School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
3 Citations (Scopus)
81 Downloads (Pure)

A call for public archives for biological image data

Ellenberg, J., Swedlow, J. R., Barlow, M., Cook, C. E., Sarkans, U., Patwardhan, A., Brazma, A. & Birney, E., 30 Oct 2018, In : Nature Methods. 15, 11, p. 849-854 6 p.

Research output: Contribution to journalArticle

Open Access
File
Bioinformatics
Imaging techniques
Computational Biology
Databases
Technology
38 Citations (Scopus)
110 Downloads (Pure)

Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2

Lang, E., Bissinger, R., Fajol, A., Salker, M. S., Singh, Y., Zelenak, C., Ghashghaeinia, M., Gu, S., Jilani, K., Lupescu, A., Reyskens, K. M. S. E., Ackermann, T. F., Föller, M., Schleicher, E., Sheffield, W. P., Arthur, J. S. C., Lang, F. & Qadri, S. M., 27 Nov 2015, In : Scientific Reports. 5, p. 1-10 10 p., 17316.

Research output: Contribution to journalArticle

Open Access
File
Mitogens
Phosphotransferases
Erythrocytes
Phosphatidylserines
Shock
6 Citations (Scopus)
139 Downloads (Pure)

Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

Rost, F., Rodrigo Albors, A., Mazurov, V., Brusch, L., Deutsch, A., Tanaka, E. M. & Chara, O., 25 Nov 2016, In : eLife. p. 1-16 16 p., e20537.

Research output: Contribution to journalArticle

Open Access
File
Ambystoma mexicanum
Cell Division
Spinal Cord
Stem cells
Cells
3 Citations (Scopus)
147 Downloads (Pure)

Accelerating root system phenotyping of seedlings through a computer-assisted processing pipeline

Dupuy, L. X., Wright, G., Thompson, J. A., Taylor, A., Dekeyser, S., White, C. P., Thomas, W. T. B., Nightingale, M., Hammond, J. P., Graham, N. S., Thomas, C. L., Broadley, M. R. & White, P. J., 13 Jul 2017, In : Plant Methods. 13, p. 1-14 14 p., 57.

Research output: Contribution to journalArticle

Open Access
File
Seedlings
root systems
Plant Roots
phenotype
Costs and Cost Analysis
35 Downloads (Pure)
Open Access
File
Heavy Metals
Catchments
Risk assessment
Heavy metals
Rivers
23 Citations (Scopus)

Accurate discretization of advection-diffusion equations

Grima, R. & Newman, T. J., 16 Sep 2004, In : Physical Review E: Statistical, Nonlinear, and Soft Matter Physics. 70, 3 , 036703.

Research output: Contribution to journalArticle

Advection-diffusion Equation
advection
Discretization
Advection-diffusion
Master Equation
17 Citations (Scopus)
81 Downloads (Pure)

Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication

Reverón-Gómez, N., González-Aguilera, C., Stewart-Morgan, K. R., Petryk, N., Flury, V., Graziano, S., Johansen, J. V., Jakobsen, J. S., Alabert, C. & Groth, A., 18 Oct 2018, In : Molecular Cell. 72, 2, p. 239-249.e5

Research output: Contribution to journalArticle

Open Access
File
Histone Code
Recycling
DNA Replication
Histones
Post Translational Protein Processing
135 Citations (Scopus)

A cdc2-like protein is involved in the initiation of DNA replication in Xenopus egg extracts

Blow, J. J. & Nurse, P., 7 Sep 1990, In : Cell. 62, 5, p. 855-862 8 p.

Research output: Contribution to journalArticle

CDC2 Protein Kinase
Xenopus
DNA Replication
Ovum
DNA

A cDNA encoding rabbit muscle protein phosphatase 1 alpha complements the Aspergillus cell cycle mutation, bimG11

Doonan, J. H., MacKintosh, C., Osmani, S., Cohen, P., Bai, G., Lee, E. Y. & Morris, N. R., 1991, In : Journal of Biological Chemistry. 266, 28, p. 18889-18894 6 p.

Research output: Contribution to journalArticle

95 Citations (Scopus)

A cell cycle regulatory network controlling NF-B subunit activity and function

Barre, B. & Perkins, N., 2007, In : The EMBO Journal. 26, 23, p. 4841-4855 15 p.

Research output: Contribution to journalArticle

Phosphorylation
G1 Phase
Cell Cycle
Genes
G2 Phase
1914 Citations (Scopus)

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

Hutvagner, G., McLachlan, J., Pasquinelli, A. E., Balint, E., Tuschl, T. & Zamore, P. D., 2001, In : Science. 293, 5531, p. 834-838 5 p.

Research output: Contribution to journalArticle

Ribonuclease III
RNA Interference
MicroRNAs
RNA
RNA Precursors
27 Citations (Scopus)
241 Downloads (Pure)

Acetazolamide-based fungal chitinase inhibitors

Schuettelkopf, A. W., Gros, L., Blair, D. E., Frearson, J. A., van Aalten, D. M. F. & Gilbert, I. H., 1 Dec 2010, In : Bioorganic & Medicinal Chemistry. 18, 23, p. 8334-8340 7 p.

Research output: Contribution to journalArticle

Open Access
File
57 Citations (Scopus)
309 Downloads (Pure)

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription

Di Cerbo, V., Mohn, F., Ryan, D. P., Montellier, E., Kacem, S., Tropberger, P., Kallis, E., Holzner, M., Hoerner, L., Feldmann, A., Richter, F. M., Bannister, A. J., Mittler, G., Michaelis, J., Khochbin, S., Feil, R., Schuebeler, D., Owen-Hughes, T., Daujat, S. & Schneider, R., 25 Mar 2014, In : eLife. 3, e01632.

Research output: Contribution to journalArticle

Open Access
File
Acetylation
Nucleosomes
Transcription
Histones
Lysine
45 Citations (Scopus)

Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei

Siegel, T. N., Kawahara, T., DeGrasse, J. A., Janzen, C. J., Horn, D. & Cross, G. A. M., Feb 2008, In : Molecular Microbiology. 67, 4, p. 762-771 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
101 Downloads (Pure)

A chemical-genetics approach to study the role of atypical Protein Kinase C in Drosophila

Hannaford, M., Loyer, N., Tonelli, F., Zoltner, M. & Januschke, J., 29 Jan 2019, In : Development. 146, 2, p. 1-11 11 p., dev170589.

Research output: Contribution to journalArticle

Open Access
File
Drosophila
Phosphotransferases
Drosophila Proteins
Cell Polarity
Nuclear Envelope
11 Citations (Scopus)

A chemo-genetic approach for the study of nucleobase participation in nucleolytic ribozymes

Lilley, D. M. J., Jul 2007, In : Biological Chemistry. 388, 7, p. 699-704 6 p.

Research output: Contribution to journalArticle

Catalytic RNA
Ligation
Catalysis
Acids
Nucleosides
21 Citations (Scopus)

A 'chemotactic dipole' mechanism for large-scale vortex motion during primitive streak formation in the chick embryo

Sandersius, S. A., Chuai, M., Weijer, C. J. & Newman, T. J., Aug 2011, In : Physical Biology. 8, 4, 11 p., 045008.

Research output: Contribution to journalArticle

79 Citations (Scopus)

A chloroplast retrograde signal regulates nuclear alternative splicing

Petrillo, E., Godoy Herz, M. A., Fuchs, A., Reifer, D., Fuller, J., Yanovsky, M. J., Simpson, C., Brown, J. W. S., Barta, A., Kalyna, M. & Kornblihtt, A. R., 25 Apr 2014, In : Science. 344, 6182, p. 427-30 4 p.

Research output: Contribution to journalArticle

Alternative Splicing
Chloroplasts
Light
Plastoquinone
Physiological Adaptation
52 Citations (Scopus)
179 Downloads (Pure)

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

Swamy, M., Beck-Garcia, K., Beck-Garcia, E., Hartl, F. A., Morath, A., Yousefi, O. S., Dopfer, E. P., Molnár, E., Schulze, A. K., Blanco, R., Borroto, A., Martín-Blanco, N., Alarcon, B., Höfer, T., Minguet, S. & Schamel, W. W. A., 17 May 2016, In : Immunity. 44, 5, p. 1091-1101 11 p.

Research output: Contribution to journalArticle

Open Access
File
T-Cell Antigen Receptor
Cholesterol
Phosphorylation
Allosteric Regulation
Adaptive Immunity
807 Citations (Scopus)

A chromosome-based draft sequence of the hexaploid bread wheat (Triticum aestivum) genome

The International Wheat Genome Sequencing Consortium (IWGSC), 18 Jul 2014, In : Science. 345, 6194, 11 p., 1251788.

Research output: Contribution to journalArticle

Bread
Triticum
Chromosomes
Genome
Genes
332 Citations (Scopus)
181 Downloads (Pure)

A chromosome conformation capture ordered sequence of the barley genome

Mascher, M., Gundlach, H., Himmelbach, A., Beier, S., Twardziok, S. O., Wicker, T., Radchuk, V., Dockter, C., Hedley, P. E., Russell, J., Bayer, M., Ramsay, L., Liu, H., Haberer, G., Zhang, X-Q., Zhang, Q., Barrero, R. A., Li, L., Taudien, S., Groth, M. & 56 others, Felder, M., Hastie, A., Šimková, H., Staňková, H., Vrána, J., Chan, S., Muñoz-Amatriaín, M., Ounit, R., Wanamaker, S., Bolser, D., Colmsee, C., Schmutzer, T., Aliyeva-Schnorr, L., Grasso, S., Tanskanen, J., Chailyan, A., Sampath, D., Heavens, D., Clissold, L., Cao, S., Chapman, B., Dai, F., Han, Y., Li, H., Li, X., Lin, C., McCooke, J. K., Tan, C., Wang, P., Wang, S., Yin, S., Zhou, G., Poland, J. A., Bellgard, M. I., Borisjuk, L., Houben, A., Doležel, J., Ayling, S., Lonardi, S., Kersey, P., Langridge, P., Muehlbauer, G. J., Clark, M. D., Caccamo, M., Schulman, A. H., Mayer, K. F. X., Platzer, M., Close, T. J., Scholz, U., Hansson, M., Zhang, G., Braumann, I., Spannagl, M., Li, C., Waugh, R. & Stein, N., 27 Apr 2017, In : Nature. 544, 7651, p. 427-433 7 p.

Research output: Contribution to journalArticle

Open Access
File
Hordeum
Chromosomes
Genome
Food
Gene Duplication
7 Citations (Scopus)

A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870

Edgar, A. J., Trost, M., Watts, C. & Zaru, R., 17 Dec 2013, In : Bioscience Reports.

Research output: Contribution to journalArticle

Labeling
Nucleotides
Phosphates
Phosphotransferases
Dendritic Cells
33 Citations (Scopus)

A comparative analysis of transcript abundance using SAGE and Affymetrix arrays

Ibrahim, A. F. M., Hedley, P. E., Cardle, L., Kruger, W., Marshall, D. F., Muehlbauer, G. J. & Waugh, R., 1 Jul 2005, In : Functional and Integrative Genomics. 5, 3, p. 163-174 12 p.

Research output: Contribution to journalArticle

Gene Expression
Gene Expression Profiling
Hordeum
Libraries
Embryonic Structures
2 Citations (Scopus)
91 Downloads (Pure)

A comparative map of macroautophagy and mitophagy in the vertebrate eye

McWilliams, T. G., Prescott, A., Villarejo-Zori, B., Ball, G., Boya, P. & Ganley, I., 1 Jul 2019, In : Autophagy. 15, 7, p. 1296-1308 13 p.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial Degradation
Autophagy
Vertebrates
Retina
Homeostasis
55 Citations (Scopus)

A comparative study of methylglyoxal metabolism in trypanosomatids

Greig, N., Wyllie, S., Patterson, S. & Fairlamb, A. H., Jan 2009, In : FEBS Journal. 276, 2, p. 376-386 11 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry

Kajbaf, M., Longhi, R., Montanari, D., Vinco, F., Rigo, M., Fontano, S. & Read, K. D., 2012, In : Drug Metabolism Letters. 5, 1, p. 30-39 10 p.

Research output: Contribution to journalArticle

Drug Industry
Drug interactions
Assays
Microsomes
Fluorescence
29 Citations (Scopus)

A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major

König, J. & Fairlamb, A. H., Nov 2007, In : FEBS Journal. 274, 21, p. 5643-5658 16 p.

Research output: Contribution to journalArticle

Leishmania major
Peroxidase
Peroxides
Glutathione Peroxidase
Hydrogen Peroxide
3 Citations (Scopus)

A comparison of in vitro nucleosome positioning mapped with chicken, frog and a variety of yeast core histones

Allan, J., Fraser, R. M., Owen-Hughes, T., Docherty, K. & Singh, V., 15 Nov 2013, In : Journal of Molecular Biology. 425, 22, p. 4206-4222 17 p.

Research output: Contribution to journalArticle

Nucleosomes
Anura
Histones
Chickens
Yeasts
1 Citation (Scopus)
55 Downloads (Pure)

A comparison of mainstream genotyping platforms for the evaluation and use of barley genetic resources

Darrier, B., Russell, J., Milner, S. G., Hedley, P. E., Shaw, P. D., Macaulay, M., Ramsay, L., Halpin, C., Mascher, M., Fleury, D. L., Langridge, P., Stein, N. & Waugh, R., 26 Apr 2019, In : Frontiers in Plant Science. 10, p. 1-14 14 p., 544.

Research output: Contribution to journalArticle

Open Access
File
genetic resources
genotyping
single nucleotide polymorphism
barley
gene frequency
9 Citations (Scopus)

A comparison of SCOP and CATH with respect to domain-domain interactions

Jefferson, E. R., Walsh, T. P. & Barton, G. J., Jan 2008, In : Proteins: Structure, Function, and Bioinformatics. 70, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

52 Citations (Scopus)

A computational study of discrete mechanical tissue models

Pathmanathan, P., Cooper, J., Fletcher, A., Mirams, G., Murray, P., Osborne, J., Pitt-Francis, J., Walter, A. & Chapman, S. J., 15 Apr 2009, In : Physical Biology. 6, 3, 036001.

Research output: Contribution to journalArticle

Cell Communication
Cell Division
Plastics
Growth
15 Citations (Scopus)
129 Downloads (Pure)

A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex

Di Santo, R., Bandau, S. & Stark, M. J. R., Jun 2014, In : Molecular Microbiology. 92, 6, p. 1227-1242 16 p.

Research output: Contribution to journalArticle

Open Access
File
Transfer RNA
Saccharomyces cerevisiae
Uridine
Eukaryota
Familial Dysautonomia
365 Citations (Scopus)

A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans

Gartner, A., Milstein, S., Ahmed, S., Hodgkin, J. & Hengartner, M. O., 2000, In : Molecular Cell. 5, 3, p. 435-443 9 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
DNA Damage
Apoptosis
Germ Cells
Cell Death
22 Citations (Scopus)

A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome

Kilkenny, M. L., De Piccoli, G., Perera, R. L., Labib, K. & Pellegrini, L., 6 Jul 2012, In : Journal of Biological Chemistry. 287, 28, p. 23740-23747 8 p.

Research output: Contribution to journalArticle

DNA Primase
DNA-Directed DNA Polymerase
Tail
Yeast
Yeasts
49 Citations (Scopus)

A conserved Myc protein domain, MBIV, regulates DNA binding, apoptosis, transformation, and G2 arrest

Cowling, V. H., Chandriani, S., Whitfield, M. L. & Cole, M. D., Jun 2006, In : Molecular and Cellular Biology. 26, 11, p. 4226-4239 14 p.

Research output: Contribution to journalArticle

Apoptosis
DNA
Transcriptional Activation
myc Genes
Chromatin Immunoprecipitation
26 Citations (Scopus)
103 Downloads (Pure)

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

García-Rodríguez, L. J., De Piccoli, G., Marchesi, V., Jones, R. C., Edmondson, R. D. & Labib, K., 15 Oct 2015, In : Nucleic Acids Research. 43, 18, p. 8830-8838

Research output: Contribution to journalArticle

Open Access
File
S Phase Cell Cycle Checkpoints
Saccharomycetales
Phosphotransferases
DNA Polymerase II
Mutation
43 Citations (Scopus)

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smo

Stasiulewicz, M., Gray, S. D., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, P. A., Booth, D., Thompson, C., Green, R. J., Hall, E. A., Serup, P. & Dale, J. K., 1 Jul 2015, In : Development. 142, 3, p. 2291-2303 13 p.

Research output: Contribution to journalArticle

Cilia
Transducers
Neuroepithelial Cells
Notochord
Neural Tube
15 Citations (Scopus)
Protein Kinases
Dictyostelium
Cysts
Cyclic AMP-Dependent Protein Kinases
Spores
9 Downloads (Pure)

A Continuous Flow Strategy for the Facile Synthesis and Elaboration of Semi-Saturated Heterobicyclic Fragments

Luise, N., Wyatt, E. W., Tarver, G. & Wyatt, P., 14 Feb 2019, In : European Journal of Organic Chemistry. 2019, 6, p. 1341-1349 9 p.

Research output: Contribution to journalArticle

Open Access
File
fragments
synthesis
Hydrogenation
Quality control
Hydrogen
85 Citations (Scopus)

A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response

Chandriani, S., Frengen, E., Cowling, V. H., Pendergrass, S. A., Perou, C. M., Whitfield, M. L. & Cole, M. D., 2009, In : PLoS ONE. 4, 8, e6693.

Research output: Contribution to journalArticle

Transcriptome
Gene expression
breast neoplasms
Genes
Breast Neoplasms
8 Citations (Scopus)
133 Downloads (Pure)
Open Access
File
phylogeny
genome
protein
proteins
Dictyostelium
19 Citations (Scopus)

A Correlated Study of Metabolic Cell Communication and Gap Junction Distribution in the Adult Frog Lens

Prescott, A., Duncan, G., Van Marle, J. & Vrensen, G., Jun 1994, In : Experimental Eye Research. 58, 6, p. 737-746 10 p.

Research output: Contribution to journalArticle

Intercellular Junctions
Gap Junctions
Cell Communication
Anura
Lenses
22 Citations (Scopus)
127 Downloads (Pure)

Acoustic devices for particle and cell manipulation and sensing

Qiu, Y., Wang, H., Demore, C. E. M., Hughes, D. A., Glynne-Jones, P., Gebhardt, S., Bolhovitins, A., Poltarjonoks, R., Weijer, K., Schönecker, A., Hill, M. & Cochran, S., 2014, In : Sensors. 14, 8, p. 14806-14838 33 p.

Research output: Contribution to journalArticle

Open Access
File
Acoustic devices
Acoustics
Ultrasonics
manipulators
Ultrasonic transducers
3 Citations (Scopus)
281 Downloads (Pure)

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Stewart, F. R., Qiu, Y., Lay, H. S., Newton, I. P., Cox, B. F., Al-Rawhani, M. A., Beeley, J., Liu, Y., Huang, Z., Cumming, D. R. S., Näthke, I. & Cochran, S., 3 Jul 2017, In : Sensors. 17, 7, p. 1-24 24 p., 1553.

Research output: Contribution to journalArticle

Open Access
File
Capsule Endoscopy
Endoscopy
capsules
Drug delivery
Acoustics
57 Citations (Scopus)
113 Downloads (Pure)

Acquisition and evolution of plant pathogenesis-associated gene clusters and candidate determinants of tissue-specificity in Xanthomonas

Lu, H., Patil, P., Van Sluys, M-A., White, F. F., Ryan, R. P., Dow, J. M., Rabinowicz, P., Salzberg, S. L., Leach, J. E., Sonti, R., Brendel, V. & Bogdanove, A. J., 27 Nov 2008, In : PLoS ONE. 3, 11, 13 p.

Research output: Contribution to journalArticle

Open Access
File
Xanthomonas
Organ Specificity
Multigene Family
multigene family
pathogenesis
52 Citations (Scopus)
126 Downloads (Pure)

A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids

Beneke, T., Madden, R., Makin, L., Valli, J., Sunter, J. & Gluenz, E., 3 May 2017, In : Royal Society Open Science. 4, 5, p. 1-16 16 p.

Research output: Contribution to journalArticle

Open Access
File
Clustered Regularly Interspaced Short Palindromic Repeats
Genes
Transfection
DNA
Guide RNA
12 Citations (Scopus)
185 Downloads (Pure)
Open Access
File
Base Pairing
Riboswitch
RNA
Hydrogen Bonding
Ribosomes
23 Citations (Scopus)
91 Downloads (Pure)

A critical base pair in k-turns that confers folding characteristics and correlates with biological function

McPhee, S. A., Huang, L. & Lilley, D. M. J., 29 Oct 2014, In : Nature Communications. 5, 6 p., 5127.

Research output: Contribution to journalArticle

Open Access
File
Riboswitch
Base Pairing
folding
Metal ions
Ions
4 Citations (Scopus)
117 Downloads (Pure)

A critical comparison of technologies for a plant genome sequencing project

Paajanen, P., Kettleborough, G., Lopez-Girona, E., Giolai, M., Heavens, D., Baker, D., Lister, A., Wilde, G., Hein, I., Macaulay, I., Bryan, G. J. & Clark, M. D., 9 Jan 2019, In : Giga Science. 8, 3, p. 1-12 12 p., giy163.

Research output: Contribution to journalArticle

Open Access
File
Plant Genome
Genes
Genome
Technology
Benchmarking
88 Citations (Scopus)

A crowdsourcing evaluation of the NIH chemical probes

Oprea, T. I., Bologa, C. G., Boyer, S., Curpan, R. F., Glen, R. C., Hopkins, A. L., Lipinski, C. A., Marshall, G. R., Martin, Y. C., Ostopovici-Halip, L., Rishton, G., Ursu, O., Vaz, R. J., Waller, C., Waldmann, H. & Sklar, L. A., Jul 2009, In : Nature Chemical Biology. 5, 7, p. 441-447 7 p.

Research output: Contribution to journalArticle