School of Life Sciences

Projects

Projects per year 2002 2010 2011 2012 2013 2014 2015 2016 2017 2018 2023 2033

• 108 Active
• 205 Not started
• 779 Finished

Projects per year

Search results

• Active

  Mechanistic Bases for Gain of Olfaction Capacity in Caenorhabditis Elegans - (Wolfson Fellowship)

  Singh, V. (Investigator)

  1/08/23 → 31/07/28

  Project: Research

• Advancement of Sperm-targeting Contraceptive Agents

  Barratt, C. (Investigator), Gilbert, I. (Investigator), Martins Da Silva, S. (Investigator), Read, K. (Investigator), Swedlow, J. (Investigator) & Wyllie, S. (Investigator)

  Bill and Melinda Gates Foundation

  5/07/23 → 4/07/26

  Project: Research

• KinoGlu: A Chemical Strategy to Illuminate CNS Biology

  Farnaby, W. (Investigator)

  Engineering and Physical Sciences Research Council

  1/07/23 → 30/06/26

  Project: Research

• Mechanisms Of Selective Protein Secretion: Towards Therapeutic Interventions

  Miller, L. (Investigator)

  1/07/23 → 30/06/31

  Project: Research

  • Protease 100%
  • COPII 100%
  • ER Export 100%
  • SURF4 100%
  • Secretory Protein 50%

• Boosting photosynthESis To deliver novel CROPs for the circular bioeconomy (BEST-CROP) (Joint with University of Milan (lead), Lund University, Heinrich Heine University Düsseldorf and 14 other organisations)

  Halpin, C. (Investigator)

  1/07/23 → 30/06/28

  Project: Research

• Developing Inhibitors Of Plasmodium Acetyl CoA Synthetase As New Multistage Antimalarials (Joint with Columbia University) DPFS Full Application

  Gilbert, I. (Investigator) & Read, K. (Investigator)

  Medical Research Council

  1/07/23 → 30/06/26

  Project: Research

• 8HUM PK characterization and TB project support

  Read, K. (Investigator) & Wolf, R. (Investigator)

  Bill and Melinda Gates Foundation

  17/06/23 → 16/10/25

  Project: Research

• Characterising Splice Site Modulation Approaches For Huntington's Disease Therapeutics

  Lamond, A. (Investigator)

  1/06/23 → 30/09/25

  Project: Research

• Louis-Jeantet Prize 2023 - Personal Award

  Alessi, D. (Investigator)

  1/06/23 → 31/05/28

  Project: Research

• Harnessing the splicing code for targeted control of gene expression (UNLEASH)

  Gray, D. (Investigator) & Lamond, A. (Investigator)

  1/06/23 → 31/05/29

  Project: Research

  • Induced Stem Cell 100%
  • Induced Pluripotent Stem Cells (iPSCs) 100%
  • Human-induced 100%
  • Embryonic Stem Cells 100%
  • Proteomic Comparison 100%

• Functional And Proteomic Characterisation Of Microglia Cell States In Neurodegeneration (Joint with The Francis Crick Institute) - Fellowship

  Lloyd, A. (Investigator)

  1/05/23 → 30/04/28

  Project: Research

• Discovery and Characterisation of Undefined Ubiquitin and Ubiquitin like E3 Ligases

  Virdee, S. (Investigator)

  10/04/23 → 9/04/31

  Project: Research

  • Ubiquitin Ligase 100%
  • Zinc Finger 87%
  • Ubiquitin 71%
  • Ubiquitin-Conjugating Enzyme 57%
  • RNF213 55%

• Shared Proteomics Platform For The MRC PPU And The UK Dementia Research Institute (UK DRI)

  Alessi, D. (Investigator)

  1/04/23 → 31/03/28

  Project: Research

• Investigating The Functions and Regulation of Non-Proline Directed CDK1 Phosphorylation

  Ly, T. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/04/23 → 31/03/26

  Project: Research

• Expanding the Chemical Range of RNA-mediated Catalysis: Structure and Mechanism

  Lilley, D. (Investigator)

  Engineering and Physical Sciences Research Council

  1/04/23 → 31/03/26

  Project: Research

  • Ribozyme 100%
  • Catalytic Mechanism 66%
  • Riboswitch 66%
  • General Acid 55%
  • PH Dependence 44%

• CRISPR Platform for MalDA Target Validation and Drug Discovery (Transfer)

  Lee, M. (Investigator)

  Bill and Melinda Gates Foundation

  1/03/23 → 28/02/26

  Project: Research

  • Plasmodium Falciparum 100%
  • Drug Resistance 100%
  • In Vitro Evolution 100%
  • Plasmodium falciparum 100%
  • Eukaryotic Pathogen 33%

• Implementation and Validation of Quantitative Lysosome-specific GCase Assays in Cell Lines and Human Peripheral Blood for use in Clinical Samples

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/03/23 → 31/08/25

  Project: Research

• Assisted Transfer Package Letter Agreement between Genome Research Limited (Sanger) the University of Dundee and Dr Marcus Lee

  Lee, M. (Investigator)

  1/01/23 → 31/12/30

  Project: Research

• Assisted Transfer Package Letter Agreement between Genome Research Limited (Sanger), The University of Dundee

  Lee, M. (Investigator)

  Wellcome Sanger Institute

  1/01/23 → 31/12/30

  Project: Research

• Understanding The Biosynthesis And Function Of Rhamnogalacturonan II In Plants

  Ndeh, D. (Investigator)

  1/01/23 → 1/01/28

  Project: Research

  • Polysaccharide Utilization Loci 100%
  • Genetic Loci 100%
  • Metabolism 100%
  • Bacteroides thetaiotaomicron 100%
  • Mucin 100%

• Towards A Molecular Understanding Of Myddosome Organization And Regulation Of IRAK Kinase Activity

  Kulathu, Y. (Investigator) & Lange, S. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/23 → 31/12/25

  Project: Research

• Temperature Responsive Control of Splicing by RNA Methylation (Joint with University of Leeds)

  Simpson, G. (Investigator)

  Biotechnology and Biological Sciences Research Council

  19/09/22 → 18/09/25

  Project: Research

  • 5′ Splice Site 100%
  • U6 snRNA 70%
  • Pre-mRNA 50%
  • Precursor mRNA 50%
  • Eukaryote 50%

• Roots2Resilience: Root phenotyping and genetic improvement for rotational crops resilient to environmental change (Root2Res) (Joint with Arvalis (Lead), James Hutton Institute, RSK Afas Limited and 20 other organisations)

  Bulgarelli, D. (Investigator) & Hein, I. (Investigator)

  1/09/22 → 31/08/27

  Project: Research

  • Microbiota 100%
  • Host Genetics 100%
  • Microflora 100%
  • Genetics 100%
  • Quantitative Traits 33%

• Delivering the Impossible - Novel Fatty Acid Delivery Reagents to Enable In Vivo Research and Discovery (Joint with Strathclyde University)

  Hemsley, P. (Investigator)

  Biotechnology and Biological Sciences Research Council

  25/07/22 → 24/02/26

  Project: Research

• Fully Functional Chemical Probe Library and Proteomic POC Enablement

  Gilbert, I. (Investigator) & Wyllie, S. (Investigator)

  Bill and Melinda Gates Foundation

  1/07/22 → 28/02/26

  Project: Research

• Using Activity-Based Probes To Study The Mechanism And Regulation Of The Giant E3 Ligase Huwe1 (lead: IMP Vienna other instn: IMBA Vienna)

  Virdee, S. (Investigator)

  Vienna Science and Technology Fund

  1/06/22 → 31/05/26

  Project: Research

• Understanding The Roles Of ERphagy During Epithelial-To-Mesenchymal Transition

  Liang, A. (Investigator)

  1/06/22 → 31/05/28

  Project: Research

• MRC IAA 2021 University of Dundee

  Ferguson, M. (Investigator), Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)

  Medical Research Council

  1/04/22 → 1/04/26

  Project: Research

  • Methyltransferase 100%
  • Small Molecules 100%
  • Guanine 100%
  • RNA 100%
  • Small Molecule 100%

• The Generation Gap, Mechanisms of Maternal Control on Grain (Joint with James Hutton Institute)

  McKim, S. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/04/22 → 31/08/25

  Project: Research

  • Video Project 100%
  • Barley 100%
  • Animal Feed 100%
  • Audio 100%
  • Scotland 100%

• Early-Stage Embryo as an Active Self-Tuning Soft Material (Lead: UoD other instn: University of Oxford, University College London)

  Sknepnek, R. (Investigator) & Weijer, K. (Investigator)

  Engineering and Physical Sciences Research Council

  1/04/22 → 31/12/25

  Project: Research

  • Vertex Model 100%
  • Cellular Level 83%
  • Tissue Mechanics 66%
  • Mechanical Force 61%
  • Viscoelastic Response 55%

• Control of Temperature Dependent Plant Development Through RNA Thermoswitches (University Research Fellowship)

  Balcerowicz, M. (Investigator) & Birch, P. (Investigator)

  1/01/22 → 1/04/27

  Project: Research

  • Gene Regulation 100%
  • RNA 100%
  • Gene Expression 97%
  • Temperature Effect 87%
  • Dynamics 87%

• Defining mechanisms of cellular stress responses driven by heterotypic ubiquitin chains (StressHUb)

  Kulathu, Y. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/22 → 31/12/26

  Project: Research

  • Ubiquitin 100%
  • Branched Ubiquitin Chain 100%
  • Branched-chain 70%
  • Cell Signaling 60%
  • Valosin-containing Protein 50%

• Establishment of Cryo-EM Screening Facility At University Of Dundee (Equipment Grant)

  Kulathu, Y. (Investigator), Labib, K. (Investigator), Masson, G. (Investigator), Moraga Gonzalez, I. (Investigator), Murray, D. (Investigator), Owen-Hughes, T. (Investigator), Stanley-Wall, N. (Investigator) & Wyatt, P. (Investigator)

  1/12/21 → 31/12/26

  Project: Research

  • Ubiquitin Ligase 100%
  • E3 Ligase 88%
  • Ubiquitination 74%
  • Bromodomain-containing Protein 4 (BRD4) 62%
  • Degrader 59%

• mRNA Cap Regulation of Gene Express, Cell Function and Fate (Investigator Award)

  Cowling, V. (Investigator)

  1/11/21 → 31/10/26

  Project: Research

  • Cap Formation 100%
  • MRNA Cap 100%
  • Cap Gene 100%
  • Gene Expression 100%
  • T Cell Activation 100%

• Halting Pulmonary Fibrosis Through Interference In The IL-25, IL-33 And TSLP Pathways ( PhD Studentship 2020)

  Arthur, S. (Investigator) & McSorley, H. (Investigator)

  20/10/21 → 20/10/25

  Project: Research

• Assessing physiological relevance, biological roles and molecular mechnisms of non-canonical ubiquitination

  De Cesare, V. (Investigator)

  Medical Research Council

  1/10/21 → 30/09/26

  Project: Research

  • Matrix-assisted Laser Desorption Ionization-time of Flight Mass Spectrometry (MALDI-TOF MS) 100%
  • Enzyme 90%
  • Ubiquitin 81%
  • Ubiquitylation 68%
  • Ubiquitination 63%

• Evaluation Of The PIM Kinases As Drug Targets For The Treatment Of Inflammatory Bowel Diseases (PhD Studentship)

  Swamy, M. (Investigator)

  20/09/21 → 20/09/25

  Project: Research

• Molecular Regulators of the Alarmin IL-33 in Health and Disease

  McSorley, H. (Investigator)

  1/07/21 → 30/06/26

  Project: Research

  • Interleukin-33 (IL-33) 100%
  • Interleukin-33 66%
  • Nematode 40%
  • Immune Response 38%
  • Cytokine 36%

• Understanding and Preventing Plant Susceptibility to Aphids (APHIDTRAP)

  Bos, J. (Investigator) & Hunter, B. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/06/21 → 31/01/27

  Project: Research

  • Effector Proteins 100%
  • Phloem 62%
  • Phloem-feeding Insects 60%
  • Saliva 50%
  • Unveiling 50%

• Chemical and Genetic Validation of Aspergillus Fumigatus Cell Wall Targets

  van Aalten, D. (Investigator)

  Medical Research Council

  1/06/21 → 31/05/26

  Project: Research

  • Cell Wall 100%
  • Aspergillus fumigatus 87%
  • Aspergillus Fumigatus 78%
  • Fumigatus 52%
  • Therapeutic Target 36%

• The fight for success: inter-bacterial competition mediated by the Type VI secretion system and its effectors

  Coulthurst, S. (Investigator)

  28/01/21 → 27/01/28

  Project: Research

  • Type VI Secretion System 100%
  • Serratia marcescens 77%
  • Serratia 73%
  • Serratia Marcescens 71%
  • Lifestyle Switch 33%

• The Jalview Resource for Biological Sequence, Structure and Function Analysis: 2019 and Beyond

  Barton, G. (Investigator) & Procter, J. (Investigator)

  1/01/21 → 31/12/26

  Project: Research

  • Ligand Binding 100%
  • Binding Site 100%
  • Missense 66%
  • Protein Binding Site 66%
  • Protein Ligand 66%

• Pilot Study of Aminacyl-Acid tRNA Synthetases as Drug Targets for TB and Malaria

  Gilbert, I. (Investigator)

  Bill and Melinda Gates Foundation

  1/12/20 → 31/12/25

  Project: Research

  • Visceral Leishmaniasis 100%
  • Benzoxaborole 100%
  • Preclinical Candidate 100%
  • Parasitic Diseases 66%
  • CPSF3 33%

• Kinetochore-Microtubule Interactions: Steps Towards Bi-Orientation (Investigator Award)

  Tanaka, T. (Investigator)

  1/12/20 → 31/12/26

  Project: Research

  • Kinetochore 100%
  • Error Correction 99%
  • Biorientation 87%
  • Chromosome Reorganization 46%
  • Condensin 46%

• Machine Learning Methods to Re-Annotate Histone Modifications with Locus-specific Functional Classification (Future Leaders Fellowship)

  Owen-Hughes, T. (Investigator) & Schweikert, G. (Investigator)

  Medical Research Council

  1/11/20 → 31/10/25

  Project: Research

  • Biological Research 100%
  • Epigenetic Modification 100%
  • Epigenetics 100%
  • Machine Learning 100%
  • Individual-specific 100%

• Multi-Scale Analysis of 4D Nucleome Structure and Function by Comprehensive Multimodal Data Integration (Joint with Carnegie Mellon University, USA)

  Swedlow, J. (Investigator)

  National Institutes of Health

  22/09/20 → 30/06/25

  Project: Research

• EUbOPEN: Enabling and Unlocking biology in the OPEN (Joint with Goethe University Frankfurt, University of Oxford, Karolinska Institute and 9 others)

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/20 → 31/10/25

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Proteolysis 87%
  • Ubiquitin Ligase 60%
  • Degrader 52%
  • E3 Ligase 43%

• Defining the Oxidative Stress-Related Mechanisms by which Activation of the Transcription Factor Nrf2 Arrests and Resolves Liver Fibrosis

  Arthur, S. (Investigator), Dillon, J. (Investigator), Dinkova-Kostova, A. (Investigator), Hayes, J. (Investigator) & Henderson, C. (Investigator)

  Medical Research Council

  1/04/20 → 30/06/25

  Project: Research

  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
  • Oxidative Stress 68%
  • Transcription Factor 49%
  • NFE2L2 46%
  • Transcription Factors 44%

• Decoding Mechanisms of gene regulation in African Trypanosomes

  Horn, D. (Investigator)

  1/03/20 → 28/02/26

  Project: Research

  • Trypanosoma 100%
  • African Trypanosomes 85%
  • Trypanosomatids 78%
  • Trypanosoma Brucei 77%
  • Trypanosomatid 75%

• Establishing the Basis for Selectivity in the SUMO Spray (Investigator Award)

  Hay, R. (Investigator)

  1/02/20 → 31/01/27

  Project: Research

  • Ubiquitin 100%
  • RNF4 59%
  • Ubiquitin Ligase 49%
  • SUMO2 40%
  • Ubiquitination 39%