MRC PPU

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• Activation of the Parkinson's disease kinase LRRK2 by Rab GTPases

  Author: Purlyte, E., 2021

  Supervisor: Alessi, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Advancing understanding of endogenous PINK1-Parkin signalling linked to Parkinson’s disease

  Author: Balk, K. R., 2019

  Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Analysis of PINK1-Parkin-dependent signalling in neurons

  Author: Antico, O., 2022

  Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• An exploration of technologies for targeted protein modification

  Author: Simpson, L. M., 2022

  Supervisor: Sapkota, G. (Supervisor) & Ganley, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• An investigation of the activation of protein kinase complexes in the MyD88 signalling network

  Author: Zhang, J., 2017

  Supervisor: Cohen, P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Cell cycle-dependent regulation of the human RNA cap methyltransferase (RNMT)

  Author: Aregger, M., 2013

  Supervisor: Cowling, V. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Characterization of Parkinson's Disease-associated LRRK2 Kinase

  Author: Katsemonova, K., 2016

  Supervisor: Alessi, D. (Supervisor) & MacKintosh, C. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase

  Author: Pao, K., 2018

  Supervisor: Virdee, S. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers

  Author: Kelly, V., 2014

  Supervisor: Pedrioli, P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Discovery and characterization of a novel Deubiquitinase ZUP1

  Author: Kwasna, D. B., 2021

  Supervisor: Kulathu, Y. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α

  Author: Bozatzi, P., 2018

  Supervisor: Sapkota, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Examining TRAF6 control of immunity and CD8+ T cells

  Author: Bennett, K., 2021

  Supervisor: Cantrell, D. (Supervisor) & Cohen, P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells

  Author: Joseph, T., 2019

  Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

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• Functions and Mechanisms of the ERK5 MAP Kinase in Pluripotent Stem Cells

  Author: Brown, H., 2021

  Supervisor: Findlay, G. (Supervisor) & Stavridis, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Functions and regulation of the RNF12 E3 ubiquitin ligase in intellectual disability

  Author: Espejo Serrano, C., 2023

  Supervisor: Findlay, G. (Supervisor) & Virdee, S. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Genetic and biochemical dissection of the ADP-heptose-ALPK1-TIFA innate immune signalling pathway

  Author: Snelling, T., 2023

  Supervisor: Cohen, P. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning

  Author: Fulcher, L. J., 2019

  Supervisor: Sapkota, G. (Supervisor) & Ganley, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification of novel protein kinase regulators of TGFβ signalling

  Author: Hutchinson, L., 2019

  Supervisor: Sapkota, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Identification of the ERK5 Kinase as a Key Regulator of Embryonic Stem Cell Pluripotency

  Author: Williams, C., 2017

  Supervisor: Findlay, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta

  Author: Tachie-Menson, T., 2020

  Supervisor: Sapkota, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating how mitophagy is regulated by the metabolic context

  Author: Montava Garriga, L., 2020

  Supervisor: Ganley, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating the cellular mechanisms that determine RNMT dependency in breast cancer cells

  Author: Dunn, S., 2014

  Supervisor: Cowling, V. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the Effect of Cytokines on the Proliferation and Metabolism of Intraepithelial Lymphocytes

  Author: Salgado Fernandez, N., 2022

  Supervisor: Swamy, M. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

• Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system

  Author: Nguyen, C., 2021

  Supervisor: Swamy, M. (Supervisor) & Nathke, I. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

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• Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease

  Author: Mulholland, K. E., 2019

  Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Investigating the role of the 14-3-3 interaction with ULK1 during autophagy and mitophagy

  Author: Longo, M., 2022

  Supervisor: MacKintosh, C. (Supervisor) & Ganley, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Investigating the role of the Nrf2-Keap1 pathway in mitophagy

  Author: Bento-Pereira, C., 2020

  Supervisor: Dinkova-Kostova, A. (Supervisor) & Muqit, M. (Supervisor)

  Student thesis: Master's Thesis › Master of Science

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• Investigating the role of ULK1 kinase activity during autophagy

  Author: Zachari, M., 2020

  Supervisor: Ganley, I. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome

  Author: Mukherjee, P., 2018

  Supervisor: Labib, K. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Mechanism underlying linkage-selective polyubiquitin recognition

  Author: Kristariyanto, Y. A., 2017

  Supervisor: Kulathu, Y. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Novel Insights into the Regulation and Function of SGK3

  Author: Malik, N., 2018

  Supervisor: Alessi, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs

  Author: Natarajan, J., 2019

  Supervisor: Kulathu, Y. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Reductionist animal models to probe protein O-GlcNAcylation

  Author: Selvan, N., 2015

  Supervisor: Van Aalten, D. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer

  Author: Tovell, H., 2020

  Supervisor: Alessi, D. (Supervisor) & Crafter, C. (External person) (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

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• Structural characterisation of a novel E3 ligase module and activity-based probe development for UBL E3 ligases

  Author: Barnsby-Greer, L., 2022

  Supervisor: Virdee, S. (Supervisor) & Sapkota, G. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets

  Author: Lange, S. M., 2020

  Supervisor: Cohen, P. (Supervisor), Kulathu, Y. (Supervisor) & Nelen, M. (External person) (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• The regulation of the Parkinson’s associated kinase PINK1

  Author: Shaw, A., 2020

  Supervisor: Muqit, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages

  Author: Bilkei-Gorzo, O., 2018

  Supervisor: Trost, M. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy

• Understanding the mechanisms of UFMylation

  Author: Peter, J., 2022

  Supervisor: Kulathu, Y. (Supervisor)

  Student thesis: Doctoral Thesis › Doctor of Philosophy