MRC PPU

Projects

Projects per year 2008 2010 2013 2015 2016 2017 2018 2020 2021 2022 2023 2024 2031

• 21 Active
• 26 Not started
• 146 Finished

Projects per year

Search results

• Finished

  Expression Of Nrf2 Target Genes In Crohn's Disease Models

  Dikovskaya, D. (Investigator)

  1/12/23 → 29/02/24

  Project: Research

• Linking the GI tract with PD

  Alessi, D. (Investigator), Mowat, C. (Investigator) & Sammler, E. (Investigator)

  1/10/23 → 30/09/24

  Project: Research

  • Parkinson's Disease 100%
  • Medical Research Council 100%
  • viewer 100%
  • Clinical 100%
  • Scientists 100%

• Interrogating LRRK2 Signalling in Bio-Samples Derived From Patients with Parkinson's Disease Carrying the Asian LRRK2 G2385R and R1628P Variants for Biomarker Discovery (Joint with University of Malaya)

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  15/09/23 → 14/03/25

  Project: Research

• Advanced Macromolecular Analysis of Human PINK1 - Joint with Universities Geottingen and Leeds

  Muqit, M. (Investigator)

  1/08/23 → 31/07/24

  Project: Research

• Validation Of LRRK2 Modifiers As Potential PD Therapeutic Targets - Joint with Universite de Lille and University of Padua

  Alessi, D. (Investigator)

  26/06/23 → 25/12/24

  Project: Research

• The Systems Biology of Oncogenic Pi3Ka-Driven Stemness Regulation (Transfer)

  Madsen, R. (Investigator)

  1/05/23 → 30/11/24

  Project: Research

  • Protein Kinase B 100%
  • Stemness 83%
  • PIK3CA 83%
  • Phosphoinositide 3-kinase (PI3K) 75%
  • Breast Cancer 69%

• Capital Equipment Award. Shared Proteomics Platform For The MRC-PPU And The UK DRI

  Alessi, D. (Investigator)

  1/04/23 → 31/03/24

  Project: Research

• Development of LRRK2 Type II Inhibitors to Understand Utility of these Compounds for the Treatment of Parkinson's Disease

  Alessi, D. (Investigator), Davies, P. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)

  1/03/23 → 29/02/24

  Project: Research

• Regulation of Protein Stbility by Lysine Hydroxylation (DP Fellowship) (Transfer)

  Maniaci, C. (Investigator)

  Biotechnology and Biological Sciences Research Council

  5/01/23 → 31/12/23

  Project: Research

  • Proteome-wide 100%
  • Degrons 100%
  • Web Server 100%
  • Proteome 100%
  • C-Terminus 100%

• Unravelling Key Cellular Machinery for Splicesome Regulation (Transfer)

  Maniaci, C. (Investigator)

  1/01/23 → 31/03/24

  Project: Research

• MRC Capital Block Grant

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Ultra-High Definition Imaging - MRC Equipment Grant

  Alessi, D. (Investigator), Banerjee, S. (Investigator), Cantley, J. (Investigator), Corner, G. (Investigator), Hayes, J. (Investigator), Hoskins, P. (Investigator), Kang, L. (Investigator), McNeilly, A. (Investigator), McSorley, H. (Investigator), Murdoch, C. (Investigator) & Rena, G. (Investigator)

  Medical Research Council

  1/11/22 → 31/03/23

  Project: Research

• Insights Into The ISG15 Transfer Cascade

  Swatek, K. (Investigator)

  17/10/22 → 16/10/23

  Project: Research

  • ISG15 100%
  • Interferon-stimulated Gene 15 (ISG15) 89%
  • Enzyme 85%
  • USP18 71%
  • UBE1L 71%

• Pharmacological Activation of Autography in Vivo - Part 2

  Ganley, I. (Investigator)

  1/10/22 → 31/10/24

  Project: Research

• LRRK2 Kinase Activity and Global Proteomic Markers in the Gut of PD and IBD Patients (Joint with Icahn School of Medicine Mount Sinai New York & Department Of Pathology & Immunology, Washington University School of Medicine)

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/07/22 → 31/08/24

  Project: Research

• High-Throughput-Analysis to Identify and Characterize PPM1H Protein Phosphatase Activity Enhancers

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/02/22 → 1/02/24

  Project: Research

• MRC Climate Crisis Network (Lead: University Of Dundee other instns: Mitocondrial Unit, Human Genetics Unit)

  Alessi, D. (Investigator) & Labib, K. (Investigator)

  Medical Research Council

  1/01/22 → 31/12/24

  Project: Research

• Cell Line Characterisation (other inst: Rutgers University)

  Alessi, D. (Investigator)

  1/11/21 → 31/10/23

  Project: Research

• Characterization of physiological substrates of the NEK1-C21ORF2 complex, and the impact of ALS-causing mutations (joint with Centre for Clinical Brain Sciences, University of Edinburgh)

  Rouse, J. (Investigator)

  1/11/21 → 31/08/24

  Project: Research

• Identifying PD Biomarkers In Peripheral Blood Immune Cells Using Mass Spectrometry And Single Cell RNA Sequencing

  Alessi, D. (Investigator)

  14/09/21 → 1/09/24

  Project: Research

• Supplement Award: Development of Tools for PINK1 Pathways Analysis In Parkinson's Disease

  Muqit, M. (Investigator)

  1/06/21 → 31/05/22

  Project: Research

• Differential LRRK2 Dependent Rab Phosphorylation Signatures in Peripheral Blood and Urine in Idiopathic and Monogenetic PD

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/06/21 → 31/07/24

  Project: Research

  • Parkinson's Disease 100%
  • Phospholipids 50%
  • Bisphosphonates 50%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 50%
  • Mutation Carriers 50%

• Determining PINK1 and PRKN Enzyme Activities In Vivo (Joint with University of Nebraska, University of Alabama at Birmingham and Mayo Clinic of Medicine and Science)

  Ganley, I. (Investigator)

  16/04/21 → 15/12/23

  Project: Research

• World Class Labs Capital Award 21/22

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

  • Ubiquitin Ligase 100%
  • E3 Ligase 88%
  • Ubiquitination 74%
  • Bromodomain-containing Protein 4 (BRD4) 62%
  • Degrader 59%

• World Class Labs Capital Funding Offer 2021/22

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/21 → 31/03/22

  Project: Research

• Stratification Of MRC Funded Scientific Technologies And Reagents For Rapid And Simple Dissemination To The Wider Scientific Community

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/01/21 → 31/03/21

  Project: Research

  • COVID-19 100%
  • Severe Acute Respiratory Syndrome Coronavirus 2 100%
  • Biochemical Characterization 50%
  • Nsp3 50%
  • Protease Activity 50%

• Determining the ligase and DUB landscape of mitochondrial and alpha-synuclein turnover

  Ganley, I. (Investigator), Sapkota, G. (Investigator) & Virdee, S. (Investigator)

  1/12/20 → 29/02/24

  Project: Research

• MRC PPU Covid Research

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  18/10/20 → 17/07/21

  Project: Research

  • COVID-19 100%
  • Coronavirus 66%
  • Coronavirinae 66%
  • Severe Acute Respiratory Syndrome Coronavirus 2 66%
  • SARS Coronavirus 66%

• World Class Labs

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/10/20 → 31/03/21

  Project: Research

• ASAP - Mapping the LRRK2 Signalling Pathway and its Interplay with other Parkinson's Disease Components

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  Aligning Science Across Parkinson's (ASAP), Michael J. Fox Foundation for Parkinson's Research

  1/10/20 → 1/10/24

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Kinase 83%
  • Phosphotransferase 83%
  • Parkinson's Disease 52%
  • Leucine-Rich Repeat 51%

• Defining Mechanisms of Protein Ufmylation

  Kulathu, Y. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/09/20 → 29/02/24

  Project: Research

  • UFMylation 100%
  • Ubiquitin 96%
  • UFM1 78%
  • E3 Ligase 78%
  • Ubiquitin Ligase 78%

• Development of better approaches to study PINK1 structure (joint application with University Medical Centre Goettingen and University of Frankfurt)

  Muqit, M. (Investigator)

  1/08/20 → 31/07/22

  Project: Research

  • Outer Membrane Complex 100%
  • Reconstituted System 100%
  • PTEN-induced Kinase 1 (PINK1) 100%
  • Kinase 100%
  • Phosphotransferase 100%

• Inhibiting SARS CoV2-PLpro Protease as a Strategy to Block Viral Replication

  Kulathu, Y. (Investigator)

  1/07/20 → 31/10/20

  Project: Research

• Funding for new Mass Spec Platform

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/04/20 → 31/03/21

  Project: Research

• RNF12 E3 Ubiquitin Ligase Substrate Degraders as a Therapeutic Strategy in Tonne-Kalscheuer Syndrome (TOKAS)

  Bustos, F. (Investigator) & Findlay, G. (Investigator)

  1/03/20 → 28/02/22

  Project: Research

  • Stem Cell 100%
  • E3 Ubiquitin Ligase 83%
  • Activity-based Probes 83%
  • Rnf12 83%
  • Stem Cells 83%

• DNA Interstrand Crosslink Repair and Chromatin Remodelling (ICL CHROM)

  Rouse, J. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/02/20 → 26/04/22

  Project: Research

  • Histone Chaperone 100%
  • Chromatin Structure 100%
  • Chromatin Function 100%
  • Metazoa 100%
  • Histone 100%

• Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/01/20 → 14/08/21

  Project: Research

• Validation of antibodies to ubiquitin-conjugated proteins for mitophagy readouts

  Muqit, M. (Investigator)

  11/12/19 → 1/12/22

  Project: Research

• Short Linear Interaction Motifs as Specificity Determinants in the Ubiquitin System - Discovery, Mechanisms and Therapuetic Opportunities (UBIMOTIF)

  Kulathu, Y. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/12/19 → 31/05/24

  Project: Research

• C5aR a Novel Immunomodulator of Metabolic Signalling and Energy Metabolism in Skeletal Muscle

  Ganley, I. (Investigator), Hundal, H. (Investigator), Lipina, C. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  4/11/19 → 25/08/23

  Project: Research

  • Novel Immunomodulators 100%
  • C5a Receptor 100%
  • Receptor 1 100%
  • Complement Receptors 100%
  • Insulin Action 100%

• PPM1H Activators for Treatment of Parkinson's Disease

  Alessi, D. (Investigator) & Gray, D. (Investigator)

  1/09/19 → 30/03/21

  Project: Research

• Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D. (Investigator)

  1/08/19 → 30/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • LRRK2 76%
  • PPM1H 38%
  • Rab Proteins 36%
  • Phosphatase 33%

• MRC Capital Prioritisation Bid 2019-20

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/19 → 31/03/20

  Project: Research

• Antigen and Validation for New pS228 PINK1 and pT257 PINK1 Antibodies at Abcam

  Muqit, M. (Investigator)

  1/03/19 → 7/02/22

  Project: Research

• Processing of Branched DNA Molecules During Cytokinesis, Uncovering New Mechanisms of Genome Maintenance

  Gartner, A. (Investigator), Lilley, D. (Investigator) & Rouse, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/12/18 → 30/06/22

  Project: Research

  • Caenorhabditis Elegans 100%
  • DNA Repair 83%
  • DNA Repair Pathways 65%
  • Mutational Signatures 55%
  • Genome Integrity 41%

• LRRK2 and IBD

  Alessi, D. (Investigator)

  1/11/18 → 31/10/19

  Project: Research

• Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/11/18 → 31/12/20

  Project: Research

• Investigating the Druggability of Undruggable Targets Using the Affinity Directed Protein Missile System (AdPROM) in Neurodegenerative Disorders

  Muqit, M. (Investigator) & Sapkota, G. (Investigator)

  10/09/18 → 9/09/21

  Project: Research

• Regulation of the Parkinson's kinase LRRK2

  Alessi, D. (Investigator)

  Parkinson's UK

  3/09/18 → 2/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • Leucine-Rich Repeat 91%
  • Kinase 85%
  • Phosphotransferase 85%
  • Parkinson's Disease 41%

• Functions and Applications of a Novel Pluripotency Signalling Pathway (Sir Henry Dale Fellowship)

  Findlay, G. (Investigator)

  1/09/18 → 31/08/23

  Project: Research

  • Rnf12 100%
  • Embryonic Stem Cell 80%
  • Ubiquitin-Conjugating Enzyme 65%
  • E3 Ubiquitin Ligase 59%
  • Stem Cell 52%