MRC PPU

  • United Kingdom

Fingerprint The fingerprint is based on mining the text of the scientific documents related to the associated persons. Based on that an index of weighted terms is created, which defines the key subjects of research unit

Phosphorylation Chemical Compounds
Phosphotransferases Medicine & Life Sciences
Ubiquitin Medicine & Life Sciences
Proteins Medicine & Life Sciences
Ubiquitin-Protein Ligases Medicine & Life Sciences
Chemical activation Chemical Compounds
Protein Kinases Medicine & Life Sciences
Cells Chemical Compounds

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Profiles

No photo of Kris Aare

Aare, Kris

No photo of Catriona Aitken

Aitken, Catriona

No photo of Dario Alessi

Alessi, Dario

19922018

Research Output 1968 2018

1 Citations

6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

Offenburger, S-L., Ho, X. Y., Tachie-Menson, T., Coakley, S., Hilliard, M. A. & Gartner, A., 18 Jan 2018, In : PLoS Genetics. 14, 1, p. 1-27 27 p., e1007125.

Research output: Contribution to journal › Article

Open Access
File
prealbumin
Prealbumin
Oxidopamine
Caenorhabditis elegans
Oxidative Stress

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism

Nanda, S. K., Nagamori, T., Windheim, M., Amu, S., Aviello, G., Patterson-Kane, J., Arthur, J. S. C., Ley, S. C., Fallon, P. & Cohen, P., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3373-3382 10 p.

Research output: Contribution to journal › Article

Colitis
Neoplasms
Myofibroblasts
Cyclooxygenase 2
Ubiquitin
3 Citations

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Pao, K-C., Wood, N. T., Knebel, A., Rafie, K., Stanley, M., Mabbitt, P. D., Sundaramoorthy, R., Hofmann, K., van Aalten, D. M. F. & Virdee, S., 11 Apr 2018, In : Nature. 556, 7701, p. 381-385 5 p.

Research output: Contribution to journal › Article

Open Access
File
Ubiquitin-Protein Ligases
Esterification
Ubiquitin
Genes
Ubiquitination

Prizes

Long-term Doctoral Fellowship (1993-1994)

Karim Labib (Recipient), 1993

Prize: Fellowship awarded competitively

Senior Cancer Research Fellowship, 2001-2007

Karim Labib (Recipient), 2001

Prize: Fellowship awarded competitively

Young Investigator Programme

Karim Labib (Recipient), 2004

Prize: Fellowship awarded competitively

time

Student theses

An investigation of the activation of protein kinase complexes in the MyD88 signalling network

Author: Zhang, J., 2017

Supervisor: Cohen, P. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase

Author: Pao, K., 2018

Supervisor: Virdee, S. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy

File

Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α

Author: Bozatzi, P., 2018

Supervisor: Sapkota, G. (Supervisor)

Student thesis: Doctoral Thesis › Doctor of Philosophy