, M. (Investigator), Saurin, A. (Investigator), Swedlow, J. (Investigator), Tanaka, T. (Investigator) & Weijer, K. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/11/20 → 31/03/21

  Project: Research

  • Drosophilidae 100%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Kelch-like 66%
  • Trophoblast 66%
  • Associated Proteins 66%

• Early Stage Challenge Fund Application - HGSP Covid Response RNACapRx (High Growth Spin Out Programme)

  Cowling, V. (Investigator) & Gray, D. (Investigator)

  14/09/20 → 31/03/21

  Project: Research

• Defining Novel Therapeutic Targets for TDP43 Associated Neurodegenerative Disease (Springboard Fellowship)

  McGurk, L. (Investigator)

  Academy of Medical Sciences

  28/07/20 → 27/11/23

  Project: Research

  • HSPA5 100%
  • Disease Pathology 100%
  • TAR DNA-binding Protein 43 (TDP-43) 100%
  • Heat Shock Proteins 100%
  • Glucose-regulated Protein 78 (GRP78) 100%

• Rapid Research in Covid -19 Programme

  Barrable, A. (Investigator), Belch, J. (Investigator), Boehnke, J. (Investigator), Booth, D. (Investigator), Brown, A. (Investigator), Cantrell, D. (Investigator), Chalmers, J. (Investigator), Coleman, S. (Investigator), Connell, D. (Investigator), Cuschieri, A. (Investigator), Dicker, A. (Investigator), Doney, A. (Investigator), Eftimie, R. (Investigator), Fang, M. (Investigator), Farre, A. (Investigator), Gamble, C. (Investigator), Howden, A. (Investigator), Krstajic, N. (Investigator), Lamond, A. (Investigator), Moraga Gonzalez, I. (Investigator), Palmer, C. (Investigator), Parcell, B. (Investigator), Pearson, E. (Investigator), Shoemark, A. (Investigator) & Sixsmith, J. (Investigator)

  1/06/20 → 30/09/21

  Project: Research

  • COVID-19 100%
  • Neutrophils 66%
  • Hyperinflammation 33%
  • Resilience 33%
  • T Cell Activation 33%

• Next Generation File Formats for BioImaging

  Swedlow, J. (Investigator)

  1/12/19 → 30/11/20

  Project: Research

• Molecular Mechanisms for the Final Step of Dissolving Sister Chromatid Cohesion at Anaphase Onset

  Tanaka, T. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/10/19 → 30/09/23

  Project: Research

  • Zooming in 100%
  • Chromosome Dynamics 100%
  • Chromosomal Region 100%
  • Chromosome Organization 100%
  • CRISPR-Cas9 Technology 100%

• 4DN supplement: Combined Cytological, Genomic, and Functional Mapping of Nuclear Genome Organization (Joint with Carnegie-Mellon University)

  Swedlow, J. (Investigator)

  National Institutes of Health

  1/08/19 → 31/07/21

  Project: Research

• Fine-Scale Regulation of Notch Signalling Dynamics : In the Context of the Vertebrate Segmentation Clock

  Dale, K. (Investigator)

  Medical Research Council

  1/08/19 → 31/03/24

  Project: Research

  • Oscillation 100%
  • Presomitic Mesoderm 64%
  • Transcription Regulation 50%
  • NICD1 50%
  • Translation Regulation 50%

• Providing an open collaborative space for digital biology in Europe (EOSC-Life) (Joint with European Molecular Biology Laboratory as lead, Biobanks and Biomolecular Resources Research Infrastructure Consortium, EATRIS ERIC and 35 others)

  Swedlow, J. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/03/19 → 31/08/23

  Project: Research

  • Biotechnology 100%
  • Data Processing 100%
  • Provenance Data 50%
  • International Organization for Standardization 50%
  • Machine-actionable 50%

• The Function of Disordered Regions in the APC Protein (UK Israel Science Lectureship)

  Nathke, I. (Investigator)

  British Council

  1/03/19 → 30/06/19

  Project: Research

• Training Network in Drug Discovery Targeting TRIM Ubiquitin Ligases in Disease (TRIM-NET) (Joint with University of Trieste as lead; CNRS; Karlsruhe Institute of Technology; Leiden University Medical Centre; French National Institute for Agricultural Research; Casa Sollievo della Sofferenza Hospital, Italy; CSIC; Netherlands Cancer Institute)

  Hay, R. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/19 → 30/06/23

  Project: Research

  • Ubiquitin 100%
  • E3 Ligase 74%
  • Ligase 74%
  • Laminopathy 66%
  • Structural Variation 66%

• Processing of Branched DNA Molecules During Cytokinesis, Uncovering New Mechanisms of Genome Maintenance

  Gartner, A. (Investigator), Lilley, D. (Investigator) & Rouse, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/12/18 → 30/06/22

  Project: Research

  • Caenorhabditis Elegans 100%
  • DNA Repair 83%
  • DNA Repair Pathways 65%
  • Mutational Signatures 55%
  • Genome Integrity 41%

• Male Contraceptive Drug Development Using a Novel Human Sperm Phenotypic Screening Platform (Grand Challenges Phase II)

  Andrews, P. (Investigator), Barratt, C. (Investigator), Gilbert, I. (Investigator), Martins Da Silva, S. (Investigator), Read, K. (Investigator) & Swedlow, J. (Investigator)

  Bill and Melinda Gates Foundation

  1/11/18 → 30/09/23

  Project: Research

  • Sperm Motility 100%
  • Male Contraceptive 70%
  • Medicinal Chemistry 58%
  • Small Molecules 58%
  • Sperm Function 58%

• Connecting and Expanding RIKENs Systems Science of Biological Dynamics and OMEs Image Data Resource Databases (International Travel Award)

  Swedlow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  5/10/18 → 4/11/18

  Project: Research

  • Image Data 100%
  • Open Images 100%
  • Biological Image 100%
  • Global View 100%
  • Microscopy Data 100%

• Polarity, membranes, and the Machinery that tethers

  Murray, D. (Investigator)

  5/10/18 → 4/10/19

  Project: Research

  • Phosphoinositide 100%
  • Phosphoinositides 55%
  • PIP5K1C 50%
  • PI(3,5)P2 50%
  • Phosphorylation Sites 50%

• Developing Small Molecule Cancer Therapeutics Targeting the RNA Splicing Machinery: Target Validation on STRAP/UNRIP

  Gray, D. (Investigator), Lamond, A. (Investigator), Petty, R. (Investigator) & Wyatt, P. (Investigator)

  1/10/18 → 31/12/20

  Project: Research

• The Image Data Resource: Making Biological Imaging Data FAIR (Joint with EMBL-EBI) (Biomedical Resources Grant)

  Swedlow, J. (Investigator)

  1/10/18 → 1/04/22

  Project: Research

  • Bioimaging 100%
  • Data Type 69%
  • File Format 46%
  • Microscopy Data 46%
  • Open Microscopy Environment 38%

• Application of Detailed Proteomics to Investigate Genetic mechanisms in Skin Differentiation and Barrier Function

  Brown, S. (Investigator) & Lamond, A. (Investigator)

  British Skin Foundation

  1/09/18 → 31/08/21

  Project: Research

• Industrial Strategy MRC DTP Studentship for the University of Dundee

  Hunter, B. (Investigator) & MacKintosh, C. (Investigator)

  Medical Research Council

  1/09/18 → 28/02/22

  Project: Research

• BioStudies and the Image Data Resource: Expanding Imaging Datasets, Linkage, Metadata and Value (Joint with EMBL-EBI) (Bioinformatics and Biological Resources Fund - BBR)

  Swedlow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/07/18 → 30/06/21

  Project: Research

  • Bioimaging 100%
  • Data Type 75%
  • File Format 56%
  • Microscopy Data 37%
  • Biological Image 37%

• mRNA Cap: Directing Cell Function and Fate (Wolfson Research Merit Award)

  Cowling, V. (Investigator)

  1/07/18 → 30/06/23

  Project: Research

  • RNA 100%
  • Methyltransferase 79%
  • MRNA Cap 68%
  • Capping Phenomenon 66%
  • Gene Expression 57%

• Regulation of Meiotic Chromosome Segregation by Post-Translational Modifications

  Pelisch, F. (Investigator)

  Medical Research Council

  14/05/18 → 13/11/23

  Project: Research

  • Caenorhabditis Elegans 100%
  • Meiosis 50%
  • Chromosome Segregation 41%
  • Meiosis I 33%
  • Meiotic Chromosome Segregation 25%

• mRNA Cap Regulation and Function in CD8 T Cells (TCAPS)

  Cowling, V. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/18 → 1/05/22

  Project: Research

  • RNA 100%
  • Capping Phenomenon 73%
  • Cap Formation 64%
  • MRNA Cap 64%
  • Messenger RNA 55%

• Cancer Ribosomics: Comprehensive Analysis of Ribosome and Translation Dynamics in Cancer

  Lamond, A. (Investigator) & Yoshikawa, H. (Investigator)

  1/04/18 → 31/03/20

  Project: Research

• In4Derm: Topical by Design - HGSP application

  Woodland, A. (Investigator)

  19/03/18 → 18/04/20

  Project: Research

  • Drug Discovery 100%
  • Small-molecule Drug Discovery 20%
  • Project Screening 20%
  • Industrial Partner 20%
  • Screening Library 20%

• Image Data Resources and Applications for the Human Cell Atlas

  Swedlow, J. (Investigator)

  1/03/18 → 28/02/19

  Project: Research

• Exploring Fundamental Mechanisms of Mutagenesis Conferred by the Chemotherapeutic DNA Cross Linking Agent Cisplantin Combining Next Generation Sequencing and Genetic Analysis Towards Selective Cancer Killing

  Gartner, A. (Investigator)

  World Cancer Research Fund International

  1/01/18 → 31/08/20

  Project: Research

  • Caenorhabditis Elegans 100%
  • DNA Repair Pathways 100%
  • DNA Repair 100%
  • Genome Integrity 62%
  • Germ Cells 60%

• Meeting the Sensitivity Grand Challenge in Pulsed Electron Paramagnetic Resonance (Joint with University of St Andrews)

  Keeble, D. (Investigator) & Norman, D. (Investigator)

  Engineering and Physical Sciences Research Council

  1/12/17 → 30/11/20

  Project: Research

  • Central Transition 100%
  • Electron-nuclear Double Resonance (ENDOR) 100%
  • Distance Measure 100%
  • Spin Label 100%
  • Gadolinium 100%

• Unravelling the Molecular Heterogeneity within the Spinal Cord Stem Cell Niche by Single Cell Transcriptomics

  Storey, K. (Investigator)

  1/10/17 → 1/11/21

  Project: Research

  • Cell Census 100%
  • Cell Maturation 100%
  • Adult Mice 100%
  • Mouse Spinal Cord 100%
  • Ependymal Cells 100%

• Advancing Tissue Imaging Capabilities with Airyscan Confocal Microscopy (Multiuser Equipment Grant)

  Ganley, I. (Investigator), Januschke, J. (Investigator), Muqit, M. (Investigator), Storey, K. (Investigator), Swedlow, J. (Investigator) & Tanaka, T. (Investigator)

  26/09/17 → 1/01/19

  Project: Research

  • Mitophagy 100%
  • Mouse 47%
  • Parkinson's Disease 38%
  • Ependymal Cells 33%
  • Scattering Volume 33%

• Molecular and Cellular Biology 4 Year PhD Studentships

  Hay, R. (Investigator)

  1/09/17 → 31/08/23

  Project: Research

  • Macrophage 100%
  • Data-independent Acquisition 83%
  • Coverage Increase 66%
  • Missense Variants 66%
  • Human Population 66%

• Targeted Small Molecule Stabilisation of Protein-Protein Interactions (TASPPI) (Joint with Universities of Eindhoven, Leeds, Charles, Siena and National Scientific Centre, Recherche)

  MacKintosh, C. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/09/17 → 31/08/20

  Project: Research

  • 14-3-3 Protein 100%
  • Protein-protein Interaction 55%
  • Protein-Protein Interaction 54%
  • Protein Regulators 50%
  • Phosphorylation 50%

• The Interplay Between Oxygen Sensors PHDs and the Cell Cycle (Joint with University of Liverpool)

  Fleming, S. (Investigator), Lamond, A. (Investigator) & Swedlow, J. (Investigator)

  1/09/17 → 31/08/24

  Project: Research

  • Chromatin 100%
  • Proteomics 100%
  • Hypoxia 86%
  • DNA Replication 77%
  • Induced Stem Cell 66%

• Acquisition of a TriSpim Lightsheet Microscope

  Gartner, A. (Investigator), Januschke, J. (Investigator), MacDonald, M. (Investigator), Nathke, I. (Investigator), Storey, K. (Investigator), Swedlow, J. (Investigator), Tanaka, T. (Investigator) & Weijer, K. (Investigator)

  Biotechnology and Biological Sciences Research Council

  15/08/17 → 14/08/18

  Project: Research

  • Gastrulation 100%
  • Vertebrates 100%
  • Chick Embryo 75%
  • Chick 75%
  • Cell Behavior 58%

• Topical Soft-Drug Smoothened Inhibitors: Reducing Surgical Burden for Gorlin Syndrome Patients (Pathfinder)

  Read, K. (Investigator) & Woodland, A. (Investigator)

  1/08/17 → 31/07/18

  Project: Research

• New Open File Formats for the Biological Imaging Community

  Swedlow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/07/17 → 30/06/18

  Project: Research

  • File Format 100%
  • Data Type 100%
  • Whole-slide Imaging 50%
  • Data Access 50%
  • Open Data 50%

• Impact of DNA Replication on Epigenetics (IDRE)

  Alabert, C. (Investigator) & Owen-Hughes, T. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/17 → 31/05/24

  Project: Research

  • Histone 100%
  • DNA Replication 88%
  • Chromatin 78%
  • Nascent Chromatin Capture 41%
  • Cell Cycle 40%

• Evolution of Multicellularity and Somatic Cell Specialisation (EVOSOM)

  Schaap, P. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/17 → 30/04/23

  Project: Research

  • Dictyostelia 100%
  • Dictyostelids 77%
  • Dictyosteliida 65%
  • Social Amoeba 53%
  • Amoeba (Life Cycle Stage) 48%

• Dissecting Spinal Cord Ependymal Cell Heterongeneity by Single-Cell Transciptomics (ECtomics) (Joint with MRC Institute of Genetics and Molecular Medicine and Sanger-EBI Single Cell Genomics Centre)

  Rodrigo Albors, A. (Investigator) & Storey, K. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/04/17 → 31/03/19

  Project: Research

  • Ependymal Cells 100%
  • Ependymal Cell 100%
  • Mouse Spinal Cord 72%
  • Adult Mice 72%
  • Spinal Cord 58%

• Genetic and Chemical Validation of Sugar Nucleotide Biosynthesis as a Target Against Candida Albicans (Joint with University of Aberdeen)

  van Aalten, D. (Investigator)

  1/03/17 → 1/03/23

  Project: Research

  • Aspergillus Fumigatus 100%
  • BslA 100%
  • Aspergillus fumigatus 100%
  • Cell Wall 100%
  • Biofilm 100%

• 32nd Genes and Cancer Meeting

  Rocha, S. (Investigator)

  1/02/17 → 30/04/17

  Project: Research

• Architecture of a Biofilm (Joint with University of Edinburgh)

  Campbell, P. (Investigator), Davidson, F. (Investigator), Ferguson, M. (Investigator), Stanley-Wall, N. (Investigator) & Swedlow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/02/17 → 31/07/23

  Project: Research

  • Biofilm 100%
  • Bacillus Subtilis 68%
  • Bacillus Subtilis (B. subtilis) 57%
  • B.subtilis 32%
  • Bacillus subtilis 28%

• Chromatin Replication and Cancer (Career Development Fellowship)

  Alabert, C. (Investigator) & Owen-Hughes, T. (Investigator)

  1/01/17 → 29/02/24

  Project: Research

  • DNA Replication 100%
  • Chromatin 79%
  • Nascent Chromatin Capture 46%
  • Histone Post-translational Modifications 37%
  • Proteomic Profiling 37%

• Harnessing the PML-SUMO-RNF4 Axis for Cancer Therapy (Programme Grant)

  Hay, R. (Investigator)

  1/12/16 → 30/09/22

  Project: Research

  • Ubiquitin 100%
  • RNF4 54%
  • Ligase 41%
  • Ubiquitination 36%
  • Ubiquitin-like 35%