MRC PPU

School of Life Sciences

23 Active
24 Not started
144 Finished

23 results

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Identification of New Therapeutic Targets for C9ORF72 Amyotrophic Lateral Sclerosis using Kinome-wide CRISPR Screen in Human Stem Cell-Derived Motor Neurons Co-Cultured with Microglia
Mehta, A. (Investigator)
Medical Research Council
4/11/24 → 3/05/27
Project: Research
Prophylactic Approaches To Treating Intestinal Damage In Coeliac Disease - Joint with University of Sheffield
Swamy, M. (Investigator)
Coeliac UK
1/09/24 → 31/08/27
Project: Research
Mutational screen of GBA1, PARKIN and LRRK2
Alessi, D. (Investigator), Muqit, M. (Investigator) & Sammler, E. (Investigator)
1/08/24 → 31/07/26
Project: Research
Sugar Ubiquitylation, A New Quality Control Mechanism For The Recognition And Elimination Of Misfolded Macromolecules
Cohen, P. (Investigator)
Biotechnology and Biological Sciences Research Council
1/06/24 → 30/11/25
Project: Research
Spatial Proteomics to Study Brain Health and Neurodegeneration
Alessi, D. (Investigator)
1/04/24 → 31/08/27
Project: Research
26S-NonoLuc: a Transformational Assay of Proteasome Assembly
Rousseau, A. (Investigator)
Biotechnology and Biological Sciences Research Council
1/02/24 → 30/09/25
Project: Research
Cleave to Modify: Illuminating the "Dark Proteome" with Novel Chemical Biology Tools (Fellowship)
Maniaci, C. (Investigator)
1/01/24 → 31/12/31
Project: Research
Irreversible Inactivation Of Ubiquitin And Ubiquitin-Like Proteins
Swatek, K. (Investigator)
19/10/23 → 18/10/28
Project: Research
Interrogating Tankyrase-mediated Control of Neuronal Degeneration in Frontotemporal Dementia (Dementia Research Leader Fellowship) (Outline) & Full
Alessi, D. (Investigator), Ashford, M. (Investigator), Davies, P. (Investigator), McGurk, L. (Investigator) & Storey, K. (Investigator)
Alzheimer's Society
2/10/23 → 1/10/28
Project: Research
How Does Dysregulated Signal Transduction Cause Intellectual Disability (Glasgow University, MRC Harwell)
Findlay, G. (Investigator)
1/09/23 → 31/08/31
Project: Research
Validation Of LRRK2 Modifiers As Potential PD Therapeutic Targets - Joint with Universite de Lille and University of Padua
Alessi, D. (Investigator)
26/06/23 → 31/12/25
Project: Research
Louis-Jeantet Prize 2023 - Personal Award
Alessi, D. (Investigator)
1/06/23 → 31/05/28
Project: Research
Discovery and Characterisation of Undefined Ubiquitin and Ubiquitin like E3 Ligases
Virdee, S. (Investigator)
10/04/23 → 9/04/31
Project: Research
Shared Proteomics Platform For The MRC PPU And The UK Dementia Research Institute (UK DRI)
Alessi, D. (Investigator)
1/04/23 → 31/03/28
Project: Research
Implementation and Validation of Quantitative Lysosome-specific GCase Assays in Cell Lines and Human Peripheral Blood for use in Clinical Samples
Alessi, D. (Investigator) & Sammler, E. (Investigator)
1/03/23 → 31/08/25
Project: Research
Towards A Molecular Understanding Of Myddosome Organization And Regulation Of IRAK Kinase Activity
Kulathu, Y. (Investigator) & Lange, S. (Investigator)
Biotechnology and Biological Sciences Research Council
1/01/23 → 31/12/25
Project: Research
Understanding The Roles Of ERphagy During Epithelial-To-Mesenchymal Transition
Liang, A. (Investigator)
1/06/22 → 31/05/28
Project: Research
Using Activity-Based Probes To Study The Mechanism And Regulation Of The Giant E3 Ligase Huwe1 (lead: IMP Vienna other instn: IMBA Vienna)
Virdee, S. (Investigator)
Vienna Science and Technology Fund
1/06/22 → 31/05/26
Project: Research
Defining mechanisms of cellular stress responses driven by heterotypic ubiquitin chains (StressHUb)
Kulathu, Y. (Investigator)
COMMISSION OF THE EUROPEAN COMMUNITIES
1/01/22 → 31/12/26
Project: Research
Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)
Kulathu, Y. (Investigator), Labib, K. (Investigator), Masson, G. (Investigator), Moraga Gonzalez, I. (Investigator), Murray, D. (Investigator), Owen-Hughes, T. (Investigator), Stanley-Wall, N. (Investigator) & Wyatt, P. (Investigator)
1/12/21 → 31/12/26
Project: Research
Assessing physiological relevance, biological roles and molecular mechnisms of non-canonical ubiquitination
De Cesare, V. (Investigator)
Medical Research Council
1/10/21 → 30/09/26
Project: Research
Evaluation Of The PIM Kinases As Drug Targets For The Treatment Of Inflammatory Bowel Diseases (PhD Studentship)
Swamy, M. (Investigator)
20/09/21 → 20/09/25
Project: Research
Young Investigator Programme
Kulathu, Y. (Investigator)
European Molecular Biology Organization
1/01/16 → 31/12/26
Project: Research