School of Life Sciences

Projects

Projects per year 2002 2010 2011 2012 2013 2014 2015 2016 2017 2018 2023 2032

• 113 Active
• 205 Not started
• 763 Finished

Projects per year

Search results

• Finished

  Investigation of the Target of Metformin

  Prescott, A. (Investigator) & Rena, G. (Investigator)

  Medical Research Council

  1/05/13 → 30/04/16

  Project: Research

  • Metformin 100%
  • Type 2 Diabetes Mellitus (T2DM) 35%
  • Diabetes 27%
  • Maturity Onset Diabetes of the Young 26%
  • Mechanism of Action 25%

• How Does Insulin in the Bloodstream Trigger Dephosphorylation of Regulatory Proteins of Cell Morphology and Dopamine Synthesis in the Brain?

  MacKintosh, C. (Investigator)

  Diabetes UK

  1/05/13 → 30/04/16

  Project: Research

• A Multi-Tool For Chromosome Maintenance: How Does Elg1 Guard Genome Stability? (Joint with Aberdeen University)

  Blow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/05/13 → 30/04/16

  Project: Research

• Can Vitamin D Supplementation Reduce Inflammation and Improve Cardiovascular Health?

  Arthur, S. (Investigator), Belch, J. (Investigator) & Khan, F. (Investigator)

  Anonymous Trust

  1/05/13 → 30/04/14

  Project: Research

• DrugE3CRL's: Probing Druggability of Multisubunit Complexes: E3 Cullin RING Ligases (ERC Starting Grant)

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/05/13 → 30/04/18

  Project: Research

  • Protein Catabolism 100%
  • Proteolysis Targeting chimera (PROTAC) 96%
  • Ubiquitin-Conjugating Enzyme 83%
  • Ligase 67%
  • Von Hippel-Lindau 60%

• A Systems Approach for the Fragment-based Development of Selective Chemical Probes of Bromodomain Function (joint with University of Oxford)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/06/15

  Project: Research

  • Bromodomain 100%
  • Small Molecule 52%
  • Chemical Probes 49%
  • Bromodomain-containing Protein 4 (BRD4) 45%
  • Protein Catabolism 43%

• Dissecting and Exploiting Molecular Recognition at Protein-Protein Interfaces (David Phillips Fellowship)

  Ciulli, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  8/04/13 → 7/07/15

  Project: Research

  • Chemical Probes 100%
  • Small Molecule 95%
  • Ubiquitin-Conjugating Enzyme 93%
  • Bromodomain 83%
  • Small Molecules 53%

• Design of Orthogonal Molecular Probes Targeting Engineered Von-Hippel Lindau (VHL) E3 Ubiquitin Ligase for the Control of Intercellular Protein Levels

  Ciulli, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  8/04/13 → 7/04/15

  Project: Research

  • Hypoxia-Inducible Factors 100%
  • Von Hippel-Lindau 94%
  • Hypoxia Inducible Factor 68%
  • Small Molecule 67%
  • E3 Ubiquitin Ligase 63%

• Developing Genomic Analysis of Clostridium Difficile

  Barton, G. (Investigator) & Marwick, C. (Investigator)

  1/04/13 → 1/07/13

  Project: Research

• Elucidation of Molecular Mechanisms that Activate the MyD88 Signaling Network (Senior Investigator Award)

  Cohen, P. (Investigator)

  1/04/13 → 31/03/18

  Project: Research

  • Ubiquitin 100%
  • Phosphorylation 82%
  • Signaling Network 78%
  • Protein Kinase 74%
  • Toll-like 72%

• SELFCC: Chromosome Self-clearing Completes Sister Chromatid Separation

  Tanaka, T. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/04/13 → 30/09/18

  Project: Research

  • Kinetochore 100%
  • Microtubule 79%
  • Biorientation 63%
  • Centromere 53%
  • Budding Yeast 52%

• Characterisation of Signal Transduction Pathways that Restrict Activation of the Innate Immune System to Prevent Inflammatory and Autoimmune Diseases (Programme Grant)

  Cohen, P. (Investigator)

  Medical Research Council

  1/04/13 → 31/03/18

  Project: Research

  • Ubiquitin 100%
  • Phosphorylation 68%
  • Ubiquitin Chains 64%
  • Toll-like 58%
  • Kinase 52%

• Mechanisms and Function of Alternative Splicing in the Plant Circadian Clock (Joint with University of Glasgow)

  Brown, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/04/13 → 30/09/16

  Project: Research

  • Alternative Splicing 100%
  • Arabidopsis 58%
  • Isoform 39%
  • RNA Sequencing 35%
  • Transcriptome 28%

• SiLAC Proteomics for Quantitation of Protein Isoforms from Alternative Splicing in Arabidopsis Seedlings

  Brown, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/04/13 → 31/03/14

  Project: Research

  • Arabidopsis 100%
  • Stable Isotope Labeling 50%
  • Transcript Level 50%
  • Transcriptome 50%
  • Quantitative Proteomics 50%

• The Molecular Basis of Phenotypic Evolution in Social Amoebas

  Schaap, P. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/04/13 → 31/03/17

  Project: Research

  • Dictyostelia 100%
  • Social Amoeba 62%
  • Dictyostelids 59%
  • Fruiting Body 59%
  • Dictyosteliida 57%

• Mid-Career Equipment Grant

  Alessi, D. (Investigator) & Kulathu, Y. (Investigator)

  Medical Research Council

  1/04/13 → 31/03/14

  Project: Research

• Molecular Characterisation of Bacterial Interspecies Signalling in Polymicrobial Chronic Lung Infection: A Potential Target for Therapeutic Intervention (Senior Research Fellowship)

  Palmer, T. (Investigator) & Ryan, R. (Investigator)

  1/03/13 → 28/02/18

  Project: Research

  • Virulence 100%
  • Signal Transduction 80%
  • Biofilm 78%
  • Cyclic GMP 75%
  • Xanthomonas campestris 62%

• The Dundee Resource for Protein Structure Prediction and Sequence Analysis

  Barton, G. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/03/13 → 31/08/18

  Project: Research

  • Missense 100%
  • Missense Variants 86%
  • Spike 76%
  • SARS Coronavirus 76%
  • Angiotensin-converting Enzyme 2 (ACE2) 66%

• Understanding the Molecular Mechanisms of HvAPETALA2 Control of Internode Length in Hordeum Vulgare (Barley)

  McKim, S. (Investigator)

  1/03/13 → 28/02/14

  Project: Research

• Cognitive Function in the Min Mouse: A Role for the APC Gene in Cognition

  Langston, R. (Investigator) & Nathke, I. (Investigator)

  Anonymous Trust

  1/03/13 → 31/08/14

  Project: Research

• Substrate-Receptor Interactions in the Tat Protein Transport Pathway (Joint with University of Oxford)

  Palmer, T. (Investigator)

  Medical Research Council

  1/03/13 → 29/02/16

  Project: Research

• The Scottish eHealth Informatics Research Centre (E-HIRCs) (Joint with Universities of Aberdeen, Glasgow, Edinburgh, Strathclyde, St Andrews & Leicester and ISD)

  Colhoun, H. (Investigator), Donnan, P. (Investigator), Guthrie, B. (Investigator), Jefferson, E. (Investigator), MacDonald, T. (Investigator), McCowan, C. (Investigator), Morris, A. (Investigator), Pearson, E. (Investigator), Sullivan, F. (Investigator) & Swedlow, J. (Investigator)

  Medical Research Council

  1/03/13 → 31/12/18

  Project: Research

  • Scottish 100%
  • Scotland 73%
  • Type 2 Diabetes Mellitus (T2DM) 39%
  • Genome-wide Association Study 30%
  • Coding Variants 28%

• Temporal Co-Regulation of Pathogenesis in Phytophthora (Joint with James Hutton Institute)

  Birch, P. (Investigator) & Huitema, E. (Investigator)

  Syngenta Limited, Biotechnology and Biological Sciences Research Council

  13/02/13 → 12/03/17

  Project: Research

  • Phytophthora Capsici 100%
  • Phytophthora capsici 100%
  • Phytophthora 66%
  • Infection Cycle 50%
  • Tomato 50%

• Recycling Polarity - Mechanisms Controlling Stem Cell Polarity in Consecutive Divisions in the Developing Drosophila Central Nervous System (Sir Henry Dale Fellowship)

  Januschke, J. (Investigator) & Storey, K. (Investigator)

  1/02/13 → 30/11/21

  Project: Research

  • Drosophilidae 100%
  • Neuroblast 65%
  • Drosophila Neuroblast 60%
  • Miranda 34%
  • Stem Cells 31%

• LSE-LSE Technology Approach To Generate Innovative Kinase Inhibitor Drugs (joint with Four Industrial Partners)

  Hopkins, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/02/13 → 31/07/15

  Project: Research

• Elucidating the Molecular Mechanism of Intracellular DNA Recognition by the Innate Immune Sensor IFI16 (Career Development Fellowship)

  Unterholzner, L. (Investigator) & Watts, C. (Investigator)

  Medical Research Council

  1/02/13 → 31/01/18

  Project: Research

  • interferon 100%
  • Cyclic GMP-AMP Synthase (cGAS) 50%
  • Human Keratinocytes (HaCaT) 50%
  • Stimulator of Interferon Genes (STING) 50%
  • Intracellular DNA 50%

• SUMO Proteomics in C. Elegans: Germ Line, Meiosis and the DNA Damage Response

  Gartner, A. (Investigator) & Hay, R. (Investigator)

  Biotechnology and Biological Sciences Research Council

  15/01/13 → 14/01/16

  Project: Research

• Ultrasound Microscopy for Clinical and Pre-Clinical Tissue Characterisation (Caledonian Research Fund)

  Demore, C. (Investigator)

  Royal Society of Edinburgh

  1/01/13 → 31/03/19

  Project: Research

• AMP-Activated Protein Kinase - A Tumour Suppressor that Opposes the Metabolic Changes in Proliferating Cells (Programme Grant)

  Hardie, G. (Investigator)

  1/01/13 → 30/09/18

  Project: Research

  • AMP-activated Protein Kinase 100%
  • Adenosine Monophosphate 34%
  • Hydroxymethylglutaryl Coenzyme A Reductase Kinase 33%
  • Adenosine Triphosphate 32%
  • Malignant Neoplasm 24%

• Dynamics of Fundamental Cellular Processes by Live Cell and Tissue Imaging

  MacDonald, M. (Investigator), McGloin, D. (Investigator), McKenna, S. (Investigator), Storey, K. (Investigator), Swedlow, J. (Investigator) & Weijer, K. (Investigator)

  Medical Research Council

  1/01/13 → 31/12/17

  Project: Research

  • Caenorhabditis Elegans 100%
  • Mitosis 52%
  • Dopaminergic 44%
  • 6-hydroxydopamine (6-OHDA) 42%
  • Trypanosoma 42%

• RETRaIN: Rewiring the Nucleus Towards Plant Immunity

  Huitema, E. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/13 → 31/12/17

  Project: Research

  • Infectious Agent 100%
  • Oomycetes 67%
  • Phytophthora capsici 60%
  • Phytophthora Capsici 59%
  • Tomato 49%

• The Role in ESX-1, a Novel Protein Secretion System, in Staphylococcus Aureus Virulence (Clinical Fellowship - James Chalmers)

  Chalmers, J. (Investigator) & Palmer, T. (Investigator)

  1/01/13 → 31/12/15

  Project: Research

  • Staphylococcus Aureus 100%
  • Mortality Risk 100%
  • Exacerbation Rate 100%
  • Microbial Diversity 100%
  • Type VII Secretion System 100%

• A Translational Engine for Biomedical Discoveries (Strategic Grant)

  Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)

  1/01/13 → 30/09/15

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Protein Catabolism 87%
  • Visceral Leishmaniasis 73%
  • Trypanosoma Brucei 67%
  • Ubiquitin-Conjugating Enzyme 64%

• Macrophage Responses to Anti-Leishmanial Drug Treatment

  Wyllie, S. (Investigator)

  British Society for Antimicrobial Chemotherapy

  1/01/13 → 30/06/14

  Project: Research

• Molecular Biology of FMDV Replication: Towards New Methods of FMDV Disease Control (joint with Universities of St Andrews, Leeds and Edinburgh and Institute for Animal Health Pirbright) (Strategic Longer Larger Grant)

  Lamond, A. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/13 → 31/12/18

  Project: Research

• European Lead Factory EUC2LID (IMI) (Joint with 29 other Partners)

  Alessi, D. (Investigator), Ferguson, M. (Investigator), Hopkins, A. (Investigator), Hopkins Navratilova, I. (Investigator) & Read, K. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES, Scottish Funding Council

  1/01/13 → 31/05/18

  Project: Research

  • Indole-2-carboxylate 100%
  • Metallo-β-lactamase 100%
  • Lactams 100%
  • β-lactamase Inhibitor 100%
  • Imitation 100%

• Mining the Lolium Perenne Genome for the Identification of Key Agriculturally Important Genes (PhD Studentship : joint with James Hutton Institute)

  Halpin, C. (Investigator)

  Teagasc - Irish Agriculture and Food Development Authority

  1/01/13 → 31/12/16

  Project: Research

• GPR55; A Novel Modulator of Insulin Sensitivity and Energy Metabolism in Skeletal Muscle

  Hundal, H. (Investigator) & Irving, A. (Investigator)

  Diabetes UK

  1/01/13 → 31/08/16

  Project: Research

• Towards Novel Anti-Infectives Against Pathogenic Bacteria

  Sargent, F. (Investigator)

  1/01/13 → 31/12/13

  Project: Research

• Strategic Award: Wellcome Trust Technology Platform

  Blow, J. (Investigator), Lamond, A. (Investigator) & Owen-Hughes, T. (Investigator)

  1/01/13 → 30/09/18

  Project: Research

  • Proteomics 100%
  • Ubiquitin 96%
  • Proteome 70%
  • Messenger RNA 59%
  • Chromatin 59%

• Imaging Chromatin Transitions Using High Performance Microscopy

  Owen-Hughes, T. (Investigator) & Swedlow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/13 → 31/12/15

  Project: Research

  • Chromatin 100%
  • High-resolution Imaging 100%
  • Chromatin State 100%
  • Cell Division 100%
  • Genomics 100%

• Cellular Mechanisms of Gastrulation: A Combined Experimental and Modelling Study (Joint with University of Liverpool)

  Weijer, K. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/13 → 30/06/16

  Project: Research

  • Chick Embryo 100%
  • Chick 92%
  • Gastrulation 80%
  • Primitive Streak 71%
  • Vertebrates 57%

• De-Risking Innovative Drug Discovery Projects Through Portfolio Management

  Ferguson, M. (Investigator) & Wyatt, P. (Investigator)

  Medical Research Council

  1/01/13 → 30/06/14

  Project: Research

  • High-throughput Screening 100%
  • Ca2+ 85%
  • High Throughput Screening 78%
  • High-Throughput Screening 78%
  • Male Infertility 71%

• Mechanism of Poly-SUMO Chain Recognition by the Ubiquitin Ligase RNF4 (joint with Imperial College London)

  Hay, R. (Investigator)

  Biotechnology and Biological Sciences Research Council

  21/12/12 → 20/01/16

  Project: Research

  • Ubiquitin 100%
  • RNF4 75%
  • Small Ubiquitin-like Modifier 50%
  • K63-linked Ubiquitin Chains 50%
  • Ubiquitin-like 50%

• A Tissue Bank Resource to Investigate the Link Between VEGF-A Signalling and Pulmonary Cyst Formation in BHD Syndrome

  Land, S. (Investigator) & Mehta, A. (Investigator)

  1/12/12 → 31/07/16

  Project: Research

• Regulation of (1,3;1,4) Beta-Glucan Synthesis in the Grasses (Joint with James Hutton Institute)

  Brown, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  5/11/12 → 4/11/15

  Project: Research

• Human iPS Cell Collection (Joint with King's College London, Sanger Centre, European Bioinformatics Institute)

  Lamond, A. (Investigator)

  1/11/12 → 1/02/18

  Project: Research

  • Induced Pluripotent Stem Cells (iPSCs) 100%
  • Induced Pluripotent Stem Cell 100%
  • Proteomics 98%
  • Proteome 87%
  • Induced Stem Cell 47%

• Application of Selected-Reaction Monitoring (SRM) Mass Spectrometry for the Global Analysis of the Phosphorylation Status of Protein Kinases

  Ashford, M. (Investigator), Dillon, J. (Investigator), Hayes, J. (Investigator), McCrimmon, R. (Investigator) & Trost, M. (Investigator)

  Medical Research Council

  1/11/12 → 31/03/16

  Project: Research

  • Prothrombin 100%
  • NFE2L2 97%
  • Nonalcoholic Steatohepatitis 72%
  • Oxidative Stress 65%
  • Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 65%

• K4DD: Kinetics for Drug Discovery (Joint With 19 Other Partners)

  Hopkins, A. (Investigator) & Hopkins Navratilova, I. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/11/12 → 31/10/17

  Project: Research

  • Fragment Screening 100%
  • Adrenergic Receptors 100%
  • G Protein-coupled Receptor 100%
  • Ligand-receptor Binding 100%
  • Ligand Discovery 100%

• Determining the Role and Mechanism of Action of SUMO Targeted Ubiquitin Ligase RNF4 in Maintaining Genome Integrity (Senior Investigator Award)

  Hay, R. (Investigator)

  1/10/12 → 31/01/20

  Project: Research

  • Ubiquitin 100%
  • Ubiquitin-like 51%
  • Small Ubiquitin-like Modifier 45%
  • Ligase 23%
  • Ubiquitin-Conjugating Enzyme 23%