School of Life Sciences

Projects

Projects per year 2002 2010 2011 2012 2013 2014 2015 2016 2017 2018 2023 2033

• 111 Active
• 204 Not started
• 778 Finished

Projects per year

Search results

• Finished

  Translating Sonoptics - Exploiting Laser Applications in Generic Non-Invasive Delivery (Joint with University of St Andrews)

  Campbell, P. (Investigator) & McLean, I. (Investigator)

  1/10/10 → 30/09/14

  Project: Research

• Pharmacodynamic Biomarkers of LRRK2 Activity

  Alessi, D. (Investigator) & Prescott, A. (Investigator)

  1/10/10 → 30/09/12

  Project: Research

• To Systematically Investigate Enzymes of the Trypanosome T. Brucel to Identify a Potential Target for Drug Action (CASE Studentship)

  Fairlamb, A. (Investigator)

  1/10/10 → 1/10/14

  Project: Research

• A Structural and Biochemical Approach to Understand the Molecular Mechanism of Glycogen Synthesis (Sir Henry Wellcome Fellowship)

  Cohen, P. (Investigator), Sakamoto, K. (Investigator) & Zeqiraj, E. (Investigator)

  1/10/10 → 31/03/15

  Project: Research

  • Protein Kinases 100%
  • Protein Kinase 89%
  • Allosteric Regulators 74%
  • Liver Glucose Production 74%
  • Cyclin Y 74%

• Research into RNA Structure and Function

  Lilley, D. (Investigator)

  Royal Society of Edinburgh

  1/10/10 → 30/09/12

  Project: Research

• EPIGENESYS: Epigenetics Towards Systems Biology (joint with 15 other partners)

  Harrison, P. (Investigator) & Lamond, A. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/10/10 → 31/03/16

  Project: Research

  • Chromatin 100%
  • Chromatin Conformation 50%
  • Edmonton 50%
  • Canada 50%
  • MMS22L 50%

• Human and Mouse Genetics Studies of Filaggrin-Related Proteins in Eczema and Allergy (Joint with Trinity College Dublin)

  Barton, G. (Investigator) & McLean, I. (Investigator)

  1/10/10 → 28/02/14

  Project: Research

  • Atopic Dermatitis 100%
  • Filaggrin 43%
  • Loss of Function Mutation 36%
  • Gain-of-function mutation 34%
  • Mutation in the Filaggrin Gene 27%

• Knockout-Replacement Gene Therapy for Dominantly Inherited Corneal Dystrophy using SnoRNA Mediated Gene Silencing (joint with University of Ulster)

  McLean, I. (Investigator)

  1/10/10 → 30/09/13

  Project: Research

• Role of the PDK1-SGK Pathway in Cancer (CASE Studentship)

  Alessi, D. (Investigator)

  1/10/10 → 30/09/14

  Project: Research

• Molecular and Cellular Biology PhD Programme (4 year PhD - Mr Jens Hukelmann)

  Cantrell, D. (Investigator) & Crocker, P. (Investigator)

  6/09/10 → 5/09/14

  Project: Research

  • Mammalian Target of Rapamycin (mTOR) 100%
  • Cell Wall Proteome 100%
  • Cytotoxic T Lymphocytes 100%
  • Cytotoxic T Cells 100%
  • Cytotoxic T Cell 100%

• Molecular and Cellular Biology PhD Programme (4 year PhD - Miss Lynne Cairns)

  Crocker, P. (Investigator)

  6/09/10 → 5/09/14

  Project: Research

  • Degu 100%
  • Control Signal 100%
  • Flagella 100%
  • Mechanical Signals 100%
  • Bacillus Subtilis (B. subtilis) 100%

• Molecular and Cellular Biology PhD Programme (4 year PhD - Miss Anna Kelner)

  Crocker, P. (Investigator)

  6/09/10 → 5/09/14

  Project: Research

  • Gene Expression 100%
  • Trypanosoma Brucei 100%
  • T. Brucei 100%
  • Messenger RNA 100%
  • Long Non-Coding RNA 66%

• Development of Novel Models for the Study of Hepatic Insulin Resistance as a Means to an Early Diagnosis and Treatment for Diabetes (Dr Kashyap Patel)

  Cantrell, D. (Investigator), Lambert, J. (Investigator), Marshall, S. (Investigator), Patel, K. (Investigator), Sakamoto, K. (Investigator) & Sutherland, C. (Investigator)

  6/09/10 → 6/04/14

  Project: Research

• Molecular and Cellular Biology PhD Programme (4 year PhD - Mr Dun Jack Fu)

  Crocker, P. (Investigator) & McLean, I. (Investigator)

  6/09/10 → 5/09/14

  Project: Research

• The Translation of Quantitative Proteomics Applied to Human Disease (Dr Kathryn Kirkwood)

  Cantrell, D. (Investigator), Kirkwood, K. (Investigator), Lambert, J. (Investigator), Lamond, A. (Investigator) & Marshall, S. (Investigator)

  6/09/10 → 5/08/14

  Project: Research

• Development of Novel Models for the Study of Hepatic Insulin Resistance as a Means to an Early Diagnosis and Treatment for Diabetes (Dr Esther Sammler)

  Alessi, D. (Investigator), Cantrell, D. (Investigator), Lambert, J. (Investigator), Marshall, S. (Investigator) & Sammler, E. (Investigator)

  6/09/10 → 6/05/14

  Project: Research

• Investigating Signalling Pathway Dysfunction Linked to LRRK2

  Alessi, D. (Investigator)

  Michael J. Fox Foundation for Parkinson's Research

  1/09/10 → 31/08/13

  Project: Research

• Biogenesis of a Respiratory Complex Essential for Viability of Pathogenic Mycobacteria

  Palmer, T. (Investigator)

  Medical Research Council

  1/09/10 → 31/08/13

  Project: Research

  • Arginine 100%
  • Membrane Protein 89%
  • Twin-arginine 66%
  • Twin-arginine Translocation 60%
  • Transport Pathway 60%

• A Systematic Investigation into the Pathogenesis and Course of Parkinson's Syndrome (Wellcome Trust and MRC Neurodegenerative Diseases Initiative) (Joint with University College London)

  Alessi, D. (Investigator)

  Medical Research Council

  1/09/10 → 31/08/15

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 53%
  • Leucine-Rich Repeat 46%
  • Phosphorylation 36%

• Combined Genetic and Biochemical Approaches to Uncover and Characterize Redundant Factors Involved in Late Stages of Recombinational Repair

  Gartner, A. (Investigator) & Lamond, A. (Investigator)

  1/08/10 → 30/04/17

  Project: Research

  • Caenorhabditis Elegans 100%
  • DNA Repair 30%
  • DNA Damage 25%
  • Programmed Cell Death 24%
  • Germ Cell 22%

• Aref#d: 21993. Control of Genome Stability by SLX-4-Containing Protein Complexes in Human Cells

  Rouse, J. (Investigator)

  Association for International Cancer Research

  1/08/10 → 31/07/13

  Project: Research

• Aref#d: 21363. RNA Folding as a Mediator of Stress Response in Plants (Joint with Pennsylvania University)

  Lilley, D. (Investigator)

  1/08/10 → 31/07/13

  Project: Research

• Aref#d: 22165. Roles of a Serine/Threonine-Specific Phosphatase in Steroid Receptor Function

  Cohen, T. (Investigator)

  Medical Research Council

  26/07/10 → 25/07/13

  Project: Research

• KTP Project with Dundee Cell Products

  Blow, J. (Investigator) & Lamont, D. (Investigator)

  5/07/10 → 4/01/13

  Project: Research

• Aref#d: 21557. Isolation of Pooled Selected Gene Segments for Allele Discovery by Next Generation Sequencing (Tools and Resources Development Fund)

  Flavell, A. (Investigator), Hasan-Syed, N. (Investigator) & Swedlow, J. (Investigator)

  1/07/10 → 31/12/12

  Project: Research

  • Data Management 100%
  • Biological Microscopy 100%
  • Flexible Model 100%
  • Experimental Biology 100%
  • Acquisition Management 100%

• Modulation of Renal NaCl Transporter Via Angiotensin II-WNK4-SPAK Signalling Pathway (joint with National University of Mexico)

  Alessi, D. (Investigator)

  1/07/10 → 31/12/13

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Cotransporter 82%
  • Alanine 80%
  • Proline 80%

• Intuitive Large Scale Image Processing for Biologists (Joint with University of Edinburgh)

  Swedlow, J. (Investigator)

  1/07/10 → 31/12/12

  Project: Research

• Aref#d: 22086. Role of Fibroblast-Growth Factor Signalling in Epithelial Remodelling

  Muller, A. (Investigator)

  Medical Research Council

  1/05/10 → 31/10/13

  Project: Research

• Aref#d: 22158. Regulation of Myosin II Filament Assembly and Stabilisation, Localisation and Cortical Anchoring (Research Career Development Fellowship)

  Griffis, E. (Investigator) & Lamond, A. (Investigator)

  1/05/10 → 30/04/15

  Project: Research

• Aref#d: 21680. The Flagellum and Cell Fate Differentiation

  Stanley-Wall, N. (Investigator) & Swedlow, J. (Investigator)

  12/04/10 → 11/04/13

  Project: Research

  • Bacillus subtilis 100%
  • Bacillus Subtilis (B. subtilis) 86%
  • Biofilm 59%
  • Degu 52%
  • Octodon Degus 52%

• Aref#d: 22289. Proteomic, Functional and Systems Analysis of Mitotic Chromosome Organisation and its Interdependence with DNA Replication

  Blow, J. (Investigator) & Swedlow, J. (Investigator)

  1/04/10 → 31/07/14

  Project: Research

• Aref#d: 21992. Form and Function in the ESX-1 Secretion System; Elucidation of Mechanism and Structural Determinants of Bacterial Virulence

  Hunter, B. (Investigator) & Palmer, T. (Investigator)

  1/04/10 → 18/08/13

  Project: Research

  • Staphylococcus Aureus 100%
  • Type VII Secretion System 100%
  • T7SS 85%
  • Nuclease 50%
  • Interspecies Competition 50%

• Aref#d: 22163. The Establishment of a Large Case Collection of Childhood Atopic Dermatitis: A Resource for Gemetoc Research (Joint with Trinity College Dublin)

  McLean, I. (Investigator)

  1/03/10 → 28/02/14

  Project: Research

  • Atopic Dermatitis 100%
  • Filaggrin 42%
  • Epidermis 33%
  • Gain-of-function mutation 27%
  • Loss of Function Mutation 24%

• Aref#d: 21938. Establishing and Exploiting C Elegans as a Simple Invertebrate Model for Parkinson's Disease

  Gartner, A. (Investigator)

  1/03/10 → 31/01/14

  Project: Research

• Aref#d: 21558. SIRNA Therapy in Dominant Skin and Eye Disorders (Programme Grant)

  McLean, I. (Investigator) & Smith, F. (Investigator)

  Medical Research Council

  18/02/10 → 17/02/15

  Project: Research

  • Luc2 100%
  • Bioluminescence 100%
  • In Vivo Evaluation 100%
  • Gene Therapy 100%
  • In Vivo 100%

• Aref#d: 22015. Investigating the Functions of Remnant Mitochondria in Human Parasitic Protozoa (Joint with University of Newcastle and others)

  Lucocq, J. (Investigator)

  1/02/10 → 31/01/15

  Project: Research

• Aref#d: 22161. Regulation of Cell Size in Multicellular Organisms (Research Career Development Fellowship)

  Bjorklund, M. (Investigator) & Hardie, G. (Investigator)

  1/02/10 → 30/04/15

  Project: Research

  • Modified Ribosomes 100%
  • NQO2 100%
  • Ribosome Profiling 100%
  • Cell Size 100%
  • 3′-untranslated Region (3′-UTR) 100%

• Aref#d: 21738. Systems Biology Profiling of SUMO Substrate Proteome in Signalling Pathways (Sir Henry Wellcome Postdoctoral Fellowship - Dr Ivan Matic)

  Lamond, A. (Investigator) & Matic, I. (Investigator)

  1/02/10 → 30/06/14

  Project: Research

  • ADPr 100%
  • Polymerase Activity 100%
  • Small Ubiquitin-like Modifier 100%
  • Proteome-wide 100%
  • Adenosine Diphosphate Ribose 100%

• Aref#d: 22242. Molecular Mechanisms of Encystation

  Schaap, P. (Investigator)

  1/01/10 → 31/01/14

  Project: Research

  • Encystation 100%
  • Dictyosteliida 100%
  • Dictyostelia 94%
  • Cyclic Adenosine Monophosphate 87%
  • Social Amoeba 82%

• Aref#d: 21422. Molecular Mechanisms for the Evolution of Multicellular Complexity in Social Amoebas

  Schaap, P. (Investigator)

  1/01/10 → 30/06/13

  Project: Research

• Aref#d: 21286. Mass Spectrometry-Based Global Analysis of Protein Phosphorylation in Cells and Tissue Extracts with Altered PINK1 Catalytic Activity: A Novel Screen for PINK1 Substrates

  Alessi, D. (Investigator) & Muqit, M. (Investigator)

  1/12/09 → 30/11/12

  Project: Research

  • Kinase 100%
  • Phosphotransferase 100%
  • Phosphorylation 95%
  • Parkin 69%
  • Leucine-rich Repeat Kinase 2 (LRRK2) 69%

• Aref#d: 21682. Bacterial Hydrogenases for Biohydrogen Technology (Joint with University of Oxford)

  Sargent, F. (Investigator)

  1/12/09 → 30/11/12

  Project: Research

• Aref#d: 21678. Elucidating Mechanisms and Roles of Alternative Polyadenylation

  Barton, G. (Investigator) & Simpson, G. (Investigator)

  1/12/09 → 16/05/13

  Project: Research

  • RNA Sequencing 100%
  • RNA Sequencing (RNA-seq) 89%
  • RNA 86%
  • Alternative Polyadenylation 80%
  • Arabidopsis Thaliana 78%

• Clinical PhD Fellowship: Shuaibu Dambatta

  Cantrell, D. (Investigator), Lambert, J. (Investigator) & Marshall, S. (Investigator)

  15/11/09 → 14/11/12

  Project: Research

• Aref#d: 21456. mTOR as a Regulator of Airway and Vascular Development in the Fetal Lung

  Jovanovic, A. (Investigator) & Land, S. (Investigator)

  9/11/09 → 8/05/13

  Project: Research

• Aref#d: 21632. The Nedd8 Ubiquitin-like Protein Conjugation System and Regulation of Cullin-Ring E3 Ligases (European Research Council)

  Kurz, T. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/11/09 → 31/10/14

  Project: Research

• Aref#d: 22417. NUCLEOSOME 4D Nucleosome Structure and Function across Biological Scales and Biological Function (EC FP7 People, Marie Curie Initial Training Networks)

  Owen-Hughes, T. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/11/09 → 31/10/13

  Project: Research

• Aref#d: 21151. Molecular Mechanisms of Assembly, Regulation and Substrate Recognition of the Heterotrimeric LKB1 Tumour Suppressor

  Alessi, D. (Investigator) & van Aalten, D. (Investigator)

  1/11/09 → 31/10/12

  Project: Research

• Aref#d: 21189. SUMMIT: Surrogate Markers for Micro- and Macro-vascular Hard Endpoints for Innovative Diabetes Tools (EC IMI)

  Belch, J. (Investigator), Colhoun, H. (Investigator), Ferguson, M. (Investigator), Houston, G. (Investigator), Khan, F. (Investigator), Leese, G. (Investigator), Morris, A. (Investigator), Palmer, C. (Investigator) & Pearson, E. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/11/09 → 31/10/14

  Project: Research

  • Excess Pressure 100%
  • Pressure Parameters 77%
  • Type 2 Diabetes Mellitus (T2DM) 66%
  • Older Adults 66%
  • Cardiovascular Risk 62%

• Aref#d: 21559. Molecular Mechanisms of Fungal Cell Wall Assembly (Programme Grant)

  van Aalten, D. (Investigator)

  Medical Research Council

  1/11/09 → 31/10/14

  Project: Research

  • O-linked N-acetylglucosamine (O-GlcNAc) 100%
  • Enzyme 81%
  • O-GlcNAcase 80%
  • Transferase 74%
  • N-Acetylglucosamine 54%