MRC PPU

Projects

Projects per year 2008 2010 2013 2015 2016 2017 2018 2020 2021 2022 2023 2031

• 21 Active
• 25 Not started
• 145 Finished

Projects per year

Search results

• Finished

  Validation of Voltage - Dependent Anion Channel Proteins as Substrates of the Parkinson Disease Gene and E3 Ubiquitin Ligase Component FBX07

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  Anonymous Trust

  1/09/14 → 31/08/16

  Project: Research

• The Dissection of Novel Signalling Networks Controlled by the Salt-Inducible Kinases During the Resolution of Inflammatory Arthritis (Career Development Fellowship)

  Alessi, D. (Investigator) & Clark, K. (Investigator)

  1/05/14 → 30/04/19

  Project: Research

• Exploring O-GlcNAc Signalling in T Cell Lymphomagenesis

  Swamy, M. (Investigator)

  15/04/14 → 14/04/16

  Project: Research

• Capital Prioritisation Panel February 2014

  Alessi, D. (Investigator)

  Medical Research Council

  1/04/14 → 1/04/15

  Project: Research

• Study of Differential TRNA Post-Transcriptional Modifications as a Mechanism to Control Proteome Composition

  Alessi, D. (Investigator) & Pedrioli, P. (Investigator)

  Biotechnology and Biological Sciences Research Council

  31/03/14 → 30/03/17

  Project: Research

  • Ubiquitin 100%
  • Kinase 92%
  • Phosphotransferase 92%
  • Phosphorylation 85%
  • Parkin 82%

• Proteomic Analysis of the Electrical Synaptosome

  Hormuzdi, S. (Investigator) & Trost, M. (Investigator)

  Anonymous Trust

  1/10/13 → 31/07/17

  Project: Research

• Development of G2019S LRRK2 Inhibitors for the Treatment of Parkinson's Disease

  Alessi, D. (Investigator)

  15/09/13 → 14/09/15

  Project: Research

• LRRK2 Cell Line Characterization

  Alessi, D. (Investigator)

  1/09/13 → 28/02/14

  Project: Research

• Development of Anti-Inflammatory Drugs that Target the IRAK2 Pseudokinase Direct Application

  Cohen, P. (Investigator)

  Medical Research Council

  1/08/13 → 31/07/14

  Project: Research

• Biochemical Analysis of the PINK-1 Parkin Signalling Pathway in Parkinson's Disease (Senior Clinical Fellowship)

  Muqit, M. (Investigator)

  1/07/13 → 31/12/23

  Project: Research

  • Parkin 100%
  • PINK1 91%
  • Kinase 80%
  • Phosphotransferase 80%
  • Ubiquitin 66%

• Functional Characterisation of the FAN1 DNA Repair Nucleases (FanDamAge)

  Lachaud, C. (Investigator) & Rouse, J. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/13 → 30/04/15

  Project: Research

• Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

  Cohen, P. (Investigator)

  Medical Research Council

  1/04/13 → 31/03/18

  Project: Research

  • Ubiquitin 100%
  • Phosphorylation 68%
  • Ubiquitin Chains 64%
  • Toll-like 58%
  • Kinase 52%

• Mid-Career Equipment Grant

  Alessi, D. (Investigator) & Kulathu, Y. (Investigator)

  Medical Research Council

  1/04/13 → 31/03/14

  Project: Research

• Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

  Cohen, P. (Investigator)

  1/04/13 → 31/03/18

  Project: Research

  • Ubiquitin 100%
  • Phosphorylation 82%
  • Signaling Network 78%
  • Protein Kinase 74%
  • Toll-like 72%

• European Lead Factory EUC2LID (IMI) (Joint with 29 other Partners)

  Alessi, D. (Investigator), Ferguson, M. (Investigator), Hopkins, A. (Investigator), Hopkins Navratilova, I. (Investigator) & Read, K. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES, Scottish Funding Council

  1/01/13 → 31/05/18

  Project: Research

  • Indole-2-carboxylate 100%
  • Metallo-β-lactamase 100%
  • Lactams 100%
  • β-lactamase Inhibitor 100%
  • Imitation 100%

• Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases

  Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator), McCrimmon, R. (Investigator) & Trost, M. (Investigator)

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • Prothrombin 100%
  • NFE2L2 97%
  • Nonalcoholic Steatohepatitis 72%
  • Oxidative Stress 65%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 65%

• Characterisation of the Anti-Leukaemic Effects of Tenovin-6 in Chronic Lymphocytic Leukaemia

  Ganley, I. (Investigator) & Tauro, S. (Investigator)

  1/08/12 → 31/01/15

  Project: Research

• Determination of Authentic Substrates for Parkinson's Disease Associated Protein Kinases, LRRK and PINK1 (supplement to Clinical Fellowship)

  Barton, G. (Investigator), Muqit, M. (Investigator) & Simpson, G. (Investigator)

  1/07/12 → 31/12/15

  Project: Research

  • RNA Sequencing 100%
  • RNA Sequencing (RNA-seq) 89%
  • RNA Sequence 84%
  • RNA 63%
  • Arabidopsis Thaliana 56%

• Generation of Phospho-Ser65 Parkin and Phospho-Thr257 PINK1 Rabbit Monoclonal Antibodies and Characterization of Total PINK1 Rabbit and Mouse Monoclonal Antibodies

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  1/06/12 → 31/05/13

  Project: Research

• A Perfusion System for Fluorescent Live Cell Imaging

  Ashford, M. (Investigator), Beall, C. (Investigator), McCrimmon, R. (Investigator), Milne, A. (Investigator), Sutherland, C. (Investigator) & Watterson, K. (Investigator)

  Anonymous Trust

  1/05/12 → 30/04/13

  Project: Research

• Combining Mass Spectrometry with Genetic and Pharmacological Approaches to Discover and Validate LRRK2 Substrates (Joint with Max Planck, University College London and Harvard University)

  Alessi, D. (Investigator) & Trost, M. (Investigator)

  Michael J. Fox Foundation for Parkinson's Research

  1/04/12 → 30/09/16

  Project: Research

• Role of fbx07 in Parkinson's Disease (Studentship)

  Alessi, D. (Investigator)

  1/10/11 → 30/09/15

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 72%
  • Phosphorylation 69%
  • Parkin 54%

• Generation of LRRK1 Protein and Characterization of LRRK1 Mouse and Rabbit Monoclonal Antibodies

  Alessi, D. (Investigator)

  1/09/11 → 31/08/12

  Project: Research

• Biochemical Analysis of the PINK1 Kinase (Bursary - Hazel Rooney)

  Muqit, M. (Investigator)

  1/08/11 → 31/07/12

  Project: Research

• Development of Selective LRRK2 Inhibitors (Joint with Harvard University)

  Alessi, D. (Investigator)

  15/07/11 → 14/09/13

  Project: Research

• Investigation of an AMPK Phosphatase

  Blow, J. (Investigator) & Cohen, T. (Investigator)

  Diabetes UK

  1/07/11 → 31/08/18

  Project: Research

• Functional Analysis of the SLX4 Regulator of DNA Repair Nucleases (Dr Jamie Wilson)

  Cantrell, D. (Investigator), Lambert, J. (Investigator), Marshall, S. (Investigator), Rouse, J. (Investigator) & Wilson, J. (Investigator)

  1/11/10 → 31/10/13

  Project: Research

• Aref#d: 21989. RNA Processing and Neurodegeneration; Exploring Mechanisms and Modelling Disease (Joint with Kings College London, University of Manchester & MRC Lab of Molecular Biology)

  Rouse, J. (Investigator)

  Medical Research Council

  1/11/10 → 31/12/14

  Project: Research

  • Splicing Factor 100%
  • Alzheimer's Disease 100%
  • Neurodegenerative Diseases 100%
  • Hyperphosphorylation 100%
  • Chromatin Structure 100%

• Pharmacodynamic Biomarkers of LRRK2 Activity

  Alessi, D. (Investigator) & Prescott, A. (Investigator)

  1/10/10 → 30/09/12

  Project: Research

• A Structural and Biochemical Approach to Understand the Molecular Mechanism of Glycogen Synthesis (Sir Henry Wellcome Fellowship)

  Cohen, P. (Investigator), Sakamoto, K. (Investigator) & Zeqiraj, E. (Investigator)

  1/10/10 → 31/03/15

  Project: Research

  • Protein Kinases 100%
  • Protein Kinase 89%
  • Allosteric Regulators 74%
  • Liver Glucose Production 74%
  • Cyclin Y 74%

• Role of the PDK1-SGK Pathway in Cancer (CASE Studentship)

  Alessi, D. (Investigator)

  1/10/10 → 30/09/14

  Project: Research

• Development of Novel Models for the Study of Hepatic Insulin Resistance as a Means to an Early Diagnosis and Treatment for Diabetes (Dr Esther Sammler)

  Alessi, D. (Investigator), Cantrell, D. (Investigator), Lambert, J. (Investigator), Marshall, S. (Investigator) & Sammler, E. (Investigator)

  6/09/10 → 6/05/14

  Project: Research

• Investigating Signalling Pathway Dysfunction Linked to LRRK2

  Alessi, D. (Investigator)

  Michael J. Fox Foundation for Parkinson's Research

  1/09/10 → 31/08/13

  Project: Research

• A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

  Alessi, D. (Investigator)

  Medical Research Council

  1/09/10 → 31/08/15

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 53%
  • Leucine-Rich Repeat 46%
  • Phosphorylation 36%

• Aref#d: 21993. Control of Genome Stability by SLX-4-Containing Protein Complexes in Human Cells

  Rouse, J. (Investigator)

  Association for International Cancer Research

  1/08/10 → 31/07/13

  Project: Research

• Aref#d: 22165. Roles of a Serine/Threonine-Specific Phosphatase in Steroid Receptor Function

  Cohen, T. (Investigator)

  Medical Research Council

  26/07/10 → 25/07/13

  Project: Research

• Modulation of Renal NaCl Transporter Via Angiotensin II-WNK4-SPAK Signalling Pathway (joint with National University of Mexico)

  Alessi, D. (Investigator)

  1/07/10 → 31/12/13

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Cotransporter 82%
  • Alanine 80%
  • Proline 80%

• Aref#d: 21286. Mass Spectrometry-Based Global Analysis of Protein Phosphorylation in Cells and Tissue Extracts with Altered PINK1 Catalytic Activity: A Novel Screen for PINK1 Substrates

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  1/12/09 → 30/11/12

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Phosphorylation 95%
  • Parkin 69%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 69%

• Aref#d: 21151. Molecular Mechanisms of Assembly, Regulation and Substrate Recognition of the Heterotrimeric LKB1 Tumour Suppressor

  Alessi, D. (Investigator) & van Aalten, D. (Investigator)

  1/11/09 → 31/10/12

  Project: Research

• Aref#d: 21632. The Nedd8 Ubiquitin-like Protein Conjugation System and Regulation of Cullin-Ring E3 Ligases (European Research Council)

  Kurz, T. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/11/09 → 31/10/14

  Project: Research

• Aref#d: 19772. Determination of Authentic Substrates for Parkinson's Disease Associated Protein Kinases, LRRK2 and PINK1 (Intermediate Clinical Fellowship - Dr M Muqit)

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  1/07/08 → 30/06/13

  Project: Research