MRC PPU

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• Activation of the Parkinson's disease kinase LRRK2 by Rab GTPases

  Purlyte, E. (Author), Alessi, D. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Advancing understanding of endogenous PINK1-Parkin signalling linked to Parkinson’s disease

  Balk, K. R. (Author), Muqit, M. (Supervisor) & Alessi, D. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Analysis of PINK1-Parkin-dependent signalling in neurons

  Antico, O. (Author), Muqit, M. (Supervisor) & Alessi, D. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• An exploration of technologies for targeted protein modification

  Simpson, L. M. (Author), Sapkota, G. (Supervisor) & Ganley, I. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• An investigation of the activation of protein kinase complexes in the MyD88 signalling network

  Zhang, J. (Author), Cohen, P. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• A novel SRPK signalling pathway to microtubules is implicated in neurological disorders

  Yang, Z. (Author), Findlay, G. (Supervisor) & McGurk, L. (Supervisor), 2025

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Biochemical and Structural Characterisation of MINDY DUBs and PLPro from SARS-CoV-2

  Armstrong, L. (Author), Kulathu, Y. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Cell cycle-dependent regulation of the human RNA cap methyltransferase (RNMT)

  Aregger, M. (Author), Cowling, V. (Supervisor), 2013

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Characterisation of novel E3 ligases for PROTAC development

  Sathyamurthi, P. (Author), Sapkota, G. (Supervisor), Swamy, M. (Supervisor) & Queisser, M. A. (Supervisor), 2025

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Characterization of Parkinson's Disease-associated LRRK2 Kinase

  Katsemonova, K. (Author), Alessi, D. (Supervisor) & MacKintosh, C. (Supervisor), 2016

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• CMG helicase disassembly is essential and mediated by two pathways in Saccharomyces cerevisiae

  Polo Rivera, C. (Author), Labib, K. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase

  Pao, K.-C. (Author), Virdee, S. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers

  Kelly, V. (Author), Pedrioli, P. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development of Next-Generation Protein Degradation Systems: BromoTag and Other PROTACs

  Bond, A. G. (Author), Ciulli, A. (Supervisor) & Sapkota, G. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Discovery and characterization of a novel Deubiquitinase ZUP1

  Kwasna, D. B. (Author), Kulathu, Y. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Dissecting molecular mechanisms mediating ERK1/2 regulation of neural differentiation

  Raga Gil, E. (Author), Storey, K. (Supervisor) & Findlay, G. (Supervisor), 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α

  Bozatzi, P. (Author), Sapkota, G. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Examining TRAF6 control of immunity and CD8+ T cells

  Bennett, K. (Author), Cantrell, D. (Supervisor) & Cohen, P. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells

  Joseph, T. (Author), Alessi, D. (Supervisor) & Muqit, M. (Supervisor), 2019

  Student thesis: Master's Thesis › Master of Science

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• Functions and Mechanisms of the ERK5 MAP Kinase in Pluripotent Stem Cells

  Brown, H. (Author), Findlay, G. (Supervisor) & Stavridis, M. (Supervisor), 2021

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Functions and regulation of the RNF12 E3 ubiquitin ligase in intellectual disability

  Espejo Serrano, C. (Author), Findlay, G. (Supervisor) & Virdee, S. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Genetic and biochemical dissection of the ADP-heptose-ALPK1-TIFA innate immune signalling pathway

  Snelling, T. (Author), Cohen, P. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning

  Fulcher, L. J. (Author), Sapkota, G. (Supervisor) & Ganley, I. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification of HOIL-1 catalysed ester-linked ubiquitylation sites and their deubiquitylation by DUBs

  McCrory, E. H. (Author), Cohen, P. (Supervisor) & Kulathu, Y. (Supervisor), 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification of novel protein kinase regulators of TGFβ signalling

  Hutchinson, L. (Author), Sapkota, G. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification of the ERK5 Kinase as a Key Regulator of Embryonic Stem Cell Pluripotency

  Williams, C. A. C. (Author), Findlay, G. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta

  Tachie-Menson, T. (Author), Sapkota, G. (Supervisor), 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating how mitophagy is regulated by the metabolic context

  Montava Garriga, L. (Author), Ganley, I. (Supervisor), 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating the cellular mechanisms that determine RNMT dependency in breast cancer cells

  Dunn, S. (Author), Cowling, V. (Supervisor), 2014

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the Effect of Cytokines on the Proliferation and Metabolism of Intraepithelial Lymphocytes

  Salgado Fernandez, N. (Author), Swamy, M. (Supervisor), 2022

  Student thesis: Master's Thesis › Master of Science

• Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system

  Nguyen, C. (Author), Swamy, M. (Supervisor) & Nathke, I. (Supervisor), 2021

  Student thesis: Master's Thesis › Master of Science

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• Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease

  Mulholland, K. E. (Author), Muqit, M. (Supervisor) & Alessi, D. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the role of protein ubiquitylation in the maintenance of genome stability

  Feeney, L. (Author), Rouse, J. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the role of the 14-3-3 interaction with ULK1 during autophagy and mitophagy

  Longo, M. (Author), MacKintosh, C. (Supervisor) & Ganley, I. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating the role of the Nrf2-Keap1 pathway in mitophagy

  Bento-Pereira, C. (Author), Dinkova-Kostova, A. (Supervisor) & Muqit, M. (Supervisor), 2020

  Student thesis: Master's Thesis › Master of Science

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• Investigating the Role of the Pseudokinase IRAK-3 in Signalling by Toll-Like Receptors

  Aitken, C. (Author), Cohen, P. (Supervisor) & Arthur, J. (Supervisor), 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the role of the ribosome associated chaperone Zuo1 under TORC1 inhibition

  Black, A. (Author), Rousseau, A. (Supervisor) & Kulathu, Y. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the role of ULK1 kinase activity during autophagy

  Zachari, M. (Author), Ganley, I. (Supervisor), 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigation of the Effects of Interleukin-27 on Human Innate Immune Responses

  Helps, T. A. (Author), McLean, M. H. (Supervisor), Swamy, M. (Supervisor) & Wilson, H. (Supervisor), 2024

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome

  Mukherjee, P. (Author), Labib, K. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Mechanism underlying linkage-selective polyubiquitin recognition

  Kristariyanto, Y. A. (Author), Kulathu, Y. (Supervisor), 2017

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Novel Insights into the Regulation and Function of SGK3

  Malik, N. (Author), Alessi, D. (Supervisor), 2018

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs

  Natarajan, J. (Author), Kulathu, Y. (Supervisor), 2019

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Reductionist animal models to probe protein O-GlcNAcylation

  Selvan, N. (Author), van Aalten, D. (Supervisor), 2015

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Regulation and new partners of the mammalian replisome

  Ainsworth, J. (Author), Labib, K. (Supervisor) & Rouse, J. (Supervisor), 2023

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Regulation of Mitophagy by Pyruvate Kinase

  Barron, S. (Author), Ganley, I. (Supervisor), 2025

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Regulation of the proteasome Regulatory Particle Assembly Chaperones upon stress

  Soubigou, F. (Author), Rousseau, A. (Supervisor) & Sapkota, G. (Supervisor), 2025

  Student thesis: Master's Thesis › Master of Science

• SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer

  Tovell, H. (Author), Alessi, D. (Supervisor) & Crafter, C. (Supervisor), 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural characterisation of a novel E3 ligase module and activity-based probe development for UBL E3 ligases

  Barnsby-Greer, L. (Author), Virdee, S. (Supervisor) & Sapkota, G. (Supervisor), 2022

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets

  Lange, S. M. (Author), Cohen, P. (Supervisor), Kulathu, Y. (Supervisor) & Nelen, M. (Supervisor), 2020

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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