Student theses
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Activation of the Parkinson's disease kinase LRRK2 by Rab GTPases
Author: Purlyte, E., 2021Supervisor: Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Advancing understanding of endogenous PINK1-Parkin signalling linked to Parkinson’s disease
Author: Balk, K. R., 2019Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Analysis of PINK1-Parkin-dependent signalling in neurons
Author: Antico, O., 2022Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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An exploration of technologies for targeted protein modification
Author: Simpson, L. M., 2022Supervisor: Sapkota, G. (Supervisor) & Ganley, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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An investigation of the activation of protein kinase complexes in the MyD88 signalling network
Author: Zhang, J., 2017Supervisor: Cohen, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Cell cycle-dependent regulation of the human RNA cap methyltransferase (RNMT)
Author: Aregger, M., 2013Supervisor: Cowling, V. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Characterization of Parkinson's Disease-associated LRRK2 Kinase
Author: Katsemonova, K., 2016Supervisor: Alessi, D. (Supervisor) & MacKintosh, C. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase
Author: Pao, K., 2018Supervisor: Virdee, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Development and Application of Mass Spectrometry Based Methodologies to Study Ubiquitin-Like Modifiers
Author: Kelly, V., 2014Supervisor: Pedrioli, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Discovery and characterization of a novel Deubiquitinase ZUP1
Author: Kwasna, D. B., 2021Supervisor: Kulathu, Y. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Elucidating the biological function of the uncharacterised protein FAM83G/PAWS1: Role in Wnt signalling through its interaction with Caseine Kinase 1α
Author: Bozatzi, P., 2018Supervisor: Sapkota, G. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Examining TRAF6 control of immunity and CD8+ T cells
Author: Bennett, K., 2021Supervisor: Cantrell, D. (Supervisor) & Cohen, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Exploring Parkinson’s disease associated LRRK2 and PINK1/Parkin signal transduction pathways within immune cells
Author: Joseph, T., 2019Supervisor: Alessi, D. (Supervisor) & Muqit, M. (Supervisor)
Student thesis: Master's Thesis › Master of Science
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Functions and Mechanisms of the ERK5 MAP Kinase in Pluripotent Stem Cells
Author: Brown, H., 2021Supervisor: Findlay, G. (Supervisor) & Stavridis, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Functions and regulation of the RNF12 E3 ubiquitin ligase in intellectual disability
Author: Espejo Serrano, C., 2023Supervisor: Findlay, G. (Supervisor) & Virdee, S. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Genetic and biochemical dissection of the ADP-heptose-ALPK1-TIFA innate immune signalling pathway
Author: Snelling, T., 2023Supervisor: Cohen, P. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Identification and characterisation of FAM83 proteins as key regulators of CK1 protein kinases in cells: FAM83D recruits CK1α to the mitotic spindle for proper spindle positioning
Author: Fulcher, L. J., 2019Supervisor: Sapkota, G. (Supervisor) & Ganley, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Identification of novel protein kinase regulators of TGFβ signalling
Author: Hutchinson, L., 2019Supervisor: Sapkota, G. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Identification of the ERK5 Kinase as a Key Regulator of Embryonic Stem Cell Pluripotency
Author: Williams, C., 2017Supervisor: Findlay, G. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta
Author: Tachie-Menson, T., 2020Supervisor: Sapkota, G. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating how mitophagy is regulated by the metabolic context
Author: Montava Garriga, L., 2020Supervisor: Ganley, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating the cellular mechanisms that determine RNMT dependency in breast cancer cells
Author: Dunn, S., 2014Supervisor: Cowling, V. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating the Effect of Cytokines on the Proliferation and Metabolism of Intraepithelial Lymphocytes
Author: Salgado Fernandez, N., 2022Supervisor: Swamy, M. (Supervisor)
Student thesis: Master's Thesis › Master of Science
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Investigating the movement of intestinal intraepithelial lymphocytes using an organoid co-culture system
Author: Nguyen, C., 2021Supervisor: Swamy, M. (Supervisor) & Nathke, I. (Supervisor)
Student thesis: Master's Thesis › Master of Science
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Investigating the role of PINK1-dependent Rab signalling in Parkinson's disease
Author: Mulholland, K. E., 2019Supervisor: Muqit, M. (Supervisor) & Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating the role of the 14-3-3 interaction with ULK1 during autophagy and mitophagy
Author: Longo, M., 2022Supervisor: MacKintosh, C. (Supervisor) & Ganley, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Investigating the role of the Nrf2-Keap1 pathway in mitophagy
Author: Bento-Pereira, C., 2020Supervisor: Dinkova-Kostova, A. (Supervisor) & Muqit, M. (Supervisor)
Student thesis: Master's Thesis › Master of Science
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Investigating the role of ULK1 kinase activity during autophagy
Author: Zachari, M., 2020Supervisor: Ganley, I. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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In vitro reconstitution of the ubiquitylation and disassembly of the eukaryotic replisome
Author: Mukherjee, P., 2018Supervisor: Labib, K. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Mechanism underlying linkage-selective polyubiquitin recognition
Author: Kristariyanto, Y. A., 2017Supervisor: Kulathu, Y. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Novel Insights into the Regulation and Function of SGK3
Author: Malik, N., 2018Supervisor: Alessi, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
Author: Natarajan, J., 2019Supervisor: Kulathu, Y. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Reductionist animal models to probe protein O-GlcNAcylation
Author: Selvan, N., 2015Supervisor: Van Aalten, D. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer
Author: Tovell, H., 2020Supervisor: Alessi, D. (Supervisor) & Crafter, C. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Structural characterisation of a novel E3 ligase module and activity-based probe development for UBL E3 ligases
Author: Barnsby-Greer, L., 2022Supervisor: Virdee, S. (Supervisor) & Sapkota, G. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Structure and Function of the Pseudokinases IRAK2 and IRAK3 and their Potential as Drug Targets
Author: Lange, S. M., 2020Supervisor: Cohen, P. (Supervisor), Kulathu, Y. (Supervisor) & Nelen, M. (External person) (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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The regulation of the Parkinson’s associated kinase PINK1
Author: Shaw, A., 2020Supervisor: Muqit, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Ubiquitylation regulates vesicle trafficking and innate immune responses on the phagosome of inflammatory macrophages
Author: Bilkei-Gorzo, O., 2018Supervisor: Trost, M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy
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Understanding the mechanisms of UFMylation
Author: Peter, J., 2022Supervisor: Kulathu, Y. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy