Molecular Cell and Developmental Biology

2024

A CDK1 phosphorylation site on Drosophila PAR-3 regulates neuroblast polarisation and sensory organ formation

Loyer, N., Hogg, E. K. J., Shaw, H. G., Pasztor, A., Murray, D. H., Findlay, G. M. & Januschke, J. (Lead / Corresponding author), 1 Jul 2024, In: eLife. 13, e97902.

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Chemo-phosphoproteomic profiling with ATR inhibitors berzosertib and gartisertib uncovers new biomarkers and DNA damage response regulators

Jadav, R., Weiland, F., Noordermeer, S. M., Carroll, T., Gao, Y., Wang, J., Zhou, H., Lamoliatte, F., Toth, R., Macartney, T., Brown, F., Hastie, J., Alabert, C., van Attikum, H., Zenke, F., Masson, J.-Y. & Rouse, J. (Lead / Corresponding author), 14 Jun 2024, (E-pub ahead of print) In: Molecular & Cellular Proteomics.

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CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection

Lukoszek, R., Inesta-Vaquera, F., Brett, N. J. .. M., Liang, S., Hepburn, L. A., Hughes, D. J., Pirillo, C., Roberts, E. W. & Cowling, V. H. (Lead / Corresponding author), 23 Jul 2024, In: Cell Reports. 43, 7, 20 p., 114405.

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Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

Liu, J. C. Y., Ackermann, L., Hoffmann, S., Gál, Z., Hendriks, I. A., Jain, C., Morlot, L., Tatham, M. H., McLelland, G. L., Hay, R. T., Nielsen, M. L., Brummelkamp, T., Haahr, P. (Lead / Corresponding author) & Mailand, N. (Lead / Corresponding author), 22 Apr 2024, (E-pub ahead of print) In: Nature Structural and Molecular Biology. 32 p.

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Cracking the Code: Enhancing Molecular Tools for Progress in Nanobiotechnology

Avila, Y. I., Rebolledo, L. P., Skelly, E., de Freitas Saito, R., Wei, H., Lilley, D., Stanley, R. E., Hou, Y. M., Yang, H., Sztuba-Solinska, J., Chen, S. J., Dokholyan, N. V., Tan, C., Li, S. K., He, X., Zhang, X., Miles, W., Franco, E., Binzel, D. W. & Guo, P. & 1 others, Afonin, K. A., 17 Jun 2024, In: ACS Applied Bio Materials. 7, 6, p. 3587-3604 18 p.

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Deletion of CD44 promotes adipogenesis by regulating PPARɣ and cell cycle-related pathways

Weng, X., Jiang, H., Walker, D. J., Zhou, H., Lin, D., Wang, J. & Kang, L. (Lead / Corresponding author), 1 May 2024, (E-pub ahead of print) In: Journal of Endocrinology.

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Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties

Li, X. H. (Lead / Corresponding author), Yu, C. W. H., Gomez-Navarro, N., Stancheva, V., Zhu, H., Murthy, A., Wozny, M., Malhotra, K., Johnson, C. M., Blackledge, M., Santhanam, B., Liu, W., Huang, J., Freund, S. M. V., Miller, E. A. (Lead / Corresponding author) & Babu, M. M. (Lead / Corresponding author), 18 Jan 2024, In: PNAS Nexus. 3, 1, p. 1-19 19 p., pgae006.

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Exploring the unmapped cysteine redox proteoform landscape

Cobley, J. N., 5 Aug 2024, (E-pub ahead of print) In: American Journal of Physiology - Cell Physiology (AJP - Cell Physiology). 67 p.

Research output: Contribution to journal › Review article › peer-review

Extensive acute and sustained changes to neutrophil proteomes post-SARS-CoV-2 infection

Long, M. B., Howden, A. J., Keir, H. R., Rollings, C. M., Giam, Y. H., Pembridge, T., Delgado, L., Abo-Leyah, H., Lloyd, A. F., Sollberger, G., Hull, R., Gilmour, A., Hughes, C., New, B. J., Cassidy, D., Shoemark, A., Richardson, H., Lamond, A. I., Cantrell, D. A. & Chalmers, J. D. (Lead / Corresponding author) & 1 others, Brenes, A. J. (Lead / Corresponding author), 7 Mar 2024, In: The European respiratory journal. 63, 3, 15 p., 2300787.

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Kinetochore-microtubule error correction for biorientation: lessons from yeast

Li, S. (Lead / Corresponding author), Kasciukovic, T. & Tanaka, T. U. (Lead / Corresponding author), Feb 2024, In: Biochemical Society Transactions. 52, 1, p. 29-39 11 p., BST20221261.

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Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

Authier, F., Ondruskova, N., Ferenbach, A., McNeilly, A. & van Aalten, D. M. F. (Lead / Corresponding author), 25 Apr 2024, In: DMM Disease Models and Mechanisms. 17, 4, 9 p., dmm050671.

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Neuroectoderm phenotypes in a human stem cell model of O-GlcNAc transferase associated with intellectual disability

Murray, M., Davidson, L., Ferenbach, A. T., Lefeber, D. & van Aalten, D. M. F. (Lead / Corresponding author), Jun 2024, In: Molecular Genetics and Metabolism. 142, 2, 11 p., 108492.

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Notch signalling influences cell fate decisions and HOX gene induction in axial progenitors

Cooper, F. (Lead / Corresponding author), Souilhol, C., Haston, S., Gray, S., Boswell, K., Gogolou, A., Frith, T. J. R., Stavish, D., James, B. M., Bose, D., Dale, J. K. & Tsakiridis, A. (Lead / Corresponding author), Feb 2024, In: Development. 151, 3, p. 1-10 10 p.

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Proteomic and functional comparison between human induced and embryonic stem cells

Brenes Murillo, A., Griesser, E., Sinclair, L., Davidson, L., Prescott, A., Singh, F., Hogg, E., Espejo-Serrano, C., Jiang, H., Yoshikawa, H., Platani, M., Swedlow, J., Findlay, G., Cantrell, D. & Lamond, A. (Lead / Corresponding author), 2024, In: eLife. p. 1-32 32 p.

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Proteomic and yeast 2-hybrid screens to identify PTEN binding partners

Tibarewal, P., Spinelli, L., Maccario, H. & Leslie, N. R. (Lead / Corresponding author), Jan 2024, In: Advances in Biological Regulation. 91, 12 p., 100989.

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Protocol for a placenta-on-a-chip model using trophoblasts differentiated from human induced pluripotent stem cells

Lermant, A., Rabussier, G., Davidson, L., Lanz, H. L. & Murdoch, C. E. (Lead / Corresponding author), 15 Mar 2024, In: STAR Protocols. 5, 1, 21 p., 102879.

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Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures

Sollberger, G. (Lead / Corresponding author), Brenes, A. J., Warner, J., Arthur, J. S. C. & Howden, A. J. M. (Lead / Corresponding author), Dec 2024, In: Scientific Reports. 14, 1, 15 p., 5966.

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RAM is upregulated during T cell activation and is required for RNA cap formation and gene expression

Knop, K., Gomez-Moreira, C., Galloway, A., Ditsova, D. & Cowling, V. H. (Lead / Corresponding author), 2024, In: Discovery Immunology. 3, 1, p. 1-11 11 p., kyad021.

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Recombinant biosensors for multiplex and super-resolution imaging of phosphoinositides

Maib, H. (Lead / Corresponding author), Adarska, P., Hunton, R., Vines, J. H., Strutt, D., Bottanelli, F. & Murray, D. H., 3 Jun 2024, In: Journal of Cell Biology. 223, 6, 16 p., e202310095.

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3 Citations (Scopus)

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Rewiring of the phosphoproteome executes two meiotic divisions in budding yeast

Koch, L. B., Spanos, C., Kelly, V., Ly, T. & Marston, A. L. (Lead / Corresponding author), 2 Apr 2024, In: EMBO Journal. 43, 7, p. 1351-1383 33 p.

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RNA polymerase II promotes the organization of chromatin following DNA replication

Bandau, S., Alvarez, V., Jiang, H., Graff, S., Sundaramoorthy, R., Gierlinski, M., Toman, M., Owen-Hughes, T., Sidoli, S., Lamond, A. & Alabert, C. (Lead / Corresponding author), 12 Mar 2024, In: EMBO Reports. 25, 3, p. 1387-1414 28 p.

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Sperm Toolbox-A selection of small molecules to study human spermatozoa

Gruber, F. S., Richardson, A., Johnston, Z. C., Myles, R., Norcross, N. R., Day, D. P., Georgiou, I., Sesma-Sanz, L., Wilson, C., Read, K. D., Martins da Silva, S., Barratt, C. L. R., Gilbert, I. H. & Swedlow, J. R. (Lead / Corresponding author), 20 Feb 2024, In: PLoS ONE. 19, 2, 16 p., e0297666.

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SSEN Annual Postgraduate Research Symposium 2024: Book of Abstracts

Saif, A., Nwigwe, J., Miller, J., Din, A., Samuel, O., Jovanovic, F., Kahar, R., Li, H., Alharbi, N., Riccio, T., Almalaq, Y., Liao, J., Oyinlola, K., Adebayo, O., Higgins, S., Robertson, S., Namanqani, H., Wang, Y., Norman, D. & Somjai, E. & 27 others, Zhao, Z., Tao, Z., Mackay, E., Orr, N., Zhao, Y., Sanner, M., Altalib, A., Pourali, A., Kordbacheh, D., Usher, J., Charbenny, S., Zhang, T., Feng, Z., Deane, N., Mubarak, S., Dong, Y., Hollauf, F., You, A., Alajlani, N., Wilson, C. Q., Watson, K., Gray, K., Baginski, S., Fang, L., Yuan, Y., Aldehani, W. & Alrashdi, M., 2024. 74 p.

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Synthesis of Unsymmetrical Difluoromethylene Bisphosphonates

Guo, J., Balić, P., Borodkin, V. S., Filippov, D. V. (Lead / Corresponding author) & Codée, J. D. C. (Lead / Corresponding author), 26 Jan 2024, In: Organic Letters. 26, 3, p. 739-744 6 p.

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Targeted protein degradation via intramolecular bivalent glues

Hsia, O., Hinterndorfer, M., Cowan, A. D., Iso, K., Ishida, T., Sundaramoorthy, R., Nakasone, M. A., Imrichova, H., Schätz, C., Rukavina, A., Husnjak, K., Wegner, M., Correa-Sáez, A., Craigon, C., Casement, R., Maniaci, C., Testa, A., Kaulich, M., Dikic, I. & Winter, G. E. (Lead / Corresponding author) & 1 others, Ciulli, A. (Lead / Corresponding author), 7 Mar 2024, In: Nature. 627, 8002, p. 204-211 8 p.

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23 Citations (Scopus)

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Ten “Cheat Codes” for Measuring Oxidative Stress in Humans

Cobley, J. N., Margaritelis, N. V., Chatzinikolaou, P. N., Nikolaidis, M. G. & Davison, G. W., 22 Jul 2024, In: Antioxidants. 13, 7, 38 p., 877.

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Ten “Cheat Codes” for Measuring Oxidative Stress in Humans

Cobley, J. (Lead / Corresponding author), Margaritelis, N. V., Chatzinikolaou, P. N., Nikolaidis, M. G. & Davison, G. W., 12 May 2024, Preprints.org, 44 p.

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The Atad5 RFC-like complex is the major unloader of proliferating cell nuclear antigen in Xenopus egg extracts

Kawasoe, Y. (Lead / Corresponding author), Shimokawa, S., Gillespie, P. J., Blow, J. J., Tsurimoto, T. & Takahashi, T. S. (Lead / Corresponding author), 16 Jan 2024, In: Journal of Biological Chemistry. 300, 1, 41 p., 105588.

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The histone chaperone SPT2 regulates chromatin structure and function in Metazoa

Saredi, G. (Lead / Corresponding author), Carelli, F. N., Rolland, S. G. M., Furlan, G., Piquet, S., Appert, A., Sanchez-Pulido, L., Price, J. L., Alcon, P., Lampersberger, L., Déclais, A.-C., Ramakrishna, N. B., Toth, R., Macartney, T., Alabert, C., Ponting, C. P., Polo, S. E., Miska, E. A., Gartner, A. & Ahringer, J. & 1 others, Rouse, J. (Lead / Corresponding author), Mar 2024, In: Nature Structural & Molecular Biology. 31, 3, p. 523-535 13 p.

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The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme

Zhan, X., Wilson, T., Li, Z., Zhang, J., Yang, Y., Lilley, D. (Lead / Corresponding author) & Liu, Y. (Lead / Corresponding author), 5 Aug 2024, In: Nature Communications. 15, 6628.

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Toward a common standard for data and specimen provenance in life sciences

Wittner, R. (Lead / Corresponding author), Holub, P., Mascia, C., Frexia, F., Müller, H., Plass, M., Allocca, C., Betsou, F., Burdett, T., Cancio, I., Chapman, A., Chapman, M., Courtot, M., Curcin, V., Eder, J., Elliot, M., Exter, K., Goble, C., Golebiewski, M. & Kisler, B. & 16 others, Kremer, A., Leo, S., Lin-Gibson, S., Marsano, A., Mattavelli, M., Moore, J., Nakae, H., Perseil, I., Salman, A., Sluka, J., Soiland-Reyes, S., Strambio-De-Castillia, C., Sussman, M., Swedlow, J. R., Zatloukal, K. & Geiger, J., 19 Jan 2024, In: Learning Health Systems. 8, 1, 9 p., e10365.

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USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes

Endo, A., Fukushima, T., Takahashi, C., Tsuchiya, H., Ohtake, F., Ono, S., Ly, T., Yoshida, Y., Tanaka, K., Saeki, Y. (Lead / Corresponding author) & Komada, M. (Lead / Corresponding author), 4 Mar 2024, In: Journal of Cell Biology. 223, 3, 21 p., e202306013.

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2023

50 shades of oxidative stress: A state-specific cysteine redox pattern hypothesis

Cobley, J. N. (Lead / Corresponding author), Nov 2023, In: Redox Biology. 67, 12 p., 102936.

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3 Citations (Scopus)

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Adenovirus E1B-55K controls SUMO-dependent degradation of antiviral cellular restriction factors

Ip, W.-H., Tatham, M. H., Krohne, S., Gruhne, J., Melling, M., Meyer, T., Gornott, B., Bertzbach, L. D., Hay, R. T., Rodriguez, E. & Dobner, T. (Lead / Corresponding author), 30 Nov 2023, In: Journal of Virology. 97, 11, 21 p., e0079123.

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A mechanochemical model recapitulates distinct vertebrate gastrulation modes

Serra, M. (Lead / Corresponding author), Serrano Nájera, G., Chuai, M., Plum, A. M., Santhosh, S., Spandan, V., Weijer, C. J. & Mahadevan, L. (Lead / Corresponding author), 6 Dec 2023, (E-pub ahead of print) In: Science Advances. 9, 49, 11 p., eadh8152.

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An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury

Rodrigo Albors, A., Singer, G. A., Llorens-Bobadilla, E., Frisén, J., May, A. P., Ponting, C. P. & Storey, K. G. (Lead / Corresponding author), 6 Feb 2023, In: Developmental Cell. 58, 3, p. 239-255.e10 17 p.

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An O-GlcNAc transferase pathogenic variant linked to intellectual disability affects pluripotent stem cell self-renewal

Omelková, M., Fenger, C. D., Murray, M., Hammer, T. B., Pravata, V. M., Bartual, S. G., Czajewski, I., Bayat, A., Ferenbach, A. T., Stavridis, M. P. & van Aalten, D. M. F., Jun 2023, In: Disease Models and Mechanisms (DMM). 16, 6, 13 p., dmm049132.

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4 Citations (Scopus)

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APC/C-dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells

Meghini, F., Martins, T., Zhang, Q., Loyer, N., Trickey, M., Abula, Y., Yamano, H., Januschke, J. (Lead / Corresponding author) & Kimata, Y. (Lead / Corresponding author), 5 Apr 2023, In: EMBO Reports. 24, 4, 18 p., e55607.

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A PI(3,5)P₂ reporter reveals PIKfyve activity and dynamics on macropinosomes and phagosomes

Vines, J. H., Maib, H., Buckley, C. M., Gueho, A., Zhu, Z., Soldati, T., Murray, D. H. & King, J. S. (Lead / Corresponding author), 29 Jun 2023, In: Journal of Cell Biology. 222, 9, 22 p., e202209077.

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A survey of the training experiences and needs on Wellcome Trust PhD programmes

Fawcett, C., Sandilands, K., Ng'ang'a, R., Muasya, W., Budriunaite, I., Andleeb, H., Gatua, W., De abreu nunes, L., Oketch, J. & Piazza, G. G., 9 Oct 2023, In: Wellcome Open Research. 8, 432, 15 p.

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Biochemical and mechanistic analysis of the cleavage of branched DNA by human ANKLE1

Freeman, A. D. J., Déclais, A.-C., Wilson, T. J. & Lilley, D. M. J. (Lead / Corresponding author), 23 Jun 2023, In: Nucleic Acids Research. 51, 11, p. 5743–5754 12 p., gkad416.

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BUB-1 and CENP-C recruit PLK-1 to control chromosome alignment and segregation during meiosis I in C. elegans oocytes

Taylor, S. J. P., Bel Borja, L., Soubigou, F., Houston, J., Cheerambathur, D. K. & Pelisch, F. (Lead / Corresponding author), 17 Apr 2023, In: eLife. 12, 26 p., e84057.

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Catalytic mechanism and pH dependence of a methyltransferase ribozyme (MTR1) from computational enzymology

McCarthy, E., Ekesan, Ş., Giese, T. J., Wilson, T. J., Deng, J., Huang, L., Lilley, D. M. J. & York, D. M. (Lead / Corresponding author), 22 May 2023, In: Nucleic Acids Research. 51, 9, p. 4508–4518 11 p., gkad260.

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CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence

Crozier, L., Foy, R., Adib, R., Kar, A., Holt, J. A., Pareri, A. U., Valverde, J. M., Rivera, R., Weston, W. A., Wilson, R., Regnault, C., Whitfield, P., Badonyi, M., Bennett, L. G., Vernon, E. G., Gamble, A., Marsh, J. A., Staples, C. J., Saurin, A. T. & Barr, A. R. & 1 others, Ly, T. (Lead / Corresponding author), 16 Nov 2023, In: Molecular Cell. 83, 22, p. 4062-4077.e5 21 p.

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Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1

De La Cruz-Herrera, C. F., Tatham, M. H., Siddiqi, U. Z., Shire, K., Marcon, E., Greenblatt, J. F., Hay, R. T. & Frappier, L. (Lead / Corresponding author), 6 Jul 2023, In: PLoS Pathogens. 19, 7, 34 p., e1011477.

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Chromosome biorientation requires Aurora B’s spatial separation from its outer kinetochore substrates but not its turnover at kinetochores

Li, S., Garcia-Rodriguez, L. J. & Tanaka, T. U. (Lead / Corresponding author), 6 Nov 2023, In: Current Biology. 33, 21, p. 4557-4569.e3 13 p.

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Core PCP mutations affect short-time mechanical properties but not tissue morphogenesis in the Drosophila pupal wing

Piscitello-Gómez, R., Gruber, F. S., Krishna, A., Duclut, C., Modes, C. D., Popović, M., Jülicher, F., Dye, N. A. (Lead / Corresponding author) & Eaton, S., 20 Dec 2023, In: eLife. 12, p. 1-21 21 p., e85581.

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Crystal structures of the NAD⁺-II riboswitch reveal two distinct ligand-binding pockets

Peng, X., Liao, W., Lin, X., Lilley, D. M. J. (Lead / Corresponding author) & Huang, L. (Lead / Corresponding author), 11 Apr 2023, In: Nucleic Acids Research. 51, 6, p. 2904-2914 11 p.

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Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation

Al-Rawi, A., Kaye, E., Korolchuk, S., Endicott, J. A. & Ly, T. (Lead / Corresponding author), 28 Mar 2023, In: Cell Reports. 42, 3, 21 p., 112139.

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Development of a 2,4-diaminothiazole series for the treatment of human African trypanosomiasis highlights the importance of static-cidal screening of analogues

Cleghorn, L. A. T., Wall, R. J., Albrecht, S., MacGowan, S. A., Norval, S., De Rycker, M., Woodland, A., Spinks, D., Thompson, S., Patterson, S., Corpas Lopez, V., Dey, G., Collie, I. T., Hallyburton, I., Kime, R., Simeons, F. R. C., Stojanovski, L., Frearson, J. A., Wyatt, P. G. & Read, K. D. & 2 others, Gilbert, I. H. (Lead / Corresponding author) & Wyllie, S. (Lead / Corresponding author), 13 Jul 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8896–8916 21 p.

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Molecular Cell and Developmental Biology

Research output

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