MRC PPU

Projects

Projects per year 2008 2010 2013 2015 2016 2017 2018 2020 2021 2022 2023 2024 2031

• 21 Active
• 26 Not started
• 146 Finished

Projects per year

Search results

• Active

  Identification of New Therapeutic Targets for C9ORF72 Amyotrophic Lateral Sclerosis using Kinome-wide CRISPR Screen in Human Stem Cell-Derived Motor Neurons Co-Cultured with Microglia

  Mehta, A. (Investigator)

  Medical Research Council

  4/11/24 → 3/05/27

  Project: Research

• Prophylactic Approaches To Treating Intestinal Damage In Coeliac Disease - Joint with University of Sheffield

  Swamy, M. (Investigator)

  Coeliac UK

  1/09/24 → 31/08/27

  Project: Research

• Mutational screen of GBA1, PARKIN and LRRK2

  Alessi, D. (Investigator), Muqit, M. (Investigator) & Sammler, E. (Investigator)

  1/08/24 → 31/07/26

  Project: Research

• Sugar Ubiquitylation, A New Quality Control Mechanism For The Recognition And Elimination Of Misfolded Macromolecules

  Cohen, P. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/06/24 → 30/11/25

  Project: Research

• Spatial Proteomics to Study Brain Health and Neurodegeneration

  Alessi, D. (Investigator)

  1/04/24 → 31/08/27

  Project: Research

• Cleave to Modify: Illuminating the "Dark Proteome" with Novel Chemical Biology Tools (Fellowship)

  Maniaci, C. (Investigator)

  1/01/24 → 31/12/31

  Project: Research

• Irreversible Inactivation Of Ubiquitin And Ubiquitin-Like Proteins

  Swatek, K. (Investigator)

  19/10/23 → 18/10/28

  Project: Research

  • USP18 100%
  • Interferon-α (IFN-α) 100%
  • Cell Growth 100%
  • ISGylation 100%
  • Interferon 100%

• Interrogating Tankyrase-mediated Control of Neuronal Degeneration in Frontotemporal Dementia (Dementia Research Leader Fellowship) (Outline) & Full

  Alessi, D. (Investigator), Ashford, M. (Investigator), Davies, P. (Investigator), McGurk, L. (Investigator) & Storey, K. (Investigator)

  Alzheimer's Society

  2/10/23 → 1/10/28

  Project: Research

• How Does Dysregulated Signal Transduction Cause Intellectual Disability (Glasgow University, MRC Harwell)

  Findlay, G. (Investigator)

  1/09/23 → 31/08/31

  Project: Research

• Louis-Jeantet Prize 2023 - Personal Award

  Alessi, D. (Investigator)

  1/06/23 → 31/05/28

  Project: Research

• Discovery and Characterisation of Undefined Ubiquitin and Ubiquitin like E3 Ligases

  Virdee, S. (Investigator)

  10/04/23 → 9/04/31

  Project: Research

  • Ubiquitin Ligase 100%
  • Zinc Finger 87%
  • Ubiquitin 71%
  • Ubiquitin-Conjugating Enzyme 57%
  • RNF213 55%

• Shared Proteomics Platform For The MRC PPU And The UK Dementia Research Institute (UK DRI)

  Alessi, D. (Investigator)

  1/04/23 → 31/03/28

  Project: Research

• Implementation and Validation of Quantitative Lysosome-specific GCase Assays in Cell Lines and Human Peripheral Blood for use in Clinical Samples

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/03/23 → 31/08/25

  Project: Research

• Towards A Molecular Understanding Of Myddosome Organization And Regulation Of IRAK Kinase Activity

  Kulathu, Y. (Investigator) & Lange, S. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/23 → 31/12/25

  Project: Research

• Using Activity-Based Probes To Study The Mechanism And Regulation Of The Giant E3 Ligase Huwe1 (lead: IMP Vienna other instn: IMBA Vienna)

  Virdee, S. (Investigator)

  Vienna Science and Technology Fund

  1/06/22 → 31/05/26

  Project: Research

• Understanding The Roles Of ERphagy During Epithelial-To-Mesenchymal Transition

  Liang, A. (Investigator)

  1/06/22 → 31/05/28

  Project: Research

• Defining mechanisms of cellular stress responses driven by heterotypic ubiquitin chains (StressHUb)

  Kulathu, Y. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/22 → 31/12/26

  Project: Research

  • Ubiquitin 100%
  • Branched Ubiquitin Chain 100%
  • Branched-chain 70%
  • Cell Signaling 60%
  • Valosin-containing Protein 50%

• Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)

  Kulathu, Y. (Investigator), Labib, K. (Investigator), Masson, G. (Investigator), Moraga Gonzalez, I. (Investigator), Murray, D. (Investigator), Owen-Hughes, T. (Investigator), Stanley-Wall, N. (Investigator) & Wyatt, P. (Investigator)

  1/12/21 → 31/12/26

  Project: Research

  • Ubiquitin Ligase 100%
  • E3 Ligase 88%
  • Ubiquitination 74%
  • Bromodomain-containing Protein 4 (BRD4) 62%
  • Degrader 59%

• Assessing physiological relevance, biological roles and molecular mechnisms of non-canonical ubiquitination

  De Cesare, V. (Investigator)

  Medical Research Council

  1/10/21 → 30/09/26

  Project: Research

  • Matrix-assisted Laser Desorption Ionization-time of Flight Mass Spectrometry (MALDI-TOF MS) 100%
  • Enzyme 90%
  • Ubiquitin 81%
  • Ubiquitylation 68%
  • Ubiquitination 63%

• Evaluation Of The PIM Kinases As Drug Targets For The Treatment Of Inflammatory Bowel Diseases (PhD Studentship)

  Swamy, M. (Investigator)

  20/09/21 → 20/09/25

  Project: Research

• Young Investigator Programme

  Kulathu, Y. (Investigator)

  European Molecular Biology Organization

  1/01/16 → 31/12/26

  Project: Research

• Not started

  Analysis of the Role of Phopho-Ubiquitin in Parkinsons Disease Signalling (Enhancement Grant)

  Muqit, M. (Investigator)

  Project: Research

• Single cell proteomics-Cellenone

  Alessi, D. (Investigator) & Nirujogi, R. (Investigator)

  Project: Research

• Activation mechanism of PINK1 in Parkinson's disease

  Muqit, M. (Investigator)

  Project: Research

• Dissection of cell autonomous and indirect pathogenic mechanisms mediating PIK3CA-driven overgrowth

  Madsen, R. (Investigator)

  Project: Research

• Aref#d: 12419. The establishment of a Post-Genomics and Molecular Interactions Centre at the University of Dundee (Joint Infrastructure Fund - supplement)

  Cohen, P. (Investigator), Downes, P. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Hunter, B. (Investigator), Lamond, A. (Investigator), Lilley, D. (Investigator), Norman, D. (Investigator), Watts, C. (Investigator) & Williams, J. (Investigator)

  Project: Research

• Investigating Nuclear UFMylation (iNUF)

  Kulathu, Y. (Investigator)

  Project: Research

• Liam Hales_Newton international fellowship with Chiara Maniaci

  Maniaci, C. (Investigator)

  Project: Research

• Faithful Epigenetic Inheritance And Germline Integrity In C Elegans

  Saredi, G. (Investigator)

  Project: Research

• MRC Public Engagement 2014-2015

  Alessi, D. (Investigator)

  Project: Research

• Validating targeted protein degradation as a therapeutic approach in Tonne-Kalscheuer Syndrome

  Findlay, G. (Investigator)

  Project: Research

• MRC QQR 2024-29

  Alessi, D. (Investigator), Davies, P. (Investigator), Ganley, I. (Investigator), Kulathu, Y. (Investigator), Liang, A. (Investigator), Rouse, J. (Investigator), Sapkota, G. (Investigator), Swamy, M. (Investigator), Swatek, K. (Investigator) & Virdee, S. (Investigator)

  Project: Research

  • Ubiquitin-Conjugating Enzyme 100%
  • E3 Ubiquitin Ligase 80%
  • RNF213 66%
  • Induced Proximity 66%
  • Amino Acids 66%

• An Optically Clear Prototype for the Culture and Detection of Circulating Tumour Cells (joint with Heriot-Watt University)

  Katz, E. (Investigator)

  Project: Research

• The Influenza Virus Toolkit: A Reagent Sharing Resource for Influenza Research (Joint with Universities of Glasgow and Oxford)

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Project: Research

• Dundee Training Programme in Integrated Molecular, Cellular and Translational Biology

  Arthur, S. (Investigator), Coulthurst, S. (Investigator), Hay, R. (Investigator) & Muqit, M. (Investigator)

  Project: Research

• Decoding the regulation of proteasome homeostasis in health and stress

  Rousseau, A. (Investigator)

  Project: Research

• Exploiting state-of-the-art mass spectrometry to identify blood-based biomarkers for TDP-43 driven Motor Neuron Disease

  Alessi, D. (Investigator) & Nirujogi, R. (Investigator)

  Project: Research

• A Simplified System to Study Regulation of the WNK Signalling Pathway (Long Term Fellowship)

  Daubner, G. (Investigator)

  Project: Research

• Aref#d: 22085. Scottish Institute for Cell Signalling (SCILLS) Strategic Research Development Grant

  Cohen, P. (Investigator)

  Project: Research

• Mapping Signalling Plasticity to Enable State-Gating Therapies (Futue Leaders Fellowship)

  Madsen, R. (Investigator)

  Project: Research

• Aref#d: 9354. The establishment of a Post-Genomics and Molecular Interactions Centre at the University of Dundee (Joint Infrastructure Fund)

  Cohen, P. (Investigator), Downes, P. (Investigator), Fairlamb, A. (Investigator), Ferguson, M. (Investigator), Hunter, B. (Investigator), Lamond, A. (Investigator), Lilley, D. (Investigator), Norman, D. (Investigator), Watts, C. (Investigator) & Williams, J. (Investigator)

  Project: Research

• Characterisation of a PLA2G6 knockin model harbouring Parkinsonism R636Q mutation

  Muqit, M. (Investigator)

  Project: Research

• Summer Studentship (2019)

  Muqit, M. (Investigator)

  Project: Research

• Generating the tools to define the interactome of NEK1 protein kinase in human spinal motor neurons

  Davidson, L. (Investigator) & Mehta, A. (Investigator)

  Project: Research

• Targeting E3 ubiquitin lifases with sall molecules (iCASE Studentship)

  Ciulli, A. (Investigator) & Virdee, S. (Investigator)

  Project: Research

• Translation-associated quality control of secretome integrity by ubiquitin-like modifiers

  Kulathu, Y. (Investigator) & Miller, L. (Investigator)

  Project: Research

• Validating a high-throughput drug discovery model for novel diabetic kidney disease

  Katz, E. (Investigator)

  Project: Research

• Finished

  Does Mitochondrial Dysfunction Contribute To Diabetes Associated Cognitive Decline

  Ganley, I. (Investigator) & McNeilly, A. (Investigator)

  1/06/24 → 31/05/25

  Project: Research

• World Class Labs Capital Equipment Funding Block Grant

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/24 → 31/03/25

  Project: Research

• 26S-NonoLuc: a Transformational Assay of Proteasome Assembly

  Rousseau, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/02/24 → 31/03/25

  Project: Research