School of Life Sciences

  • United Kingdom

Research Output 1968 2020

2020

A Modular Tray Growth System for Barley

Arrieta, M., Colas, I., Macaulay, M., Waugh, R. & Ramsay, L., 2020, Plant Meiosis: Methods and Protocols. Pradillo, M. & Heckmann, S. (eds.). New York: Humana Press, p. 367-379 13 p. (Methods in Molecular Biology; vol. 2061).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Hordeum
Meiosis
Growth
Genetic Recombination
Cell Biology
6 Downloads (Pure)
Open Access
File
Point Mutation
Proteins
Intellectual Disability
Mutation
Protein Folding

Following the Formation of Synaptonemal Complex Formation in Wheat and Barley by High-Resolution Microscopy

Darrier, B., Arrieta, M., Mittmann, S. U., Sourdille, P., Ramsay, L., Waugh, R. & Colas, I., 2020, Plant Meiosis: Methods and Protocols. Pradillo, M. & Heckmann, S. (eds.). New York: Humana Press, p. 207-215 9 p. (Methods in Molecular Biology; vol. 2061).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Synaptonemal Complex
Hordeum
Genetic Recombination
Triticum
Microscopy

Genetic Manipulation of Cryptosporidium parvum with CRISPR/Cas9

Sateriale, A., Pawlowic, M., Vinayak, S., Brooks, C. & Striepen, B., 2020, Cryptosporidium. Mead, J. R. & Arrowood, M. J. (eds.). New York: Humana Press, p. 219-228 10 p. (Methods in Molecular Biology; vol. 2052).

Research output: Chapter in Book/Report/Conference proceedingChapter

Clustered Regularly Interspaced Short Palindromic Repeats
Cryptosporidium parvum
Transfection
Infection

Improved models of the effects of winter chilling on blackcurrant (Ribes nigrum L.) show cultivar specific sensitivity to warm winters

Preedy, K., Brennan, R., Jones, H. & Gordon, S., 15 Jan 2020, In : Agricultural and Forest Meteorology. 280, p. 1-30 30 p., 107777.

Research output: Contribution to journalArticle

Ribes nigrum
black currants
cultivar
winter
cultivars

Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ

Harper, A. A., Rimmer, K., Dyavanapalli, J., McArthur, J. R. & Adams, D. J., 3 Jan 2020, In : Neuropharmacology. 165, p. 1-8 8 p., 107932.

Research output: Contribution to journalArticle

Ketamine
Nicotinic Receptors
Synaptic Transmission
Ganglia
Nicotine
1 Downloads (Pure)

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

Parker, M. T., Knop, K., Sherwood, A. V., Schurch, N. J., Mackinnon, K., Gould, P. D., Hall, A. JW., Barton, G. J. & Simpson, G. G., 14 Jan 2020, In : eLife. 9, p. 1-35 35 p., e49658.

Research output: Contribution to journalArticle

Open Access
File
Nanopores
RNA Sequence Analysis
Arabidopsis
RNA
Messenger RNA
5 Downloads (Pure)

Nature Connection in Early Childhood: A Quantitative Cross-Sectional Study

Barrable, A. & Booth, D., Jan 2020, In : Sustainability. 12, 1, p. 1-15 15 p., 375.

Research output: Contribution to journalArticle

Open Access
File
cross-sectional study
Sustainable development
Education
childhood
dose-response relationship

Neoproterozoic origin and multiple transitions to macroscopic growth in green seaweeds

Del Cortona, A., Jackson, C. J., Bucchini, F., Van Bel, M., D'hondt, S., Škaloud, P., Delwiche, C. F., Knoll, A. H., Raven, J. A., Verbruggen, H., Vandepoele, K., De Clerck, O. & Leliaert, F., 7 Jan 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 9 p.

Research output: Contribution to journalArticle

Seaweed
Ecosystem
Growth
Chlorophyta
Ice
12 Downloads (Pure)

Semi-automated quantitation of mitophagy in cells and tissues

Montava-Garriga, L., Singh, F., Ball, G. & Ganley, I., Jan 2020, In : Mechanisms of Ageing and Development. 185, p. 1-12 12 p., 111196.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Lysosomes
Mitochondria
Autophagy
Mitochondrial Membranes
15 Downloads (Pure)

Wnt regulates amino-acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos

Poncet, N., Halley, P., Lipina, C., Gierlinski, M., Dady, A., Singer, G., Febrer, M., Shi, Y-B., Yamaguchi, T. P., Taylor, P. & Storey, K., 7 Jan 2020, In : EMBO Reports. 21, 1, p. 1-20 20 p., e48469.

Research output: Contribution to journalArticle

Open Access
File
Amino Acid Transport Systems
Embryonic Structures
Morphogenesis
Tissue
Defects
2019

2D-DIGE as a tool in neuroproteomics

Weiland, F., 2019, Neuroproteomics. Li, K. W. (ed.). New York: Humana Press Inc., p. 143-159 17 p. (Neuromethods; vol. 146).

Research output: Chapter in Book/Report/Conference proceedingChapter

Two-Dimensional Difference Gel Electrophoresis
Neurology
Proteome
Electrophoresis
Protein Isoforms
32 Downloads (Pure)

A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites

Zhang, S., Sakuma, M., Deora, G. S., Levy, C. W., Klausing, A., Breda, C., Read, K. D., Edlin, C. D., Ross, B. P., Wright Muelas, M., Day, P. J., O'Hagan, S., Kell, D. B., Schwarcz, R., Leys, D., Heyes, D. J., Giorgini, F. & Scrutton, N. S., 24 Jul 2019, In : Communications Biology. 2, p. 1-10 10 p., 271.

Research output: Contribution to journalArticle

Open Access
File
Kynurenine 3-Monooxygenase
Kynurenine
Neurodegenerative Diseases
Huntington Disease
Prodrugs
35 Downloads (Pure)
Open Access
File
Heavy Metals
Catchments
Risk assessment
Heavy metals
Rivers
4 Citations (Scopus)
98 Downloads (Pure)

A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

Hannaford, M., Loyer, N., Tonelli, F., Zoltner, M. & Januschke, J., 29 Jan 2019, In : Development. 146, 2, p. 1-11 11 p., dev170589.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Phosphotransferases
Drosophila Proteins
Cell Polarity
Nuclear Envelope
2 Citations (Scopus)
91 Downloads (Pure)

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Autophagy
Vertebrates
Retina
Homeostasis
1 Citation (Scopus)
52 Downloads (Pure)

A comparison of mainstream genotyping platforms for the evaluation and use of barley genetic resources

Darrier, B., Russell, J., Milner, S. G., Hedley, P. E., Shaw, P. D., Macaulay, M., Ramsay, L., Halpin, C., Mascher, M., Fleury, D. L., Langridge, P., Stein, N. & Waugh, R., 26 Apr 2019, In : Frontiers in Plant Science. 10, p. 1-14 14 p., 544.

Research output: Contribution to journalArticle

Open Access
File
genetic resources
genotyping
single nucleotide polymorphism
barley
gene frequency
8 Downloads (Pure)

A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments

Luise, N., Wyatt, E. W., Tarver, G. & Wyatt, P., 14 Feb 2019, In : European Journal of Organic Chemistry. 2019, 6, p. 1341-1349 9 p.

Research output: Contribution to journalArticle

Open Access
File
fragments
synthesis
Hydrogenation
Quality control
Hydrogen
4 Citations (Scopus)
117 Downloads (Pure)

A critical comparison of technologies for a plant genome sequencing project

Paajanen, P., Kettleborough, G., Lopez-Girona, E., Giolai, M., Heavens, D., Baker, D., Lister, A., Wilde, G., Hein, I., Macaulay, I., Bryan, G. J. & Clark, M. D., 9 Jan 2019, In : Giga Science. 8, 3, p. 1-12 12 p., giy163.

Research output: Contribution to journalArticle

Open Access
File
Plant Genome
Genes
Genome
Technology
Benchmarking
3 Citations (Scopus)
76 Downloads (Pure)
Open Access
File
Stainless Steel
Polytetrafluoroethylene
Polytetrafluoroethylenes
titanium oxides
Titanium dioxide
1 Citation (Scopus)
188 Downloads (Pure)

Advances in targeted degradation of endogenous proteins

Roth, S., Fulcher, L. & Sapkota, G., 27 Apr 2019, In : Cellular and Molecular Life Sciences. 76, 14, p. 2761-2777 17 p.

Research output: Contribution to journalReview article

Open Access
File
Proteolysis
Proteins
Clustered Regularly Interspaced Short Palindromic Repeats
Gene Targeting
Protein Biosynthesis
1 Citation (Scopus)
22 Downloads (Pure)

A family of Type VI secretion system effector proteins that form ion-selective pores

Mariano, G., Trunk, K., Williams, D. J., Monlezun, L., Strahl, H., Pitt, S. J. & Coulthurst, S., 2 Dec 2019, In : Nature Communications. 10, 1, p. 1-15 15 p., 5484.

Research output: Contribution to journalArticle

Open Access
File
effectors
secretions
Genes
Ions
proteins

A fitness cost resulting from Hamiltonella defensa infection is associated with altered probing and feeding behaviour in Rhopalosiphum padi

Leybourne, D. J., Valentine, T. A., Bos, J. I. B. & Karley, A. J., 10 Dec 2019, In : Journal of Experimental Biology. 207936.

Research output: Contribution to journalArticle

Rhopalosiphum padi
Aphids
Feeding Behavior
feeding behavior
aphid
6 Citations (Scopus)

A Gadolinium Spin Label with Both a Narrow Central Transition and Short Tether for Use in Double Electron Electron Resonance Distance Measurements

Shah, A., Roux, A., Starck, M., Mosely, J. A., Stevens, M., Norman, D. G., Hunter, R. I., El Mkami, H., Smith, G. M., Parker, D. & Lovett, J. E., 4 Mar 2019, In : Inorganic Chemistry. 58, 5, p. 3015-3025 11 p.

Research output: Contribution to journalArticle

Electron resonance
Spin Labels
Distance measurement
Gadolinium
gadolinium
1 Citation (Scopus)
27 Downloads (Pure)

Aggregation of nontuberculous mycobacteria is regulated by carbon-nitrogen balance

Depas, W. H., Bergkessel, M. & Newman, D. K., Aug 2019, In : MBio. 10, 4, p. 1-17 17 p., e01715-19.

Research output: Contribution to journalArticle

Open Access
File
Nontuberculous Mycobacteria
Nitrogen
Carbon
Biofilms
Mycobacterium smegmatis
45 Downloads (Pure)

A highly mutagenised barley (cv. Golden Promise) TILLING population coupled with strategies for screening-by-sequencing

Schreiber, M., Barakate, A., Uzrek, N., Macaulay, M., Sourdille, A., Morris, J., Hedley, P. E., Ramsay, L. & Waugh, R., 24 Aug 2019, In : Plant Methods. 15, p. 1-14 14 p., 99.

Research output: Contribution to journalArticle

Open Access
File
Hordeum
barley
screening
mutation
Mutation
54 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Müller, B. & Connolly, B., Aug 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression
3 Citations (Scopus)
78 Downloads (Pure)

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., 5 Feb 2019, In : Scientific Reports. 9, 1, p. 1-11 11 p., 1407.

Research output: Contribution to journalArticle

Open Access
File
temozolomide
Precision Medicine
Glioblastoma
Brain Neoplasms
Doxorubicin
5 Citations (Scopus)
90 Downloads (Pure)

Albugo candida race diversity, ploidy and host-associated microbes revealed using DNA sequence capture on diseased plants in the field

Jouet, A., Saunders, D. G. O., McMullan, M., Ward, B., Furzer, O., Jupe, F., Cevik, V., Hein, I., Thilliez, G. J. A., Holub, E., Oosterhout, C. V. & Jones, J. D. G., 1 Feb 2019, In : New Phytologist. 221, 3, p. 1529-1543 15 p.

Research output: Contribution to journalArticle

Open Access
File
Albugo candida
Plant Diseases
Ploidies
ploidy
Candida

Allosteric mechanism for site-specific ubiquitination of FANCD2

Chaugule, V. K., Arkinson, C., Rennie, M. L., Kämäräinen, O., Toth, R. & Walden, H., 23 Dec 2019, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Allosteric Site
Fanconi Anemia
Ubiquitination
DNA Repair
Catalytic Domain
48 Downloads (Pure)

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice

Kline, R. A., Dissanayake, K. N., Hurtado, M. L., Martínez, N. W., Ahl, A., Mole, A. J., Lamont, D. J., Court, F. A., Ribchester, R. R., Wishart, T. M. & Murray, L. M., 1 Oct 2019, In : Neurobiology of Disease. 130, p. 1-16 16 p., 104496.

Research output: Contribution to journalArticle

Open Access
File
Wallerian Degeneration
Energy Metabolism
Axons
Oxidative Phosphorylation
Wounds and Injuries

Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane

Dantas, L. L. B., Calixto, C. P. G., Dourado, M. M., Carneiro, M. S., Brown, J. W. S. & Hotta, C. T., 23 Dec 2019, In : Frontiers in Plant Science. 10, p. 1-15 15 p., 1614.

Research output: Contribution to journalArticle

Open Access
File
alternative splicing
circadian rhythm
sugarcane
temperature
genes
2 Citations (Scopus)
39 Downloads (Pure)
Open Access
File
Carbonates
Nanoparticles
Fungi
Minerals
Amino Acids
15 Downloads (Pure)

Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA

Gottschald Chiodi, C., Baptista-Hon, D., Hunter, W. & Hales, T., 15 Feb 2019, In : Journal of Biological Chemistry. 294, 7, p. 2375-2385 11 p.

Research output: Contribution to journalArticle

Open Access
File
GABA-A Receptors
Amino Acid Substitution
gamma-Aminobutyric Acid
Substitution reactions
Chemical activation
1 Citation (Scopus)

A missense mutation in the catalytic domain of O-GlcNAc transferase links perturbations in protein O-GlcNAcylation to X-linked intellectual disability

Pravata, V. M., Gundogdu, M., Bartual, S. G., Ferenbach, A. T., Stavridis, M., Õunap, K., Pajusalu, S., Žordania, R., Wojcik, M. H. & van Aalten, D. M. F., 7 Nov 2019, In : FEBS Letters.

Research output: Contribution to journalArticle

Missense Mutation
Intellectual Disability
Catalytic Domain
X ray crystallography
Stem cells

Analysis of DrkA kinase's role in STATa activation

Saga, Y., Iwade, Y., Araki, T., Ishikawa, M. & Kawata, T., 17 Jun 2019, In : Genes to Cells. 24, 6, p. 422-435 14 p.

Research output: Contribution to journalArticle

Phosphotransferases
Tyrosine
Dictyostelium
Phosphorylation
Protein-Tyrosine Kinases
92 Downloads (Pure)
Open Access
File
Methylenetetrahydrofolate Dehydrogenase (NADP)
dehydrogenases
inhibitors
Ligands
enzymes
1 Citation (Scopus)
64 Downloads (Pure)

A New Front in Microbial Warfare—Delivery of Antifungal Effectors by the Type VI Secretion System

Trunk, K., Coulthurst, S. & Quinn, J., Jun 2019, In : Journal of Fungi. 5, 2, p. 1-13 13 p., 50.

Research output: Contribution to journalReview article

Open Access
File
Weapons
Fungi
Microbiota
Autophagy
Gram-Negative Bacteria
1 Citation (Scopus)
46 Downloads (Pure)

An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials

Henderson, C. J., Kapelyukh, Y., Scheer, N., Rode, A., McLaren, A., MacLeod, K., Lin, D., Wright, J., Stanley, L. A. & Wolf, C. R., Jun 2019, In : Drug Metabolism and Disposition. 47, 6, p. 601-615 15 p.

Research output: Contribution to journalArticle

Open Access
File
Drug Interactions
Clinical Trials
Pharmaceutical Preparations
Pharmacokinetics
Cytochrome P-450 CYP3A
1 Citation (Scopus)
42 Downloads (Pure)

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Schmidt, N., Domingues, P., Golebiowski, F., Patzina, C., Tatham, M. H., Hay, R. T. & Hale, B. G., 27 Aug 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 35, p. 17399-17408 10 p.

Research output: Contribution to journalArticle

Open Access
File
Endogenous Retroviruses
Ubiquitin
Orthomyxoviridae
Antiviral Agents
Immunity
7 Citations (Scopus)
66 Downloads (Pure)

Antigen receptor control of methionine metabolism in T cells

Sinclair, L. V., Howden, A., Brenes Murillo, A., Spinelli, L., Hukelmann, J., Macintyre, A. N., Liu, X., Thomson, S., Taylor, P., Rathmell, J. C., Locasale, J. W., Lamond, A. & Cantrell, D. A., 27 Mar 2019, In : eLife. 8, 29 p., e44210.

Research output: Contribution to journalArticle

Open Access
File
Antigen Receptors
T-cells
Metabolism
Methionine
T-Lymphocytes
1 Citation (Scopus)
41 Downloads (Pure)

APETALA2 control of barley internode elongation

Patil, V., McDermott, H. I., Mcallister, T., Cummins, M., Clara Silva, J., Mollison, E., Meikle, R., Morris, J. A., Hedley, P. E., Waugh, R., Dockter, C., Hansson, M. & McKim, S., 12 Jun 2019, In : Development. 146, 11, p. 1-16 16 p., 170373.

Research output: Contribution to journalArticle

Open Access
File
Gibberellins
Hordeum
Inflorescence
Growth
MicroRNAs
12 Downloads (Pure)

A platform for target prediction of phenotypic screening hit molecules

Homeyer, N., van Deursen, R., Ochoa-Montaño, B., Heikamp, K., Ray, P., Zuccotto, F., Blundell, T. L. & Gilbert, I. H., 24 Oct 2019, In : Journal of Molecular Graphics & Modelling. 95, p. 1-9 9 p., 107485.

Research output: Contribution to journalArticle

Open Access
File
Screening
screening
platforms
Ligands
Proteins
20 Downloads (Pure)

A post-transcriptional respiratome regulon in trypanosomes

Trenaman, A., Glover, L., Hutchinson, S. & Horn, D., 26 Jul 2019, In : Nucleic Acids Research. 47, 13, p. 7063-7077 15 p.

Research output: Contribution to journalArticle

Open Access
File
Regulon
Trypanosomiasis
Membrane Glycoproteins
Trypanosoma brucei brucei
RNA-Binding Proteins
64 Downloads (Pure)

Application of a Sensitive and Reproducible Label-Free Proteomic Approach to Explore the Proteome of Individual Meiotic-Phase Barley Anthers

Lewandowska, D., Zhang, R., Colas, I., Uzrek, N. & Waugh, R., 2 Apr 2019, In : Frontiers in Plant Science. 10, p. 1-15 15 p., 393.

Research output: Contribution to journalArticle

Open Access
File
proteome
proteomics
anthers
meiosis
barley

A Practical Guide to Barley Crossing

Thomas, W. T. B., Bull, H., Booth, A., Hamilton, R., Forster, B. P. & Franckowiak, J. D., 1 Jan 2019, Barley: Methods and Protocols. Harwood, W. A. (ed.). New York: Humana Press, Vol. 1900. p. 21-36 16 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Hordeum
Inbreeding
Pollen
Seeds
1 Citation (Scopus)

Arsenic Toxicity: An Arsenic-Hyperaccumulating Fern Uses a Bacterial-like Tolerance Mechanism

Gadd, G. M., 17 Jun 2019, In : Current Biology. 29, 12, p. R580-R582 3 p.

Research output: Contribution to journalArticle

Ferns
Arsenic
arsenic
ferns and fern allies
Toxicity

Association mapping and genetic dissection of drought-induced canopy temperature differences in rice

Melandri, G., Prashar, A., Mccouch, S. R., Van Der Linden, G., Jones, H. G., Kadam, N., Jagadish, K., Bouwmeester, H. & Ruyter-Spira, C., 17 Dec 2019, In : Journal of Experimental Botany. erz527.

Research output: Contribution to journalArticle

Open Access
Droughts
chromosome mapping
Dissection
drought
canopy
Ligand-Gated Ion Channels
Bicuculline
Glycine
Glycine Receptors
Carrier Proteins
4 Citations (Scopus)
70 Downloads (Pure)

Aurora B–INCENP localization at centromeres/inner kinetochores is required for chromosome bi-orientation in budding yeast

García-Rodríguez, L. J., Kasciukovic, T., Denninger, V. & Tanaka, T., 6 May 2019, In : Current Biology. 29, 9, p. 1536-1544.e4 13 p.

Research output: Contribution to journalArticle

Open Access
File
Kinetochores
kinetochores
Saccharomycetales
Centromere
centromeres