School of Life Sciences

Projects

Projects per year 2002 2010 2011 2012 2013 2014 2015 2016 2017 2018 2023 2033

• 110 Active
• 205 Not started
• 778 Finished

Projects per year

Search results

• Finished

  Target Enrichment-Based Potato Disease Resistance Gene Studies and Late-Blight Pathogen Diversity Research (Joint with China Agricultural University) (Newton Advanced Fellowship 2020)

  Hein, I. (Investigator)

  31/03/20 → 30/03/22

  Project: Research

  • Phytophthora infestans 100%
  • Lycopersicon 80%
  • Potato 73%
  • RenSeq 73%
  • Disease Genes 66%

• Dundee - Confidence in Concept 2019

  Brady, J. (Investigator), Brady, J. (Investigator), Ferguson, M. (Investigator), Gray, D. (Investigator) & Wyatt, P. (Investigator)

  Medical Research Council

  31/03/20 → 1/04/23

  Project: Research

  • COVID-19 100%
  • Guanine 100%
  • SARS Coronavirus 100%
  • N7-methyltransferase 66%
  • Biochemical Characterization 50%

• RNF12 E3 Ubiquitin Ligase Substrate Degraders as a Therapeutic Strategy in Tonne-Kalscheuer Syndrome (TOKAS)

  Bustos, F. (Investigator) & Findlay, G. (Investigator)

  1/03/20 → 28/02/22

  Project: Research

  • Stem Cell 100%
  • E3 Ubiquitin Ligase 83%
  • Activity-based Probes 83%
  • Rnf12 83%
  • Stem Cells 83%

• DNA Interstrand Crosslink Repair and Chromatin Remodelling (ICL CHROM)

  Rouse, J. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/02/20 → 26/04/22

  Project: Research

  • Histone Chaperone 100%
  • Chromatin Structure 100%
  • Chromatin Function 100%
  • Metazoa 100%
  • Histone 100%

• MICA: Modulation of IL-33-dependent Responses Using Parasite Products (Transfer)

  McSorley, H. (Investigator)

  Medical Research Council

  1/02/20 → 30/06/22

  Project: Research

  • Interleukin-33 100%
  • Interleukin-33 (IL-33) 96%
  • Cytokine 33%
  • Immune Response 30%
  • H. Polygyrus 29%

• Investigation of Mechanics of Gastrulation Using New Transgenic Lines

  Weijer, K. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/20 → 31/12/24

  Project: Research

  • Gastrulation 100%
  • Chick Embryo 67%
  • Chick 64%
  • Vertebrates 53%
  • Primitive Streak 41%

• A World Without Asthma - Natures Approach to Prevent Asthma by Targeting Barrier Immunity and Microbes (AWWA-NATURE) (Joint with Leiden University, Monash University and 5 Others) (Year 3)

  McSorley, H. (Investigator)

  1/01/20 → 1/01/24

  Project: Research

  • Interleukin-33 100%
  • Interleukin-33 (IL-33) 93%
  • H. Polygyrus 56%
  • Alarmins 50%
  • Helminths 48%

• Characterization of pT73 Rab10 Protein from XProChem and Supply of pRab8A and pRab10 Protein to Abcam for Assay Development

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  1/01/20 → 14/08/21

  Project: Research

• Validation of antibodies to ubiquitin-conjugated proteins for mitophagy readouts

  Muqit, M. (Investigator)

  11/12/19 → 1/12/22

  Project: Research

• Studying Co Evolution in Agriculture to Inform NLR Deployment (Industrial Partnership Award - IPA)

  Hein, I. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/12/19 → 31/08/23

  Project: Research

  • Potato 100%
  • Infectious Agent 91%
  • Phytophthora infestans 89%
  • Enrichment Sequencing 88%
  • Phytophthora Infestans 79%

• Short Linear Interaction Motifs as Specificity Determinants in the Ubiquitin System - Discovery, Mechanisms and Therapuetic Opportunities (UBIMOTIF)

  Kulathu, Y. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/12/19 → 31/05/24

  Project: Research

• Next Generation File Formats for BioImaging

  Swedlow, J. (Investigator)

  1/12/19 → 30/11/20

  Project: Research

• C5aR a Novel Immunomodulator of Metabolic Signalling and Energy Metabolism in Skeletal Muscle

  Ganley, I. (Investigator), Hundal, H. (Investigator), Lipina, C. (Investigator) & McCrimmon, R. (Investigator)

  Diabetes UK

  4/11/19 → 25/08/23

  Project: Research

  • Novel Immunomodulators 100%
  • C5a Receptor 100%
  • Receptor 1 100%
  • Complement Receptors 100%
  • Insulin Action 100%

• Microglia Proteome

  Cantrell, D. (Investigator)

  1/11/19 → 30/09/24

  Project: Research

• Characterising Late Blight Disease Resistance Genes in Potato and Studying their Role in Shaping Pathogen Effector Diversity (International Exchanges) (Joint with the James Hutton Institute and the Federal Research Centre NI - Russian Institute of Plant Genetic Resources)

  Birch, P. (Investigator) & Hein, I. (Investigator)

  1/11/19 → 31/10/21

  Project: Research

  • Potato 100%
  • James Hutton 50%
  • Disease Resistant 50%
  • Dundee 50%
  • New Disease 50%

• A Drug Target for Shigella (Open Lab Programme)

  Gilbert, I. (Investigator), Gray, D. (Investigator) & Read, K. (Investigator)

  17/10/19 → 16/02/23

  Project: Research

• Molecular Mechanisms for the Final Step of Dissolving Sister Chromatid Cohesion at Anaphase Onset

  Tanaka, T. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/10/19 → 30/09/23

  Project: Research

  • Chromosome Reorganization 100%
  • Condensin 100%
  • Mitotic Chromosomes 100%
  • Sister Chromatid Resolution 100%
  • Prophase 100%

• Dundee Centre for Antimicrobial Resistance

  Chalmers, J. (Investigator), Coulthurst, S. (Investigator), Jefferson, E. (Investigator), Marwick, C. (Investigator), Nathwani, D. (Investigator) & Palmer, C. (Investigator)

  1/09/19 → 31/03/22

  Project: Research

• PPM1H Activators for Treatment of Parkinson's Disease

  Alessi, D. (Investigator) & Gray, D. (Investigator)

  1/09/19 → 30/03/21

  Project: Research

• Genetic Validation of a Promising Drug Target for Cryptosporidiosis

  Baragana, B. (Investigator), Gilbert, I. (Investigator), Pawlowic, M. C. (Investigator) & Wyllie, S. (Investigator)

  Carnegie Trust for the Universities of Scotland

  20/08/19 → 19/02/21

  Project: Research

  • Mode of Action 100%
  • Target Engagement 100%
  • LysR Family 100%
  • Selection Marker 100%
  • Cryptosporidium 100%

• 4DN supplement: Combined Cytological, Genomic, and Functional Mapping of Nuclear Genome Organization (Joint with Carnegie-Mellon University)

  Swedlow, J. (Investigator)

  National Institutes of Health

  1/08/19 → 31/07/21

  Project: Research

• Unravelling how Protein Signalling Networks Integrate to Control T Cell Fate (Fellowship)

  Cantrell, D. (Investigator) & Marchingo, J. (Investigator)

  Walter and Eliza Hall Institute of Medical Research

  1/08/19 → 31/07/21

  Project: Research

  • Protein Energetics 100%
  • T Cell Immunity 100%
  • Protein Degradation 100%
  • Protein Synthesis 100%
  • T Cells 100%

• Genome-wide and chemical screens to uncover novel upstream regulators of the LRRK2 signaling network

  Alessi, D. (Investigator)

  1/08/19 → 30/09/21

  Project: Research

  • Leucine-rich Repeat Kinase 2 (LRRK2) 100%
  • LRRK2 76%
  • PPM1H 38%
  • Rab Proteins 36%
  • Phosphatase 33%

• The Innovative Targets Portfolio: Basic Life Sciences Research to Novel Therapies, through a Portfolio of Small Molecule Translational Projects

  Ferguson, M. (Investigator), Gray, D. (Investigator) & Wyatt, P. (Investigator)

  Medical Research Council

  1/07/19 → 30/06/22

  Project: Research

  • COVID-19 100%
  • SARS Coronavirus 100%
  • Biochemical Characterization 50%
  • Nsp3 50%
  • Protease Activity 50%

• Development of New Agents for the Treatment of Cryptosporidiosis (DPFS) (Joint with University of Vermont)

  Gilbert, I. (Investigator), Gray, D. (Investigator), Pawlowic, M. C. (Investigator), Read, K. (Investigator) & Wyatt, P. (Investigator)

  Medical Research Council

  1/05/19 → 31/01/23

  Project: Research

  • Anticryptosporidial 100%
  • LysR Family 100%
  • Efficacy in Vivo 100%
  • Cryptosporidium 100%
  • Lysine Transfer RNA Ligase 100%

• Unravelling the Composition of the Maize Seed Microbiota and its Potential Contribution to Pathogen Protection

  Bulgarelli, D. (Investigator)

  29/04/19 → 28/07/19

  Project: Research

• Converting Natural Product Leads into Structure and Ligand Based Drug Discovery Campaigns against Leishmaniasis and Chagas' Disease (Joint with Sao Paulo State University)

  Gilbert, I. (Investigator), Read, K. (Investigator) & Wyllie, S. (Investigator)

  Medical Research Council

  1/04/19 → 31/03/22

  Project: Research

• MRC Capital Prioritisation Bid 2019-20

  Alessi, D. (Investigator) & Davies, P. (Investigator)

  Medical Research Council

  1/04/19 → 31/03/20

  Project: Research

• Structure and Function of Chromatin Remodelling ATPases and their Dysfunction in Human Disease

  Owen-Hughes, T. (Investigator) & Sundaramoorthy, R. (Investigator)

  Medical Research Council

  1/04/19 → 31/03/25

  Project: Research

  • Enzyme 100%
  • Chromatin Remodeling 95%
  • Isoform 88%
  • Chromatin 77%
  • Histone 66%

• Defining the Function of Cryptosporidium Oocyst Wall Proteins in Parasite Transmission

  Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)

  27/03/19 → 26/03/20

  Project: Research

• The Function of Disordered Regions in the APC Protein (UK Israel Science Lectureship)

  Nathke, I. (Investigator)

  British Council

  1/03/19 → 30/06/19

  Project: Research

• Antigen and Validation for New pS228 PINK1 and pT257 PINK1 Antibodies at Abcam

  Muqit, M. (Investigator)

  1/03/19 → 7/02/22

  Project: Research

• Identification and Validation of the Targets of Compounds Demonstrating In Vitro Activity Against Trypanosoma Cruzi (Newton International Fellowship)

  Wyllie, S. (Investigator)

  1/03/19 → 1/09/21

  Project: Research

  • Aryl Aldehydes 100%
  • In Vitro Assessment 100%
  • Benzofuran-3(2H)-one 100%
  • Trypanosoma Cruzi (T. cruzi) 100%
  • Bioactivation 100%

• The Roles of Extracellular Vesicle Transport in Late Blight Disease Development (Industrial Partnership Award (IPA))

  Birch, P. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/03/19 → 30/09/24

  Project: Research

  • Infectious Agent 100%
  • Phytophthora infestans 49%
  • Oomycetes 47%
  • Phytophthora Infestans 45%
  • Extracellular Vesicles 43%

• Providing an open collaborative space for digital biology in Europe (EOSC-Life) (Joint with European Molecular Biology Laboratory as lead, Biobanks and Biomolecular Resources Research Infrastructure Consortium, EATRIS ERIC and 35 others)

  Swedlow, J. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/03/19 → 31/08/23

  Project: Research

  • Biotechnology 100%
  • Data Processing 100%
  • Provenance Data 50%
  • International Organization for Standardization 50%
  • Machine-actionable 50%

• Assess the Potential of a New Method to Prevent Potato Blight Disease

  Birch, P. (Investigator) & He, Q. (Investigator)

  1/02/19 → 31/03/19

  Project: Research

• Defining Oocyst Wall Biogenesis and Function in Cryptosporidium Transmission (Reference #UNS68421) (Sir Henry Dale Fellowship)

  Gilbert, I. (Investigator) & Pawlowic, M. C. (Investigator)

  1/02/19 → 30/04/25

  Project: Research

  • Cryptosporidium 100%
  • LysR Family 50%
  • Transfer RNA 50%
  • Oocyst 28%
  • Mode of Action 25%

• Delineating the Roles of GPR55 in Cellular Metaboloism and Energy Homeostasis (Joint with Robert Gordon University)

  Hundal, H. (Investigator) & Lipina, C. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/01/19 → 31/08/22

  Project: Research

  • Skeletal muscle 100%
  • Skeletal Muscle 94%
  • Insulin Signaling 56%
  • Impaired Insulin Secretion 50%
  • Integrated Stress Response 42%

• Training Network in Drug Discovery Targeting TRIM Ubiquitin Ligases in Disease (TRIM-NET) (Joint with University of Trieste as lead; CNRS; Karlsruhe Institute of Technology; Leiden University Medical Centre; French National Institute for Agricultural Research; Casa Sollievo della Sofferenza Hospital, Italy; CSIC; Netherlands Cancer Institute)

  Hay, R. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/01/19 → 30/06/23

  Project: Research

  • Ubiquitin 100%
  • E3 Ligase 74%
  • Ubiquitin Ligase 74%
  • Laminopathy 66%
  • Structural Variation 66%

• Structure-Guided Drug Discovery for Malaria and Tuberculosis (joint with Structural Genomics Consortium)

  Gilbert, I. (Investigator), Gray, D. (Investigator), Read, K. (Investigator) & Wyatt, P. (Investigator)

  Bill and Melinda Gates Foundation

  1/01/19 → 6/07/24

  Project: Research

  • Transfer RNA 100%
  • Plasmodium Falciparum 80%
  • Pullout 60%
  • Lysine Transfer RNA Ligase 60%
  • LysR Family 53%

• Unravelling the Barley Genetic Control of the Rhizosphere Microbiota

  Barton, G. (Investigator), Bulgarelli, D. (Investigator) & Waugh, R. (Investigator)

  Biotechnology and Biological Sciences Research Council

  17/12/18 → 16/05/22

  Project: Research

  • Microflora 100%
  • Barley 68%
  • Microbiota 61%
  • Rhizosphere Microbiome 58%
  • Plant Microbiome 56%

• Processing of Branched DNA Molecules During Cytokinesis, Uncovering New Mechanisms of Genome Maintenance

  Gartner, A. (Investigator), Lilley, D. (Investigator) & Rouse, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  1/12/18 → 30/06/22

  Project: Research

  • Caenorhabditis Elegans 100%
  • DNA Repair 83%
  • DNA Repair Pathways 65%
  • Mutational Signatures 55%
  • Genome Integrity 41%

• LRRK2 and IBD

  Alessi, D. (Investigator)

  1/11/18 → 31/10/19

  Project: Research

• Male Contraceptive Drug Development Using a Novel Human Sperm Phenotypic Screening Platform (Grand Challenges Phase II)

  Andrews, P. (Investigator), Barratt, C. (Investigator), Gilbert, I. (Investigator), Martins Da Silva, S. (Investigator), Read, K. (Investigator) & Swedlow, J. (Investigator)

  Bill and Melinda Gates Foundation

  1/11/18 → 30/09/23

  Project: Research

  • Sperm Motility 100%
  • Male Contraceptive 70%
  • Medicinal Chemistry 58%
  • Small Molecules 58%
  • Sperm Function 58%

• Correlating LRRK2 Activation Status to Phospho-Lipids in Parkinson's Disease

  Alessi, D. (Investigator) & Sammler, E. (Investigator)

  1/11/18 → 31/12/20

  Project: Research

• Controlling mIcRobiomes CircuLations for bEtter food Systems (CIRCLES) (joint with Alma Mater Studiorum - Universita di Bologna as lead, PanepistimioThessalias, Bolton Alimentari and 26 others)

  Bulgarelli, D. (Investigator)

  COMMISSION OF THE EUROPEAN COMMUNITIES

  1/11/18 → 31/10/24

  Project: Research

  • Microbiota 100%
  • Microflora 100%
  • Rhizosphere Microbiome 75%
  • Barley 68%
  • Rhizosphere 54%

• Structural Mechanics in Cellular Substructure Formation (Sir Henry Dale Fellowship)

  Murray, D. (Investigator) & Storey, K. (Investigator)

  1/11/18 → 30/04/25

  Project: Research

  • Phosphoinositide 100%
  • Phosphoinositides 70%
  • PI(3,5)P2 40%
  • PIKfyve 40%
  • Drosophilidae 40%

• Polarity, membranes, and the Machinery that tethers

  Murray, D. (Investigator)

  5/10/18 → 4/10/19

  Project: Research

  • Phosphoinositide 100%
  • Phosphoinositides 55%
  • PIP5K1C 50%
  • PI(3,5)P2 50%
  • Phosphorylation Sites 50%

• Connecting and Expanding RIKENs Systems Science of Biological Dynamics and OMEs Image Data Resource Databases (International Travel Award)

  Swedlow, J. (Investigator)

  Biotechnology and Biological Sciences Research Council

  5/10/18 → 4/11/18

  Project: Research

  • Image Data 100%
  • Open Images 100%
  • Biological Image 100%
  • Global View 100%
  • Microscopy Data 100%

• The Image Data Resource: Making Biological Imaging Data FAIR (Joint with EMBL-EBI) (Biomedical Resources Grant)

  Swedlow, J. (Investigator)

  1/10/18 → 1/04/22

  Project: Research

  • Bioimaging 100%
  • Data Type 69%
  • File Format 46%
  • Microscopy Data 46%
  • Open Microscopy Environment 38%