School of Life Sciences

  • United Kingdom

Research Output 1968 2020

Article
9 Citations (Scopus)

Algae

Raven, J. A. & Giordano, M., 7 Jul 2014, In : Current Biology. 24, 13, p. R590-R595 6 p.

Research output: Contribution to journalArticle

algae
Algae
Eutrophication
Whales
Seaweed
202 Citations (Scopus)
185 Downloads (Pure)

Algae as nutritional and functional food sources: revisiting our understanding

Wells, M. L., Potin, P., Craigie, J. S., Raven, J. A., Merchant, S. S., Helliwell, K. E., Smith, A. G., Camire, M. E. & Brawley, S. H., Apr 2017, In : Journal of Applied Phycology. 29, 2, p. 949-982 34 p.

Research output: Contribution to journalArticle

Open Access
File
algae
functional foods
nutritive value
alga
food preparation
55 Citations (Scopus)

Algae influence the hydrophysical parameters of a sandy soil

Lichner, L., Hallett, P. D., Drongová, Z., Czachor, H., Kovacik, L., Mataix-Solera, J. & Homolák, M., Sep 2013, In : CATENA. 108, p. 58-68 11 p.

Research output: Contribution to journalArticle

sandy soil
alga
sand
crust
soil crust
6 Citations (Scopus)

Algal biogeography: Metagenomics shows distribution of a picoplanktonic pelagophyte

Raven, J. A., 2012, In : Current Biology. 22, 17

Research output: Contribution to journalArticle

algae
Chloroplast Genome
Metagenomics
Algae
Microorganisms
20 Citations (Scopus)

Alignment-free design of highly discriminatory diagnostic primer sets for Escherichia coli O104: H4 outbreak strains

Pritchard, L., Holden, N. J., Bielaszewska, M., Karch, H. & Toth, I. K., 5 Apr 2012, In : PLoS ONE. 7, 4, 8 p., e34498.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Alignment of an acoustic manipulation device with cepstral analysis of electronic impedance data

Hughes, D. A., Qiu, Y., Démoré, C., Weijer, C. J. & Cochran, S., Feb 2015, In : Ultrasonics. 56, p. 172-177 6 p.

Research output: Contribution to journalArticle

cepstral analysis
manipulators
resonators
alignment
impedance
3 Citations (Scopus)
118 Downloads (Pure)

Allelic diversity of S-RNase alleles in diploid potato species

Dzidzienyo, D. K., Bryan, G. J., Wilde, G. & Robbins, T. P., Oct 2016, In : Theoretical and Applied Genetics. 129, 10, p. 1985-2001 17 p.

Research output: Contribution to journalArticle

Open Access
File
ribonucleases
Solanum tuberosum
Diploidy
diploidy
Solanum okadae
12 Citations (Scopus)

Allelic variation at Fr-H1/Vrn-H1 and Fr-H2 loci is the main determinant of frost tolerance in spring barley

Tondelli, A., Pagani, D., Ghafoori, I. N., Rahimi, M., Ataei, R., Rizza, F., Flavell, A. J. & Cattivelli, L., 1 Oct 2014, In : Environmental and Experimental Botany. 106, p. 148-155 8 p.

Research output: Contribution to journalArticle

frost resistance
spring barley
frost
barley
chromosome mapping
32 Citations (Scopus)
49 Downloads (Pure)

Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog

Nguyen, S., Jones, D. C., Wyllie, S., Fairlamb, A. H. & Phillips, M. A., 24 May 2013, In : Journal of Biological Chemistry. 288, 21, p. 15256-15267 12 p.

Research output: Contribution to journalArticle

Open Access
File
Spermidine
Eflornithine
Chemical activation
Biosynthesis
Polyamines
15 Citations (Scopus)

Allosteric competitive inhibitors of the glucose-1-phosphate Thymidylyltransferase (RmlA) from  seudomonas aeruginosa

Alphey, M. S., Pirrie, L., Torrie, L. S., Boulkeroua, W. A., Gardiner, M., Sarkar, A., Maringer, M., Oehlmann, W., Brenk, R., Scherman, M. S., McNeil, M., Rejzek, M., Field, R. A., Singh, M., Gray, D., Westwood, N. J. & Naismith, J. H., 2012, In : ACS Chemical Biology.

Research output: Contribution to journalArticle

glucose-1-phosphate thymidylyltransferase
Rhamnose
Mycobacterium tuberculosis
Pseudomonas aeruginosa
Catalytic Domain

Allosteric mechanism for site-specific ubiquitination of FANCD2

Chaugule, V. K., Arkinson, C., Rennie, M. L., Kämäräinen, O., Toth, R. & Walden, H., 23 Dec 2019, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Allosteric Site
Fanconi Anemia
Ubiquitination
DNA Repair
Catalytic Domain
4 Citations (Scopus)
131 Downloads (Pure)

Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening

Morreale, F., Bortoluzzi, A., Chaugule, V., Arkinson, C., Walden, H. & Ciulli, A., 11 May 2017, In : Journal of Medicinal Chemistry. 60, 9, p. 4093-4098 6 p.

Research output: Contribution to journalArticle

Open Access
File
Ubiquitin-Conjugating Enzymes
Fanconi Anemia
Ubiquitin
DNA Repair
Binding Sites
2 Citations (Scopus)
51 Downloads (Pure)

AlmostSignificant: simplifying quality control of high-throughput sequencing data

Ward, J., Cole, C., Febrer, M. & Barton, G. J., 15 Dec 2016, In : Bioinformatics. 32, 24, p. 3850-3851 2 p.

Research output: Contribution to journalArticle

Open Access
File
Quality Control
DNA Sequence Analysis
Sequencing
High Throughput
Quality control
91 Citations (Scopus)
1084 Citations (Scopus)

ALSCRIPT: a tool to format multiple sequence alignments

Barton, G. J., Jan 1993, In : Protein Science. 6, 1, p. 37-40 4 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)

Alterations on the growth and ultrastructure of Leishmania chagasi induced by squalene synthase inhibitors

Granthon, A. C., Braga, M. V., Rodrigues, J. C. F., Cammerer, S., Lorente, S. O., Gilbert, I. H., Urbina, J. A. & de Souza, W., 15 May 2007, In : Veterinary Parasitology. 146, 1-2, p. 25-34 10 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Altered aggregation properties of mutant γ-crystallins cause inherited cataract

Sandilands, A., Hutcheson, A. M., Long, H. A., Prescott, A. R., Vrensen, G., Loster, J., Klopp, N., Lutz, R. B., Graw, J., Masaki, S., Dobson, C. M., MacPhee, C. E. & Quinlan, R. A., Nov 2002, In : The EMBO Journal. 21, 22, p. 6005-6014 10 p.

Research output: Contribution to journalArticle

Crystallins
Cataract
Agglomeration
Amyloid
Lenses
123 Citations (Scopus)

Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

Muqit, M. M. K., Abou-Sleiman, P. M., Saurin, A. T., Harvey, K., Gandhi, S., Deas, E., Eaton, S., Payne Smith, M. D., Venner, K., Matilla, A., Healy, D. G., Gilks, W. P., Lees, A. J., Holton, J., Revesz, T., Parker, P. J., Harvey, R. J., Wood, N. W. & Latchman, D. S., Jul 2006, In : Journal of Neurochemistry. 98, 1, p. 156-169 14 p.

Research output: Contribution to journalArticle

Parkinson Disease
Lewy Bodies
Mitochondria
Mitochondrial Proteins
Brain
48 Downloads (Pure)

Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice

Kline, R. A., Dissanayake, K. N., Hurtado, M. L., Martínez, N. W., Ahl, A., Mole, A. J., Lamont, D. J., Court, F. A., Ribchester, R. R., Wishart, T. M. & Murray, L. M., 1 Oct 2019, In : Neurobiology of Disease. 130, p. 1-16 16 p., 104496.

Research output: Contribution to journalArticle

Open Access
File
Wallerian Degeneration
Energy Metabolism
Axons
Oxidative Phosphorylation
Wounds and Injuries
1 Citation (Scopus)

Alternate thermoregulation and functional binding of Escherichia coli type 1 fimbriae in environmental and animal isolates

Marshall, J., Rossez, Y., Mainda, G., Gally, D. L., Daniell, T. J. & Holden, N. J., Nov 2016, In : FEMS Microbiology Letters. 363, 22, p. 1-8 8 p.

Research output: Contribution to journalArticle

Mannans
Body Temperature Regulation
Escherichia coli
Plant Roots
Temperature
22 Citations (Scopus)

Alternative polyadenylation of antisense RNAs and flowering time control

Hornyik, C., Duc, C., Rataj, K., Terzi, L. C. & Simpson, G. G., Aug 2010, In : Biochemical Society Transactions. 38, p. 1077-1081 5 p.

Research output: Contribution to journalArticle

216 Citations (Scopus)

Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis

Kalyna, M., Simpson, C. G., Syed, N. H., Lewandowska, D., Marquez, Y., Kusenda, B., Marshall, J., Fuller, J., Cardle, L., McNicol, J., Dinh, H. Q., Barta, A. & Brown, J. W. S., Mar 2012, In : Nucleic Acids Research. 40, 6, p. 2454-2469 16 p.

Research output: Contribution to journalArticle

242 Citations (Scopus)

Alternative splicing at the intersection of biological timing, development, and stress responses

Staiger, D. & Brown, J. W. S., Oct 2013, In : Plant Cell. 25, 10, p. 3640-56 17 p.

Research output: Contribution to journalArticle

alternative splicing
Alternative Splicing
stress response
Genes
Circadian Clocks
29 Citations (Scopus)

Alternative splicing in plants

Simpson, C. G., Lewandowska, D., Fuller, J., Maronova, M., Kalyna, M., Davidson, D., McNicol, J., Raczynska, D., Jarmolowski, A., Barta, A. & Brown, J. W. S., 2008, In : Biochemical Society Transactions. 36, 3, p. 508-10 3 p.

Research output: Contribution to journalArticle

Alternative Splicing
Genes
Proteome
Transcription
Regulator Genes
209 Citations (Scopus)

Alternative splicing in plants-coming of age

Hasan-Syed, N., Kalyna, M., Marquez, Y., Barta, A. & Brown, J. W. S., 2012, In : Trends in Plant Science. 17, 10, p. 616-623 8 p.

Research output: Contribution to journalArticle

alternative splicing
plant age
plant adaptation
gene expression regulation
introns
182 Citations (Scopus)

Alternative splicing mediates responses of the Arabidopsis circadian clock to temperature changes

James, A. B., Syed, N. H., Bordage, S., Marshall, J., Nimmo, G. A., Jenkins, G. I., Herzyk, P., Brown, J. W. S. & Nimmo, H. G., 2012, In : Plant Cell. 24, 3, p. 961-981 21 p.

Research output: Contribution to journalArticle

Circadian Clocks
alternative splicing
Alternative Splicing
Arabidopsis
circadian rhythm
8 Citations (Scopus)
118 Downloads (Pure)

Alternative splicing of barley clock genes in response to low temperature: evidence for alternative splicing conservation

Calixto, C. P. G., Simpson, C. G., Waugh, R. & Brown, J. W. S., 13 Dec 2016, In : PLoS ONE. 11, 12, p. 1-24 24 p., e0168028.

Research output: Contribution to journalArticle

Open Access
File
alternative splicing
Alternative Splicing
Hordeum
Clocks
Conservation

Alternative Splicing of Circadian Clock Genes Correlates With Temperature in Field-Grown Sugarcane

Dantas, L. L. B., Calixto, C. P. G., Dourado, M. M., Carneiro, M. S., Brown, J. W. S. & Hotta, C. T., 23 Dec 2019, In : Frontiers in Plant Science. 10, p. 1-15 15 p., 1614.

Research output: Contribution to journalArticle

Open Access
File
alternative splicing
circadian rhythm
sugarcane
temperature
genes
5 Citations (Scopus)

Alternative splicing of mini-exons in the Arabidopsis leaf rust receptor-like kinase LRK10 genes affects subcellular localisation

Shin, K. H., Yang, S. H., Lee, J. Y., Lim, C. W., Lee, S. C., Brown, J. W. S. & Kim, S. H., Mar 2015, In : Plant Cell Reports. 34, 3, p. 495-505 11 p.

Research output: Contribution to journalArticle

leaf rust
alternative splicing
exons
phosphotransferases (kinases)
Arabidopsis
37 Citations (Scopus)

Alternative splicing of the human IgA Fc receptor CD89 in neutrophils and eosinophils

Pleass, R. J., Andrews, P. D., Kerr, M. A. & Woof, J. M., 15 Sep 1996, In : Biochemical Journal. 318, 3, p. 771-777 7 p.

Research output: Contribution to journalArticle

Fc Receptors
Alternative Splicing
Eosinophils
Immunoglobulin A
Neutrophils
10 Citations (Scopus)

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

Cookson, T. V. M., Castell, A., Bulloch, E. M. M., Evans, G. L., Short, F. L., Baker, E. N., Lott, J. S. & Parker, E. J., 9 Apr 2014, In : Biochemical Journal. 461, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

Anthranilate Phosphoribosyltransferase
Mycobacterium tuberculosis
Phosphoribosyl Pyrophosphate
Substrates
Catalytic Domain
39 Citations (Scopus)
58 Downloads (Pure)

AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia

Virts, E. L., Jankowska, A., Mackay, C., Glaas, M. F., Wiek, C., Kelich, S. L., Lottmann, N., Kennedy, F. M., Marchal, C., Lehnert, E., Scharf, R. E., Dufour, C., Lanciotti, M., Farruggia, P., Santoro, A., Savasan, S., Scheckenbach, K., Schipper, J., Wagenmann, M., Lewis, T. & 12 others, Leffak, M., Farlow, J. L., Foroud, T. M., Honisch, E., Niederacher, D., Chakraborty, S. C., Vance, G. H., Pruss, D., Timms, K. M., Lanchbury, J. S., Alpi, A. F. & Hanenberg, H., 15 Sep 2015, In : Human Molecular Genetics. 24, 18, p. 5093-5108 16 p.

Research output: Contribution to journalArticle

Open Access
File
Fanconi Anemia
Adult Stem Cells
Exons
Germ-Line Mutation
Mothers
60 Citations (Scopus)

A mass balance based numerical method for the fractional advection-dispersion equation: theory and application

Zhang, X., Crawford, J. W., Deeks, L. K., Stutter, M. I., Bengough, A. G. & Young, I. M., 27 Jul 2005, In : Water Resources Research. 41, 7, p. - 11 p., W07029.

Research output: Contribution to journalArticle

17 Citations (Scopus)

A mathematical approach to studying fungal mycelia

Boswell, G., Jacobs, H., Ritz, K., Gadd, G. & Davidson, F., Nov 2003, In : Mycologist. 17, 4, p. 165-171 7 p.

Research output: Contribution to journalArticle

mycelium
mathematical models
prediction
microbial growth
fungi
20 Citations (Scopus)

A mathematical model of mucilage expansion in myxospermous seeds of Capsella bursa-pastoris (shepherd's purse)

Deng, W., Jeng, D-S., Toorop, P. E., Squire, G. R. & Iannetta, P. P. M., Feb 2012, In : Annals of Botany. 109, 2, p. 419-427 9 p.

Research output: Contribution to journalArticle

67 Citations (Scopus)

A mechanical signal transmitted by the flagellum controls signalling in Bacillus subtilis

Cairns, L. S., Marlow, V. L., Bissett, E., Ostrowski, A. & Stanley-Wall, N. R., Oct 2013, In : Molecular Microbiology. 90, 1, p. 6-21 16 p.

Research output: Contribution to journalArticle

Flagella
Biofilms
Bacillus subtilis
Signal Transduction
Exopeptidases
249 Citations (Scopus)

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

Wilkinson, S. R., Taylor, M. C., Horn, D., Kelly, J. M. & Cheeseman, I., 1 Apr 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 13, p. 5022-5027 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
154 Downloads (Pure)

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis

Naeem, A. S., Tommasi, C., Cole, C., Brown, S. J., Zhu, Y., Way, B., Willis Owen, S. A. G., Moffatt, M., Cookson, W. O., Harper, J. I., Di, W. L., Brown, S. J., Reinheckel, T. & O'Shaughnessy, R. F. L., Apr 2017, In : Journal of Allergy and Clinical Immunology. 139, 4, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

Open Access
File
Cathepsin H
Thymoma
Atopic Dermatitis
Oncogenes
Skin
9 Citations (Scopus)
81 Downloads (Pure)

A metagenetics approach to determine the diversity and distribution of cyst nematodes at the level of the country, the field and the individual

Eves-van den Akker, S., Lilley, C. J., Reid, A., Pickup, J., Anderson, E., Cock, P. J. A., Blaxter, M., Urwin, P. E., Jones, J. T. & Blok, V. C., Dec 2015, In : Molecular Ecology. 24, 23, p. 5842-5851 10 p.

Research output: Contribution to journalArticle

Open Access
File
cyst nematodes
Solanum tuberosum
cyst
potato
nematode
7 Citations (Scopus)
103 Downloads (Pure)

A method for automatic segmentation and splitting of hyperspectral images of raspberry plants collected in field conditions

Williams, D., Britten, A., McCallum, S., Jones, H., Aitkenhead, M., Karley, A., Loades, K., Prashar, A. & Graham, J., 1 Nov 2017, In : Plant Methods. 13, p. 1-12 12 p., 74.

Research output: Contribution to journalArticle

Open Access
File
hyperspectral imagery
raspberries
methodology
reflectance
Rubus
305 Citations (Scopus)

A method for genetically installing site-specific acetylation in recombinant histories defines the effects of H3 K56 acetylation

Neumann, H., Hancock, S. M., Buning, R., Routh, A., Chapman, L., Somers, J., Owen-Hughes, T., van Noort, J., Rhodes, D. & Chin, J. W., 9 Oct 2009, In : Molecular Cell. 36, 1, p. 153-163 11 p.

Research output: Contribution to journalArticle

184 Citations (Scopus)

A methyl transferase links the circadian clock to the regulation of alternative splicing

Sanchez, S. E., Petrillo, E., Beckwith, E. J., Zhang, X., Rugnone, M. L., Hernando, C. E., Cuevas, J. C., Godoy Herz, M. A., Depetris-Chauvin, A., Simpson, C. G., Brown, J. W. S., Cerdán, P. D., Borevitz, J. O., Mas, P., Ceriani, M. F., Kornblihtt, A. R. & Yanovsky, M. J., 2010, In : Nature. 468, 7320, p. 112-116 5 p.

Research output: Contribution to journalArticle

Circadian Clocks
Alternative Splicing
Transferases
Arginine
Circadian Rhythm
50 Citations (Scopus)

A microarray-based high throughput molecular marker genotyping method: the tagged microarray marker (TAM) approach

Flavell, A. J., Bolshakov, V. N., Booth, A., Jing, R., Russell, J., Ellis, T. H. N. & Isaac, P., Oct 2003, In : Nucleic Acids Research. 31, 19, p. e115

Research output: Contribution to journalArticle

Glass
Polymerase Chain Reaction
DNA Primers
Streptavidin
DNA Probes
30 Citations (Scopus)

A microprocessor-controlled psychomotor tester for minimal access surgery

Hanna, G. B., Drew, T., Clinch, P., Hunter, B., Shimi, S., Dunkley, M. P. & Cuschieri, A., Oct 1996, In : Surgical Endoscopy. 10, 10, p. 965-968 4 p.

Research output: Contribution to journalArticle

1472 Citations (Scopus)

A microRNA in a multiple-turnover RNAi enzyme complex

Hutvagner, G. & Zamore, P. D., 2002, In : Science. 297, 5589, p. 2056-2060 5 p.

Research output: Contribution to journalArticle

RNA Interference
MicroRNAs
Enzymes
RNA
Small Interfering RNA
19 Citations (Scopus)

Amide bond replacements: incorporation of a 2,5,5-trisubstituted imidazoline into dipeptides and into a CCK-4 derivative

Gilbert, I., Rees, D. C. & Richardson, R. S., 13 May 1991, In : Tetrahedron Letters. 32, 20, p. 2277-2280 4 p.

Research output: Contribution to journalArticle

51 Citations (Scopus)
Amiloride
Biosynthesis
Amplification
Lipopolysaccharides
Anti-Inflammatory Agents
90 Downloads (Pure)

Amine Containing Analogs of Sulindac for Cancer Prevention

Mathew, B., Hobrath, J. V., Connelly, M. C., Guy, R. K. & Reynolds, R. C., 31 Jan 2018, In : Open Medicinal Chemistry Journal. 12, p. 1-12 12 p.

Research output: Contribution to journalArticle

Open Access
File
Sulindac
Amines
Libraries
Neoplasms
Adenomatous Polyps
6 Citations (Scopus)
44 Downloads (Pure)

A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

Hulshof, L., Hack, D. P., Hasnoe, Q. C. J., Dontje, B., Jakasa, I., Riethmüller, C., McLean, W. H. I., van Aalderen, W. M. C., Van't Land, B., Kezic, S., Sprikkelman, A. B. & Middelkamp-Hup, M. A., 10 Jul 2018, In : British Journal of Dermatology. 10 p.

Research output: Contribution to journalArticle

Open Access
File
Atopic Dermatitis
Skin
Biomarkers
Interleukins
Chemokine CCL8
24 Citations (Scopus)
100 Downloads (Pure)

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice

Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. & Finlay, D. K., 14 Jun 2018, In : Nature Communications. 9, 1, p. 1-15 15 p., 2341.

Research output: Contribution to journalArticle

Open Access
File
Natural Killer Cells
mice
amino acids
Lymphocytes
Glutamine